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Illumina Body Map 2

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Results for TLX1_NFIC

Z-value: 1.96

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Transcription factors associated with TLX1_NFIC

Gene Symbol Gene ID Gene Info
ENSG00000107807.8 T cell leukemia homeobox 1
ENSG00000141905.13 nuclear factor I C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
NFIChg19_v2_chr19_+_3359561_33596810.421.8e-02Click!
TLX1hg19_v2_chr10_+_102891048_102891078-0.057.9e-01Click!

Activity profile of TLX1_NFIC motif

Sorted Z-values of TLX1_NFIC motif

Promoter Log-likelihood Transcript Gene Gene Info
chrX_-_128788914 12.41 ENST00000429967.1
ENST00000307484.6
apelin
chr2_-_217560248 7.59 ENST00000233813.4
insulin-like growth factor binding protein 5
chr8_-_42065075 6.95 ENST00000429089.2
ENST00000519510.1
ENST00000429710.2
ENST00000524009.1
plasminogen activator, tissue
chr7_+_116165038 6.91 ENST00000393470.1
caveolin 1, caveolae protein, 22kDa
chr1_-_153588765 6.68 ENST00000368701.1
ENST00000344616.2
S100 calcium binding protein A14
chr8_-_42065187 6.37 ENST00000270189.6
ENST00000352041.3
ENST00000220809.4
plasminogen activator, tissue
chr3_-_12200851 5.85 ENST00000287814.4
TIMP metallopeptidase inhibitor 4
chr14_+_24867992 5.59 ENST00000382554.3
NYN domain and retroviral integrase containing
chrX_+_46937745 5.54 ENST00000397180.1
ENST00000457380.1
ENST00000352078.4
regucalcin
chr1_-_16344500 5.50 ENST00000406363.2
ENST00000411503.1
ENST00000545268.1
ENST00000487046.1
heat shock 27kDa protein family, member 7 (cardiovascular)
chr12_-_56105880 5.45 ENST00000557257.1
integrin, alpha 7
chrX_+_2746850 5.37 ENST00000381163.3
ENST00000338623.5
ENST00000542787.1
glycogenin 2
chr12_-_56106060 5.37 ENST00000452168.2
integrin, alpha 7
chr12_+_13349711 5.17 ENST00000538364.1
ENST00000396301.3
epithelial membrane protein 1
chr12_+_13349650 5.15 ENST00000256951.5
ENST00000431267.2
ENST00000542474.1
ENST00000544053.1
epithelial membrane protein 1
chr3_-_58613323 5.09 ENST00000474531.1
ENST00000465970.1
family with sequence similarity 107, member A
chr14_+_85996471 5.09 ENST00000330753.4
fibronectin leucine rich transmembrane protein 2
chr11_-_111783919 5.05 ENST00000531198.1
ENST00000533879.1
crystallin, alpha B
chr6_-_46922659 4.97 ENST00000265417.7
G protein-coupled receptor 116
chr7_-_16844611 4.97 ENST00000401412.1
ENST00000419304.2
anterior gradient 2
chr19_+_46806856 4.95 ENST00000300862.3
hypoxia inducible factor 3, alpha subunit
chr1_-_153538292 4.92 ENST00000497140.1
ENST00000368708.3
S100 calcium binding protein A2
chr20_-_60942361 4.87 ENST00000252999.3
laminin, alpha 5
chrX_+_2746818 4.80 ENST00000398806.3
glycogenin 2
chr14_+_85996507 4.65 ENST00000554746.1
fibronectin leucine rich transmembrane protein 2
chr11_+_74862032 4.58 ENST00000289575.5
ENST00000341411.4
solute carrier organic anion transporter family, member 2B1
chr11_-_111784005 4.57 ENST00000527899.1
crystallin, alpha B
chr15_-_68724490 4.57 ENST00000315757.7
ENST00000423218.2
integrin, alpha 11
chr11_+_74862140 4.49 ENST00000525650.1
ENST00000454962.2
solute carrier organic anion transporter family, member 2B1
chr15_+_71228826 4.41 ENST00000558456.1
ENST00000560158.2
ENST00000558808.1
ENST00000559806.1
ENST00000559069.1
leucine rich repeat containing 49
chr19_+_45312347 4.38 ENST00000270233.6
ENST00000591520.1
basal cell adhesion molecule (Lutheran blood group)
chr13_+_113622757 4.37 ENST00000375604.2
MCF.2 cell line derived transforming sequence-like
chr17_-_74533963 4.35 ENST00000293230.5
cytoglobin
chr8_-_22785404 4.29 ENST00000256404.6
phosphatidylethanolamine-binding protein 4
chr13_+_113622810 4.26 ENST00000397030.1
MCF.2 cell line derived transforming sequence-like
chr9_+_102584128 4.15 ENST00000338488.4
ENST00000395097.2
nuclear receptor subfamily 4, group A, member 3
chr17_+_77030267 4.11 ENST00000581774.1
C1q and tumor necrosis factor related protein 1
chr9_+_136399929 4.07 ENST00000393060.1
ADAMTS-like 2
chr18_+_21529811 4.04 ENST00000588004.1
laminin, alpha 3
chr20_+_58251716 3.85 ENST00000355648.4
phosphatase and actin regulator 3
chr7_+_22766766 3.84 ENST00000426291.1
ENST00000401651.1
ENST00000258743.5
ENST00000420258.2
ENST00000407492.1
ENST00000401630.3
ENST00000406575.1
interleukin 6 (interferon, beta 2)
chr15_-_40213080 3.79 ENST00000561100.1
G protein-coupled receptor 176
chr19_+_45312310 3.71 ENST00000589651.1
basal cell adhesion molecule (Lutheran blood group)
chr11_+_74862100 3.69 ENST00000532236.1
ENST00000531756.1
solute carrier organic anion transporter family, member 2B1
chr1_-_161168834 3.62 ENST00000367995.3
ENST00000367996.5
ADAM metallopeptidase with thrombospondin type 1 motif, 4
chr2_-_218843623 3.60 ENST00000413280.1
tensin 1
chr8_-_82395461 3.59 ENST00000256104.4
fatty acid binding protein 4, adipocyte
chr11_-_111781454 3.57 ENST00000533280.1
crystallin, alpha B
chr7_-_150652924 3.55 ENST00000330883.4
potassium voltage-gated channel, subfamily H (eag-related), member 2
chr5_+_71475449 3.51 ENST00000504492.1
microtubule-associated protein 1B
chr8_-_13134246 3.44 ENST00000503161.2
deleted in liver cancer 1
chr15_+_63682335 3.37 ENST00000559379.1
ENST00000559821.1
RP11-321G12.1
chr10_-_100174900 3.33 ENST00000370575.4
pyridine nucleotide-disulphide oxidoreductase domain 2
chrX_-_102319092 3.31 ENST00000372728.3
brain expressed, X-linked 1
chr17_-_41910505 3.28 ENST00000398389.4
membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
chr17_+_37894179 3.27 ENST00000577695.1
ENST00000309156.4
ENST00000309185.3
growth factor receptor-bound protein 7
chr16_-_19896220 3.26 ENST00000562469.1
ENST00000300571.2
G protein-coupled receptor, family C, group 5, member B
chrX_-_133119476 3.23 ENST00000543339.1
glypican 3
chr19_+_677885 3.22 ENST00000591552.2
follistatin-like 3 (secreted glycoprotein)
chr4_-_110723134 3.16 ENST00000510800.1
ENST00000512148.1
complement factor I
chr8_+_144295067 3.15 ENST00000330824.2
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr17_+_19314505 3.12 ENST00000461366.1
ring finger protein 112
chr5_+_92919043 3.09 ENST00000327111.3
nuclear receptor subfamily 2, group F, member 1
chr6_+_31949801 3.09 ENST00000428956.2
ENST00000498271.1
complement component 4A (Rodgers blood group)
chr11_-_30608413 3.06 ENST00000528686.1
metallophosphoesterase domain containing 2
chrX_-_133119670 3.02 ENST00000394299.2
glypican 3
chr3_-_112356944 3.00 ENST00000461431.1
coiled-coil domain containing 80
chr15_-_65503801 2.95 ENST00000261883.4
cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
chr1_-_41950342 2.93 ENST00000372587.4
endothelin 2
chr4_-_110723335 2.91 ENST00000394634.2
complement factor I
chr17_-_74533734 2.83 ENST00000589342.1
cytoglobin
chr19_-_36247910 2.83 ENST00000587965.1
ENST00000004982.3
heat shock protein, alpha-crystallin-related, B6
chr1_+_19967014 2.77 ENST00000428975.1
neuroblastoma 1, DAN family BMP antagonist
chr16_+_226658 2.75 ENST00000320868.5
ENST00000397797.1
hemoglobin, alpha 1
chrX_-_133119895 2.75 ENST00000370818.3
glypican 3
chr1_+_185703513 2.74 ENST00000271588.4
ENST00000367492.2
hemicentin 1
chr6_+_31982539 2.71 ENST00000435363.2
ENST00000425700.2
complement component 4B (Chido blood group)
chr8_+_104384616 2.71 ENST00000520337.1
collagen triple helix repeat containing 1
chr11_-_62457371 2.67 ENST00000317449.4
LRRN4 C-terminal like
chr4_-_110723194 2.65 ENST00000394635.3
complement factor I
chr8_-_80680078 2.64 ENST00000337919.5
ENST00000354724.3
hes-related family bHLH transcription factor with YRPW motif 1
chrX_+_99899180 2.64 ENST00000373004.3
sushi-repeat containing protein, X-linked 2
chr6_+_31950150 2.64 ENST00000537134.1
complement component 4A (Rodgers blood group)
chr21_+_17792672 2.62 ENST00000602620.1
long intergenic non-protein coding RNA 478
chr5_+_140855495 2.55 ENST00000308177.3
protocadherin gamma subfamily C, 3
chr19_-_33716750 2.53 ENST00000253188.4
solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10
chr1_+_156095951 2.52 ENST00000448611.2
ENST00000368297.1
lamin A/C
chr19_+_11651942 2.47 ENST00000587087.1
calponin 1, basic, smooth muscle
chr14_+_105939276 2.44 ENST00000483017.3
cysteine-rich protein 2
chr1_-_153538011 2.44 ENST00000368707.4
S100 calcium binding protein A2
chr16_+_23765948 2.41 ENST00000300113.2
calcineurin-like EF-hand protein 2
chr1_+_33231268 2.40 ENST00000373480.1
KIAA1522
chr20_+_56136136 2.37 ENST00000319441.4
ENST00000543666.1
phosphoenolpyruvate carboxykinase 1 (soluble)
chrX_-_114468605 2.34 ENST00000538422.1
ENST00000317135.8
leucine-rich repeats and calponin homology (CH) domain containing 2
chr2_+_220325977 2.34 ENST00000396686.1
ENST00000396689.2
SPEG complex locus
chr15_-_40633101 2.34 ENST00000559313.1
chromosome 15 open reading frame 52
chr17_+_37894570 2.31 ENST00000394211.3
growth factor receptor-bound protein 7
chr17_+_38599693 2.31 ENST00000542955.1
ENST00000269593.4
insulin-like growth factor binding protein 4
chr18_+_33877654 2.30 ENST00000257209.4
ENST00000445677.1
ENST00000590592.1
ENST00000359247.4
formin homology 2 domain containing 3
chr8_+_91952750 2.27 ENST00000521366.1
N-terminal EF-hand calcium binding protein 1
chr1_-_153588334 2.27 ENST00000476873.1
S100 calcium binding protein A14
chr1_-_151345159 2.25 ENST00000458566.1
ENST00000447402.3
ENST00000426705.2
ENST00000435071.1
ENST00000368868.5
selenium binding protein 1
chr18_-_55470320 2.25 ENST00000536015.1
ATPase, aminophospholipid transporter, class I, type 8B, member 1
chr1_+_110453109 2.20 ENST00000525659.1
colony stimulating factor 1 (macrophage)
chr16_-_19896150 2.20 ENST00000570142.1
G protein-coupled receptor, family C, group 5, member B
chr11_+_27062502 2.17 ENST00000263182.3
butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1
chr1_-_32169920 2.15 ENST00000373672.3
ENST00000373668.3
collagen, type XVI, alpha 1
chr12_+_53491220 2.15 ENST00000548547.1
ENST00000301464.3
insulin-like growth factor binding protein 6
chr16_+_222846 2.14 ENST00000251595.6
ENST00000397806.1
hemoglobin, alpha 2
chr5_-_115872124 2.13 ENST00000515009.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chrX_+_102631844 2.12 ENST00000372634.1
ENST00000299872.7
nerve growth factor receptor (TNFRSF16) associated protein 1
chr9_+_27109133 2.11 ENST00000519097.1
ENST00000380036.4
TEK tyrosine kinase, endothelial
chr5_+_150020240 2.11 ENST00000519664.1
synaptopodin
chr5_-_115872142 2.10 ENST00000510263.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr7_+_73242069 2.10 ENST00000435050.1
claudin 4
chr19_+_46801639 2.07 ENST00000244303.6
ENST00000339613.2
ENST00000533145.1
ENST00000472815.1
hypoxia inducible factor 3, alpha subunit
chr20_+_43343476 2.03 ENST00000372868.2
WNT1 inducible signaling pathway protein 2
chr12_+_119616447 2.02 ENST00000281938.2
heat shock 22kDa protein 8
chr7_+_73242490 2.00 ENST00000431918.1
claudin 4
chr2_+_220325441 1.99 ENST00000396688.1
SPEG complex locus
chr5_+_150020214 1.98 ENST00000307662.4
synaptopodin
chr1_+_156096336 1.98 ENST00000504687.1
ENST00000473598.2
lamin A/C
chr9_-_14180778 1.92 ENST00000380924.1
ENST00000543693.1
nuclear factor I/B
chr17_+_7344057 1.91 ENST00000575398.1
ENST00000575082.1
fibroblast growth factor 11
chr10_+_88718314 1.91 ENST00000348795.4
synuclein, gamma (breast cancer-specific protein 1)
chr2_+_102721023 1.90 ENST00000409589.1
ENST00000409329.1
interleukin 1 receptor, type I
chr20_+_43343886 1.90 ENST00000190983.4
WNT1 inducible signaling pathway protein 2
chr6_-_28321971 1.89 ENST00000396838.2
ENST00000426434.1
ENST00000434036.1
ENST00000439628.1
zinc finger and SCAN domain containing 31
chr1_-_32169761 1.89 ENST00000271069.6
collagen, type XVI, alpha 1
chr20_+_33759854 1.88 ENST00000216968.4
protein C receptor, endothelial
chr7_+_128470431 1.87 ENST00000325888.8
ENST00000346177.6
filamin C, gamma
chr15_+_48051920 1.85 ENST00000559196.1
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D
chr7_-_7575477 1.85 ENST00000399429.3
collagen, type XXVIII, alpha 1
chr9_+_124030338 1.83 ENST00000449773.1
ENST00000432226.1
ENST00000436847.1
ENST00000394353.2
ENST00000449733.1
ENST00000412819.1
ENST00000341272.2
ENST00000373808.2
gelsolin
chr11_+_120110863 1.81 ENST00000543440.2
POU class 2 homeobox 3
chr20_+_9049682 1.79 ENST00000334005.3
ENST00000378473.3
phospholipase C, beta 4
chr21_+_33784670 1.77 ENST00000300255.2
eva-1 homolog C (C. elegans)
chr21_+_17791648 1.77 ENST00000602892.1
ENST00000418813.2
ENST00000435697.1
long intergenic non-protein coding RNA 478
chr8_-_27469196 1.77 ENST00000546343.1
ENST00000560566.1
clusterin
chr1_+_151512775 1.77 ENST00000368849.3
ENST00000392712.3
ENST00000353024.3
ENST00000368848.2
ENST00000538902.1
tuftelin 1
chr4_+_141264597 1.76 ENST00000338517.4
ENST00000394203.3
ENST00000506322.1
short coiled-coil protein
chrX_+_102631248 1.75 ENST00000361298.4
ENST00000372645.3
ENST00000372635.1
nerve growth factor receptor (TNFRSF16) associated protein 1
chr1_+_65775204 1.74 ENST00000371069.4
DnaJ (Hsp40) homolog, subfamily C, member 6
chr8_-_27468945 1.72 ENST00000405140.3
clusterin
chr7_-_16840820 1.72 ENST00000450569.1
anterior gradient 2
chr19_-_49258606 1.72 ENST00000310160.3
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr21_-_28217721 1.71 ENST00000284984.3
ADAM metallopeptidase with thrombospondin type 1 motif, 1
chr6_-_28321827 1.68 ENST00000444081.1
zinc finger and SCAN domain containing 31
chr8_-_27468842 1.68 ENST00000523500.1
clusterin
chr10_+_106034884 1.65 ENST00000369707.2
ENST00000429569.2
glutathione S-transferase omega 2
chr6_-_34524049 1.65 ENST00000374037.3
SAM pointed domain containing ETS transcription factor
chr5_+_39520499 1.64 ENST00000604954.1
CTD-2078B5.2
chr21_-_35773370 1.64 ENST00000410005.1
chromosome 21 open reading frame 140
chr8_-_13134045 1.62 ENST00000512044.2
deleted in liver cancer 1
chrX_-_13956737 1.61 ENST00000454189.2
glycoprotein M6B
chr3_-_50340996 1.60 ENST00000266031.4
ENST00000395143.2
ENST00000457214.2
ENST00000447605.2
ENST00000418723.1
ENST00000395144.2
hyaluronoglucosaminidase 1
chr9_-_13279589 1.59 ENST00000319217.7
multiple PDZ domain protein
chr20_+_34742650 1.58 ENST00000373945.1
ENST00000338074.2
erythrocyte membrane protein band 4.1-like 1
chr20_-_60942326 1.56 ENST00000370677.3
ENST00000370692.3
laminin, alpha 5
chr11_+_1244288 1.55 ENST00000529681.1
ENST00000447027.1
mucin 5B, oligomeric mucus/gel-forming
chr22_+_31518938 1.55 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
inositol polyphosphate-5-phosphatase J
chr9_-_25678856 1.55 ENST00000358022.3
tumor suppressor candidate 1
chr2_-_238323007 1.55 ENST00000295550.4
collagen, type VI, alpha 3
chr11_+_34663913 1.54 ENST00000532302.1
ets homologous factor
chr1_+_33231221 1.54 ENST00000294521.3
KIAA1522
chr9_-_13279563 1.53 ENST00000541718.1
multiple PDZ domain protein
chr22_+_41763274 1.52 ENST00000406644.3
thyrotrophic embryonic factor
chr15_+_84322827 1.51 ENST00000286744.5
ENST00000567476.1
ADAMTS-like 3
chr16_-_51185172 1.51 ENST00000251020.4
spalt-like transcription factor 1
chr6_-_34524093 1.50 ENST00000544425.1
SAM pointed domain containing ETS transcription factor
chr16_-_86542455 1.48 ENST00000595886.1
ENST00000597578.1
ENST00000593604.1
FOXF1 adjacent non-coding developmental regulatory RNA
chr21_+_33784957 1.48 ENST00000401402.3
ENST00000382699.3
eva-1 homolog C (C. elegans)
chr2_-_238322800 1.47 ENST00000392004.3
ENST00000433762.1
ENST00000347401.3
ENST00000353578.4
ENST00000346358.4
ENST00000392003.2
collagen, type VI, alpha 3
chr1_-_160040038 1.45 ENST00000368089.3
potassium inwardly-rectifying channel, subfamily J, member 10
chr21_+_17791838 1.43 ENST00000453910.1
long intergenic non-protein coding RNA 478
chr22_-_24641027 1.43 ENST00000398292.3
ENST00000263112.7
ENST00000418439.2
ENST00000424217.1
ENST00000327365.4
gamma-glutamyltransferase 5
chr2_-_238322770 1.41 ENST00000472056.1
collagen, type VI, alpha 3
chr8_-_21988558 1.40 ENST00000312841.8
hair growth associated
chr14_-_50999190 1.40 ENST00000557390.1
mitogen-activated protein kinase kinase kinase kinase 5
chr20_+_43343517 1.39 ENST00000372865.4
WNT1 inducible signaling pathway protein 2
chr1_-_44497024 1.39 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr14_-_85996332 1.38 ENST00000380722.1
RP11-497E19.1
chr1_+_110453462 1.38 ENST00000488198.1
colony stimulating factor 1 (macrophage)
chr1_-_44497118 1.37 ENST00000537678.1
ENST00000466926.1
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr19_-_42927251 1.37 ENST00000597001.1
lipase, hormone-sensitive
chr22_+_40390930 1.37 ENST00000333407.6
family with sequence similarity 83, member F
chr15_-_35088340 1.37 ENST00000290378.4
actin, alpha, cardiac muscle 1
chr20_-_44519839 1.35 ENST00000372518.4
neuralized E3 ubiquitin protein ligase 2
chr8_+_98881268 1.35 ENST00000254898.5
ENST00000524308.1
ENST00000522025.2
matrilin 2
chr19_-_49864746 1.35 ENST00000598810.1
TEA domain family member 2
chr1_-_95392635 1.33 ENST00000538964.1
ENST00000394202.4
ENST00000370206.4
calponin 3, acidic
chr8_-_27468717 1.32 ENST00000520796.1
ENST00000520491.1
clusterin
chr17_-_34329084 1.32 ENST00000354059.4
ENST00000536149.1
chemokine (C-C motif) ligand 15
chemokine (C-C motif) ligand 14
chr17_-_39677971 1.32 ENST00000393976.2
keratin 15
chr8_-_141728760 1.30 ENST00000430260.2
protein tyrosine kinase 2
chr1_+_32674675 1.30 ENST00000409358.1
doublecortin domain containing 2B
chr8_+_24772455 1.29 ENST00000433454.2
neurofilament, medium polypeptide
chr2_-_233877912 1.27 ENST00000264051.3
neuronal guanine nucleotide exchange factor
chr10_+_124320156 1.27 ENST00000338354.3
ENST00000344338.3
ENST00000330163.4
ENST00000368909.3
ENST00000368955.3
ENST00000368956.2
deleted in malignant brain tumors 1
chr17_-_10707410 1.23 ENST00000581851.1
long intergenic non-protein coding RNA 675

Network of associatons between targets according to the STRING database.

First level regulatory network of TLX1_NFIC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.4 GO:0051466 positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
2.5 7.6 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
2.3 6.9 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
1.8 5.5 GO:1903625 negative regulation of DNA catabolic process(GO:1903625) regulation of aminoacyl-tRNA ligase activity(GO:1903630)
1.7 13.9 GO:0060481 lobar bronchus epithelium development(GO:0060481)
1.6 9.7 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
1.4 7.0 GO:1904141 mammary gland fat development(GO:0060611) positive regulation of macrophage colony-stimulating factor signaling pathway(GO:1902228) positive regulation of response to macrophage colony-stimulating factor(GO:1903971) positive regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903974) positive regulation of microglial cell migration(GO:1904141)
1.4 4.1 GO:0032765 positive regulation of mast cell cytokine production(GO:0032765)
1.3 9.0 GO:0072180 mesonephric duct morphogenesis(GO:0072180)
1.2 3.6 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
1.0 7.2 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
1.0 2.9 GO:0003099 positive regulation of the force of heart contraction by chemical signal(GO:0003099)
1.0 3.8 GO:1990637 response to prolactin(GO:1990637)
1.0 7.6 GO:1902998 regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
0.9 2.8 GO:0061536 glycine secretion(GO:0061536) glycine secretion, neurotransmission(GO:0061537)
0.9 4.5 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.7 4.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.7 2.6 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
0.6 1.2 GO:0042704 uterine wall breakdown(GO:0042704)
0.6 2.8 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.5 3.2 GO:0043932 ossification involved in bone remodeling(GO:0043932)
0.5 13.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.5 5.8 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.5 4.1 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.5 1.5 GO:0001300 chronological cell aging(GO:0001300)
0.5 8.4 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.5 3.2 GO:0071503 positive regulation of lipoprotein particle clearance(GO:0010986) response to heparin(GO:0071503)
0.4 2.2 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.4 13.3 GO:0031639 plasminogen activation(GO:0031639)
0.4 1.3 GO:0033693 neurofilament bundle assembly(GO:0033693)
0.4 2.5 GO:0019355 nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.4 1.2 GO:0060488 orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060488) planar dichotomous subdivision of terminal units involved in lung branching morphogenesis(GO:0060489) lateral sprouting involved in lung morphogenesis(GO:0060490)
0.4 1.8 GO:1903906 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.4 9.1 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.3 5.6 GO:0015074 DNA integration(GO:0015074)
0.3 10.3 GO:0032060 bleb assembly(GO:0032060)
0.3 2.0 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
0.3 1.9 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
0.3 1.6 GO:1900104 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.3 1.9 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.3 1.1 GO:0060262 regulation of N-terminal protein palmitoylation(GO:0060254) negative regulation of N-terminal protein palmitoylation(GO:0060262) negative regulation of protein lipidation(GO:1903060)
0.3 0.8 GO:0030505 inorganic diphosphate transport(GO:0030505)
0.3 1.6 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.3 0.8 GO:2000393 negative regulation of lamellipodium morphogenesis(GO:2000393)
0.3 2.1 GO:0048014 Tie signaling pathway(GO:0048014)
0.3 1.0 GO:1900241 response to mycophenolic acid(GO:0071505) cellular response to mycophenolic acid(GO:0071506) metanephric glomerular mesangial cell development(GO:0072255) reversible differentiation(GO:0090677) cell dedifferentiation involved in phenotypic switching(GO:0090678) positive regulation of phenotypic switching(GO:1900241) regulation of vascular smooth muscle cell dedifferentiation(GO:1905174) positive regulation of vascular smooth muscle cell dedifferentiation(GO:1905176) vascular smooth muscle cell dedifferentiation(GO:1990936)
0.2 1.0 GO:0018963 insecticide metabolic process(GO:0017143) phthalate metabolic process(GO:0018963)
0.2 1.0 GO:0006114 glycerol biosynthetic process(GO:0006114)
0.2 1.9 GO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000795)
0.2 3.0 GO:0042940 D-amino acid transport(GO:0042940)
0.2 5.1 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.2 3.2 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.2 10.6 GO:0005980 glycogen catabolic process(GO:0005980)
0.2 1.1 GO:0002528 regulation of vascular permeability involved in acute inflammatory response(GO:0002528)
0.2 0.7 GO:0097359 UDP-glucosylation(GO:0097359)
0.2 5.6 GO:0034063 stress granule assembly(GO:0034063)
0.2 12.0 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.2 2.5 GO:0001886 endothelial cell morphogenesis(GO:0001886)
0.2 1.4 GO:0051935 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
0.2 0.6 GO:0051758 homologous chromosome movement towards spindle pole involved in homologous chromosome segregation(GO:0051758)
0.2 0.6 GO:0001579 medium-chain fatty acid transport(GO:0001579)
0.2 3.6 GO:0071285 cellular response to lithium ion(GO:0071285)
0.2 0.9 GO:0015670 carbon dioxide transport(GO:0015670)
0.2 0.2 GO:0035995 detection of muscle stretch(GO:0035995)
0.2 0.7 GO:0099640 axo-dendritic protein transport(GO:0099640)
0.2 4.2 GO:2001224 positive regulation of neuron migration(GO:2001224)
0.2 2.2 GO:0045329 carnitine biosynthetic process(GO:0045329)
0.2 0.8 GO:0003095 pressure natriuresis(GO:0003095) vitamin E metabolic process(GO:0042360)
0.2 0.8 GO:0061107 seminal vesicle development(GO:0061107)
0.2 4.6 GO:0038065 collagen-activated signaling pathway(GO:0038065)
0.2 3.8 GO:0060907 positive regulation of macrophage cytokine production(GO:0060907)
0.2 3.5 GO:0061339 establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.2 1.7 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.2 13.3 GO:0035987 endodermal cell differentiation(GO:0035987)
0.2 0.9 GO:0022614 membrane to membrane docking(GO:0022614)
0.2 1.5 GO:0060523 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737) epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751)
0.2 1.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1 1.6 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.1 2.8 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.1 2.0 GO:0038007 netrin-activated signaling pathway(GO:0038007)
0.1 1.8 GO:0015705 iodide transport(GO:0015705)
0.1 2.8 GO:0015671 oxygen transport(GO:0015671)
0.1 1.1 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.1 4.1 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 1.1 GO:0048539 bone marrow development(GO:0048539)
0.1 0.4 GO:2000824 negative regulation of androgen receptor activity(GO:2000824)
0.1 2.5 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.1 0.6 GO:0046086 adenosine biosynthetic process(GO:0046086)
0.1 4.0 GO:0033622 integrin activation(GO:0033622)
0.1 0.3 GO:0070309 lens fiber cell morphogenesis(GO:0070309)
0.1 1.7 GO:0042355 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 0.9 GO:1905150 regulation of voltage-gated sodium channel activity(GO:1905150)
0.1 1.2 GO:0097475 motor neuron migration(GO:0097475)
0.1 0.5 GO:0015862 uridine transport(GO:0015862)
0.1 0.5 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.1 0.9 GO:0070995 NADPH oxidation(GO:0070995)
0.1 3.7 GO:0055003 cardiac myofibril assembly(GO:0055003)
0.1 0.3 GO:0033241 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901204) negative regulation of adrenergic receptor signaling pathway involved in heart process(GO:1901205) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.1 2.3 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.1 1.8 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.1 2.4 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.1 1.3 GO:0061002 negative regulation of dendritic spine morphogenesis(GO:0061002)
0.1 2.1 GO:0060044 negative regulation of cardiac muscle cell proliferation(GO:0060044)
0.1 1.3 GO:0048368 lateral mesoderm development(GO:0048368)
0.1 2.8 GO:0010667 negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1 1.1 GO:0051451 myoblast migration(GO:0051451)
0.1 0.3 GO:0018874 benzoate metabolic process(GO:0018874)
0.1 0.9 GO:0018230 peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.1 1.7 GO:0070314 G1 to G0 transition(GO:0070314)
0.1 1.5 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 6.4 GO:0001755 neural crest cell migration(GO:0001755)
0.1 1.0 GO:0009407 toxin catabolic process(GO:0009407) secondary metabolite catabolic process(GO:0090487)
0.1 2.6 GO:0071625 vocalization behavior(GO:0071625)
0.1 3.9 GO:0046710 GDP metabolic process(GO:0046710)
0.1 0.7 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465)
0.1 1.0 GO:0046415 urate metabolic process(GO:0046415)
0.1 1.3 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.1 1.6 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 8.9 GO:0030449 regulation of complement activation(GO:0030449)
0.1 2.6 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.1 0.2 GO:0034970 histone H3-R2 methylation(GO:0034970)
0.1 3.8 GO:0030818 negative regulation of cAMP biosynthetic process(GO:0030818)
0.1 4.4 GO:0030574 collagen catabolic process(GO:0030574)
0.1 0.3 GO:0032713 negative regulation of interleukin-4 production(GO:0032713)
0.1 1.0 GO:0030322 stabilization of membrane potential(GO:0030322)
0.1 2.7 GO:0045687 positive regulation of glial cell differentiation(GO:0045687)
0.1 1.9 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 0.3 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.1 0.7 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.8 GO:0060134 prepulse inhibition(GO:0060134)
0.0 1.4 GO:0033169 histone H3-K9 demethylation(GO:0033169)
0.0 0.3 GO:0051012 microtubule sliding(GO:0051012)
0.0 0.8 GO:0019532 oxalate transport(GO:0019532)
0.0 0.3 GO:0042758 long-chain fatty acid catabolic process(GO:0042758)
0.0 0.2 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.0 0.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0 0.3 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.0 0.7 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0 0.6 GO:0090037 positive regulation of protein kinase C signaling(GO:0090037)
0.0 0.9 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.0 0.3 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
0.0 0.7 GO:0048569 post-embryonic organ development(GO:0048569)
0.0 1.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.6 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.2 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.0 5.4 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.0 1.9 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 1.2 GO:0042755 eating behavior(GO:0042755)
0.0 0.5 GO:0048251 elastic fiber assembly(GO:0048251)
0.0 0.5 GO:0072189 ureter development(GO:0072189)
0.0 0.1 GO:1990022 RNA polymerase II complex import to nucleus(GO:0044376) RNA polymerase III complex localization to nucleus(GO:1990022)
0.0 0.6 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.0 1.5 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.5 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.0 0.3 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.2 GO:0097264 self proteolysis(GO:0097264)
0.0 1.2 GO:0043030 regulation of macrophage activation(GO:0043030)
0.0 0.3 GO:0050966 detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0 0.3 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.0 0.1 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.0 1.4 GO:0008347 glial cell migration(GO:0008347)
0.0 3.6 GO:0070268 cornification(GO:0070268)
0.0 1.3 GO:0030593 neutrophil chemotaxis(GO:0030593)
0.0 2.3 GO:0043647 inositol phosphate metabolic process(GO:0043647)
0.0 0.7 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.0 4.7 GO:0043542 endothelial cell migration(GO:0043542)
0.0 3.0 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.0 2.4 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.0 0.1 GO:0036148 phosphatidylglycerol acyl-chain remodeling(GO:0036148)
0.0 0.8 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.0 4.0 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)
0.0 0.2 GO:2000680 rubidium ion transport(GO:0035826) regulation of rubidium ion transport(GO:2000680)
0.0 0.5 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.0 1.0 GO:0048747 muscle fiber development(GO:0048747)
0.0 1.2 GO:0007029 endoplasmic reticulum organization(GO:0007029)
0.0 1.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.5 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.9 GO:0010761 fibroblast migration(GO:0010761)
0.0 0.3 GO:0016578 histone deubiquitination(GO:0016578)
0.0 0.3 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.0 0.1 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.2 GO:0030252 growth hormone secretion(GO:0030252)
0.0 0.8 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.0 0.3 GO:0016242 negative regulation of macroautophagy(GO:0016242)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:0097444 spine apparatus(GO:0097444)
1.3 6.4 GO:0043260 laminin-11 complex(GO:0043260)
1.1 4.6 GO:0034681 integrin alpha11-beta1 complex(GO:0034681)
1.0 7.0 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.8 9.7 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.7 13.2 GO:0097512 cardiac myofibril(GO:0097512)
0.7 3.6 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.7 2.8 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.5 1.6 GO:0036117 hyaluranon cable(GO:0036117)
0.5 1.5 GO:0072563 endothelial microparticle(GO:0072563)
0.5 8.9 GO:0097418 neurofibrillary tangle(GO:0097418)
0.4 4.5 GO:0005638 lamin filament(GO:0005638)
0.4 4.0 GO:0005610 laminin-5 complex(GO:0005610)
0.4 6.9 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.3 4.0 GO:0005593 FACIT collagen trimer(GO:0005593)
0.3 0.9 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
0.3 1.5 GO:0070701 mucus layer(GO:0070701)
0.3 4.4 GO:0005589 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.3 1.2 GO:0060187 cell pole(GO:0060187)
0.3 0.3 GO:0034665 integrin alpha1-beta1 complex(GO:0034665)
0.3 1.4 GO:0042643 actomyosin, actin portion(GO:0042643)
0.3 1.3 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.2 0.8 GO:0036026 protein C inhibitor-TMPRSS7 complex(GO:0036024) protein C inhibitor-TMPRSS11E complex(GO:0036025) protein C inhibitor-PLAT complex(GO:0036026) protein C inhibitor-PLAU complex(GO:0036027) protein C inhibitor-thrombin complex(GO:0036028) protein C inhibitor-KLK3 complex(GO:0036029) protein C inhibitor-plasma kallikrein complex(GO:0036030) serine protease inhibitor complex(GO:0097180) protein C inhibitor-coagulation factor V complex(GO:0097181) protein C inhibitor-coagulation factor Xa complex(GO:0097182) protein C inhibitor-coagulation factor XI complex(GO:0097183)
0.2 11.9 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.2 7.2 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 0.8 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.2 1.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
0.2 9.7 GO:0008305 integrin complex(GO:0008305)
0.1 1.8 GO:0030478 actin cap(GO:0030478)
0.1 2.0 GO:0042629 mast cell granule(GO:0042629)
0.1 1.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.1 1.9 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.1 3.0 GO:0005614 interstitial matrix(GO:0005614)
0.1 0.7 GO:0043194 axon initial segment(GO:0043194)
0.1 1.6 GO:0042589 zymogen granule membrane(GO:0042589)
0.1 10.7 GO:0005581 collagen trimer(GO:0005581)
0.1 0.6 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.1 1.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 1.0 GO:0030061 mitochondrial crista(GO:0030061)
0.1 4.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 0.8 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 33.7 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 2.0 GO:0010369 chromocenter(GO:0010369)
0.1 1.5 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 15.6 GO:0031012 extracellular matrix(GO:0031012)
0.1 4.3 GO:0016235 aggresome(GO:0016235)
0.1 6.9 GO:0043202 lysosomal lumen(GO:0043202)
0.1 0.4 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 1.7 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.9 GO:0002178 palmitoyltransferase complex(GO:0002178)
0.0 0.1 GO:0042025 host cell nucleus(GO:0042025)
0.0 3.5 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 5.1 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 4.4 GO:0005811 lipid particle(GO:0005811)
0.0 0.9 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.0 1.1 GO:0043034 costamere(GO:0043034)
0.0 1.5 GO:0032420 stereocilium(GO:0032420)
0.0 2.3 GO:0045095 keratin filament(GO:0045095)
0.0 3.6 GO:0001750 photoreceptor outer segment(GO:0001750)
0.0 15.5 GO:0016607 nuclear speck(GO:0016607)
0.0 1.5 GO:0043198 dendritic shaft(GO:0043198)
0.0 5.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 0.2 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 2.3 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 18.4 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.0 1.3 GO:0043197 dendritic spine(GO:0043197)
0.0 0.3 GO:0030014 CCR4-NOT complex(GO:0030014)
0.0 0.1 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.0 0.5 GO:0030673 axolemma(GO:0030673)
0.0 1.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.0 3.8 GO:0060076 excitatory synapse(GO:0060076)
0.0 0.9 GO:0005882 intermediate filament(GO:0005882)
0.0 0.8 GO:0030315 T-tubule(GO:0030315)
0.0 2.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 8.1 GO:0005055 laminin receptor activity(GO:0005055)
2.3 6.9 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
2.3 9.0 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
2.0 10.2 GO:0008466 glycogenin glucosyltransferase activity(GO:0008466)
1.8 7.2 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.9 7.0 GO:0005157 macrophage colony-stimulating factor receptor binding(GO:0005157)
0.9 12.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.8 2.4 GO:0004613 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
0.7 2.8 GO:0015375 glycine:sodium symporter activity(GO:0015375)
0.7 4.1 GO:0050436 microfibril binding(GO:0050436)
0.7 2.6 GO:0035939 microsatellite binding(GO:0035939)
0.6 4.9 GO:0098639 collagen binding involved in cell-matrix adhesion(GO:0098639)
0.6 2.9 GO:0031708 endothelin B receptor binding(GO:0031708)
0.6 5.7 GO:0001849 complement component C1q binding(GO:0001849)
0.5 2.2 GO:0008336 gamma-butyrobetaine dioxygenase activity(GO:0008336)
0.5 15.9 GO:0005212 structural constituent of eye lens(GO:0005212)
0.5 1.4 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.4 2.5 GO:0000309 nicotinamide-nucleotide adenylyltransferase activity(GO:0000309)
0.4 11.3 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.4 3.6 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.4 3.2 GO:0035473 lipase binding(GO:0035473)
0.4 9.7 GO:0045499 chemorepellent activity(GO:0045499)
0.4 3.0 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.3 1.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.3 0.9 GO:0043849 Ras palmitoyltransferase activity(GO:0043849)
0.3 4.8 GO:0036122 BMP binding(GO:0036122)
0.3 1.2 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.3 1.9 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.3 12.4 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 1.8 GO:0030021 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.2 0.7 GO:0003980 UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980)
0.2 1.0 GO:0050220 prostaglandin-E synthase activity(GO:0050220)
0.2 0.8 GO:1990175 EH domain binding(GO:1990175)
0.2 2.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.2 6.9 GO:0051787 misfolded protein binding(GO:0051787)
0.2 6.7 GO:0002162 dystroglycan binding(GO:0002162)
0.2 0.6 GO:0036328 VEGF-C-activated receptor activity(GO:0036328)
0.2 2.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 1.1 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.2 5.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.2 5.5 GO:0031005 filamin binding(GO:0031005)
0.2 0.7 GO:0008426 protein kinase C inhibitor activity(GO:0008426)
0.2 4.9 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 2.2 GO:1901612 cardiolipin binding(GO:1901612)
0.2 1.5 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.2 1.0 GO:0050610 oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610)
0.2 6.2 GO:0001968 fibronectin binding(GO:0001968)
0.2 0.8 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.2 0.8 GO:0035529 NADH pyrophosphatase activity(GO:0035529)
0.2 1.4 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.2 2.8 GO:0005344 oxygen transporter activity(GO:0005344)
0.1 4.1 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.1 10.3 GO:0042379 chemokine receptor binding(GO:0042379)
0.1 2.5 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 0.8 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1 0.6 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 0.7 GO:0051185 coenzyme transporter activity(GO:0051185)
0.1 1.8 GO:0045159 myosin II binding(GO:0045159)
0.1 1.3 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.1 1.1 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.1 1.5 GO:0052658 inositol-polyphosphate 5-phosphatase activity(GO:0004445) inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 10.0 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 2.3 GO:0008430 selenium binding(GO:0008430)
0.1 1.6 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.1 0.9 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.9 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 0.3 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.1 1.9 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 6.5 GO:0042169 SH2 domain binding(GO:0042169)
0.1 2.7 GO:0001848 complement binding(GO:0001848)
0.1 1.7 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 3.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 0.3 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 12.8 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 0.8 GO:0032190 acrosin binding(GO:0032190)
0.1 0.8 GO:0005138 interleukin-6 receptor binding(GO:0005138)
0.1 0.7 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.1 0.6 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.1 2.9 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 3.4 GO:0005504 fatty acid binding(GO:0005504)
0.1 3.9 GO:0004385 guanylate kinase activity(GO:0004385)
0.1 0.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 0.4 GO:1902444 riboflavin binding(GO:1902444)
0.1 1.9 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.1 0.6 GO:0003872 6-phosphofructokinase activity(GO:0003872)
0.1 1.0 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1 1.4 GO:0017022 myosin binding(GO:0017022)
0.1 0.7 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.1 2.7 GO:0005109 frizzled binding(GO:0005109)
0.1 1.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.1 1.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.1 1.0 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 0.8 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.0 0.5 GO:0015501 glutamate:sodium symporter activity(GO:0015501)
0.0 8.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.5 GO:0008142 oxysterol binding(GO:0008142)
0.0 1.0 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.0 0.2 GO:0035241 protein-arginine omega-N monomethyltransferase activity(GO:0035241)
0.0 0.3 GO:0071532 ankyrin repeat binding(GO:0071532)
0.0 7.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 4.1 GO:0005518 collagen binding(GO:0005518)
0.0 1.5 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.0 1.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 3.8 GO:0030295 protein kinase activator activity(GO:0030295)
0.0 4.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.0 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.4 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0 0.5 GO:0019864 IgG binding(GO:0019864)
0.0 0.5 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 1.0 GO:0030506 ankyrin binding(GO:0030506)
0.0 3.4 GO:0019838 growth factor binding(GO:0019838)
0.0 5.0 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 2.7 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 0.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0 0.2 GO:0071253 connexin binding(GO:0071253)
0.0 0.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 0.5 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.3 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0 0.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 0.4 GO:0070410 co-SMAD binding(GO:0070410)
0.0 2.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 10.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 14.6 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.3 3.8 ST STAT3 PATHWAY STAT3 Pathway
0.2 10.0 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.2 9.6 PID ALK1 PATHWAY ALK1 signaling events
0.2 11.9 NABA COLLAGENS Genes encoding collagen proteins
0.1 7.0 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 5.0 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 6.0 ST GA12 PATHWAY G alpha 12 Pathway
0.1 4.0 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.1 3.1 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 26.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.7 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 3.7 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 6.2 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.4 PID HNF3A PATHWAY FOXA1 transcription factor network
0.1 4.2 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 6.1 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 2.7 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.9 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 14.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.0 PID NECTIN PATHWAY Nectin adhesion pathway
0.0 11.2 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.9 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.9 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.0 1.3 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 2.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.6 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 1.4 ST G ALPHA I PATHWAY G alpha i Pathway
0.0 1.5 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
0.0 1.6 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.7 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.0 0.2 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 1.3 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.7 PID SHP2 PATHWAY SHP2 signaling
0.0 1.0 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.1 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.5 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 1.0 PID RHOA REG PATHWAY Regulation of RhoA activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 13.4 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.4 14.4 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.4 12.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 9.9 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.3 11.9 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 9.0 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.2 7.2 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.2 7.0 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.2 5.3 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.9 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.1 1.6 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.1 10.0 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 1.0 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 2.8 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.3 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 8.2 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 3.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 7.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.8 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 11.0 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.1 5.9 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 0.7 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.1 2.5 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 6.0 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 1.8 REACTOME RNA POL III TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase III Transcription Termination
0.0 5.9 REACTOME CELL DEATH SIGNALLING VIA NRAGE NRIF AND NADE Genes involved in Cell death signalling via NRAGE, NRIF and NADE
0.0 0.9 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 0.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 2.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 2.3 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.0 1.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.0 0.7 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.7 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.0 1.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 1.0 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.0 2.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.5 REACTOME TRAFFICKING OF AMPA RECEPTORS Genes involved in Trafficking of AMPA receptors
0.0 1.8 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.0 0.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.4 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules