ISMARA results: TCF12

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Illumina Body Map 2

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Results for TCF12_ASCL2

Z-value: 2.16

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Transcription factors associated with TCF12_ASCL2

Gene Symbol	Gene ID	Gene Info
TCF12 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000140262.13	transcription factor 12
ASCL2 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000183734.4	achaete-scute family bHLH transcription factor 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ASCL2	hg19_v2_chr11_-_2292182_2292212	0.19	2.9e-01	Click!
TCF12	hg19_v2_chr15_+_57211318_57211355	-0.18	3.3e-01	Click!

Activity profile of TCF12_ASCL2 motif

Sorted Z-values of TCF12_ASCL2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr17_-_39258461 Show fit	8.43	ENST00000440582.1	KRTAP4-16P Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin associated protein 4-16, pseudogene
chr22_+_22730353 Show fit	8.29	ENST00000390296.2	IGLV5-45 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 5-45
chr16_+_23847267 Show fit	8.27	ENST00000321728.7	PRKCB Ensembl NCBI GeneCards UniProt NextProt Show fit	protein kinase C, beta
chr1_+_27668505 Show fit	7.01	ENST00000318074.5	SYTL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	synaptotagmin-like 1
chr16_+_23847339 Show fit	7.01	ENST00000303531.7	PRKCB Ensembl NCBI GeneCards UniProt NextProt Show fit	protein kinase C, beta
chr5_-_176936844 Show fit	6.66	ENST00000510380.1 ENST00000510898.1 ENST00000357198.4	DOK3 Ensembl NCBI GeneCards UniProt NextProt Show fit	docking protein 3
chr22_-_37882395 Show fit	6.40	ENST00000416983.3 ENST00000424765.2 ENST00000356998.3	MFNG Ensembl NCBI GeneCards UniProt NextProt Show fit	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr22_+_22707260 Show fit	6.38	ENST00000390293.1	IGLV5-48 Ensembl NCBI GeneCards UniProt NextProt Show fit	immunoglobulin lambda variable 5-48 (non-functional)
chr16_+_23847355 Show fit	6.10	ENST00000498058.1	PRKCB Ensembl NCBI GeneCards UniProt NextProt Show fit	protein kinase C, beta
chr5_-_176936817 Show fit	5.64	ENST00000502885.1 ENST00000506493.1	DOK3 Ensembl NCBI GeneCards UniProt NextProt Show fit	docking protein 3

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF12_ASCL2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	93.5	GO:0002377	immunoglobulin production(GO:0002377)
0.9	76.7	GO:0006910	phagocytosis, recognition(GO:0006910)
0.6	76.7	GO:0006958	complement activation, classical pathway(GO:0006958)
0.0	23.6	GO:0043312	neutrophil activation involved in immune response(GO:0002283) neutrophil degranulation(GO:0043312)
0.1	21.5	GO:0002250	adaptive immune response(GO:0002250)
5.3	21.4	GO:0035408	histone H3-T6 phosphorylation(GO:0035408)
3.1	15.4	GO:0000738	DNA catabolic process, exonucleolytic(GO:0000738)
0.2	15.2	GO:0002260	lymphocyte homeostasis(GO:0002260)
0.2	13.5	GO:0042100	B cell proliferation(GO:0042100)
0.4	10.5	GO:0090023	positive regulation of neutrophil chemotaxis(GO:0090023)

Showing 1 to 10 of 715 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	74.1	GO:0042571	immunoglobulin complex, circulating(GO:0042571)
0.0	40.0	GO:0005615	extracellular space(GO:0005615)
0.3	29.9	GO:0101003	ficolin-1-rich granule membrane(GO:0101003)
0.7	25.8	GO:0042101	T cell receptor complex(GO:0042101)
0.1	17.6	GO:0072562	blood microparticle(GO:0072562)
0.1	15.2	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3	13.0	GO:0042629	mast cell granule(GO:0042629)
0.1	12.7	GO:1904724	tertiary granule lumen(GO:1904724)
0.1	11.5	GO:0015030	Cajal body(GO:0015030)
0.1	11.5	GO:0035578	azurophil granule lumen(GO:0035578)

Showing 1 to 10 of 288 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	150.0	GO:0003823	antigen binding(GO:0003823)
1.2	78.8	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.0	26.1	GO:0005096	GTPase activator activity(GO:0005096)
5.3	21.4	GO:0035403	histone kinase activity (H3-T6 specific)(GO:0035403)
0.2	20.7	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
5.1	15.4	GO:0008859	exoribonuclease II activity(GO:0008859)
0.3	12.3	GO:0042287	MHC protein binding(GO:0042287)
0.7	11.1	GO:0042608	T cell receptor binding(GO:0042608)
0.9	10.4	GO:0030369	ICAM-3 receptor activity(GO:0030369)
0.2	10.4	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)

Showing 1 to 10 of 447 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	44.9	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
1.0	27.8	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.3	27.8	PID BCR 5PATHWAY	BCR signaling pathway
0.3	21.3	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.2	17.9	PID IL12 2PATHWAY	IL12-mediated signaling events
0.2	12.7	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.0	9.9	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.2	9.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	9.2	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.3	9.1	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5

Showing 1 to 10 of 87 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	30.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.3	25.9	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.3	22.7	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.5	21.4	REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS	Genes involved in Trafficking of GluR2-containing AMPA receptors
0.2	20.2	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	16.5	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.1	12.1	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.4	11.1	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.4	9.8	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
0.0	8.4	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events

Showing 1 to 10 of 129 entries

Results for TCF12_ASCL2

Z-value: 2.16

Motif logo

Transcription factors associated with TCF12_ASCL2

Activity-expression correlation:

Activity profile of TCF12_ASCL2 motif

Sorted Z-values of TCF12_ASCL2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF12_ASCL2

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: