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Illumina Body Map 2
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Results for TWIST1_SNAI1
Z-value: 2.70
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Transcription factors associated with TWIST1_SNAI1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| SNAI1 | hg19_v2_chr20_+_48599506_48599536 | 0.32 | 7.8e-02 | Click! |
| TWIST1 | hg19_v2_chr7_-_19157248_19157295 | 0.22 | 2.2e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_47596287 Show fit | 9.75 |
ENST00000263735.4
|
epithelial cell adhesion molecule |
|
| chr19_+_35532612 Show fit | 9.74 |
ENST00000600390.1
ENST00000597419.1 |
hepsin |
|
| chr12_+_52626898 Show fit | 9.59 |
ENST00000331817.5
|
keratin 7 |
|
| chr4_-_77819002 Show fit | 8.59 |
ENST00000334306.2
|
sosondowah ankyrin repeat domain family member B |
|
| chr9_+_17579084 Show fit | 8.29 |
ENST00000380607.4
|
SH3-domain GRB2-like 2 |
|
| chrX_+_105969893 Show fit | 8.29 |
ENST00000255499.2
|
ring finger protein 128, E3 ubiquitin protein ligase |
|
| chr16_+_4838393 Show fit | 7.29 |
ENST00000589721.1
|
small integral membrane protein 22 |
|
| chr7_+_73242069 Show fit | 6.78 |
ENST00000435050.1
|
claudin 4 |
|
| chr19_+_6464243 Show fit | 6.74 |
ENST00000600229.1
ENST00000356762.3 |
crumbs homolog 3 (Drosophila) |
|
| chr19_-_3480540 Show fit | 6.61 |
ENST00000215531.4
|
chromosome 19 open reading frame 77 |
Network of associatons between targets according to the STRING database.
First level regulatory network of TWIST1_SNAI1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 28.3 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.1 | 17.8 | GO:0070268 | cornification(GO:0070268) |
| 0.2 | 17.0 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 3.9 | 15.5 | GO:0097195 | pilomotor reflex(GO:0097195) |
| 0.9 | 11.5 | GO:0045329 | carnitine biosynthetic process(GO:0045329) |
| 0.2 | 11.0 | GO:0090004 | positive regulation of establishment of protein localization to plasma membrane(GO:0090004) |
| 0.3 | 10.8 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.7 | 10.6 | GO:0048672 | positive regulation of collateral sprouting(GO:0048672) |
| 0.8 | 10.5 | GO:0046598 | positive regulation of viral entry into host cell(GO:0046598) |
| 1.9 | 9.5 | GO:0097089 | methyl-branched fatty acid metabolic process(GO:0097089) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 40.8 | GO:0070160 | occluding junction(GO:0070160) |
| 0.8 | 31.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 20.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.2 | 18.9 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 17.8 | GO:0016324 | apical plasma membrane(GO:0016324) |
| 0.1 | 16.4 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.1 | 16.1 | GO:0030658 | transport vesicle membrane(GO:0030658) |
| 0.0 | 15.8 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.2 | 15.2 | GO:0030669 | clathrin-coated endocytic vesicle membrane(GO:0030669) |
| 0.3 | 12.2 | GO:0030057 | desmosome(GO:0030057) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 20.2 | GO:0098641 | cadherin binding involved in cell-cell adhesion(GO:0098641) |
| 0.0 | 19.1 | GO:0005198 | structural molecule activity(GO:0005198) |
| 0.1 | 18.1 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.1 | 16.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.4 | 12.9 | GO:0070008 | serine-type exopeptidase activity(GO:0070008) |
| 0.1 | 12.7 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.4 | 11.8 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 2.9 | 11.5 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.5 | 10.4 | GO:0015245 | fatty acid transporter activity(GO:0015245) |
| 0.8 | 10.2 | GO:0086007 | voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.1 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.2 | 16.2 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 12.5 | PID EPHA FWDPATHWAY | EPHA forward signaling |
| 0.2 | 11.1 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 0.1 | 9.3 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 8.1 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.2 | 7.9 | PID HEDGEHOG 2PATHWAY | Signaling events mediated by the Hedgehog family |
| 0.1 | 6.4 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 6.1 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.1 | 5.5 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 40.5 | REACTOME TIGHT JUNCTION INTERACTIONS | Genes involved in Tight junction interactions |
| 0.2 | 15.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.0 | 13.2 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.5 | 12.2 | REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS | Genes involved in Apoptotic cleavage of cell adhesion proteins |
| 0.2 | 10.7 | REACTOME AMINE COMPOUND SLC TRANSPORTERS | Genes involved in Amine compound SLC transporters |
| 0.1 | 10.5 | REACTOME O LINKED GLYCOSYLATION OF MUCINS | Genes involved in O-linked glycosylation of mucins |
| 0.7 | 10.4 | REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL | Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol |
| 0.3 | 9.0 | REACTOME GAP JUNCTION ASSEMBLY | Genes involved in Gap junction assembly |
| 0.3 | 8.1 | REACTOME RETROGRADE NEUROTROPHIN SIGNALLING | Genes involved in Retrograde neurotrophin signalling |
| 0.1 | 8.1 | REACTOME PHASE II CONJUGATION | Genes involved in Phase II conjugation |