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Illumina Body Map 2
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Results for TBX15_MGA
Z-value: 1.52
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Transcription factors associated with TBX15_MGA
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX15 | hg19_v2_chr1_-_119530428_119530572 | 0.10 | 5.7e-01 | Click! |
| MGA | hg19_v2_chr15_+_41952591_41952672 | 0.03 | 8.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX15_MGA
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.1 | GO:0035235 | ionotropic glutamate receptor signaling pathway(GO:0035235) |
| 0.0 | 14.0 | GO:0010466 | negative regulation of peptidase activity(GO:0010466) |
| 0.2 | 9.6 | GO:0097120 | receptor localization to synapse(GO:0097120) |
| 0.1 | 7.1 | GO:0007602 | phototransduction(GO:0007602) |
| 0.3 | 6.1 | GO:0007196 | adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196) |
| 2.0 | 6.0 | GO:2000854 | positive regulation of corticosterone secretion(GO:2000854) |
| 0.3 | 5.4 | GO:2000766 | negative regulation of cytoplasmic translation(GO:2000766) |
| 0.0 | 5.4 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 1.8 | 5.3 | GO:0051466 | positive regulation of corticotropin-releasing hormone secretion(GO:0051466) |
| 0.2 | 5.2 | GO:0032793 | positive regulation of CREB transcription factor activity(GO:0032793) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 19.0 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 15.6 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.1 | 14.2 | GO:0030018 | Z disc(GO:0030018) |
| 0.3 | 14.1 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.3 | 13.8 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.1 | 11.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.1 | 8.0 | GO:0030286 | dynein complex(GO:0030286) |
| 0.0 | 7.2 | GO:0098793 | presynapse(GO:0098793) |
| 0.0 | 6.6 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.2 | 6.1 | GO:0005922 | connexon complex(GO:0005922) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 14.7 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.3 | 13.6 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.1 | 13.3 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 12.4 | GO:0005525 | GTP binding(GO:0005525) |
| 1.6 | 9.7 | GO:0019828 | aspartic-type endopeptidase inhibitor activity(GO:0019828) |
| 0.1 | 9.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.2 | 8.7 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.4 | 8.4 | GO:0045504 | dynein heavy chain binding(GO:0045504) |
| 0.2 | 7.7 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.2 | 7.0 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 6.3 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.0 | 6.0 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.0 | 6.0 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.0 | 5.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.1 | 4.9 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 4.6 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.1 | 4.3 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.1 | 3.9 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 3.9 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 18.3 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 8.3 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.2 | 6.5 | REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS | Genes involved in Na+/Cl- dependent neurotransmitter transporters |
| 0.2 | 6.3 | REACTOME SIGNALING BY NODAL | Genes involved in Signaling by NODAL |
| 0.2 | 5.9 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.1 | 5.1 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.1 | 4.9 | REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING | Genes involved in Downregulation of ERBB2:ERBB3 signaling |
| 0.2 | 4.7 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |
| 0.0 | 4.7 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.1 | 4.6 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |