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Illumina Body Map 2

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Results for TP53

Z-value: 1.39

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Transcription factors associated with TP53

Gene Symbol Gene ID Gene Info
TP53
ENSG00000141510.11 tumor protein p53

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TP53hg19_v2_chr17_-_7590745_75908560.392.6e-02Click!

Activity profile of TP53 motif

Sorted Z-values of TP53 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_89417335 4.57 ENST00000490686.1
IGKV1-17
immunoglobulin kappa variable 1-17
chr8_+_22960426 4.13 ENST00000540813.1
TNFRSF10C
tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
chr14_-_106692191 3.92 ENST00000390607.2
IGHV3-21
immunoglobulin heavy variable 3-21
chr19_+_827823 2.75 ENST00000233997.2
AZU1
azurocidin 1
chr19_-_6591113 2.68 ENST00000423145.3
ENST00000245903.3
CD70
CD70 molecule
chr6_+_36098262 2.57 ENST00000373761.6
ENST00000373766.5
MAPK13
mitogen-activated protein kinase 13
chr11_+_289110 2.51 ENST00000409548.2
ATHL1
ATH1, acid trehalase-like 1 (yeast)
chr11_+_289155 2.46 ENST00000409655.1
ATHL1
ATH1, acid trehalase-like 1 (yeast)
chr8_-_23021533 2.45 ENST00000312584.3
TNFRSF10D
tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain
chr11_-_47400078 2.30 ENST00000378538.3
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_47400032 2.26 ENST00000533968.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_47399942 2.22 ENST00000227163.4
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr8_-_23082580 2.20 ENST00000221132.3
TNFRSF10A
tumor necrosis factor receptor superfamily, member 10a
chr11_-_47400062 2.16 ENST00000533030.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr6_-_30712313 2.11 ENST00000376377.2
ENST00000259874.5
IER3
immediate early response 3
chr11_-_44972390 2.08 ENST00000395648.3
ENST00000531928.2
TP53I11
tumor protein p53 inducible protein 11
chr1_-_54483842 1.98 ENST00000371362.3
ENST00000420619.1
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr18_+_57567180 1.97 ENST00000316660.6
ENST00000269518.9
PMAIP1
phorbol-12-myristate-13-acetate-induced protein 1
chr19_+_3136115 1.96 ENST00000262958.3
GNA15
guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
chr1_-_54483803 1.83 ENST00000371360.1
ENST00000545928.1
LDLRAD1
low density lipoprotein receptor class A domain containing 1
chr11_-_44972476 1.76 ENST00000527685.1
ENST00000308212.5
TP53I11
tumor protein p53 inducible protein 11
chr11_+_67171391 1.75 ENST00000312390.5
TBC1D10C
TBC1 domain family, member 10C
chr1_-_160832490 1.75 ENST00000322302.7
ENST00000368033.3
CD244
CD244 molecule, natural killer cell receptor 2B4
chr17_+_76210267 1.70 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
BIRC5
baculoviral IAP repeat containing 5
chr11_+_67171358 1.70 ENST00000526387.1
TBC1D10C
TBC1 domain family, member 10C
chr1_-_209825674 1.69 ENST00000367030.3
ENST00000356082.4
LAMB3
laminin, beta 3
chr3_-_52479043 1.69 ENST00000231721.2
ENST00000475739.1
SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr19_+_49458107 1.67 ENST00000539787.1
ENST00000345358.7
ENST00000391871.3
ENST00000415969.2
ENST00000354470.3
ENST00000506183.1
ENST00000293288.8
BAX
BCL2-associated X protein
chr3_+_122785895 1.64 ENST00000316218.7
PDIA5
protein disulfide isomerase family A, member 5
chr1_-_160832642 1.61 ENST00000368034.4
CD244
CD244 molecule, natural killer cell receptor 2B4
chr20_+_33759854 1.60 ENST00000216968.4
PROCR
protein C receptor, endothelial
chr1_-_38412683 1.58 ENST00000373024.3
ENST00000373023.2
INPP5B
inositol polyphosphate-5-phosphatase, 75kDa
chr20_-_1373726 1.55 ENST00000400137.4
FKBP1A
FK506 binding protein 1A, 12kDa
chr1_-_153588334 1.52 ENST00000476873.1
S100A14
S100 calcium binding protein A14
chr17_-_61523535 1.52 ENST00000584031.1
ENST00000392976.1
CYB561
cytochrome b561
chr10_-_105212059 1.52 ENST00000260743.5
CALHM2
calcium homeostasis modulator 2
chr20_-_1373606 1.51 ENST00000381715.1
ENST00000439640.2
ENST00000381719.3
FKBP1A
FK506 binding protein 1A, 12kDa
chrX_-_153583257 1.48 ENST00000438732.1
FLNA
filamin A, alpha
chr12_-_53207842 1.48 ENST00000458244.2
KRT4
keratin 4
chr10_+_47746929 1.47 ENST00000340243.6
ENST00000374277.5
ENST00000449464.2
ENST00000538825.1
ENST00000335083.5
ANXA8L2
AL603965.1
annexin A8-like 2
Protein LOC100996760
chr1_+_10057274 1.46 ENST00000294435.7
RBP7
retinol binding protein 7, cellular
chr2_-_157198860 1.45 ENST00000409572.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr11_+_5712234 1.41 ENST00000414641.1
TRIM22
tripartite motif containing 22
chr6_+_36097992 1.41 ENST00000211287.4
MAPK13
mitogen-activated protein kinase 13
chrX_+_99899180 1.40 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr8_-_22926526 1.39 ENST00000347739.3
ENST00000542226.1
TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr10_+_48255253 1.38 ENST00000357718.4
ENST00000344416.5
ENST00000456111.2
ENST00000374258.3
ANXA8
AL591684.1
annexin A8
Protein LOC100996760
chr17_-_61523622 1.37 ENST00000448884.2
ENST00000582297.1
ENST00000582034.1
ENST00000578072.1
ENST00000360793.3
CYB561
cytochrome b561
chr19_+_42364460 1.35 ENST00000593863.1
RPS19
ribosomal protein S19
chr8_-_10588010 1.34 ENST00000304501.1
SOX7
SRY (sex determining region Y)-box 7
chr17_+_76210367 1.32 ENST00000592734.1
ENST00000587746.1
BIRC5
baculoviral IAP repeat containing 5
chr19_-_6481776 1.29 ENST00000543576.1
ENST00000590173.1
ENST00000381480.2
DENND1C
DENN/MADD domain containing 1C
chr5_-_131826457 1.28 ENST00000437654.1
ENST00000245414.4
IRF1
interferon regulatory factor 1
chr3_+_184279566 1.27 ENST00000330394.2
EPHB3
EPH receptor B3
chr20_-_1373682 1.27 ENST00000381724.3
FKBP1A
FK506 binding protein 1A, 12kDa
chr10_+_90750493 1.26 ENST00000357339.2
ENST00000355279.2
FAS
Fas cell surface death receptor
chr11_+_706595 1.26 ENST00000531348.1
ENST00000530636.1
EPS8L2
EPS8-like 2
chr7_+_100770328 1.25 ENST00000223095.4
ENST00000445463.2
SERPINE1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr1_-_160832670 1.25 ENST00000368032.2
CD244
CD244 molecule, natural killer cell receptor 2B4
chr11_-_44972299 1.24 ENST00000528473.1
TP53I11
tumor protein p53 inducible protein 11
chr10_-_105212141 1.24 ENST00000369788.3
CALHM2
calcium homeostasis modulator 2
chr11_+_36397528 1.24 ENST00000311599.5
ENST00000378867.3
PRR5L
proline rich 5 like
chr8_-_22926623 1.21 ENST00000276431.4
TNFRSF10B
tumor necrosis factor receptor superfamily, member 10b
chr11_-_65626797 1.20 ENST00000525451.2
CFL1
cofilin 1 (non-muscle)
chr19_+_42364313 1.20 ENST00000601492.1
ENST00000600467.1
ENST00000221975.2
RPS19
ribosomal protein S19
chr1_-_156051789 1.19 ENST00000532414.2
MEX3A
mex-3 RNA binding family member A
chr1_+_28206150 1.19 ENST00000456990.1
THEMIS2
thymocyte selection associated family member 2
chr1_-_150738261 1.19 ENST00000448301.2
ENST00000368985.3
CTSS
cathepsin S
chr22_-_18257178 1.18 ENST00000342111.5
BID
BH3 interacting domain death agonist
chr11_-_65626753 1.17 ENST00000526975.1
ENST00000531413.1
CFL1
cofilin 1 (non-muscle)
chr1_+_25599018 1.17 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
RHD
Rh blood group, D antigen
chr2_+_208104497 1.16 ENST00000430494.1
AC007879.7
AC007879.7
chr18_-_28622774 1.15 ENST00000434452.1
DSC3
desmocollin 3
chr12_+_22778291 1.14 ENST00000545979.1
ETNK1
ethanolamine kinase 1
chr14_-_36990354 1.13 ENST00000518149.1
NKX2-1
NK2 homeobox 1
chr6_+_36098363 1.12 ENST00000373759.1
MAPK13
mitogen-activated protein kinase 13
chr17_+_74372662 1.11 ENST00000591651.1
ENST00000545180.1
SPHK1
sphingosine kinase 1
chr5_+_121647386 1.10 ENST00000542191.1
ENST00000506272.1
ENST00000508681.1
ENST00000509154.2
SNCAIP
synuclein, alpha interacting protein
chr1_+_2477831 1.10 ENST00000606645.1
RP3-395M20.12
RP3-395M20.12
chr18_-_28622699 1.10 ENST00000360428.4
DSC3
desmocollin 3
chr11_+_124761200 1.09 ENST00000524433.1
RP11-664I21.6
Uncharacterized protein
chr19_+_3585471 1.09 ENST00000322315.5
GIPC3
GIPC PDZ domain containing family, member 3
chr7_-_72439997 1.09 ENST00000285805.3
TRIM74
tripartite motif containing 74
chr4_+_153457404 1.09 ENST00000604157.1
ENST00000594836.1
MIR4453
microRNA 4453
chr2_+_95691445 1.08 ENST00000353004.3
ENST00000354078.3
ENST00000349807.3
MAL
mal, T-cell differentiation protein
chr20_+_30946106 1.06 ENST00000375687.4
ENST00000542461.1
ASXL1
additional sex combs like 1 (Drosophila)
chr19_+_18492973 1.05 ENST00000595973.2
GDF15
growth differentiation factor 15
chr11_-_73694346 1.05 ENST00000310473.3
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr22_+_37447771 1.03 ENST00000402077.3
ENST00000403888.3
ENST00000456470.1
KCTD17
potassium channel tetramerization domain containing 17
chr9_-_130517309 1.03 ENST00000414380.1
SH2D3C
SH2 domain containing 3C
chr4_-_10118348 1.02 ENST00000502702.1
WDR1
WD repeat domain 1
chr2_+_95691417 1.01 ENST00000309988.4
MAL
mal, T-cell differentiation protein
chr16_-_75467274 1.01 ENST00000566254.1
CFDP1
craniofacial development protein 1
chr11_-_44972418 1.01 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
TP53I11
tumor protein p53 inducible protein 11
chr15_+_100347228 1.00 ENST00000559714.1
ENST00000560059.1
CTD-2054N24.2
Uncharacterized protein
chr19_+_42746927 0.97 ENST00000378108.1
AC006486.1
AC006486.1
chr14_-_75078725 0.97 ENST00000556690.1
LTBP2
latent transforming growth factor beta binding protein 2
chr4_-_10118573 0.96 ENST00000382452.2
ENST00000382451.2
WDR1
WD repeat domain 1
chr10_-_47173994 0.95 ENST00000414655.2
ENST00000545298.1
ENST00000359178.4
ENST00000358140.4
ENST00000503031.1
ANXA8L1
LINC00842
annexin A8-like 1
long intergenic non-protein coding RNA 842
chr7_+_75024903 0.95 ENST00000323819.3
ENST00000430211.1
TRIM73
tripartite motif containing 73
chr16_-_14788526 0.95 ENST00000438167.3
PLA2G10
phospholipase A2, group X
chr7_+_116165754 0.94 ENST00000405348.1
CAV1
caveolin 1, caveolae protein, 22kDa
chr1_+_17634689 0.94 ENST00000375453.1
ENST00000375448.4
PADI4
peptidyl arginine deiminase, type IV
chr1_-_54518865 0.92 ENST00000371337.3
TMEM59
transmembrane protein 59
chr11_+_61717535 0.91 ENST00000534553.1
ENST00000301774.9
BEST1
bestrophin 1
chr11_+_827553 0.91 ENST00000528542.2
ENST00000450448.1
EFCAB4A
EF-hand calcium binding domain 4A
chr2_+_11295498 0.90 ENST00000295083.3
ENST00000441908.2
PQLC3
PQ loop repeat containing 3
chr3_+_14166440 0.88 ENST00000306077.4
TMEM43
transmembrane protein 43
chr17_+_25621102 0.88 ENST00000581440.1
ENST00000262394.2
ENST00000583742.1
ENST00000579733.1
ENST00000583193.1
ENST00000581185.1
ENST00000427287.2
ENST00000348811.2
WSB1
WD repeat and SOCS box containing 1
chr5_+_121647877 0.88 ENST00000514497.2
ENST00000261367.7
SNCAIP
synuclein, alpha interacting protein
chr4_-_10117949 0.87 ENST00000508079.1
WDR1
WD repeat domain 1
chr19_+_35861831 0.87 ENST00000454971.1
GPR42
G protein-coupled receptor 42 (gene/pseudogene)
chr1_-_154941350 0.85 ENST00000444179.1
ENST00000414115.1
SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr19_-_42721819 0.84 ENST00000336034.4
ENST00000598200.1
ENST00000598727.1
ENST00000596251.1
DEDD2
death effector domain containing 2
chr1_+_3607228 0.84 ENST00000378285.1
ENST00000378280.1
ENST00000378288.4
TP73
tumor protein p73
chr14_-_75079026 0.84 ENST00000261978.4
LTBP2
latent transforming growth factor beta binding protein 2
chr1_-_113249734 0.83 ENST00000484054.3
ENST00000369636.2
ENST00000369637.1
ENST00000285735.2
ENST00000369638.2
RHOC
ras homolog family member C
chr12_-_14721283 0.82 ENST00000240617.5
PLBD1
phospholipase B domain containing 1
chr4_-_129209221 0.82 ENST00000512483.1
PGRMC2
progesterone receptor membrane component 2
chr19_+_56652556 0.81 ENST00000337080.3
ZNF444
zinc finger protein 444
chr2_+_11295624 0.81 ENST00000402361.1
ENST00000428481.1
PQLC3
PQ loop repeat containing 3
chr22_-_39715600 0.81 ENST00000427905.1
ENST00000402527.1
ENST00000216146.4
RPL3
ribosomal protein L3
chr22_+_42949925 0.81 ENST00000327678.5
ENST00000340239.4
ENST00000407614.4
ENST00000335879.5
SERHL2
serine hydrolase-like 2
chr12_-_113772835 0.81 ENST00000552014.1
ENST00000548186.1
ENST00000202831.3
ENST00000549181.1
SLC8B1
solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
chr1_+_11796126 0.81 ENST00000376637.3
AGTRAP
angiotensin II receptor-associated protein
chr1_-_113249678 0.80 ENST00000369633.2
ENST00000425265.2
ENST00000369632.2
ENST00000436685.2
RHOC
ras homolog family member C
chr16_-_15149917 0.80 ENST00000287706.3
NTAN1
N-terminal asparagine amidase
chrX_-_65858865 0.80 ENST00000374719.3
ENST00000450752.1
ENST00000451436.2
EDA2R
ectodysplasin A2 receptor
chr13_+_31480328 0.80 ENST00000380482.4
MEDAG
mesenteric estrogen-dependent adipogenesis
chr19_-_51530916 0.79 ENST00000594768.1
KLK11
kallikrein-related peptidase 11
chr19_+_55999771 0.79 ENST00000594321.1
SSC5D
scavenger receptor cysteine rich domain containing (5 domains)
chr2_+_177053307 0.78 ENST00000331462.4
HOXD1
homeobox D1
chr17_-_74528128 0.78 ENST00000590175.1
CYGB
cytoglobin
chr5_+_27472371 0.77 ENST00000512067.1
ENST00000510165.1
ENST00000505775.1
ENST00000514844.1
ENST00000503107.1
LINC01021
long intergenic non-protein coding RNA 1021
chr16_-_75467318 0.77 ENST00000283882.3
CFDP1
craniofacial development protein 1
chr19_+_35849723 0.77 ENST00000594310.1
FFAR3
free fatty acid receptor 3
chr9_-_135996537 0.76 ENST00000372050.3
ENST00000372047.3
RALGDS
ral guanine nucleotide dissociation stimulator
chr22_-_50708781 0.76 ENST00000449719.2
ENST00000330651.6
MAPK11
mitogen-activated protein kinase 11
chr1_-_3528034 0.76 ENST00000356575.4
MEGF6
multiple EGF-like-domains 6
chr19_-_6481759 0.76 ENST00000588421.1
DENND1C
DENN/MADD domain containing 1C
chr11_+_827248 0.76 ENST00000527089.1
ENST00000530183.1
EFCAB4A
EF-hand calcium binding domain 4A
chr3_+_52529346 0.76 ENST00000321725.6
STAB1
stabilin 1
chr19_+_35862192 0.75 ENST00000597214.1
GPR42
G protein-coupled receptor 42 (gene/pseudogene)
chr19_+_55999916 0.74 ENST00000587166.1
ENST00000389623.6
SSC5D
scavenger receptor cysteine rich domain containing (5 domains)
chr17_-_9929581 0.74 ENST00000437099.2
ENST00000396115.2
GAS7
growth arrest-specific 7
chr19_-_28284793 0.73 ENST00000590523.1
LINC00662
long intergenic non-protein coding RNA 662
chr12_+_69186125 0.73 ENST00000399333.3
AC124890.1
HCG1774533, isoform CRA_a; PRO2268; Uncharacterized protein
chr3_-_58196688 0.73 ENST00000486455.1
DNASE1L3
deoxyribonuclease I-like 3
chr19_-_47735918 0.72 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BBC3
BCL2 binding component 3
chr1_-_155990580 0.72 ENST00000531917.1
ENST00000480567.1
ENST00000526212.1
ENST00000529008.1
ENST00000496742.1
ENST00000295702.4
SSR2
signal sequence receptor, beta (translocon-associated protein beta)
chrX_+_192989 0.71 ENST00000399012.1
ENST00000430923.2
PLCXD1
phosphatidylinositol-specific phospholipase C, X domain containing 1
chr20_+_43595115 0.70 ENST00000372806.3
ENST00000396731.4
ENST00000372801.1
ENST00000499879.2
STK4
serine/threonine kinase 4
chr5_+_121647764 0.70 ENST00000261368.8
ENST00000379533.2
ENST00000379536.2
ENST00000379538.3
SNCAIP
synuclein, alpha interacting protein
chr1_-_45805752 0.70 ENST00000354383.6
ENST00000355498.2
ENST00000372100.5
ENST00000531105.1
MUTYH
mutY homolog
chr1_+_25598989 0.69 ENST00000454452.2
RHD
Rh blood group, D antigen
chr4_-_10118469 0.69 ENST00000499869.2
WDR1
WD repeat domain 1
chr19_-_52150053 0.68 ENST00000599649.1
ENST00000429354.3
ENST00000360844.6
ENST00000222107.4
SIGLEC5
SIGLEC14
SIGLEC5
SIGLEC5
sialic acid binding Ig-like lectin 14
sialic acid binding Ig-like lectin 5
chr16_-_31106048 0.68 ENST00000300851.6
VKORC1
vitamin K epoxide reductase complex, subunit 1
chr2_+_47168313 0.68 ENST00000319190.5
ENST00000394850.2
ENST00000536057.1
TTC7A
tetratricopeptide repeat domain 7A
chr16_+_30207122 0.68 ENST00000395137.2
SULT1A3
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3
chr11_+_64126671 0.67 ENST00000530504.1
RPS6KA4
ribosomal protein S6 kinase, 90kDa, polypeptide 4
chr1_+_27153173 0.66 ENST00000374142.4
ZDHHC18
zinc finger, DHHC-type containing 18
chr16_-_31106211 0.66 ENST00000532364.1
ENST00000529564.1
ENST00000319788.7
ENST00000354895.4
ENST00000394975.2
RP11-196G11.1
VKORC1
Uncharacterized protein
vitamin K epoxide reductase complex, subunit 1
chr11_+_65222698 0.66 ENST00000309775.7
AP000769.1
Uncharacterized protein
chr10_-_126847276 0.66 ENST00000531469.1
CTBP2
C-terminal binding protein 2
chr19_+_56652686 0.66 ENST00000592949.1
ZNF444
zinc finger protein 444
chr19_-_39926268 0.65 ENST00000599705.1
RPS16
ribosomal protein S16
chr10_-_73611046 0.65 ENST00000394934.1
ENST00000394936.3
PSAP
prosaposin
chr17_+_14204389 0.65 ENST00000360954.2
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr1_+_114447763 0.64 ENST00000369563.3
DCLRE1B
DNA cross-link repair 1B
chr15_+_42867857 0.64 ENST00000290607.7
STARD9
StAR-related lipid transfer (START) domain containing 9
chr6_+_116692102 0.64 ENST00000359564.2
DSE
dermatan sulfate epimerase
chr14_-_36990061 0.63 ENST00000546983.1
NKX2-1
NK2 homeobox 1
chr15_-_42386752 0.63 ENST00000290472.3
PLA2G4D
phospholipase A2, group IVD (cytosolic)
chr22_+_21336267 0.62 ENST00000215739.8
LZTR1
leucine-zipper-like transcription regulator 1
chr16_+_29467780 0.62 ENST00000395400.3
SULT1A4
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4
chr15_-_64455404 0.61 ENST00000300026.3
PPIB
peptidylprolyl isomerase B (cyclophilin B)
chr3_-_149510553 0.61 ENST00000462519.2
ENST00000446160.1
ENST00000383050.3
ANKUB1
ankyrin repeat and ubiquitin domain containing 1
chr9_-_116037840 0.61 ENST00000374206.3
CDC26
cell division cycle 26
chr19_-_17014408 0.61 ENST00000594249.1
CPAMD8
C3 and PZP-like, alpha-2-macroglobulin domain containing 8
chr2_+_109745655 0.59 ENST00000418513.1
SH3RF3
SH3 domain containing ring finger 3
chr5_+_121647924 0.58 ENST00000414317.2
SNCAIP
synuclein, alpha interacting protein
chr11_+_64126614 0.57 ENST00000528057.1
ENST00000334205.4
ENST00000294261.4
RPS6KA4
ribosomal protein S6 kinase, 90kDa, polypeptide 4
chr14_-_36789783 0.57 ENST00000605579.1
ENST00000604336.1
ENST00000359527.7
ENST00000603139.1
ENST00000318473.7
MBIP
MAP3K12 binding inhibitory protein 1
chr14_-_103989033 0.56 ENST00000553878.1
ENST00000557530.1
CKB
creatine kinase, brain
chr1_+_11796177 0.56 ENST00000400895.2
ENST00000376629.4
ENST00000376627.2
ENST00000314340.5
ENST00000452018.2
ENST00000510878.1
AGTRAP
angiotensin II receptor-associated protein
chr1_-_45805667 0.56 ENST00000488731.2
ENST00000435155.1
MUTYH
mutY homolog
chr1_-_45806053 0.55 ENST00000412971.1
ENST00000372098.3
ENST00000372110.3
ENST00000529984.1
ENST00000528332.2
ENST00000372115.3
ENST00000450313.1
MUTYH
mutY homolog
chr20_+_62289640 0.53 ENST00000508582.2
ENST00000360203.5
ENST00000356810.4
RTEL1
regulator of telomere elongation helicase 1
chr8_-_69243711 0.52 ENST00000512294.3
RP11-664D7.4
HCG1787533; Uncharacterized protein
chr11_+_61717279 0.51 ENST00000378043.4
BEST1
bestrophin 1
chr16_-_31105870 0.51 ENST00000394971.3
VKORC1
vitamin K epoxide reductase complex, subunit 1
chr16_+_57406437 0.51 ENST00000564948.1
CX3CL1
chemokine (C-X3-C motif) ligand 1
chr12_-_6451186 0.51 ENST00000540022.1
ENST00000536194.1
TNFRSF1A
tumor necrosis factor receptor superfamily, member 1A
chr19_-_44259136 0.50 ENST00000270066.6
SMG9
SMG9 nonsense mediated mRNA decay factor
chr17_-_37308824 0.50 ENST00000415163.1
ENST00000441877.1
ENST00000444911.2
PLXDC1
plexin domain containing 1
chr11_+_61717336 0.50 ENST00000378042.3
BEST1
bestrophin 1
chr6_+_52285131 0.50 ENST00000433625.2
EFHC1
EF-hand domain (C-terminal) containing 1
chr11_-_9286627 0.49 ENST00000530044.1
DENND5A
DENN/MADD domain containing 5A
chr11_-_68611721 0.49 ENST00000561996.1
CPT1A
carnitine palmitoyltransferase 1A (liver)

Network of associatons between targets according to the STRING database.

First level regulatory network of TP53

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 8.9 GO:0044027 hypermethylation of CpG island(GO:0044027)
1.2 4.6 GO:0071613 granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
0.9 2.7 GO:0050720 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720)
0.9 3.5 GO:0042247 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
0.6 2.6 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
0.6 1.3 GO:2000564 CD8-positive, alpha-beta T cell proliferation(GO:0035740) regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.6 1.7 GO:0002352 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597) positive regulation of apoptotic DNA fragmentation(GO:1902512)
0.5 1.5 GO:1905000 regulation of membrane repolarization during atrial cardiac muscle cell action potential(GO:1905000)
0.4 1.3 GO:0001300 chronological cell aging(GO:0001300)
0.4 1.1 GO:0046521 sphingoid catabolic process(GO:0046521)
0.4 1.5 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.4 1.8 GO:0090285 negative regulation of protein glycosylation in Golgi(GO:0090285)
0.4 1.1 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.3 3.5 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.3 1.4 GO:1900138 negative regulation of phospholipase A2 activity(GO:1900138)
0.3 2.4 GO:2000782 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) positive regulation of barbed-end actin filament capping(GO:2000814)
0.3 4.3 GO:0022417 protein maturation by protein folding(GO:0022417)
0.3 0.9 GO:1900085 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
0.3 1.6 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.3 0.8 GO:0051040 regulation of calcium-independent cell-cell adhesion(GO:0051040)
0.3 0.5 GO:1904430 negative regulation of t-circle formation(GO:1904430)
0.3 1.5 GO:0042494 detection of bacterial lipoprotein(GO:0042494)
0.3 1.0 GO:0007231 osmosensory signaling pathway(GO:0007231)
0.2 6.1 GO:0097296 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.2 1.8 GO:0045007 depurination(GO:0045007)
0.2 2.0 GO:0007207 phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
0.2 1.2 GO:0043988 histone H3-S28 phosphorylation(GO:0043988)
0.2 0.6 GO:1901873 regulation of post-translational protein modification(GO:1901873)
0.2 0.6 GO:0045083 negative regulation of interleukin-12 biosynthetic process(GO:0045083)
0.2 0.8 GO:0002879 positive regulation of acute inflammatory response to non-antigenic stimulus(GO:0002879)
0.2 0.9 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.2 1.3 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.2 0.9 GO:0036414 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.2 4.8 GO:1902043 positive regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902043)
0.2 1.8 GO:2000270 negative regulation of fibroblast apoptotic process(GO:2000270)
0.2 1.9 GO:0042373 vitamin K metabolic process(GO:0042373)
0.1 1.8 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.8 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.1 0.8 GO:2001184 positive regulation of interleukin-12 secretion(GO:2001184)
0.1 0.4 GO:2000588 positive regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000588)
0.1 0.2 GO:1902731 negative regulation of chondrocyte proliferation(GO:1902731)
0.1 3.0 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.1 1.9 GO:0030321 transepithelial chloride transport(GO:0030321)
0.1 0.8 GO:2000490 negative regulation of hepatic stellate cell activation(GO:2000490)
0.1 0.6 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1 0.6 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.1 0.4 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.1 0.6 GO:0031860 telomeric loop formation(GO:0031627) telomeric 3' overhang formation(GO:0031860)
0.1 0.5 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
0.1 0.6 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.1 1.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.1 1.0 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.1 0.7 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.1 1.3 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.1 1.4 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.1 0.4 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
0.1 3.3 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.1 0.7 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.1 0.4 GO:0042816 vitamin B6 metabolic process(GO:0042816)
0.1 0.3 GO:0032915 positive regulation of transforming growth factor beta2 production(GO:0032915)
0.1 0.2 GO:0043132 NAD transport(GO:0043132)
0.1 1.7 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 1.2 GO:0038203 TORC2 signaling(GO:0038203)
0.1 1.4 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.1 0.2 GO:0000454 snoRNA guided rRNA pseudouridine synthesis(GO:0000454)
0.1 0.9 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 0.4 GO:0090131 mesenchyme migration(GO:0090131)
0.1 0.4 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 0.2 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
0.1 0.4 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.1 0.8 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 1.5 GO:1901741 positive regulation of myoblast fusion(GO:1901741)
0.1 1.1 GO:0010623 programmed cell death involved in cell development(GO:0010623)
0.1 0.4 GO:1901341 activation of store-operated calcium channel activity(GO:0032237) positive regulation of store-operated calcium channel activity(GO:1901341)
0.1 1.5 GO:0036149 phosphatidylinositol acyl-chain remodeling(GO:0036149)
0.1 0.4 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.1 0.3 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.1 8.5 GO:0006958 complement activation, classical pathway(GO:0006958)
0.1 1.7 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.5 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.1 0.8 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.0 0.2 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 1.9 GO:0097435 fibril organization(GO:0097435)
0.0 0.5 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
0.0 0.3 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.3 GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
0.0 1.2 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
0.0 0.5 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.2 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
0.0 0.2 GO:0043335 protein unfolding(GO:0043335)
0.0 0.3 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0 0.2 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
0.0 0.2 GO:2000174 regulation of pro-T cell differentiation(GO:2000174) positive regulation of pro-T cell differentiation(GO:2000176)
0.0 5.1 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 0.7 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 1.4 GO:0015695 organic cation transport(GO:0015695)
0.0 0.3 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 1.0 GO:0048714 positive regulation of oligodendrocyte differentiation(GO:0048714)
0.0 1.7 GO:0030517 negative regulation of axon extension(GO:0030517)
0.0 1.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0 1.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.0 0.5 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 5.2 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154)
0.0 0.2 GO:0060214 endocardium formation(GO:0060214)
0.0 0.2 GO:1902510 regulation of apoptotic DNA fragmentation(GO:1902510)
0.0 0.7 GO:0060742 epithelial cell differentiation involved in prostate gland development(GO:0060742)
0.0 0.8 GO:0016075 rRNA catabolic process(GO:0016075)
0.0 1.3 GO:0022038 corpus callosum development(GO:0022038)
0.0 0.4 GO:0007258 JUN phosphorylation(GO:0007258)
0.0 0.2 GO:0070235 regulation of activation-induced cell death of T cells(GO:0070235) negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.2 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.3 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.0 0.2 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.5 GO:0002934 desmosome organization(GO:0002934)
0.0 0.4 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
0.0 0.1 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.8 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.7 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 0.6 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.0 1.0 GO:0032469 endoplasmic reticulum calcium ion homeostasis(GO:0032469)
0.0 3.4 GO:0070268 cornification(GO:0070268)
0.0 0.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 2.3 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 0.8 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.3 GO:2000574 regulation of microtubule motor activity(GO:2000574)
0.0 0.1 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 1.4 GO:0070206 protein trimerization(GO:0070206)
0.0 0.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.4 GO:0070986 left/right axis specification(GO:0070986)
0.0 1.3 GO:0001706 endoderm formation(GO:0001706)
0.0 1.6 GO:0050819 negative regulation of coagulation(GO:0050819)
0.0 0.9 GO:0021795 cerebral cortex cell migration(GO:0021795)
0.0 0.7 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.0 0.6 GO:0050427 purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.4 GO:0050901 leukocyte tethering or rolling(GO:0050901)
0.0 0.1 GO:0034472 snRNA 3'-end processing(GO:0034472)
0.0 0.4 GO:0003334 keratinocyte development(GO:0003334)
0.0 0.1 GO:0098886 modification of dendritic spine(GO:0098886)
0.0 0.3 GO:0036010 protein localization to endosome(GO:0036010)
0.0 0.6 GO:0007257 activation of JUN kinase activity(GO:0007257)
0.0 0.2 GO:0015705 iodide transport(GO:0015705)
0.0 0.1 GO:0071344 diphosphate metabolic process(GO:0071344)
0.0 0.5 GO:0032259 methylation(GO:0032259)
0.0 0.2 GO:0006265 DNA topological change(GO:0006265)
0.0 0.6 GO:0070979 protein K11-linked ubiquitination(GO:0070979)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 4.3 GO:1990425 ryanodine receptor complex(GO:1990425)
0.7 3.5 GO:0042643 actomyosin, actin portion(GO:0042643)
0.4 3.0 GO:0032133 chromosome passenger complex(GO:0032133)
0.4 1.5 GO:0031523 Myb complex(GO:0031523)
0.2 1.8 GO:0005797 Golgi medial cisterna(GO:0005797)
0.2 1.2 GO:0036021 endolysosome lumen(GO:0036021)
0.2 1.7 GO:0005610 laminin-5 complex(GO:0005610)
0.1 1.7 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 0.9 GO:0070435 Shc-EGFR complex(GO:0070435)
0.1 0.8 GO:0005638 lamin filament(GO:0005638)
0.1 0.5 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.1 3.9 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.1 0.2 GO:0005921 gap junction(GO:0005921)
0.1 3.2 GO:0031527 filopodium membrane(GO:0031527)
0.1 2.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.1 0.4 GO:0030485 smooth muscle contractile fiber(GO:0030485)
0.1 0.2 GO:0071001 U4/U6 snRNP(GO:0071001)
0.1 0.2 GO:0043293 apoptosome(GO:0043293)
0.1 2.7 GO:0030057 desmosome(GO:0030057)
0.1 1.3 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 0.5 GO:0031415 NatA complex(GO:0031415)
0.1 0.8 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.1 0.9 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.8 GO:0030061 mitochondrial crista(GO:0030061)
0.0 1.2 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.3 GO:1902560 GMP reductase complex(GO:1902560)
0.0 0.7 GO:0097470 ribbon synapse(GO:0097470)
0.0 1.0 GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671)
0.0 3.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.6 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.0 0.3 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.0 1.1 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0 0.2 GO:0016035 zeta DNA polymerase complex(GO:0016035)
0.0 0.3 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.0 3.6 GO:0035577 azurophil granule membrane(GO:0035577)
0.0 0.4 GO:0005642 annulate lamellae(GO:0005642)
0.0 0.2 GO:0072589 box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
0.0 0.9 GO:0016580 Sin3 complex(GO:0016580)
0.0 0.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.3 GO:0097443 sorting endosome(GO:0097443)
0.0 1.7 GO:0015030 Cajal body(GO:0015030)
0.0 3.6 GO:0042734 presynaptic membrane(GO:0042734)
0.0 1.7 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.0 4.6 GO:0072562 blood microparticle(GO:0072562)
0.0 0.8 GO:0005721 pericentric heterochromatin(GO:0005721)
0.0 10.2 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.3 GO:0032420 stereocilium(GO:0032420)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.2 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.1 GO:1990393 3M complex(GO:1990393)
0.0 1.5 GO:0045095 keratin filament(GO:0045095)
0.0 0.6 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 1.6 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 0.1 GO:0002177 manchette(GO:0002177)
0.0 4.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666) DNA-directed RNA polymerase I complex(GO:0005736)
0.0 0.1 GO:1990769 proximal neuron projection(GO:1990769)
0.0 0.2 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 1.8 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 1.0 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:0030131 clathrin adaptor complex(GO:0030131)
0.0 1.1 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 11.4 GO:0045569 TRAIL binding(GO:0045569)
0.7 2.9 GO:0022865 transmembrane electron transfer carrier(GO:0022865)
0.7 8.9 GO:0051525 NFAT protein binding(GO:0051525)
0.5 1.8 GO:0032408 MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408)
0.4 1.9 GO:0047057 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.4 2.6 GO:0043120 tumor necrosis factor binding(GO:0043120)
0.3 1.0 GO:0030366 molybdopterin synthase activity(GO:0030366)
0.3 0.9 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
0.3 1.2 GO:0004711 ribosomal protein S6 kinase activity(GO:0004711)
0.3 4.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 1.5 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.2 6.3 GO:0004707 MAP kinase activity(GO:0004707)
0.2 1.4 GO:0001595 angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945)
0.2 0.8 GO:0047888 fatty acid peroxidase activity(GO:0047888)
0.2 0.9 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.2 0.5 GO:1990698 palmitoleoyltransferase activity(GO:1990698)
0.2 0.5 GO:0004019 adenylosuccinate synthase activity(GO:0004019)
0.2 1.1 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 1.0 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 0.4 GO:0098640 integrin binding involved in cell-matrix adhesion(GO:0098640)
0.1 1.7 GO:0051434 BH3 domain binding(GO:0051434)
0.1 0.6 GO:0004047 aminomethyltransferase activity(GO:0004047)
0.1 0.6 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 2.7 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.6 GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.1 0.7 GO:0047685 amine sulfotransferase activity(GO:0047685)
0.1 4.6 GO:0042288 MHC class I protein binding(GO:0042288)
0.1 0.3 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.1 1.1 GO:0004305 ethanolamine kinase activity(GO:0004305)
0.1 0.9 GO:0048408 epidermal growth factor binding(GO:0048408)
0.1 0.2 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
0.1 1.8 GO:0044213 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.1 0.3 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.1 2.6 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
0.1 0.7 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.1 0.6 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.1 0.8 GO:0070883 pre-miRNA binding(GO:0070883)
0.1 0.2 GO:0033149 FFAT motif binding(GO:0033149)
0.1 3.9 GO:0034987 immunoglobulin receptor binding(GO:0034987)
0.1 0.4 GO:0008097 5S rRNA binding(GO:0008097)
0.1 2.6 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 2.7 GO:0001968 fibronectin binding(GO:0001968)
0.1 1.6 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 0.8 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.1 0.2 GO:0031493 nucleosomal histone binding(GO:0031493)
0.1 0.6 GO:0004111 creatine kinase activity(GO:0004111)
0.1 1.5 GO:0019841 retinol binding(GO:0019841)
0.1 1.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 0.6 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.1 3.0 GO:0008536 Ran GTPase binding(GO:0008536)
0.1 0.7 GO:0004565 beta-galactosidase activity(GO:0004565)
0.0 2.7 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.6 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0 0.3 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.0 0.5 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
0.0 1.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.2 GO:0098808 mRNA cap binding(GO:0098808)
0.0 0.3 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0 0.2 GO:0015111 iodide transmembrane transporter activity(GO:0015111)
0.0 1.3 GO:0005003 ephrin receptor activity(GO:0005003)
0.0 0.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.0 1.4 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0 1.7 GO:0038191 neuropilin binding(GO:0038191)
0.0 2.3 GO:0042379 chemokine receptor binding(GO:0042379)
0.0 1.8 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 1.0 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.1 GO:0060001 minus-end directed microfilament motor activity(GO:0060001)
0.0 1.2 GO:0005123 death receptor binding(GO:0005123)
0.0 0.3 GO:0043426 MRF binding(GO:0043426)
0.0 0.3 GO:1990446 U1 snRNP binding(GO:1990446)
0.0 1.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.0 1.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 2.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.2 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.6 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.5 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.8 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.4 GO:0034452 dynactin binding(GO:0034452)
0.0 4.8 GO:0003823 antigen binding(GO:0003823)
0.0 0.8 GO:0030169 low-density lipoprotein particle binding(GO:0030169)
0.0 1.4 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 3.7 GO:0019838 growth factor binding(GO:0019838)
0.0 0.4 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.2 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 0.3 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.8 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.0 6.1 GO:0051015 actin filament binding(GO:0051015)
0.0 0.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 0.3 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.4 GO:0008483 transaminase activity(GO:0008483)
0.0 0.7 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 3.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.3 GO:0001054 RNA polymerase I activity(GO:0001054) RNA polymerase II activity(GO:0001055)
0.0 1.1 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.0 0.4 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.0 1.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 4.3 PID ALK2 PATHWAY ALK2 signaling events
0.2 3.6 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.2 11.4 PID TRAIL PATHWAY TRAIL signaling pathway
0.2 3.2 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 3.1 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 9.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.1 1.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.1 1.9 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.0 1.2 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 3.3 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 3.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.0 1.6 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.0 3.0 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.9 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 0.6 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.0 1.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 2.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.3 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.3 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 0.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 4.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 0.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.6 PID TNF PATHWAY TNF receptor signaling pathway
0.0 0.2 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.8 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 5.2 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.2 2.0 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 4.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1 3.9 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.1 1.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
0.1 1.9 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1 2.4 REACTOME ACYL CHAIN REMODELLING OF PI Genes involved in Acyl chain remodelling of PI
0.1 1.8 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.1 3.0 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.0 3.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 1.1 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 4.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.3 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.0 0.8 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.0 1.1 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.5 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.0 0.9 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 0.6 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.5 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 5.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.7 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.0 1.1 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.5 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 3.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.8 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 0.6 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.0 0.7 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.0 0.3 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0 2.3 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.0 0.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.5 REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION Genes involved in RORA Activates Circadian Expression
0.0 0.3 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 0.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines