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Illumina Body Map 2
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Results for WRNIP1
Z-value: 2.51
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Transcription factors associated with WRNIP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| WRNIP1 | hg19_v2_chr6_+_2765595_2765797 | 0.23 | 2.1e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of WRNIP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 47.8 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.2 | 36.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 1.4 | 34.3 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.4 | 30.9 | GO:0048791 | calcium ion-regulated exocytosis of neurotransmitter(GO:0048791) |
| 2.7 | 29.4 | GO:0051612 | negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.4 | 27.8 | GO:0051965 | positive regulation of synapse assembly(GO:0051965) |
| 1.1 | 26.8 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.2 | 26.3 | GO:1902476 | chloride transmembrane transport(GO:1902476) |
| 1.0 | 25.9 | GO:0038065 | collagen-activated signaling pathway(GO:0038065) |
| 0.8 | 23.9 | GO:0032291 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 150.5 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.3 | 89.4 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.2 | 57.0 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.4 | 56.5 | GO:0043204 | perikaryon(GO:0043204) |
| 0.5 | 49.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.3 | 46.0 | GO:0034705 | potassium channel complex(GO:0034705) |
| 0.3 | 46.0 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.2 | 41.1 | GO:0043209 | myelin sheath(GO:0043209) |
| 2.1 | 38.4 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 1.0 | 37.7 | GO:1902711 | GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 58.9 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.3 | 57.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 39.1 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.2 | 33.5 | GO:0005178 | integrin binding(GO:0005178) |
| 0.4 | 33.3 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.3 | 29.6 | GO:0005254 | chloride channel activity(GO:0005254) |
| 0.9 | 29.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.9 | 26.4 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.7 | 25.7 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.2 | 24.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 93.5 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.7 | 51.6 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.1 | 39.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.5 | 33.9 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 33.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.4 | 23.8 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
| 0.3 | 23.5 | PID WNT NONCANONICAL PATHWAY | Noncanonical Wnt signaling pathway |
| 0.8 | 21.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.3 | 20.1 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.3 | 20.0 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 39.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.5 | 36.7 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.5 | 35.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.8 | 34.9 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 0.1 | 25.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.4 | 24.3 | REACTOME NITRIC OXIDE STIMULATES GUANYLATE CYCLASE | Genes involved in Nitric oxide stimulates guanylate cyclase |
| 0.3 | 23.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.9 | 22.1 | REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS | Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors) |
| 0.2 | 22.1 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.3 | 21.2 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |