Motif ID: AGUGGUU

Z-value: 1.481


Mature miRNA associated with seed AGUGGUU:

NamemiRBase Accession
hsa-miR-140-5p MIMAT0000431



Activity profile for motif AGUGGUU.

activity profile for motif AGUGGUU


Sorted Z-values histogram for motif AGUGGUU

Sorted Z-values for motif AGUGGUU



Network of associatons between targets according to the STRING database.



First level regulatory network of AGUGGUU

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_68299047 42.844 NM_018841
GNG12
guanine nucleotide binding protein (G protein), gamma 12
chr2_+_10262694 37.257 NM_001165931
RRM2
ribonucleotide reductase M2
chr2_+_10262853 36.289 NM_001034
RRM2
ribonucleotide reductase M2
chr8_+_38854431 36.098 NM_003816
ADAM9
ADAM metallopeptidase domain 9
chr1_-_205719340 34.255 NM_022731
NUCKS1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr3_-_195808958 31.065 NM_003234
TFRC
transferrin receptor (p90, CD71)
chr3_-_195808997 30.842 NM_001128148
TFRC
transferrin receptor (p90, CD71)
chr1_+_182992329 30.390 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr6_+_57037058 30.153 NM_004282
BAG2
BCL2-associated athanogene 2
chr9_+_112887780 29.840 NM_001136562
AKAP2
A kinase (PRKA) anchor protein 2
chr3_+_180630054 29.584 NM_001013438
NM_001013439
NM_005087
FXR1


fragile X mental retardation, autosomal homolog 1


chr9_+_112810877 27.994 NM_001004065
NM_001198656
AKAP2

A kinase (PRKA) anchor protein 2

chr9_+_112542496 27.457 NM_053016
NM_007203
NM_147150
PALM2
PALM2-AKAP2

paralemmin 2
PALM2-AKAP2 readthrough

chr11_-_102323353 27.291 NM_052932
TMEM123
transmembrane protein 123
chr3_-_32544358 27.187 NM_017801
CMTM6
CKLF-like MARVEL transmembrane domain containing 6
chr18_-_812268 26.163 NM_005433
YES1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr20_-_48729664 24.171 NM_001032288
UBE2V1
ubiquitin-conjugating enzyme E2 variant 1
chr11_+_86511490 23.884 NM_007173
PRSS23
protease, serine, 23
chr20_-_48732479 22.486 NM_022442
NM_021988
NM_199144
UBE2V1


ubiquitin-conjugating enzyme E2 variant 1


chr12_+_69004614 22.422 NM_001010942
NM_001251917
NM_001251918
NM_001251921
NM_001251922
NM_015646
RAP1B





RAP1B, member of RAS oncogene family





chr7_+_128379345 21.980 NM_001130674
NM_001199671
NM_001199672
NM_001199673
NM_001199674
NM_001219
CALU





calumenin





chr7_+_39663140 21.588 NM_005402
RALA
v-ral simian leukemia viral oncogene homolog A (ras related)
chr12_-_46766563 21.119 NM_018976
SLC38A2
solute carrier family 38, member 2
chr1_-_32385258 20.882 NM_001195100
NM_001195101
PTP4A2

protein tyrosine phosphatase type IVA, member 2

chrX_-_20284708 20.686 NM_004586
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr7_-_30029904 20.404 NM_001145514
SCRN1
secernin 1
chr1_+_33116748 20.217 NM_001135255
NM_005610
NM_001135256
RBBP4


retinoblastoma binding protein 4


chrX_+_119737743 20.116 NM_014060
MCTS1
malignant T cell amplified sequence 1
chr6_-_131291480 19.543 NM_001199389
EPB41L2
erythrocyte membrane protein band 4.1-like 2
chrX_+_119738542 19.247 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr11_-_61584451 18.912 NM_013402
FADS1
fatty acid desaturase 1
chr1_-_32403975 18.465 NM_080391
PTP4A2
protein tyrosine phosphatase type IVA, member 2
chr6_+_80714321 18.220 NM_001166691
NM_003318
TTK

TTK protein kinase

chr5_-_172756505 18.049 NM_003714
STC2
stanniocalcin 2
chr19_+_11200037 18.041 NM_000527
NM_001195798
NM_001195799
NM_001195800
NM_001195802
NM_001195803
LDLR





low density lipoprotein receptor





chr7_-_30029284 17.955 NM_001145515
NM_014766
NM_001145513
SCRN1


secernin 1


chr11_-_10830581 17.249 NM_001042559
NM_001418
EIF4G2

eukaryotic translation initiation factor 4 gamma, 2

chr5_+_65222381 16.568 NM_001006600
NM_001253697
NM_001253698
NM_001253699
NM_001253701
NM_018695
ERBB2IP





erbb2 interacting protein





chr11_+_61560108 16.212 NM_004111
FEN1
flap structure-specific endonuclease 1
chr6_+_47445440 16.136 NM_012120
CD2AP
CD2-associated protein
chr12_-_111180730 15.992 NM_001244974
NM_002710
PPP1CC

protein phosphatase 1, catalytic subunit, gamma isozyme

chr11_-_47510518 15.354 NM_001025596
NM_001172640
CELF1

CUGBP, Elav-like family member 1

chr2_+_208394615 14.746 NM_004379
NM_134442
CREB1

cAMP responsive element binding protein 1

chr5_-_16936371 14.460 NM_012334
MYO10
myosin X
chr1_+_11994710 14.151 NM_000302
PLOD1
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr11_+_64948685 14.122 NM_001198868
CAPN1
calpain 1, (mu/I) large subunit
chr5_+_122110737 14.021 NM_003100
SNX2
sorting nexin 2
chr11_-_47516072 14.010 NM_198700
CELF1
CUGBP, Elav-like family member 1
chrX_+_47082416 13.460 NM_001170460
CDK16
cyclin-dependent kinase 16
chr17_-_56065596 13.416 NM_007146
VEZF1
vascular endothelial zinc finger 1
chr20_-_34330179 13.403 NM_001242599
NM_001242600
NM_004902
NM_184234
RBM39



RNA binding motif protein 39



chr15_-_48937795 13.213 NM_000138
FBN1
fibrillin 1
chrX_+_150151757 13.040 NM_005342
HMGB3
high mobility group box 3
chr11_+_9406123 12.899 NM_006391
IPO7
importin 7
chr6_-_131384387 12.715 NM_001135554
NM_001135555
NM_001199388
NM_001431
EPB41L2



erythrocyte membrane protein band 4.1-like 2



chr17_+_33914278 12.654 NM_001030006
NM_001282
AP2B1

adaptor-related protein complex 2, beta 1 subunit

chr6_-_108395939 12.413 NM_014028
OSTM1
osteopetrosis associated transmembrane protein 1
chr12_+_2904101 12.300 NM_002014
FKBP4
FK506 binding protein 4, 59kDa
chr7_-_132766697 12.135 NM_017812
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr17_-_35656691 11.981 NM_198837
NM_198838
ACACA

acetyl-CoA carboxylase alpha

chr14_+_96001297 11.698 NM_016417
GLRX5
glutaredoxin 5
chr22_+_25202135 11.692 NM_001039948
NM_001098497
NM_001098498
NM_133454
SGSM1



small G protein signaling modulator 1



chr17_-_47439326 11.674 NM_001145365
NM_014897
ZNF652

zinc finger protein 652

chr15_+_81071708 11.618 NM_018689
KIAA1199
KIAA1199
chr3_-_124774735 11.565 NM_020733
HEG1
HEG homolog 1 (zebrafish)
chr12_-_80307690 11.383 NM_001143886
PPP1R12A
protein phosphatase 1, regulatory subunit 12A
chr16_-_20911560 11.072 NM_173475
DCUN1D3
DCN1, defective in cullin neddylation 1, domain containing 3 (S. cerevisiae)
chr1_+_198125890 11.051 NM_133494
NEK7
NIMA (never in mitosis gene a)-related kinase 7
chr2_+_242255270 10.939 NM_001008492
NM_004404
SEPT2

septin 2

chr22_-_36784055 10.929 NM_002473
MYH9
myosin, heavy chain 9, non-muscle
chr2_-_200329810 10.901 NM_001172517
SATB2
SATB homeobox 2
chr5_+_138629419 10.897 NM_001194955
NM_001194956
MATR3

matrin 3

chr10_+_70091767 10.845 NM_012207
NM_021644
HNRNPH3

heterogeneous nuclear ribonucleoprotein H3 (2H9)

chr3_+_135741576 10.236 NM_181897
PPP2R3A
protein phosphatase 2, regulatory subunit B'', alpha
chr5_+_138629330 9.896 NM_018834
MATR3
matrin 3
chr10_-_51623214 9.737 NM_006327
TIMM23
translocase of inner mitochondrial membrane 23 homolog (yeast)
chr2_-_9771101 9.585 NM_006826
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
chr11_+_64949279 9.557 NM_005186
CAPN1
calpain 1, (mu/I) large subunit
chr2_-_148779172 9.493 NM_181742
ORC4
origin recognition complex, subunit 4
chr5_+_149887673 9.428 NM_001543
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr5_-_83016850 9.333 NM_001884
HAPLN1
hyaluronan and proteoglycan link protein 1
chr12_-_80329234 9.314 NM_001143885
NM_001244990
PPP1R12A

protein phosphatase 1, regulatory subunit 12A

chr5_+_126112314 9.244 NM_005573
LMNB1
lamin B1
chr11_-_47574766 9.225 NM_006560
CELF1
CUGBP, Elav-like family member 1
chr7_-_25164902 9.209 NM_018947
CYCS
cytochrome c, somatic
chr11_+_64949149 9.162 NM_001198869
CAPN1
calpain 1, (mu/I) large subunit
chr5_+_138609440 9.066 NM_001194954
NM_199189
MATR3

matrin 3

chr5_-_77944341 8.712 NM_005779
LHFPL2
lipoma HMGIC fusion partner-like 2
chr20_-_57617836 8.652 NM_016045
SLMO2
slowmo homolog 2 (Drosophila)
chr17_-_35766762 8.433 NM_198834
NM_198839
ACACA

acetyl-CoA carboxylase alpha

chr3_-_149688638 8.381 NM_002628
NM_053024
PFN2

profilin 2

chr20_-_30310597 8.349 NM_001191
NM_138578
BCL2L1

BCL2-like 1

chr12_-_49177876 8.259 NM_015270
ADCY6
adenylate cyclase 6
chr6_+_143999058 8.230 NM_001100164
NM_001100165
PHACTR2

phosphatase and actin regulator 2

chr6_+_143929316 8.130 NM_001100166
NM_014721
PHACTR2

phosphatase and actin regulator 2

chr6_-_82462374 8.118 NM_017633
FAM46A
family with sequence similarity 46, member A
chr14_-_95599794 8.078 NM_001195573
DICER1
dicer 1, ribonuclease type III
chr1_-_109825767 7.971 NM_001005290
NM_001032291
NM_032636
PSRC1


proline/serine-rich coiled-coil 1


chr21_-_15755439 7.922 NM_006948
HSPA13
heat shock protein 70kDa family, member 13
chr18_-_55253785 7.883 NM_000140
NM_001012515
FECH

ferrochelatase

chr17_-_60142598 7.791 NM_005121
MED13
mediator complex subunit 13
chr11_+_57529233 7.692 NM_001085458
NM_001085459
NM_001085460
NM_001085461
NM_001085462
NM_001085463
NM_001085464
NM_001085465
NM_001085466
NM_001085467
NM_001085468
NM_001085469
NM_001206883
NM_001206884
NM_001206885
NM_001206886
NM_001206887
NM_001206888
NM_001206889
NM_001206890
NM_001206891
NM_001331
CTNND1





















catenin (cadherin-associated protein), delta 1





















chr16_+_69220940 7.627 NM_006750
SNTB2
syntrophin, beta 2 (dystrophin-associated protein A1, 59kDa, basic component 2)
chr2_+_242254722 7.619 NM_001008491
NM_006155
SEPT2

septin 2

chr5_+_38845962 7.615 NM_003999
OSMR
oncostatin M receptor
chr6_+_4836331 7.608 NM_001143970
CDYL
chromodomain protein, Y-like
chr3_-_52713728 7.573 NM_018165
NM_181042
PBRM1

polybromo 1

chr19_-_49496566 7.563 NM_001161587
NM_002103
GYS1

glycogen synthase 1 (muscle)

chr3_+_160118346 7.393 NM_005496
SMC4
structural maintenance of chromosomes 4
chr18_-_34409084 7.388 NM_015476
TPGS2
tubulin polyglutamylase complex subunit 2
chr5_+_6746100 7.313 NM_001171806
PAPD7
PAP associated domain containing 7
chr1_+_87380317 7.308 NM_001134492
NM_012262
HS2ST1

heparan sulfate 2-O-sulfotransferase 1

chr5_+_126112819 7.295 NM_001198557
LMNB1
lamin B1
chr14_+_23775970 7.194 NM_001199864
NM_004050
NM_001199839
BCL2L2-PABPN1
BCL2L2

BCL2L2-PABPN1 readthrough
BCL2-like 2

chr21_+_40759688 7.148 NM_001146218
WRB
tryptophan rich basic protein
chr2_-_200335988 7.088 NM_015265
SATB2
SATB homeobox 2
chrX_-_77395108 7.080 NM_015975
TAF9B
TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
chr2_-_200322699 7.065 NM_001172509
SATB2
SATB homeobox 2
chr6_+_4890225 6.873 NM_001143971
CDYL
chromodomain protein, Y-like
chr16_-_48399783 6.863 NM_001006610
SIAH1
seven in absentia homolog 1 (Drosophila)
chr1_-_86043932 6.811 NM_001134445
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr15_-_30114536 6.651 NM_003257
NM_175610
TJP1

tight junction protein 1 (zona occludens 1)

chr5_+_6714717 6.649 NM_001171805
NM_006999
PAPD7

PAP associated domain containing 7

chr12_-_49182718 6.545 NM_020983
ADCY6
adenylate cyclase 6
chr10_+_104535887 6.514 NM_017787
C10orf26
chromosome 10 open reading frame 26
chr14_-_89883306 6.471 NM_005197
FOXN3
forkhead box N3
chr6_+_21593963 6.441 NM_003107
SOX4
SRY (sex determining region Y)-box 4
chr16_-_66785511 6.336 NM_006141
DYNC1LI2
dynein, cytoplasmic 1, light intermediate chain 2
chr20_-_48770302 6.293 NM_001162505
NM_199129
NM_199203
TMEM189

TMEM189-UBE2V1
transmembrane protein 189

TMEM189-UBE2V1 readthrough
chr12_-_123834984 6.146 NM_001167856
NM_018183
SBNO1

strawberry notch homolog 1 (Drosophila)

chr21_-_16437125 6.096 NM_003489
NRIP1
nuclear receptor interacting protein 1
chr9_-_99801365 6.094 NM_001333
CTSL2
cathepsin L2
chr1_+_166808721 6.016 NM_017542
POGK
pogo transposable element with KRAB domain
chr6_-_42185603 5.957 NM_018141
MRPS10
mitochondrial ribosomal protein S10
chr3_+_150126705 5.894 NM_014779
TSC22D2
TSC22 domain family, member 2
chr9_-_107690526 5.811 NM_005502
ABCA1
ATP-binding cassette, sub-family A (ABC1), member 1
chr4_+_55095263 5.772 NM_006206
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr15_+_99192696 5.741 NM_000875
IGF1R
insulin-like growth factor 1 receptor
chr9_-_99801924 5.706 NM_001201575
CTSL2
cathepsin L2
chrX_-_73834460 5.670 NM_016120
NM_183353
RLIM

ring finger protein, LIM domain interacting

chr10_+_102106771 5.582 NM_005063
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr5_-_127873734 5.554 NM_001999
FBN2
fibrillin 2
chr1_-_222885653 5.333 NM_022831
AIDA
axin interactor, dorsalization associated
chr2_+_119981383 5.300 NM_001008410
NM_018234
NM_182915
STEAP3


STEAP family member 3, metalloreductase


chr6_+_43737937 5.197 NM_001025366
NM_001025367
NM_001025368
NM_001025369
NM_001025370
NM_001033756
NM_001171622
NM_001171623
NM_001171624
NM_001171625
NM_001171626
NM_001171627
NM_001171628
NM_001171629
NM_001171630
NM_001204384
NM_001204385
NM_003376
VEGFA

















vascular endothelial growth factor A

















chr1_-_52456292 5.109 NM_002867
RAB3B
RAB3B, member RAS oncogene family
chr2_-_178128527 4.996 NM_001145412
NM_001145413
NFE2L2

nuclear factor (erythroid-derived 2)-like 2

chr5_+_32585604 4.955 NM_006713
SUB1
SUB1 homolog (S. cerevisiae)
chr1_-_85930733 4.823 NM_012137
DDAH1
dimethylarginine dimethylaminohydrolase 1
chr5_+_32710742 4.669 NM_001204376
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr20_-_10654429 4.652 NM_000214
JAG1
jagged 1
chr3_-_168865521 4.586 NM_001164000
MECOM
MDS1 and EVI1 complex locus
chr12_-_25055966 4.487 NM_001178093
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr22_-_18507151 4.486 NM_001122731
NM_001136004
NM_015241
MICAL3


microtubule associated monoxygenase, calponin and LIM domain containing 3


chr10_-_3827418 4.478 NM_001160124
NM_001160125
NM_001300
KLF6


Kruppel-like factor 6


chr1_+_93913566 4.476 NM_001024948
NM_001164473
NM_017737
FNBP1L


formin binding protein 1-like


chr8_+_70405027 4.455 NM_001128205
NM_001128206
SULF1

sulfatase 1

chr9_-_79009265 4.435 NM_018339
RFK
riboflavin kinase
chr12_-_80328926 4.418 NM_002480
PPP1R12A
protein phosphatase 1, regulatory subunit 12A
chr21_+_40752212 4.369 NM_004627
WRB
tryptophan rich basic protein
chr18_-_45456925 4.344 NM_005901
SMAD2
SMAD family member 2
chr1_-_117210301 4.301 NM_001007237
NM_001542
IGSF3

immunoglobulin superfamily, member 3

chr17_+_18684579 4.258 NM_016078
FAM18B1
family with sequence similarity 18, member B1
chr13_-_95953572 4.231 NM_001105515
NM_005845
ABCC4

ATP-binding cassette, sub-family C (CFTR/MRP), member 4

chr20_+_1093905 4.212 NM_178578
PSMF1
proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
chr12_-_27167332 4.190 NM_016551
TM7SF3
transmembrane 7 superfamily member 3
chrX_+_41192650 4.127 NM_001193416
NM_001193417
NM_001356
DDX3X


DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked


chr12_-_25055228 4.077 NM_001178094
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr3_+_152880024 4.045 NM_002886
RAP2B
RAP2B, member of RAS oncogene family
chr11_-_47545539 4.004 NM_001172639
CELF1
CUGBP, Elav-like family member 1
chr12_-_25102281 3.955 NM_001178091
NM_001178092
NM_005504
BCAT1


branched chain amino-acid transaminase 1, cytosolic


chr3_-_196159304 3.892 NM_015562
UBXN7
UBX domain protein 7
chr2_-_148778262 3.786 NM_001190882
NM_001190879
NM_002552
NM_001190881
NM_181741
ORC4




origin recognition complex, subunit 4




chr10_-_104262404 3.782 NM_005736
ACTR1A
ARP1 actin-related protein 1 homolog A, centractin alpha (yeast)
chr6_+_10695155 3.769 NM_017906
PAK1IP1
PAK1 interacting protein 1
chr1_+_45477801 3.760 NM_000374
UROD
uroporphyrinogen decarboxylase
chr16_+_83841572 3.749 NM_001537
HSBP1
heat shock factor binding protein 1
chr7_-_35077652 3.690 NM_015283
DPY19L1
dpy-19-like 1 (C. elegans)
chr13_-_110959441 3.588 NM_001845
COL4A1
collagen, type IV, alpha 1
chr1_+_147013181 3.525 NM_004326
BCL9
B-cell CLL/lymphoma 9
chr5_-_180230889 3.487 NM_001114619
NM_001114620
MGAT1

mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase

chr2_-_183903225 3.468 NM_013436
NM_205842
NCKAP1

NCK-associated protein 1

chr10_-_14996008 3.435 NM_001033855
NM_001033857
NM_001033858
NM_022487
DCLRE1C



DNA cross-link repair 1C



chr14_-_95623665 3.257 NM_177438
DICER1
dicer 1, ribonuclease type III
chr2_+_28974608 3.249 NM_206876
NM_002709
PPP1CB

protein phosphatase 1, catalytic subunit, beta isozyme

chr20_-_54967221 3.243 NM_003600
NM_198433
NM_198434
NM_198435
NM_198436
NM_198437
AURKA





aurora kinase A





chr1_-_212004113 3.238 NM_014873
LPGAT1
lysophosphatidylglycerol acyltransferase 1
chr2_-_178129858 3.224 NM_006164
NFE2L2
nuclear factor (erythroid-derived 2)-like 2
chr6_-_47277646 3.099 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr7_-_112430408 3.074 NM_022484
TMEM168
transmembrane protein 168
chr11_+_30252562 3.057 NM_000510
NM_001018080
FSHB

follicle stimulating hormone, beta polypeptide

chr3_+_49506079 3.037 NM_001177643
DAG1
dystroglycan 1 (dystrophin-associated glycoprotein 1)
chr19_-_44143943 2.981 NM_145296
CADM4
cell adhesion molecule 4
chr3_-_168864325 2.979 NM_001105078
MECOM
MDS1 and EVI1 complex locus
chr8_+_70378858 2.948 NM_001128204
NM_015170
SULF1

sulfatase 1

chr11_-_6502563 2.942 NM_001242854
NM_001242855
NM_001242856
NM_012402
ARFIP2



ADP-ribosylation factor interacting protein 2



chr8_-_95907423 2.878 NM_057749
CCNE2
cyclin E2
chr10_+_102672325 2.769 NM_001136123
NM_001243770
NM_018121
FAM178A


family with sequence similarity 178, member A


chr12_-_10766130 2.767 NM_018048
MAGOHB
mago-nashi homolog B (Drosophila)
chr10_+_97803064 2.723 NM_001134375
NM_001134376
NM_019084
CCNJ


cyclin J



Gene Ontology Analysis

Nothing significant found in process category.

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.19 5.31e-03 GO:0044424 intracellular part
4.43 1.96e-02 GO:0005769 early endosome
1.16 2.88e-02 GO:0005622 intracellular
1.24 4.54e-02 GO:0005737 cytoplasm
1.96 4.86e-02 GO:0000267 cell fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.41 9.00e-06 GO:0005515 protein binding