ISMARA results: TCF21

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Illumina Body Map 2

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Results for TCF21

Z-value: 1.37

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Transcription factors associated with TCF21

Gene Symbol	Gene ID	Gene Info
TCF21 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000118526.6	transcription factor 21

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
TCF21	hg19_v2_chr6_+_134210243_134210276	0.02	9.2e-01	Click!

Activity profile of TCF21 motif

Sorted Z-values of TCF21 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr19_-_45826125 Show fit	5.92	ENST00000221476.3	CKM Ensembl NCBI GeneCards UniProt NextProt Show fit	creatine kinase, muscle
chr11_+_1944054 Show fit	4.65	ENST00000397301.1 ENST00000397304.2 ENST00000446240.1	TNNT3 Ensembl NCBI GeneCards UniProt NextProt Show fit	troponin T type 3 (skeletal, fast)
chr17_+_45286387 Show fit	3.72	ENST00000572316.1 ENST00000354968.1 ENST00000576874.1 ENST00000536623.2	MYL4 Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin, light chain 4, alkali; atrial, embryonic
chr1_+_171154347 Show fit	3.47	ENST00000209929.7 ENST00000441535.1	FMO2 Ensembl NCBI GeneCards UniProt NextProt Show fit	flavin containing monooxygenase 2 (non-functional)
chr16_-_31439735 Show fit	3.16	ENST00000287490.4	COX6A2 Ensembl NCBI GeneCards UniProt NextProt Show fit	cytochrome c oxidase subunit VIa polypeptide 2
chr3_+_8775466 Show fit	2.94	ENST00000343849.2 ENST00000397368.2	CAV3 Ensembl NCBI GeneCards UniProt NextProt Show fit	caveolin 3
chr17_+_4487294 Show fit	2.81	ENST00000338859.4	SMTNL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	smoothelin-like 2
chr3_+_148583043 Show fit	2.73	ENST00000296046.3	CPA3 Ensembl NCBI GeneCards UniProt NextProt Show fit	carboxypeptidase A3 (mast cell)
chr8_+_86351056 Show fit	2.63	ENST00000285381.2	CA3 Ensembl NCBI GeneCards UniProt NextProt Show fit	carbonic anhydrase III, muscle specific
chr2_-_152590946 Show fit	2.63	ENST00000172853.10	NEB Ensembl NCBI GeneCards UniProt NextProt Show fit	nebulin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF21

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	12.5	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.4	10.0	GO:0048739	cardiac muscle fiber development(GO:0048739)
0.7	6.7	GO:0070995	NADPH oxidation(GO:0070995)
0.8	6.4	GO:0003065	positive regulation of heart rate by epinephrine(GO:0003065)
0.3	5.9	GO:0006600	creatine metabolic process(GO:0006600)
0.0	4.0	GO:0030449	regulation of complement activation(GO:0030449)
0.1	3.8	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4	3.1	GO:2001288	positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.4	2.8	GO:0048014	Tie signaling pathway(GO:0048014)
0.1	2.7	GO:0035090	maintenance of apical/basal cell polarity(GO:0035090) maintenance of epithelial cell apical/basal polarity(GO:0045199)

Showing 1 to 10 of 189 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	19.5	GO:0030018	Z disc(GO:0030018)
0.1	12.3	GO:0031672	A band(GO:0031672)
0.3	6.9	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
0.2	4.6	GO:0005861	troponin complex(GO:0005861)
0.0	3.8	GO:0090575	RNA polymerase II transcription factor complex(GO:0090575)
0.2	3.6	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	3.2	GO:0045095	keratin filament(GO:0045095)
0.1	3.0	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	2.8	GO:0000118	histone deacetylase complex(GO:0000118)
0.1	2.7	GO:0009925	basal plasma membrane(GO:0009925)

Showing 1 to 10 of 83 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	22.2	GO:0008307	structural constituent of muscle(GO:0008307)
0.8	7.2	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
1.2	6.2	GO:0032038	myosin II heavy chain binding(GO:0032038)
0.6	5.9	GO:0004111	creatine kinase activity(GO:0004111)
0.0	5.2	GO:0004222	metalloendopeptidase activity(GO:0004222)
0.0	5.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.2	4.6	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.1	4.2	GO:0004129	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.1	4.1	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.1	3.2	GO:0004181	metallocarboxypeptidase activity(GO:0004181)

Showing 1 to 10 of 119 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	5.6	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.0	3.8	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	3.8	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.0	3.1	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	3.1	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.0	3.0	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	2.9	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0	2.8	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling
0.0	2.5	PID ILK PATHWAY	Integrin-linked kinase signaling
0.0	2.3	PID ENDOTHELIN PATHWAY	Endothelins

Showing 1 to 10 of 32 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	16.8	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.1	7.2	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.0	3.6	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.0	3.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	2.8	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	2.8	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	2.6	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.1	2.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	2.2	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1	2.0	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators

Showing 1 to 10 of 48 entries

Results for TCF21

Z-value: 1.37

Motif logo

Transcription factors associated with TCF21

Activity-expression correlation:

Activity profile of TCF21 motif

Sorted Z-values of TCF21 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF21

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: