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Illumina Body Map 2
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Results for SPIC
Z-value: 3.23
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Transcription factors associated with SPIC
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SPIC | hg19_v2_chr12_+_101869096_101869199 | 0.15 | 4.0e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of SPIC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 50.2 | GO:0038094 | Fc-gamma receptor signaling pathway(GO:0038094) |
| 0.3 | 33.6 | GO:0032945 | negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672) |
| 3.1 | 31.2 | GO:0000821 | regulation of arginine metabolic process(GO:0000821) |
| 8.6 | 25.7 | GO:0034125 | negative regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034125) |
| 0.0 | 25.1 | GO:0050776 | regulation of immune response(GO:0050776) |
| 0.6 | 23.0 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.9 | 22.7 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.8 | 22.0 | GO:0035589 | G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589) |
| 0.6 | 19.5 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 19.1 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 107.2 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 88.4 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.2 | 76.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.4 | 43.8 | GO:0035577 | azurophil granule membrane(GO:0035577) |
| 0.0 | 38.1 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.3 | 31.0 | GO:0101003 | ficolin-1-rich granule membrane(GO:0101003) |
| 2.1 | 20.5 | GO:0032010 | phagolysosome(GO:0032010) |
| 1.1 | 20.3 | GO:0031209 | SCAR complex(GO:0031209) |
| 1.5 | 20.0 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 0.1 | 17.5 | GO:0031225 | anchored component of membrane(GO:0031225) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 46.6 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.1 | 32.0 | GO:0003823 | antigen binding(GO:0003823) |
| 1.3 | 29.6 | GO:0015174 | basic amino acid transmembrane transporter activity(GO:0015174) |
| 0.1 | 29.0 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.6 | 23.1 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.2 | 22.5 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.8 | 22.0 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 1.1 | 20.2 | GO:0016176 | superoxide-generating NADPH oxidase activator activity(GO:0016176) |
| 0.7 | 19.5 | GO:0008349 | MAP kinase kinase kinase kinase activity(GO:0008349) |
| 1.6 | 19.0 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 92.5 | PID BCR 5PATHWAY | BCR signaling pathway |
| 0.7 | 45.8 | PID INTEGRIN2 PATHWAY | Beta2 integrin cell surface interactions |
| 0.3 | 30.5 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 21.9 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 19.4 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 18.3 | PID CMYB PATHWAY | C-MYB transcription factor network |
| 0.4 | 16.1 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 13.4 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.4 | 12.7 | PID ANTHRAX PATHWAY | Cellular roles of Anthrax toxin |
| 0.3 | 11.8 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 85.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.1 | 47.6 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.6 | 46.7 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.6 | 41.3 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.1 | 34.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.5 | 29.0 | REACTOME BASIGIN INTERACTIONS | Genes involved in Basigin interactions |
| 0.1 | 25.6 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.9 | 21.8 | REACTOME P2Y RECEPTORS | Genes involved in P2Y receptors |
| 0.1 | 21.5 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.4 | 20.4 | REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS | Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis |