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Illumina Body Map 2
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Results for TEAD3_TEAD1
Z-value: 4.56
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Transcription factors associated with TEAD3_TEAD1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TEAD1 | hg19_v2_chr11_+_12766583_12766592 | 0.90 | 2.1e-12 | Click! |
| TEAD3 | hg19_v2_chr6_-_35464817_35464894 | 0.79 | 8.3e-08 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TEAD3_TEAD1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 70.6 | GO:0003301 | physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049) |
| 2.4 | 61.1 | GO:0048739 | cardiac muscle fiber development(GO:0048739) |
| 2.4 | 60.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.0 | 56.1 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.3 | 54.1 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 0.4 | 52.0 | GO:0002027 | regulation of heart rate(GO:0002027) |
| 9.8 | 39.2 | GO:0014724 | regulation of twitch skeletal muscle contraction(GO:0014724) |
| 0.6 | 38.5 | GO:2000249 | regulation of actin cytoskeleton reorganization(GO:2000249) |
| 0.2 | 37.6 | GO:0048706 | embryonic skeletal system development(GO:0048706) |
| 0.5 | 35.6 | GO:0048747 | muscle fiber development(GO:0048747) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 178.5 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 84.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 4.3 | 78.2 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.3 | 52.5 | GO:0042383 | sarcolemma(GO:0042383) |
| 2.0 | 52.0 | GO:0032982 | myosin filament(GO:0032982) |
| 0.2 | 51.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.7 | 42.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.1 | 40.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.1 | 40.1 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 37.8 | GO:0005769 | early endosome(GO:0005769) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 121.4 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 1.7 | 75.4 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 1.5 | 63.8 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 1.8 | 56.9 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 56.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.4 | 45.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 40.1 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.1 | 39.8 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.1 | 36.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.1 | 35.0 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 33.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.3 | 31.0 | PID NOTCH PATHWAY | Notch signaling pathway |
| 0.3 | 30.7 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.5 | 29.6 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.7 | 28.3 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.3 | 25.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.9 | 25.4 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.6 | 24.1 | PID WNT CANONICAL PATHWAY | Canonical Wnt signaling pathway |
| 0.1 | 23.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 21.3 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 144.5 | REACTOME MUSCLE CONTRACTION | Genes involved in Muscle contraction |
| 1.6 | 82.3 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.3 | 37.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 1.0 | 36.4 | REACTOME SIGNALING BY HIPPO | Genes involved in Signaling by Hippo |
| 0.9 | 33.9 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 30.5 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.3 | 28.7 | REACTOME NETRIN1 SIGNALING | Genes involved in Netrin-1 signaling |
| 0.6 | 25.7 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.6 | 25.2 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.7 | 19.5 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |