ISMARA results: TCF3

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Illumina Body Map 2

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Results for TCF3_MYOG

Z-value: 2.15

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Transcription factors associated with TCF3_MYOG

Gene Symbol	Gene ID	Gene Info
TCF3 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000071564.10	transcription factor 3
MYOG Ensembl NCBI GeneCards UniProt NextProt	ENSG00000122180.4	myogenin

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MYOG	hg19_v2_chr1_-_203055129_203055164	0.30	9.2e-02	Click!
TCF3	hg19_v2_chr19_-_1652575_1652621	-0.03	8.7e-01	Click!

Activity profile of TCF3_MYOG motif

Sorted Z-values of TCF3_MYOG motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr9_-_35689900 Show fit	13.70	ENST00000378300.5 ENST00000329305.2 ENST00000360958.2	TPM2 Ensembl NCBI GeneCards UniProt NextProt Show fit	tropomyosin 2 (beta)
chr19_-_45826125 Show fit	12.92	ENST00000221476.3	CKM Ensembl NCBI GeneCards UniProt NextProt Show fit	creatine kinase, muscle
chr2_+_220283091 Show fit	9.94	ENST00000373960.3	DES Ensembl NCBI GeneCards UniProt NextProt Show fit	desmin
chr4_+_114214125 Show fit	8.41	ENST00000509550.1	ANK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin 2, neuronal
chr3_-_195310802 Show fit	8.27	ENST00000421243.1 ENST00000453131.1	APOD Ensembl NCBI GeneCards UniProt NextProt Show fit	apolipoprotein D
chr8_-_33455268 Show fit	7.95	ENST00000522982.1	DUSP26 Ensembl NCBI GeneCards UniProt NextProt Show fit	dual specificity phosphatase 26 (putative)
chr22_+_31489344 Show fit	7.90	ENST00000404574.1	SMTN Ensembl NCBI GeneCards UniProt NextProt Show fit	smoothelin
chr4_+_113970772 Show fit	7.40	ENST00000504454.1 ENST00000394537.3 ENST00000357077.4 ENST00000264366.6	ANK2 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin 2, neuronal
chr1_+_78354330 Show fit	7.36	ENST00000440324.1	NEXN Ensembl NCBI GeneCards UniProt NextProt Show fit	nexilin (F actin binding protein)
chr2_-_152590946 Show fit	7.34	ENST00000172853.10	NEB Ensembl NCBI GeneCards UniProt NextProt Show fit	nebulin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF3_MYOG

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	64.8	GO:0033275	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
1.2	31.7	GO:0048739	cardiac muscle fiber development(GO:0048739)
1.3	19.0	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
1.1	18.1	GO:0006600	creatine metabolic process(GO:0006600)
3.2	15.8	GO:0036371	protein localization to T-tubule(GO:0036371)
1.4	15.7	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.1	15.4	GO:0006936	muscle contraction(GO:0006936)
0.9	13.3	GO:0071688	striated muscle myosin thick filament assembly(GO:0071688)
0.6	12.8	GO:0045475	locomotor rhythm(GO:0045475)
3.2	12.6	GO:0021966	corticospinal neuron axon guidance(GO:0021966)

Showing 1 to 10 of 501 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	86.3	GO:0030018	Z disc(GO:0030018)
0.7	40.4	GO:0031430	M band(GO:0031430)
1.0	33.3	GO:0005865	striated muscle thin filament(GO:0005865)
1.2	27.8	GO:0005861	troponin complex(GO:0005861)
0.8	21.4	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
0.4	17.6	GO:0033017	sarcoplasmic reticulum membrane(GO:0033017)
0.1	16.0	GO:0043204	perikaryon(GO:0043204)
0.0	15.7	GO:0014069	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
1.7	13.3	GO:1990393	3M complex(GO:1990393)
0.1	13.3	GO:0005901	caveola(GO:0005901)

Showing 1 to 10 of 186 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	112.1	GO:0008307	structural constituent of muscle(GO:0008307)
0.1	19.1	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
1.8	18.2	GO:0004111	creatine kinase activity(GO:0004111)
0.3	17.0	GO:0030507	spectrin binding(GO:0030507)
0.1	17.0	GO:0003729	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.8	15.7	GO:0005523	tropomyosin binding(GO:0005523)
0.0	14.0	GO:0003779	actin binding(GO:0003779)
0.4	13.1	GO:0043495	protein anchor(GO:0043495)
3.2	12.6	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.2	12.2	GO:0030332	cyclin binding(GO:0030332)

Showing 1 to 10 of 310 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	33.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.1	14.4	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.1	11.8	PID ILK PATHWAY	Integrin-linked kinase signaling
0.1	10.1	PID AURORA B PATHWAY	Aurora B signaling
0.2	8.7	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.3	8.4	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	8.2	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.2	7.9	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	7.9	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.1	7.1	PID CDC42 REG PATHWAY	Regulation of CDC42 activity

Showing 1 to 10 of 52 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	64.4	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.7	35.8	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	12.2	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.4	10.8	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	10.7	REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES	Genes involved in Loss of Nlp from mitotic centrosomes
0.1	10.2	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.3	10.0	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1	9.7	REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE	Genes involved in Nitric oxide stimulates guanylate cyclase
0.1	8.7	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.2	8.1	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction

Showing 1 to 10 of 86 entries

Results for TCF3_MYOG

Z-value: 2.15

Motif logo

Transcription factors associated with TCF3_MYOG

Activity-expression correlation:

Activity profile of TCF3_MYOG motif

Sorted Z-values of TCF3_MYOG motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF3_MYOG

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: