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Illumina Body Map 2
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Results for TCF7L1
Z-value: 1.09
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Transcription factors associated with TCF7L1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF7L1 | hg19_v2_chr2_+_85360499_85360598 | -0.55 | 1.0e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF7L1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 10.1 | GO:0061152 | trachea submucosa development(GO:0061152) trachea gland development(GO:0061153) |
| 0.2 | 9.9 | GO:0045577 | regulation of B cell differentiation(GO:0045577) |
| 0.1 | 7.6 | GO:0006509 | membrane protein ectodomain proteolysis(GO:0006509) |
| 0.3 | 6.7 | GO:0060670 | branching involved in labyrinthine layer morphogenesis(GO:0060670) |
| 0.1 | 6.3 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.5 | 6.0 | GO:2000334 | blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334) |
| 0.1 | 4.9 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
| 0.5 | 4.8 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.6 | 4.5 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
| 0.9 | 4.4 | GO:0000117 | regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 13.9 | GO:1990907 | beta-catenin-TCF complex(GO:1990907) |
| 0.2 | 7.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 1.5 | 6.1 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.0 | 5.9 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 5.0 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.5 | 4.8 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.1 | 4.6 | GO:0030673 | axolemma(GO:0030673) |
| 0.2 | 4.4 | GO:0031932 | TORC2 complex(GO:0031932) |
| 0.1 | 4.1 | GO:0005719 | nuclear euchromatin(GO:0005719) |
| 0.3 | 3.9 | GO:0097486 | multivesicular body lumen(GO:0097486) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 14.3 | GO:0045295 | gamma-catenin binding(GO:0045295) |
| 0.5 | 6.0 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.0 | 5.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 5.5 | GO:0008201 | heparin binding(GO:0008201) |
| 0.3 | 5.2 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.1 | 4.8 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.0 | 4.8 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.0 | 4.7 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 4.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.2 | 4.3 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.8 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.1 | 10.6 | PID IL2 1PATHWAY | IL2-mediated signaling events |
| 0.1 | 6.1 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 4.8 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.0 | 4.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.2 | PID NFAT TFPATHWAY | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| 0.1 | 4.1 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.1 | 3.9 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 3.9 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.8 | PID AP1 PATHWAY | AP-1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 6.0 | REACTOME ANTIGEN PROCESSING CROSS PRESENTATION | Genes involved in Antigen processing-Cross presentation |
| 0.2 | 4.8 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 4.8 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 4.3 | REACTOME EFFECTS OF PIP2 HYDROLYSIS | Genes involved in Effects of PIP2 hydrolysis |
| 0.1 | 4.1 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 3.9 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.0 | 2.9 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 2.9 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 2.6 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |