ISMARA results: TFAP4

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Illumina Body Map 2

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Results for TFAP4_MSC

Z-value: 2.05

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Transcription factors associated with TFAP4_MSC

Gene Symbol	Gene ID	Gene Info
TFAP4 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000090447.7	transcription factor AP-4
MSC Ensembl NCBI GeneCards UniProt NextProt	ENSG00000178860.8	musculin

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
MSC	hg19_v2_chr8_-_72756667_72756736	-0.52	2.3e-03	Click!
TFAP4	hg19_v2_chr16_-_4323015_4323076	-0.14	4.5e-01	Click!

Activity profile of TFAP4_MSC motif

Sorted Z-values of TFAP4_MSC motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr2_-_152590946 Show fit	13.64	ENST00000172853.10	NEB Ensembl NCBI GeneCards UniProt NextProt Show fit	nebulin
chr1_+_167063282 Show fit	13.43	ENST00000361200.2	DUSP27 Ensembl NCBI GeneCards UniProt NextProt Show fit	dual specificity phosphatase 27 (putative)
chr14_+_32964258 Show fit	10.84	ENST00000556638.1	AKAP6 Ensembl NCBI GeneCards UniProt NextProt Show fit	A kinase (PRKA) anchor protein 6
chr3_+_8775466 Show fit	10.13	ENST00000343849.2 ENST00000397368.2	CAV3 Ensembl NCBI GeneCards UniProt NextProt Show fit	caveolin 3
chr2_-_175629135 Show fit	9.77	ENST00000409542.1 ENST00000409219.1	CHRNA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cholinergic receptor, nicotinic, alpha 1 (muscle)
chr2_-_175629164 Show fit	9.69	ENST00000409323.1 ENST00000261007.5 ENST00000348749.5	CHRNA1 Ensembl NCBI GeneCards UniProt NextProt Show fit	cholinergic receptor, nicotinic, alpha 1 (muscle)
chr16_+_30383613 Show fit	9.59	ENST00000568749.1	MYLPF Ensembl NCBI GeneCards UniProt NextProt Show fit	myosin light chain, phosphorylatable, fast skeletal muscle
chr4_-_177190364 Show fit	8.88	ENST00000296525.3	ASB5 Ensembl NCBI GeneCards UniProt NextProt Show fit	ankyrin repeat and SOCS box containing 5
chr17_+_65040678 Show fit	7.97	ENST00000226021.3	CACNG1 Ensembl NCBI GeneCards UniProt NextProt Show fit	calcium channel, voltage-dependent, gamma subunit 1
chr2_+_27505260 Show fit	7.50	ENST00000380075.2 ENST00000296098.4	TRIM54 Ensembl NCBI GeneCards UniProt NextProt Show fit	tripartite motif containing 54

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP4_MSC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	22.3	GO:0048630	skeletal muscle tissue growth(GO:0048630)
0.3	20.7	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.9	18.4	GO:0048739	cardiac muscle fiber development(GO:0048739)
3.5	17.4	GO:0007525	somatic muscle development(GO:0007525)
2.0	16.4	GO:1902261	positive regulation of delayed rectifier potassium channel activity(GO:1902261)
2.0	15.8	GO:0035995	detection of muscle stretch(GO:0035995)
2.2	15.2	GO:0032971	regulation of muscle filament sliding(GO:0032971)
0.0	15.2	GO:0016567	protein ubiquitination(GO:0016567)
0.2	14.7	GO:0045214	sarcomere organization(GO:0045214)
0.2	11.7	GO:0007274	neuromuscular synaptic transmission(GO:0007274)

Showing 1 to 10 of 256 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	59.7	GO:0031674	I band(GO:0031674)
1.0	27.8	GO:0005892	acetylcholine-gated channel complex(GO:0005892)
0.5	25.0	GO:0005859	muscle myosin complex(GO:0005859)
1.1	19.2	GO:0014701	junctional sarcoplasmic reticulum membrane(GO:0014701)
0.4	15.3	GO:0090665	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	15.0	GO:0005730	nucleolus(GO:0005730)
0.0	14.8	GO:0005802	trans-Golgi network(GO:0005802)
0.2	14.6	GO:0030017	sarcomere(GO:0030017)
0.3	14.2	GO:0031430	M band(GO:0031430)
0.3	14.0	GO:0043034	costamere(GO:0043034)

Showing 1 to 10 of 111 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	63.9	GO:0008307	structural constituent of muscle(GO:0008307)
1.1	27.8	GO:0022848	acetylcholine-gated cation channel activity(GO:0022848)
0.8	16.4	GO:0008179	adenylate cyclase binding(GO:0008179)
2.9	14.7	GO:0032038	myosin II heavy chain binding(GO:0032038)
0.2	13.5	GO:0018024	histone-lysine N-methyltransferase activity(GO:0018024)
0.0	11.8	GO:0008017	microtubule binding(GO:0008017)
0.1	11.0	GO:0044325	ion channel binding(GO:0044325)
0.2	10.9	GO:0005245	voltage-gated calcium channel activity(GO:0005245)
1.1	10.8	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.8	10.1	GO:0071253	connexin binding(GO:0071253)

Showing 1 to 10 of 180 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	16.4	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.2	13.9	SIG CHEMOTAXIS	Genes related to chemotaxis
0.2	11.7	ST MYOCYTE AD PATHWAY	Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.1	9.0	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.0	5.0	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.1	4.5	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.1	4.2	PID MYC PATHWAY	C-MYC pathway
0.0	4.0	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.1	3.8	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	3.0	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation

Showing 1 to 10 of 37 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	45.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.5	27.8	REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1	21.1	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2	12.6	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	7.2	REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE	Genes involved in Reversible Hydration of Carbon Dioxide
0.1	6.9	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.1	6.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	6.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.1	6.0	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	4.6	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production

Showing 1 to 10 of 76 entries

Results for TFAP4_MSC

Z-value: 2.05

Motif logo

Transcription factors associated with TFAP4_MSC

Activity-expression correlation:

Activity profile of TFAP4_MSC motif

Sorted Z-values of TFAP4_MSC motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of TFAP4_MSC

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: