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Illumina Body Map 2
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Results for XBP1
Z-value: 1.32
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Transcription factors associated with XBP1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| XBP1 | hg19_v2_chr22_-_29196511_29196541 | 0.58 | 4.7e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of XBP1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.1 | GO:0043589 | skin morphogenesis(GO:0043589) |
| 0.5 | 5.9 | GO:0006621 | protein retention in ER lumen(GO:0006621) |
| 0.4 | 5.9 | GO:0031584 | activation of phospholipase D activity(GO:0031584) |
| 0.3 | 5.9 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.1 | 5.7 | GO:0006882 | cellular zinc ion homeostasis(GO:0006882) zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 4.8 | GO:0036498 | IRE1-mediated unfolded protein response(GO:0036498) |
| 0.4 | 4.4 | GO:0071569 | protein ufmylation(GO:0071569) |
| 0.2 | 4.4 | GO:0090110 | cargo loading into COPII-coated vesicle(GO:0090110) |
| 0.2 | 3.9 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 1.0 | 3.8 | GO:0036483 | neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0036483) regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903381) negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903382) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.5 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 10.6 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 7.3 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 6.7 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 2.0 | 6.1 | GO:0005584 | collagen type I trimer(GO:0005584) |
| 0.0 | 5.6 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.0 | 5.6 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.6 | 4.3 | GO:0005784 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.2 | 4.1 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.2 | 3.8 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 9.5 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.2 | 6.9 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.3 | 6.1 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 1.5 | 5.9 | GO:0070991 | medium-chain-acyl-CoA dehydrogenase activity(GO:0070991) |
| 0.7 | 5.9 | GO:0046923 | ER retention sequence binding(GO:0046923) |
| 0.0 | 4.6 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 4.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.0 | 3.9 | GO:0003978 | UDP-N-acetylglucosamine 4-epimerase activity(GO:0003974) UDP-glucose 4-epimerase activity(GO:0003978) |
| 1.3 | 3.8 | GO:0004779 | adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781) |
| 0.1 | 3.0 | GO:1990381 | ubiquitin-specific protease binding(GO:1990381) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.8 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.0 | 5.3 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.1 | 2.5 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.0 | 2.0 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.0 | 1.5 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.0 | 1.3 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 0.0 | 1.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 0.9 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 0.5 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 11.5 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 0.3 | 9.1 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.3 | 6.1 | REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN | Genes involved in Platelet Adhesion to exposed collagen |
| 0.1 | 4.1 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
| 0.2 | 3.8 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |
| 0.1 | 2.3 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 2.2 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 2.0 | REACTOME MITOCHONDRIAL TRNA AMINOACYLATION | Genes involved in Mitochondrial tRNA aminoacylation |
| 0.0 | 1.7 | REACTOME IRON UPTAKE AND TRANSPORT | Genes involved in Iron uptake and transport |