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Illumina Body Map 2

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Results for ZIC1

Z-value: 0.92

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Transcription factors associated with ZIC1

Gene Symbol Gene ID Gene Info
ENSG00000152977.5 Zic family member 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZIC1hg19_v2_chr3_+_147127142_1471271710.355.3e-02Click!

Activity profile of ZIC1 motif

Sorted Z-values of ZIC1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_-_177134024 4.03 ENST00000367654.3
astrotactin 1
chr6_-_117086873 3.23 ENST00000368557.4
family with sequence similarity 162, member B
chr7_-_107880508 3.22 ENST00000425651.2
neuronal cell adhesion molecule
chr9_+_132934835 3.14 ENST00000372398.3
neuronal calcium sensor 1
chr1_+_233749739 3.09 ENST00000366621.3
potassium channel, subfamily K, member 1
chr3_-_58563094 2.83 ENST00000464064.1
family with sequence similarity 107, member A
chr4_+_24797085 2.78 ENST00000382120.3
superoxide dismutase 3, extracellular
chr19_-_35992780 2.61 ENST00000593342.1
ENST00000601650.1
ENST00000408915.2
dermokine
chr6_+_31949801 2.56 ENST00000428956.2
ENST00000498271.1
complement component 4A (Rodgers blood group)
chr1_-_177133998 2.35 ENST00000367657.3
astrotactin 1
chr19_+_45409011 2.31 ENST00000252486.4
ENST00000446996.1
ENST00000434152.1
apolipoprotein E
chr8_-_120685608 2.13 ENST00000427067.2
ectonucleotide pyrophosphatase/phosphodiesterase 2
chr3_+_50192499 1.98 ENST00000413852.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr1_-_71513471 1.96 ENST00000370931.3
ENST00000356595.4
ENST00000306666.5
ENST00000370932.2
ENST00000351052.5
ENST00000414819.1
ENST00000370924.4
prostaglandin E receptor 3 (subtype EP3)
chr3_-_73483055 1.93 ENST00000479530.1
PDZ domain containing ring finger 3
chr22_+_41956767 1.91 ENST00000306149.7
cold shock domain containing C2, RNA binding
chr8_+_85097110 1.89 ENST00000517638.1
ENST00000522647.1
RALY RNA binding protein-like
chr11_-_2160180 1.88 ENST00000381406.4
insulin-like growth factor 2 (somatomedin A)
chr11_-_57417405 1.86 ENST00000524669.1
ENST00000300022.3
yippee-like 4 (Drosophila)
chr3_+_50192457 1.85 ENST00000414301.1
ENST00000450338.1
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F
chr14_+_38677123 1.84 ENST00000267377.2
somatostatin receptor 1
chr14_+_101361107 1.74 ENST00000553584.1
ENST00000554852.1
maternally expressed 8 (non-protein coding)
chr17_-_43045439 1.68 ENST00000253407.3
complement component 1, q subcomponent-like 1
chr16_+_23194033 1.67 ENST00000300061.2
sodium channel, non-voltage-gated 1, gamma subunit
chr7_-_135412925 1.66 ENST00000354042.4
solute carrier family 13 (sodium/sulfate symporter), member 4
chr15_+_73976545 1.65 ENST00000318443.5
ENST00000537340.2
ENST00000318424.5
CD276 molecule
chr12_-_15038779 1.64 ENST00000228938.5
ENST00000539261.1
matrix Gla protein
chrX_+_70364667 1.64 ENST00000536169.1
ENST00000395855.2
ENST00000374051.3
ENST00000358741.3
neuroligin 3
chr17_+_40913210 1.57 ENST00000253796.5
receptor (G protein-coupled) activity modifying protein 2
chr15_+_63340553 1.57 ENST00000334895.5
tropomyosin 1 (alpha)
chr17_+_60704762 1.53 ENST00000303375.5
mannose receptor, C type 2
chr5_+_140514782 1.52 ENST00000231134.5
protocadherin beta 5
chrX_+_18725758 1.50 ENST00000472826.1
ENST00000544635.1
ENST00000496075.2
protein phosphatase, EF-hand calcium binding domain 1
chr12_+_77718388 1.47 ENST00000550042.1
RP1-34H18.1
chr1_+_46668994 1.47 ENST00000371980.3
leucine rich adaptor protein 1
chr12_-_106477805 1.46 ENST00000553094.1
ENST00000549704.1
NUAK family, SNF1-like kinase, 1
chr21_-_39870339 1.45 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
v-ets avian erythroblastosis virus E26 oncogene homolog
chr4_-_186733363 1.45 ENST00000393523.2
ENST00000393528.3
ENST00000449407.2
sorbin and SH3 domain containing 2
chr17_-_53809473 1.44 ENST00000575734.1
transmembrane protein 100
chr3_-_79816965 1.43 ENST00000464233.1
roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr11_-_62689046 1.43 ENST00000306960.3
ENST00000543973.1
cholinergic receptor, muscarinic 1
chr1_+_16370271 1.42 ENST00000375679.4
chloride channel, voltage-sensitive Kb
chr9_+_124329336 1.40 ENST00000394340.3
ENST00000436835.1
ENST00000259371.2
DAB2 interacting protein
chr9_-_79267432 1.35 ENST00000424866.1
prune homolog 2 (Drosophila)
chr2_-_208989225 1.33 ENST00000264376.4
crystallin, gamma D
chr2_+_120189422 1.33 ENST00000306406.4
transmembrane protein 37
chr7_-_73256838 1.32 ENST00000297873.4
Williams Beuren syndrome chromosome region 27
chr1_-_94586651 1.32 ENST00000535735.1
ENST00000370225.3
ATP-binding cassette, sub-family A (ABC1), member 4
chr19_+_46806856 1.30 ENST00000300862.3
hypoxia inducible factor 3, alpha subunit
chr4_+_95916947 1.29 ENST00000506363.1
bone morphogenetic protein receptor, type IB
chr19_-_58609570 1.27 ENST00000600845.1
ENST00000240727.6
ENST00000600897.1
ENST00000421612.2
ENST00000601063.1
ENST00000601144.1
zinc finger and SCAN domain containing 18
chr12_-_59314246 1.25 ENST00000320743.3
leucine-rich repeats and immunoglobulin-like domains 3
chrX_+_53078273 1.23 ENST00000332582.4
G protein-coupled receptor 173
chr4_+_95917383 1.23 ENST00000512312.1
bone morphogenetic protein receptor, type IB
chr2_-_68546530 1.23 ENST00000409559.3
cannabinoid receptor interacting protein 1
chr5_+_150406527 1.18 ENST00000520059.1
glutathione peroxidase 3 (plasma)
chr22_-_24622080 1.16 ENST00000425408.1
gamma-glutamyltransferase 5
chr1_+_65613217 1.14 ENST00000545314.1
adenylate kinase 4
chr17_-_56609302 1.14 ENST00000581607.1
ENST00000317256.6
ENST00000426861.1
ENST00000580809.1
ENST00000577729.1
ENST00000583291.1
septin 4
chr2_-_99552620 1.13 ENST00000428096.1
ENST00000397899.2
ENST00000420294.1
KIAA1211-like
chr7_+_29874341 1.12 ENST00000409290.1
ENST00000242140.5
WAS/WASL interacting protein family, member 3
chr4_-_176812842 1.12 ENST00000507540.1
glycoprotein M6A
chr18_+_11752783 1.12 ENST00000585642.1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr13_+_102104952 1.09 ENST00000376180.3
integrin, beta-like 1 (with EGF-like repeat domains)
chr7_-_107968921 1.09 ENST00000442580.1
neuronal cell adhesion molecule
chr13_+_102104980 1.07 ENST00000545560.2
integrin, beta-like 1 (with EGF-like repeat domains)
chr13_-_29069232 1.07 ENST00000282397.4
ENST00000541932.1
ENST00000539099.1
fms-related tyrosine kinase 1
chr1_+_22962948 1.03 ENST00000374642.3
complement component 1, q subcomponent, A chain
chr17_-_3794021 1.03 ENST00000381769.2
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr2_-_142888573 1.02 ENST00000434794.1
low density lipoprotein receptor-related protein 1B
chr13_-_45048386 1.01 ENST00000472477.1
TSC22 domain family, member 1
chr5_-_149516966 0.99 ENST00000517957.1
platelet-derived growth factor receptor, beta polypeptide
chr1_+_16348366 0.99 ENST00000375692.1
ENST00000420078.1
chloride channel, voltage-sensitive Ka
chr9_-_125391852 0.97 ENST00000304833.3
olfactory receptor, family 1, subfamily B, member 1
chr11_+_65779283 0.97 ENST00000312134.2
cystatin E/M
chr1_+_65775204 0.95 ENST00000371069.4
DnaJ (Hsp40) homolog, subfamily C, member 6
chr17_-_4464081 0.95 ENST00000574154.1
gamma-glutamyltransferase 6
chr11_-_57417367 0.95 ENST00000534810.1
yippee-like 4 (Drosophila)
chr9_+_35792151 0.94 ENST00000342694.2
natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)
chr1_+_22963158 0.93 ENST00000438241.1
complement component 1, q subcomponent, A chain
chr4_-_66535653 0.93 ENST00000354839.4
ENST00000432638.2
EPH receptor A5
chr19_+_38880695 0.91 ENST00000587947.1
ENST00000338502.4
sprouty-related, EVH1 domain containing 3
chr5_-_126409159 0.90 ENST00000607731.1
ENST00000535381.1
ENST00000296662.5
ENST00000509733.3
chromosome 5 open reading frame 63
chr4_+_14113592 0.90 ENST00000502759.1
ENST00000511200.1
ENST00000512754.1
ENST00000506739.1
long intergenic non-protein coding RNA 1085
chr9_-_127263265 0.89 ENST00000373587.3
nuclear receptor subfamily 5, group A, member 1
chr4_+_111397216 0.88 ENST00000265162.5
glutamyl aminopeptidase (aminopeptidase A)
chr22_-_30953587 0.85 ENST00000453479.1
galactose-3-O-sulfotransferase 1
chr2_+_79347577 0.83 ENST00000233735.1
regenerating islet-derived 1 alpha
chr17_+_5981270 0.82 ENST00000571973.1
WSC domain containing 1
chr2_+_7118755 0.81 ENST00000433456.1
ring finger protein 144A
chr4_-_66536057 0.80 ENST00000273854.3
EPH receptor A5
chr1_-_112903150 0.79 ENST00000427290.1
RP5-965F6.2
chr10_-_49701686 0.77 ENST00000417247.2
Rho GTPase activating protein 22
chr17_+_37894570 0.77 ENST00000394211.3
growth factor receptor-bound protein 7
chr15_-_81202118 0.77 ENST00000560560.1
Uncharacterized protein
chr1_+_16348497 0.76 ENST00000439316.2
chloride channel, voltage-sensitive Ka
chr2_+_11679963 0.75 ENST00000263834.5
growth regulation by estrogen in breast cancer 1
chr12_-_11036844 0.74 ENST00000428168.2
proline-rich protein HaeIII subfamily 1
chr6_-_168720382 0.74 ENST00000610183.1
ENST00000607983.1
ENST00000366795.3
dishevelled-binding antagonist of beta-catenin 2
chr16_+_28857957 0.74 ENST00000567536.1
SH2B adaptor protein 1
chr11_-_40315640 0.73 ENST00000278198.2
leucine rich repeat containing 4C
chr7_-_107968999 0.71 ENST00000456431.1
neuronal cell adhesion molecule
chr15_+_41245160 0.70 ENST00000444189.2
ENST00000446533.3
ChaC, cation transport regulator homolog 1 (E. coli)
chr5_+_152870734 0.70 ENST00000521843.2
glutamate receptor, ionotropic, AMPA 1
chr9_-_93195771 0.69 ENST00000425666.1
ENST00000436671.1
RP11-389K14.3
chr19_-_42931567 0.68 ENST00000244289.4
lipase, hormone-sensitive
chr19_-_46142637 0.68 ENST00000590043.1
ENST00000589876.1
echinoderm microtubule associated protein like 2
chr11_-_74022658 0.67 ENST00000427714.2
ENST00000331597.4
prolyl 4-hydroxylase, alpha polypeptide III
chrX_+_72064876 0.66 ENST00000373532.3
ENST00000333826.5
DMRT-like family C1B
chr11_-_2193025 0.66 ENST00000333684.5
ENST00000381178.1
ENST00000381175.1
ENST00000352909.3
tyrosine hydroxylase
chr19_+_54024251 0.64 ENST00000253144.9
zinc finger protein 331
chr20_+_61924532 0.63 ENST00000358894.6
ENST00000326996.6
ENST00000435874.1
collagen, type XX, alpha 1
chr17_-_3796334 0.63 ENST00000381771.2
ENST00000348335.2
ENST00000158166.5
calcium/calmodulin-dependent protein kinase kinase 1, alpha
chr10_-_33624002 0.62 ENST00000432372.2
neuropilin 1
chr9_+_34992846 0.60 ENST00000443266.1
DnaJ (Hsp40) homolog, subfamily B, member 5
chr15_-_78112553 0.60 ENST00000562933.1
leucine rich repeat and Ig domain containing 1
chr15_+_73976715 0.59 ENST00000558689.1
ENST00000560786.2
ENST00000561213.1
ENST00000563584.1
ENST00000561416.1
CD276 molecule
chr1_+_65613340 0.59 ENST00000546702.1
adenylate kinase 4
chr16_+_28857916 0.59 ENST00000563591.1
SH2B adaptor protein 1
chr12_+_13197218 0.58 ENST00000197268.8
KIAA1467
chr4_-_4228616 0.58 ENST00000296358.4
otopetrin 1
chr4_+_26578293 0.58 ENST00000512840.1
TBC1 domain family, member 19
chr22_+_27727733 0.58 ENST00000413244.1
CTA-929C8.8
chr19_-_14586125 0.57 ENST00000292513.3
prostaglandin E receptor 1 (subtype EP1), 42kDa
chr17_-_67057203 0.56 ENST00000340001.4
ATP-binding cassette, sub-family A (ABC1), member 9
chrX_+_72064690 0.56 ENST00000438696.1
DMRT-like family C1B
chr10_-_33623826 0.56 ENST00000374867.2
neuropilin 1
chr17_-_67057114 0.56 ENST00000370732.2
ATP-binding cassette, sub-family A (ABC1), member 9
chr2_-_29297127 0.55 ENST00000331664.5
chromosome 2 open reading frame 71
chr21_+_18811205 0.55 ENST00000440664.1
chromosome 21 open reading frame 37
chr18_+_11752040 0.54 ENST00000423027.3
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr4_-_186733119 0.54 ENST00000419063.1
sorbin and SH3 domain containing 2
chr17_-_67057047 0.54 ENST00000495634.1
ENST00000453985.2
ENST00000585714.1
ATP-binding cassette, sub-family A (ABC1), member 9
chr19_+_13135790 0.53 ENST00000358552.3
nuclear factor I/X (CCAAT-binding transcription factor)
chr5_+_167181917 0.52 ENST00000519204.1
teneurin transmembrane protein 2
chr14_+_36295638 0.52 ENST00000543183.1
breast cancer metastasis-suppressor 1-like
chr11_+_15095108 0.52 ENST00000324229.6
ENST00000533448.1
calcitonin-related polypeptide beta
chr1_+_17559776 0.52 ENST00000537499.1
ENST00000413717.2
ENST00000536552.1
peptidyl arginine deiminase, type I
chr16_+_28858004 0.51 ENST00000322610.8
SH2B adaptor protein 1
chr6_+_90272488 0.51 ENST00000485637.1
ENST00000522705.1
ankyrin repeat domain 6
chr5_+_167182003 0.51 ENST00000520394.1
teneurin transmembrane protein 2
chr4_-_66536196 0.50 ENST00000511294.1
EPH receptor A5
chr2_+_105050794 0.50 ENST00000429464.1
ENST00000414442.1
ENST00000447380.1
long intergenic non-protein coding RNA 1102
chr4_-_121993673 0.50 ENST00000379692.4
neuron-derived neurotrophic factor
chr1_-_43833628 0.50 ENST00000413844.2
ENST00000372458.3
ELOVL fatty acid elongase 1
chr6_+_90272339 0.48 ENST00000522779.1
ankyrin repeat domain 6
chr1_-_231004220 0.47 ENST00000366663.5
chromosome 1 open reading frame 198
chr19_+_13135731 0.47 ENST00000587260.1
nuclear factor I/X (CCAAT-binding transcription factor)
chr9_-_112260531 0.47 ENST00000374541.2
ENST00000262539.3
protein tyrosine phosphatase, non-receptor type 3
chr21_+_45148735 0.47 ENST00000327574.4
pyridoxal (pyridoxine, vitamin B6) kinase
chr6_+_132891461 0.47 ENST00000275198.1
trace amine associated receptor 6
chr2_-_97534312 0.46 ENST00000442264.1
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
chr19_-_6433765 0.45 ENST00000321510.6
solute carrier family 25, member 41
chr10_-_33623564 0.45 ENST00000374875.1
ENST00000374822.4
neuropilin 1
chr16_+_3185125 0.45 ENST00000576416.1
zinc finger protein 213
chr7_-_4877677 0.45 ENST00000538469.1
Ras association and DIL domains
chr19_-_46142362 0.45 ENST00000586770.1
ENST00000591721.1
echinoderm microtubule associated protein like 2
chr3_+_4345287 0.45 ENST00000358950.4
SET domain and mariner transposase fusion gene
chrX_+_46772065 0.44 ENST00000455411.1
jade family PHD finger 3
chr9_-_16870704 0.44 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
basonuclin 2
chr14_+_36295504 0.44 ENST00000216807.7
breast cancer metastasis-suppressor 1-like
chr11_+_66824303 0.43 ENST00000533360.1
ras homolog family member D
chr13_+_42712178 0.42 ENST00000536612.1
diacylglycerol kinase, eta
chr4_-_47839966 0.42 ENST00000273857.4
ENST00000505909.1
ENST00000502252.1
corin, serine peptidase
chr17_+_16945820 0.40 ENST00000577514.1
myosin phosphatase Rho interacting protein
chr3_+_71803201 0.40 ENST00000304411.2
G protein-coupled receptor 27
chrX_+_91034260 0.39 ENST00000395337.2
protocadherin 11 X-linked
chr14_-_50999190 0.39 ENST00000557390.1
mitogen-activated protein kinase kinase kinase kinase 5
chr5_-_64920115 0.38 ENST00000381018.3
ENST00000274327.7
tripartite motif containing 23
chr4_-_7941596 0.37 ENST00000420658.1
ENST00000358461.2
actin filament associated protein 1
chr11_+_89443467 0.37 ENST00000398290.3
tripartite motif containing 77
chr11_-_59612969 0.36 ENST00000541311.1
ENST00000257248.2
gastric intrinsic factor (vitamin B synthesis)
chr19_-_3028354 0.35 ENST00000586422.1
transducin-like enhancer of split 2 (E(sp1) homolog, Drosophila)
chr22_-_23922410 0.35 ENST00000249053.3
immunoglobulin lambda-like polypeptide 1
chr6_+_44187242 0.35 ENST00000393844.1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr3_-_45837959 0.33 ENST00000353278.4
ENST00000456124.2
solute carrier family 6 (proline IMINO transporter), member 20
chr18_+_76829441 0.33 ENST00000458297.2
ATPase, class II, type 9B
chr19_-_46142680 0.32 ENST00000245925.3
echinoderm microtubule associated protein like 2
chr4_+_66536248 0.30 ENST00000514260.1
ENST00000507117.1
RP11-807H7.1
chr11_-_134123142 0.30 ENST00000392595.2
ENST00000341541.3
ENST00000352327.5
ENST00000392594.3
thymocyte nuclear protein 1
chr6_-_138428613 0.30 ENST00000421351.3
PERP, TP53 apoptosis effector
chr14_-_24017647 0.29 ENST00000555334.1
zinc finger homeobox 2
chr8_+_21946681 0.29 ENST00000289921.7
family with sequence similarity 160, member B2
chr19_+_39647271 0.29 ENST00000599657.1
p21 protein (Cdc42/Rac)-activated kinase 4
chr12_-_11002063 0.29 ENST00000544994.1
ENST00000228811.4
ENST00000540107.1
proline rich 4 (lacrimal)
chr18_+_61420169 0.27 ENST00000425392.1
ENST00000336429.2
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr11_+_89443818 0.27 ENST00000534392.2
tripartite motif containing 77
chrX_+_52926322 0.27 ENST00000430150.2
ENST00000452021.2
ENST00000412319.1
family with sequence similarity 156, member B
chr12_-_2966193 0.26 ENST00000382678.3
Uncharacterized protein ENSP00000372125
chr11_+_66824276 0.26 ENST00000308831.2
ras homolog family member D
chr3_+_49027771 0.25 ENST00000475629.1
ENST00000444213.1
prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
chr6_+_31730773 0.25 ENST00000415669.2
ENST00000425424.1
suppressor APC domain containing 1
chrX_-_11369656 0.25 ENST00000413512.3
Rho GTPase activating protein 6
chrX_+_46771711 0.25 ENST00000424392.1
ENST00000397189.1
jade family PHD finger 3
chr10_-_62493223 0.25 ENST00000373827.2
ankyrin 3, node of Ranvier (ankyrin G)
chr22_+_21369316 0.24 ENST00000413302.2
ENST00000402329.3
ENST00000336296.2
ENST00000401443.1
ENST00000443995.3
purinergic receptor P2X, ligand-gated ion channel, 6
chr6_-_87804815 0.24 ENST00000369582.2
glycoprotein hormones, alpha polypeptide
chr11_-_110582773 0.24 ENST00000524756.1
Rho GTPase activating protein 20
chr1_-_211307315 0.24 ENST00000271751.4
potassium voltage-gated channel, subfamily H (eag-related), member 1
chr6_-_168476511 0.24 ENST00000440994.2
FERM domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of ZIC1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:2000646 lipid transport involved in lipid storage(GO:0010877) positive regulation of receptor catabolic process(GO:2000646)
0.6 1.7 GO:0099558 maintenance of synapse structure(GO:0099558)
0.4 2.0 GO:0060455 negative regulation of gastric acid secretion(GO:0060455)
0.4 5.5 GO:0035290 trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486)
0.4 2.6 GO:1903575 cornified envelope assembly(GO:1903575)
0.4 1.8 GO:0038169 somatostatin receptor signaling pathway(GO:0038169) somatostatin signaling pathway(GO:0038170)
0.4 2.5 GO:0001550 ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165)
0.3 1.0 GO:0060981 cell migration involved in coronary angiogenesis(GO:0060981)
0.3 1.6 GO:0060024 rhythmic synaptic transmission(GO:0060024) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.3 5.0 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.3 1.4 GO:0021825 substrate-dependent cerebral cortex tangential migration(GO:0021825)
0.3 1.4 GO:0043553 vascular endothelial growth factor receptor-2 signaling pathway(GO:0036324) negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.3 3.1 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.3 1.3 GO:0032474 otolith morphogenesis(GO:0032474)
0.2 1.1 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.2 0.7 GO:0042214 terpene metabolic process(GO:0042214) phytoalexin metabolic process(GO:0052314)
0.2 1.5 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.2 1.6 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
0.2 1.4 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.2 0.9 GO:0007538 primary sex determination(GO:0007538)
0.2 1.7 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.2 2.2 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.2 1.9 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028) positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.2 1.2 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.2 3.0 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.2 6.4 GO:0007158 neuron cell-cell adhesion(GO:0007158)
0.2 1.1 GO:0097211 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.2 0.5 GO:0009443 pyridoxal 5'-phosphate salvage(GO:0009443)
0.2 0.6 GO:1900108 inner medullary collecting duct development(GO:0072061) negative regulation of nodal signaling pathway(GO:1900108)
0.1 2.8 GO:0006751 glutathione catabolic process(GO:0006751)
0.1 0.4 GO:0003050 regulation of systemic arterial blood pressure by atrial natriuretic peptide(GO:0003050)
0.1 0.7 GO:0046340 diacylglycerol catabolic process(GO:0046340)
0.1 0.9 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.1 0.3 GO:0045646 regulation of erythrocyte differentiation(GO:0045646)
0.1 2.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.1 1.5 GO:0035507 regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.1 2.1 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.1 0.9 GO:0002005 angiotensin catabolic process in blood(GO:0002005)
0.1 0.5 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.1 1.4 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.1 2.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)
0.1 1.0 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.1 0.4 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.1 0.4 GO:0097676 histone H3-K36 dimethylation(GO:0097676)
0.1 0.7 GO:0099566 regulation of postsynaptic cytosolic calcium ion concentration(GO:0099566)
0.1 0.3 GO:0015862 uridine transport(GO:0015862)
0.1 1.7 GO:0008272 sulfate transport(GO:0008272)
0.1 0.9 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
0.1 2.0 GO:0045332 phospholipid translocation(GO:0045332)
0.1 1.6 GO:0001502 cartilage condensation(GO:0001502)
0.1 0.3 GO:0090362 positive regulation of platelet-derived growth factor production(GO:0090362)
0.1 2.6 GO:0046688 response to copper ion(GO:0046688)
0.1 1.7 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
0.1 2.8 GO:0001558 regulation of cell growth(GO:0001558)
0.1 0.4 GO:0006824 cobalt ion transport(GO:0006824)
0.1 1.1 GO:0030949 positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0 0.2 GO:0006272 leading strand elongation(GO:0006272)
0.0 3.2 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.0 1.0 GO:0097264 self proteolysis(GO:0097264)
0.0 1.0 GO:2000096 positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0 0.5 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
0.0 0.6 GO:1903546 protein localization to photoreceptor outer segment(GO:1903546)
0.0 0.5 GO:0019368 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0 0.2 GO:0072660 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.0 2.0 GO:0061049 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.5 GO:0061042 vascular wound healing(GO:0061042)
0.0 0.5 GO:0015824 proline transport(GO:0015824)
0.0 1.5 GO:0022400 regulation of rhodopsin mediated signaling pathway(GO:0022400)
0.0 1.5 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0 2.0 GO:0010039 response to iron ion(GO:0010039)
0.0 0.2 GO:1903998 response to isolation stress(GO:0035900) regulation of eating behavior(GO:1903998)
0.0 0.8 GO:0034063 stress granule assembly(GO:0034063)
0.0 0.7 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
0.0 0.5 GO:0015866 ADP transport(GO:0015866)
0.0 1.3 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.0 0.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.0 0.8 GO:0008284 positive regulation of cell proliferation(GO:0008284)
0.0 1.7 GO:0055078 sodium ion homeostasis(GO:0055078)
0.0 1.9 GO:0007528 neuromuscular junction development(GO:0007528)
0.0 0.1 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
0.0 0.1 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 0.2 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.0 2.4 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.3 GO:0002934 desmosome organization(GO:0002934)
0.0 1.5 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.1 GO:0060789 hair follicle placode formation(GO:0060789)
0.0 5.6 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.4 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.0 0.4 GO:0003416 endochondral bone growth(GO:0003416)
0.0 0.5 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.3 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
0.8 3.1 GO:0044301 climbing fiber(GO:0044301)
0.6 3.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
0.4 2.0 GO:0005602 complement component C1 complex(GO:0005602)
0.2 1.6 GO:1903439 calcitonin family receptor complex(GO:1903439) amylin receptor complex(GO:1903440)
0.2 5.3 GO:0043194 axon initial segment(GO:0043194)
0.2 2.5 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.1 1.6 GO:0097443 sorting endosome(GO:0097443)
0.1 0.7 GO:0044308 axonal spine(GO:0044308)
0.1 3.1 GO:0031045 dense core granule(GO:0031045)
0.1 1.6 GO:0032059 bleb(GO:0032059)
0.1 0.2 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.1 1.1 GO:0097227 sperm annulus(GO:0097227)
0.1 1.7 GO:0034706 sodium channel complex(GO:0034706)
0.0 0.2 GO:0097232 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
0.0 8.5 GO:0043204 perikaryon(GO:0043204)
0.0 1.3 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 1.1 GO:0044295 axonal growth cone(GO:0044295)
0.0 0.3 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 1.7 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 2.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.0 GO:0070822 Sin3-type complex(GO:0070822)
0.0 2.5 GO:0034707 chloride channel complex(GO:0034707)
0.0 0.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.0 2.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.0 1.8 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.2 GO:0042622 photoreceptor outer segment membrane(GO:0042622)
0.0 1.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.3 GO:0098794 postsynapse(GO:0098794)
0.0 1.0 GO:0001533 cornified envelope(GO:0001533)
0.0 1.9 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.6 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 0.6 GO:0042571 immunoglobulin complex, circulating(GO:0042571)
0.0 4.5 GO:0060076 excitatory synapse(GO:0060076)
0.0 1.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 1.4 GO:0043202 lysosomal lumen(GO:0043202)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:0070326 very-low-density lipoprotein particle receptor binding(GO:0070326)
0.4 2.1 GO:0047391 alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.4 1.1 GO:0004968 gonadotropin-releasing hormone receptor activity(GO:0004968)
0.4 1.8 GO:0004994 somatostatin receptor activity(GO:0004994)
0.3 2.8 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.3 1.7 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.3 2.5 GO:0004957 prostaglandin E receptor activity(GO:0004957)
0.3 2.6 GO:0001849 complement component C1q binding(GO:0001849)
0.2 1.0 GO:0005019 platelet-derived growth factor beta-receptor activity(GO:0005019)
0.2 0.7 GO:0033878 hormone-sensitive lipase activity(GO:0033878)
0.2 1.6 GO:0097643 amylin receptor activity(GO:0097643)
0.2 2.5 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.2 1.4 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.2 2.2 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.2 5.0 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.2 1.4 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.2 0.7 GO:0003839 gamma-glutamylcyclotransferase activity(GO:0003839)
0.2 3.8 GO:0045499 chemorepellent activity(GO:0045499)
0.2 1.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.2 2.7 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.2 0.5 GO:0008478 pyridoxal kinase activity(GO:0008478)
0.1 3.1 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.1 0.9 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 2.1 GO:0036374 glutathione hydrolase activity(GO:0036374)
0.1 3.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 0.5 GO:0004668 protein-arginine deiminase activity(GO:0004668)
0.1 0.7 GO:0034617 tetrahydrobiopterin binding(GO:0034617)
0.1 1.7 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.1 1.7 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.1 0.7 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.1 0.9 GO:0050694 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
0.1 0.7 GO:0099583 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration(GO:0099583) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.1 1.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.5 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 0.6 GO:0070097 delta-catenin binding(GO:0070097)
0.1 0.4 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.1 1.2 GO:0008430 selenium binding(GO:0008430)
0.1 1.6 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 3.1 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.3 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.5 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0 1.7 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.0 1.9 GO:0030546 receptor activator activity(GO:0030546)
0.0 0.2 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.5 GO:0015217 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.0 0.9 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 1.2 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.4 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.0 0.2 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)
0.0 1.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 0.2 GO:0035381 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
0.0 2.5 GO:0005262 calcium channel activity(GO:0005262)
0.0 0.2 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.3 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.0 1.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 1.0 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.4 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.2 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0 0.4 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
0.0 0.8 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.0 0.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 1.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.5 GO:0038191 neuropilin binding(GO:0038191)
0.0 0.1 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0 1.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 1.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.5 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.1 0.8 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 1.7 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 2.2 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 1.0 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 2.5 PID BMP PATHWAY BMP receptor signaling
0.0 2.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 3.1 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.0 7.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0 1.6 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 1.4 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.5 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 1.0 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.7 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.9 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.5 REACTOME PROSTANOID LIGAND RECEPTORS Genes involved in Prostanoid ligand receptors
0.2 4.5 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.2 3.1 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.1 2.5 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 5.3 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 2.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.1 1.7 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 1.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.3 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 1.3 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0 2.1 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.0 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 1.9 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.0 0.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 2.4 REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS Genes involved in Activation of NMDA receptor upon glutamate binding and postsynaptic events
0.0 1.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.0 0.7 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 1.5 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.8 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.0 1.0 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.0 0.4 REACTOME SIGNALING BY FGFR MUTANTS Genes involved in Signaling by FGFR mutants
0.0 2.1 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.5 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 0.9 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.2 REACTOME POL SWITCHING Genes involved in Polymerase switching