Motif ID: ADNP_IRX_SIX_ZHX.p2

Z-value: 1.217


Transcription factors associated with ADNP_IRX_SIX_ZHX.p2:

Gene SymbolEntrez IDGene Name
ADNP 23394 activity-dependent neuroprotector homeobox
IRX4 50805 iroquois homeobox 4
IRX5 10265 iroquois homeobox 5
SIX2 10736 SIX homeobox 2
SIX5 147912 SIX homeobox 5
ZHX1 11244 zinc fingers and homeoboxes 1
ZHX2 22882 zinc fingers and homeoboxes 2
ZHX3 23051 zinc fingers and homeoboxes 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ZHX3chr20_-_39928708-0.236.6e-04Click!
IRX4chr5_-_1882764-0.202.4e-03Click!
SIX2chr2_-_45236521-0.171.4e-02Click!
ZHX2chr8_+_123793988,
chr8_+_123794043		-0.144.4e-02Click!
SIX5chr19_-_46272496-0.127.0e-02Click!
ADNPchr20_-_495474510.101.2e-01Click!
IRX5chr16_+_549651100.027.3e-01Click!


Activity profile for motif ADNP_IRX_SIX_ZHX.p2.

activity profile for motif ADNP_IRX_SIX_ZHX.p2


Sorted Z-values histogram for motif ADNP_IRX_SIX_ZHX.p2

Sorted Z-values for motif ADNP_IRX_SIX_ZHX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ADNP_IRX_SIX_ZHX.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr10_+_5136556 37.019 NM_003739
 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr10_+_5136589 33.584 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr10_+_5136613 33.233 AKR1C3
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr2_-_10942642 30.126 PDIA6
protein disulfide isomerase family A, member 6
chr5_+_115898218 21.633


chr12_-_102512277 20.577 NM_024057
 NUP37
nucleoporin 37kDa
chr8_-_86290333 17.994 NM_001128829
NM_001128830
NM_001128831
NM_001738
 CA1



carbonic anhydrase I



chr14_-_55650348 17.271 DLGAP5
discs, large (Drosophila) homolog-associated protein 5
chr3_-_141747434 16.114 NM_001178141
NM_001178142
NM_006286
 TFDP2


transcription factor Dp-2 (E2F dimerization partner 2)


chr13_+_53035227 14.944 CKAP2
cytoskeleton associated protein 2
chr19_+_13134782 14.356 NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chr18_+_33234532 14.009 NM_020474
 GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr10_+_5005685 13.699 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr1_+_167298280 13.582 NM_001198783
 POU2F1
POU class 2 homeobox 1
chr4_-_72649734 13.171 NM_000583
 GC
group-specific component (vitamin D binding protein)
chr11_-_118900078 11.907 NM_001164280
 SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr4_+_146031528 11.854 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr6_+_21593963 11.688 NM_003107
 SOX4
SRY (sex determining region Y)-box 4
chr20_-_34243118 11.633 RBM12
RNA binding motif protein 12
chr9_-_14086901 11.325 NFIB
nuclear factor I/B

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 99 entries
enrichment   p-value GO term description
9.12 1.40e-03 GO:0060416 response to growth hormone stimulus
4.91 7.87e-03 GO:0030193 regulation of blood coagulation
4.56 1.87e-02 GO:0045639 positive regulation of myeloid cell differentiation
4.56 1.87e-02 GO:0050818 regulation of coagulation
3.44 1.75e-02 GO:0048706 embryonic skeletal system development
3.31 2.97e-02 GO:0045637 regulation of myeloid cell differentiation
2.76 2.30e-02 GO:0006805 xenobiotic metabolic process
2.76 2.30e-02 GO:0071466 cellular response to xenobiotic stimulus
2.74 2.61e-02 GO:0009410 response to xenobiotic stimulus
2.65 2.59e-03 GO:0048732 gland development
2.38 2.01e-04 GO:0001501 skeletal system development
2.38 2.34e-02 GO:0043193 positive regulation of gene-specific transcription
2.23 1.83e-03 GO:0045597 positive regulation of cell differentiation
2.21 2.42e-02 GO:0007346 regulation of mitotic cell cycle
2.19 2.89e-02 GO:0048545 response to steroid hormone stimulus
2.16 4.16e-07 GO:0045893 positive regulation of transcription, DNA-dependent
2.15 7.92e-05 GO:0045944 positive regulation of transcription from RNA polymerase II promoter
2.14 3.26e-03 GO:0010551 regulation of gene-specific transcription from RNA polymerase II promoter
2.13 4.45e-04 GO:0032583 regulation of gene-specific transcription
2.12 2.31e-07 GO:0010628 positive regulation of gene expression

Gene overrepresentation in compartment category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
3.74 4.59e-02 GO:0031093 platelet alpha granule lumen
2.23 3.43e-03 GO:0005667 transcription factor complex
1.86 4.30e-06 GO:0005615 extracellular space
1.75 3.43e-06 GO:0044421 extracellular region part
1.74 7.61e-04 GO:0044451 nucleoplasm part
1.59 6.64e-05 GO:0005654 nucleoplasm
1.54 2.43e-06 GO:0031981 nuclear lumen
1.51 1.71e-07 GO:0043233 organelle lumen
1.49 6.87e-07 GO:0031974 membrane-enclosed lumen
1.49 2.36e-06 GO:0044428 nuclear part
1.47 3.70e-06 GO:0070013 intracellular organelle lumen
1.36 6.78e-03 GO:0005576 extracellular region
1.26 3.89e-02 GO:0043234 protein complex
1.25 1.31e-02 GO:0032991 macromolecular complex
1.21 6.53e-04 GO:0005634 nucleus
1.14 2.69e-03 GO:0005737 cytoplasm
1.13 2.96e-03 GO:0043227 membrane-bounded organelle
1.13 3.36e-03 GO:0043231 intracellular membrane-bounded organelle
1.12 1.74e-03 GO:0043226 organelle
1.12 2.36e-03 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
5.70 2.64e-03 GO:0015020 glucuronosyltransferase activity
2.30 1.94e-02 GO:0010843 promoter binding
2.29 1.56e-02 GO:0000975 regulatory region DNA binding
2.29 1.56e-02 GO:0001067 regulatory region nucleic acid binding
2.29 1.56e-02 GO:0044212 transcription regulatory region DNA binding
2.01 7.30e-07 GO:0043565 sequence-specific DNA binding
2.01 3.23e-02 GO:0008134 transcription factor binding
1.89 2.93e-02 GO:0003712 transcription cofactor activity
1.88 3.13e-02 GO:0000988 protein binding transcription factor activity
1.88 3.13e-02 GO:0000989 transcription factor binding transcription factor activity
1.75 9.67e-06 GO:0001071 nucleic acid binding transcription factor activity
1.75 9.67e-06 GO:0003700 sequence-specific DNA binding transcription factor activity
1.66 2.23e-04 GO:0030528 transcription regulator activity
1.64 4.50e-04 GO:0005102 receptor binding
1.62 1.97e-02 GO:0019899 enzyme binding
1.56 4.78e-02 GO:0003723 RNA binding
1.32 2.63e-02 GO:0003677 DNA binding
1.30 5.80e-14 GO:0005515 protein binding
1.28 6.38e-03 GO:0003676 nucleic acid binding
1.14 8.39e-10 GO:0005488 binding