Motif ID: AHR_ARNT_ARNT2.p2

Z-value: 2.047


Transcription factors associated with AHR_ARNT_ARNT2.p2:

Gene SymbolEntrez IDGene Name
AHR 196 aryl hydrocarbon receptor
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ARNT2chr15_+_80696569-0.483.2e-14Click!
AHRchr7_+_173381820.314.2e-06Click!
ARNTchr1_-_150849211-0.045.9e-01Click!


Activity profile for motif AHR_ARNT_ARNT2.p2.

activity profile for motif AHR_ARNT_ARNT2.p2


Sorted Z-values histogram for motif AHR_ARNT_ARNT2.p2

Sorted Z-values for motif AHR_ARNT_ARNT2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AHR_ARNT_ARNT2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_+_151151514 34.815 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr5_+_151151516 29.043 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr5_+_151151462 27.757 NM_005754
NM_198395
G3BP1

GTPase activating protein (SH3 domain) binding protein 1

chr5_+_151151511 25.340 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr21_-_40720938 22.053 HMGN1
high mobility group nucleosome binding domain 1
chr6_-_86352650 20.457 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr19_+_17666457 19.256 GLT25D1
glycosyltransferase 25 domain containing 1
chr15_-_69113213 18.968 ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr15_-_69113089 18.244 ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr6_-_86352656 18.229 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr20_-_33872505 18.170 NM_181468
EIF6
eukaryotic translation initiation factor 6
chr12_-_46662533 18.100 SLC38A1
solute carrier family 38, member 1
chr20_-_33872289 17.102 EIF6
eukaryotic translation initiation factor 6
chr3_+_52719935 16.852 NM_014366
NM_206825
NM_206826
GNL3


guanine nucleotide binding protein-like 3 (nucleolar)


chr5_+_170814707 16.796 NM_001037738
NM_002520
NM_199185
NPM1


nucleophosmin (nucleolar phosphoprotein B23, numatrin)


chr4_-_103748649 15.875 NM_181887
NM_181891
UBE2D3

ubiquitin-conjugating enzyme E2D 3

chr6_-_86352635 15.863 NM_001159673
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr12_+_64798050 15.847 NM_007235
XPOT
exportin, tRNA (nuclear export receptor for tRNAs)
chr6_-_86352982 15.744 NM_001159677
NM_006372
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr6_-_86352564 15.714 NM_001159674
NM_001253771
SYNCRIP

synaptotagmin binding, cytoplasmic RNA interacting protein

chr3_-_184870727 15.615 NM_001025266
C3orf70
chromosome 3 open reading frame 70
chr12_-_27091207 15.586 NM_018164
ASUN
asunder, spermatogenesis regulator homolog (Drosphila)
chr5_-_133340358 15.543 VDAC1
voltage-dependent anion channel 1
chr12_-_31479038 14.794 FAM60A
family with sequence similarity 60, member A
chr5_+_170814952 14.725 NPM1
nucleophosmin (nucleolar phosphoprotein B23, numatrin)
chr6_-_86352696 14.634 SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr5_+_151151483 14.564 G3BP1
GTPase activating protein (SH3 domain) binding protein 1
chr5_-_133340380 14.499 VDAC1
voltage-dependent anion channel 1
chr4_-_103748254 14.434 NM_181892
UBE2D3
ubiquitin-conjugating enzyme E2D 3
chr7_+_75931991 14.270 HSPB1
heat shock 27kDa protein 1
chr9_-_113018711 14.222 TXN
thioredoxin
chr6_+_34204647 14.207 NM_145901
NM_145902
HMGA1

high mobility group AT-hook 1

chr19_+_797448 14.184 PTBP1
polypyrimidine tract binding protein 1
chr9_-_113018802 14.172 TXN
thioredoxin
chr4_-_103748966 14.047 NM_003340
NM_181886
NM_181888
NM_181889
UBE2D3



ubiquitin-conjugating enzyme E2D 3



chr12_-_31479120 14.034 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr12_-_27090877 14.020 ASUN
asunder, spermatogenesis regulator homolog (Drosphila)
chr7_+_75931829 13.967 NM_001540
HSPB1
heat shock 27kDa protein 1
chr19_+_17666502 13.846 NM_024656
GLT25D1
glycosyltransferase 25 domain containing 1
chr12_-_31479084 13.725 FAM60A
family with sequence similarity 60, member A
chr3_+_184081178 13.634 NM_006232
POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr5_-_133340427 13.486 VDAC1
voltage-dependent anion channel 1
chr5_-_133340389 13.435 VDAC1
voltage-dependent anion channel 1
chr15_-_69113255 12.998 NM_006305
ANP32A
acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
chr7_+_16685757 12.959 NM_001159767
NM_014038
BZW2

basic leucine zipper and W2 domains 2

chr2_-_198364997 12.878 NM_199440
HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr21_-_40721010 12.776 NM_004965
HMGN1
high mobility group nucleosome binding domain 1
chr4_-_120987890 12.420 NM_002358
MAD2L1
MAD2 mitotic arrest deficient-like 1 (yeast)
chr9_-_113018869 12.408 NM_001244938
NM_003329
TXN

thioredoxin

chr18_+_55019720 12.294 NM_015879
ST8SIA3
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3
chrX_-_20284708 12.243 NM_004586
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr17_-_4851797 12.237 NM_005022
PFN1
profilin 1
chr22_+_20105145 12.223 RANBP1
RAN binding protein 1
chr17_-_40075153 11.944 ACLY
ATP citrate lyase
chr19_-_2456954 11.554 NM_032737
LMNB2
lamin B2
chr3_+_40498781 11.515 NM_003973
NM_001034996
RPL14

ribosomal protein L14

chr17_-_4851827 11.318 PFN1
profilin 1
chr17_-_56084611 11.247 SRSF1
serine/arginine-rich splicing factor 1
chr20_-_1373702 11.147 FKBP1A-SDCBP2
FKBP1A
FKBP1A-SDCBP2 readthrough (non-protein coding)
FK506 binding protein 1A, 12kDa
chr22_+_20105076 11.060 RANBP1
RAN binding protein 1
chr3_+_151986731 11.021 MBNL1
muscleblind-like (Drosophila)
chr17_-_40075238 10.785 NM_001096
NM_198830
ACLY

ATP citrate lyase

chr20_-_33872571 10.679 NM_002212
NM_181466
EIF6

eukaryotic translation initiation factor 6

chr4_-_129208967 10.673 PGRMC2
progesterone receptor membrane component 2
chr1_+_162531349 10.651 UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chr1_+_182992329 10.506 NM_002293
LAMC1
laminin, gamma 1 (formerly LAMB2)
chr2_+_198365012 10.410 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr7_-_105925410 10.359 NM_005746
NAMPT
nicotinamide phosphoribosyltransferase
chr1_+_86046434 10.350 NM_001554
CYR61
cysteine-rich, angiogenic inducer, 61
chr2_-_69614321 10.198 NM_001244710
NM_002056
GFPT1

glutamine--fructose-6-phosphate transaminase 1

chr3_-_49066760 10.156 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr22_+_20105095 10.105 RANBP1
RAN binding protein 1
chr12_+_104359557 10.002 NM_003211
TDG
thymine-DNA glycosylase
chr4_-_129208928 9.937 PGRMC2
progesterone receptor membrane component 2
chr19_-_2427530 9.932 TIMM13
translocase of inner mitochondrial membrane 13 homolog (yeast)
chr3_-_49066858 9.908 NM_000884
IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chrX_-_109561298 9.775 AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr19_+_797452 9.717 PTBP1
polypyrimidine tract binding protein 1
chr20_-_1373744 9.688 NM_000801
NM_001199786
NM_054014
FKBP1A


FK506 binding protein 1A, 12kDa


chr7_+_139044997 9.642 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr8_+_126010748 9.630 SQLE
squalene epoxidase
chr6_+_34204576 9.535 NM_002131
NM_145899
NM_145903
HMGA1


high mobility group AT-hook 1


chr17_-_40075190 9.439 ACLY
ATP citrate lyase
chr17_-_62658311 9.413 NM_022739
SMURF2
SMAD specific E3 ubiquitin protein ligase 2
chrX_-_109561314 9.390 NM_001025580
NM_015365
AMMECR1

Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1

chr1_+_1447495 9.298 NM_001170535
NM_018188
ATAD3A

ATPase family, AAA domain containing 3A

chr3_-_49066813 9.257 IMPDH2
IMP (inosine 5'-monophosphate) dehydrogenase 2
chr12_+_108079516 9.176 NM_007062
PWP1
PWP1 homolog (S. cerevisiae)
chr2_+_198365113 8.942 HSPE1
heat shock 10kDa protein 1 (chaperonin 10)
chr6_+_34204663 8.919 HMGA1
high mobility group AT-hook 1
chr12_+_69004614 8.878 NM_001010942
NM_001251917
NM_001251918
NM_001251921
NM_001251922
NM_015646
RAP1B





RAP1B, member of RAS oncogene family





chr18_-_51750934 8.874 MBD2
methyl-CpG binding domain protein 2
chr17_-_40075229 8.842 ACLY
ATP citrate lyase
chr12_+_69004710 8.838 RAP1B
RAP1B, member of RAS oncogene family
chr5_-_133340823 8.795 NM_003374
VDAC1
voltage-dependent anion channel 1
chr1_-_150208134 8.792 ANP32E
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr2_+_29117503 8.723 NM_015131
WDR43
WD repeat domain 43
chrX_-_153599581 8.680 FLNA
filamin A, alpha
chr1_+_154947166 8.666 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr8_+_126442557 8.646 NM_025195
TRIB1
tribbles homolog 1 (Drosophila)
chr19_+_797390 8.618 NM_002819
NM_031990
NM_031991
NM_175847
PTBP1



polypyrimidine tract binding protein 1



chr1_+_1447871 8.614 NM_001170536
ATAD3A
ATPase family, AAA domain containing 3A
chr12_+_69004684 8.570 RAP1B
RAP1B, member of RAS oncogene family
chr11_-_76091866 8.552 NM_004705
PRKRIR
protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)
chr10_+_17271276 8.551 VIM
vimentin
chr1_-_6259616 8.516 NM_000983
RPL22
ribosomal protein L22
chr6_-_28891409 8.485 TRIM27
tripartite motif containing 27
chr1_+_154947147 8.483 CKS1B
CDC28 protein kinase regulatory subunit 1B
chr2_+_201171411 8.460 SPATS2L
spermatogenesis associated, serine-rich 2-like
chr5_+_68462985 8.444 CCNB1
cyclin B1
chr7_-_45960738 8.380 NM_000598
NM_001013398
IGFBP3

insulin-like growth factor binding protein 3

chr7_+_73097897 8.350 NM_001202560
NM_017528
WBSCR22

Williams Beuren syndrome chromosome region 22

chr8_+_126010719 8.341 NM_003129
SQLE
squalene epoxidase
chr8_+_110346549 8.321 NM_001193557
NM_020189
ENY2

enhancer of yellow 2 homolog (Drosophila)

chr5_+_68462836 8.313 NM_031966
CCNB1
cyclin B1
chr1_+_112162397 8.291 NM_001010935
NM_002884
RAP1A

RAP1A, member of RAS oncogene family

chr7_-_132766697 8.284 NM_017812
CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr5_+_68462948 8.263 CCNB1
cyclin B1
chr14_-_69445948 8.220 ACTN1
actinin, alpha 1
chr16_-_66864864 8.210 NM_001018159
NM_001018160
NM_003905
NAE1


NEDD8 activating enzyme E1 subunit 1


chr4_+_57301898 8.178 NM_006452
PAICS
phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
chr7_+_73097930 8.170 WBSCR22
Williams Beuren syndrome chromosome region 22
chr1_+_43148359 8.142 YBX1
Y box binding protein 1
chr17_-_56084514 8.111 SRSF1
serine/arginine-rich splicing factor 1
chr14_-_69445989 8.097 ACTN1
actinin, alpha 1
chr15_+_52311432 8.090 MAPK6
mitogen-activated protein kinase 6
chr19_+_3572958 8.038 HMG20B
high mobility group 20B
chr10_+_17271341 8.003 VIM
vimentin
chr5_+_132387775 8.000 HSPA4
heat shock 70kDa protein 4
chr1_+_54412007 7.988 NM_052940
LRRC42
leucine rich repeat containing 42
chr14_-_69446038 7.966 NM_001102
NM_001130004
NM_001130005
ACTN1


actinin, alpha 1


chr8_+_97274106 7.928 PTDSS1
phosphatidylserine synthase 1
chr14_-_69446008 7.892 ACTN1
actinin, alpha 1
chr11_-_2950593 7.889 NM_003311
PHLDA2
pleckstrin homology-like domain, family A, member 2
chr12_-_9102262 7.888 NM_001207024
NM_002355
M6PR

mannose-6-phosphate receptor (cation dependent)

chr16_-_66864803 7.871 NAE1
NEDD8 activating enzyme E1 subunit 1
chr14_-_69445978 7.868 ACTN1
actinin, alpha 1
chr12_-_54069856 7.834 ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr5_+_52095929 7.797 PELO
pelota homolog (Drosophila)
chr8_+_37887990 7.742 NM_004095
EIF4EBP1
eukaryotic translation initiation factor 4E binding protein 1
chr10_+_17271302 7.693 VIM
vimentin
chrX_+_19362010 7.628 NM_000284
NM_001173454
NM_001173455
NM_001173456
PDHA1



pyruvate dehydrogenase (lipoamide) alpha 1



chr3_-_156877882 7.626 CCNL1
cyclin L1
chr10_+_17271277 7.619 VIM
vimentin
chr19_+_3572950 7.616 HMG20B
high mobility group 20B
chr9_+_131452253 7.615 NM_001248001
SET
SET nuclear oncogene
chr7_-_148581403 7.596 NM_001203247
NM_001203248
NM_004456
NM_152998
EZH2



enhancer of zeste homolog 2 (Drosophila)



chr14_-_69445974 7.589 ACTN1
actinin, alpha 1
chr5_+_132387699 7.578 HSPA4
heat shock 70kDa protein 4
chr10_-_13390018 7.540 SEPHS1
selenophosphate synthetase 1
chr7_-_105925329 7.503 NAMPT
nicotinamide phosphoribosyltransferase
chr7_-_148581377 7.500 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr1_-_150208462 7.492 NM_001136478
NM_030920
ANP32E

acidic (leucine-rich) nuclear phosphoprotein 32 family, member E

chr1_-_54304107 7.475 NM_001168551
NM_018087
TMEM48

transmembrane protein 48

chr5_+_132387734 7.375 HSPA4
heat shock 70kDa protein 4
chr7_+_2394525 7.362 EIF3B
eukaryotic translation initiation factor 3, subunit B
chr1_+_154947116 7.356 NM_001826
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr17_-_56084590 7.328 SRSF1
serine/arginine-rich splicing factor 1
chr7_+_128379345 7.315 NM_001130674
NM_001199671
NM_001199672
NM_001199673
NM_001199674
NM_001219
CALU





calumenin





chr7_+_139044696 7.307 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr20_-_10654139 7.288 JAG1
jagged 1
chr7_-_132766834 7.264 CHCHD3
coiled-coil-helix-coiled-coil-helix domain containing 3
chr1_+_155658881 7.245 NM_001199849
NM_001199850
NM_001199851
NM_004632
NM_033657
DAP3




death associated protein 3




chr19_-_8373157 7.237 NM_001165895
NM_016579
CD320

CD320 molecule

chr20_+_56964289 7.234 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr5_+_132387579 7.231 NM_002154
HSPA4
heat shock 70kDa protein 4
chr12_-_58146108 7.211 CDK4
cyclin-dependent kinase 4
chr4_-_24586176 7.210 DHX15
DEAH (Asp-Glu-Ala-His) box polypeptide 15
chr7_+_128379428 7.143 CALU
calumenin
chr1_+_165797060 7.106 UCK2
uridine-cytidine kinase 2
chr12_+_104324157 7.092 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr2_-_33824294 7.085 NM_015475
FAM98A
family with sequence similarity 98, member A
chr7_+_128379452 7.083 CALU
calumenin
chr17_+_73201528 7.080 NM_024844
NUP85
nucleoporin 85kDa
chr1_-_33282844 7.068 YARS
tyrosyl-tRNA synthetase
chr21_-_30445949 7.017 CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr7_+_139044701 7.013 LUC7L2
LUC7-like 2 (S. cerevisiae)
chr21_-_30445913 6.996 CCT8
chaperonin containing TCP1, subunit 8 (theta)
chr12_-_58146025 6.987 CDK4
cyclin-dependent kinase 4
chr1_+_162531229 6.982 NM_003115
UAP1
UDP-N-acteylglucosamine pyrophosphorylase 1
chr9_-_15510899 6.981 NM_001128217
NM_033222
PSIP1

PC4 and SFRS1 interacting protein 1

chr4_+_146019368 6.980 ABCE1
ATP-binding cassette, sub-family E (OABP), member 1
chr5_+_33440801 6.963 NM_152295
TARS
threonyl-tRNA synthetase
chr7_-_148581379 6.956 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr12_-_54070108 6.936 NM_005176
ATP5G2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr6_-_10412606 6.928 NM_001032280
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr1_+_165796652 6.926 NM_012474
UCK2
uridine-cytidine kinase 2
chr6_+_34204928 6.925 HMGA1
high mobility group AT-hook 1
chr17_-_48474910 6.922 NM_018509
LRRC59
leucine rich repeat containing 59
chr12_+_104324192 6.917 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr7_+_128379400 6.914 CALU
calumenin
chrX_+_153991106 6.893 DKC1
dyskeratosis congenita 1, dyskerin
chr12_-_58146110 6.892 CDK4
cyclin-dependent kinase 4
chr12_-_46662779 6.866 SLC38A1
solute carrier family 38, member 1
chr7_-_148581359 6.844 EZH2
enhancer of zeste homolog 2 (Drosophila)
chr19_+_58898634 6.839 NM_001009
RPS5
ribosomal protein S5
chr7_+_117824085 6.824 NM_016200
NAA38
N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr20_+_56964162 6.799 NM_001195677
NM_004738
VAPB

VAMP (vesicle-associated membrane protein)-associated protein B and C

chr10_+_75936546 6.792 ADK
adenosine kinase
chr12_-_106641675 6.790 NM_006825
CKAP4
cytoskeleton-associated protein 4

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.52 5.06e-51 GO:0044237 cellular metabolic process
1.67 7.42e-50 GO:0044260 cellular macromolecule metabolic process
1.24 1.47e-41 GO:0009987 cellular process
1.55 1.53e-40 GO:0043170 macromolecule metabolic process
1.45 3.09e-39 GO:0044238 primary metabolic process
1.40 2.59e-38 GO:0008152 metabolic process
1.81 3.42e-38 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
2.00 1.53e-35 GO:0010467 gene expression
1.71 1.77e-35 GO:0034641 cellular nitrogen compound metabolic process
1.69 4.47e-35 GO:0006807 nitrogen compound metabolic process
1.87 1.07e-33 GO:0090304 nucleic acid metabolic process
1.94 6.91e-29 GO:0016070 RNA metabolic process
1.68 5.30e-24 GO:0009058 biosynthetic process
1.69 1.89e-23 GO:0044249 cellular biosynthetic process
1.85 3.76e-23 GO:0009059 macromolecule biosynthetic process
1.86 5.90e-23 GO:0034645 cellular macromolecule biosynthetic process
1.65 6.86e-22 GO:0044267 cellular protein metabolic process
2.39 5.62e-20 GO:0006396 RNA processing
3.02 1.15e-18 GO:0006412 translation
1.55 3.54e-17 GO:0071841 cellular component organization or biogenesis at cellular level
1.55 1.61e-16 GO:0071842 cellular component organization at cellular level
1.45 1.67e-15 GO:0071840 cellular component organization or biogenesis
1.49 2.51e-15 GO:0019538 protein metabolic process
1.45 3.53e-15 GO:0016043 cellular component organization
1.45 1.07e-14 GO:0060255 regulation of macromolecule metabolic process
2.74 9.64e-14 GO:0008380 RNA splicing
3.46 2.04e-13 GO:0022415 viral reproductive process
2.45 2.01e-12 GO:0006397 mRNA processing
1.48 2.03e-12 GO:0048518 positive regulation of biological process
2.20 3.71e-12 GO:0016071 mRNA metabolic process
1.37 3.91e-12 GO:0019222 regulation of metabolic process
3.51 1.08e-11 GO:0019058 viral infectious cycle
1.21 1.78e-11 GO:0065007 biological regulation
1.49 2.05e-11 GO:0048522 positive regulation of cellular process
1.81 9.23e-11 GO:0032774 RNA biosynthetic process
1.37 2.09e-10 GO:0031323 regulation of cellular metabolic process
1.21 4.29e-10 GO:0050789 regulation of biological process
2.88 6.88e-10 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.88 6.88e-10 GO:0000398 nuclear mRNA splicing, via spliceosome
1.22 1.02e-09 GO:0050794 regulation of cellular process
1.70 1.51e-09 GO:0010604 positive regulation of macromolecule metabolic process
1.36 1.96e-09 GO:0080090 regulation of primary metabolic process
2.81 2.25e-09 GO:0000375 RNA splicing, via transesterification reactions
1.65 3.16e-09 GO:0009893 positive regulation of metabolic process
1.72 1.16e-08 GO:0032268 regulation of cellular protein metabolic process
1.55 1.39e-08 GO:0006996 organelle organization
1.69 1.79e-08 GO:0051246 regulation of protein metabolic process
2.06 1.95e-08 GO:0034621 cellular macromolecular complex subunit organization
2.79 1.96e-08 GO:0022411 cellular component disassembly
2.79 1.96e-08 GO:0071845 cellular component disassembly at cellular level
1.43 3.23e-08 GO:0048519 negative regulation of biological process
1.41 3.28e-08 GO:0010468 regulation of gene expression
1.64 3.62e-08 GO:0031325 positive regulation of cellular metabolic process
1.45 7.87e-08 GO:0048523 negative regulation of cellular process
2.40 1.02e-07 GO:0010608 posttranscriptional regulation of gene expression
1.79 1.11e-07 GO:0046907 intracellular transport
1.60 1.30e-07 GO:0051641 cellular localization
1.69 1.44e-07 GO:0009892 negative regulation of metabolic process
2.60 2.25e-07 GO:0071843 cellular component biogenesis at cellular level
2.64 3.16e-07 GO:0022613 ribonucleoprotein complex biogenesis
1.71 3.39e-07 GO:0010605 negative regulation of macromolecule metabolic process
1.63 4.59e-07 GO:0051649 establishment of localization in cell
2.08 5.69e-07 GO:0016032 viral reproduction
3.56 6.95e-07 GO:0019080 viral genome expression
3.56 6.95e-07 GO:0019083 viral transcription
2.15 7.07e-07 GO:0044419 interspecies interaction between organisms
3.32 7.68e-07 GO:0006414 translational elongation
1.72 9.29e-07 GO:0043933 macromolecular complex subunit organization
1.69 1.12e-06 GO:0031324 negative regulation of cellular metabolic process
2.32 1.25e-06 GO:0034660 ncRNA metabolic process
1.44 1.38e-06 GO:0043412 macromolecule modification
3.13 2.39e-06 GO:0032984 macromolecular complex disassembly
3.13 2.39e-06 GO:0034623 cellular macromolecular complex disassembly
2.79 6.45e-06 GO:0031016 pancreas development
1.44 6.75e-06 GO:0006464 protein modification process
1.37 8.26e-06 GO:2000112 regulation of cellular macromolecule biosynthetic process
3.32 9.02e-06 GO:0006415 translational termination
1.36 1.12e-05 GO:0010556 regulation of macromolecule biosynthetic process
1.65 1.54e-05 GO:0006351 transcription, DNA-dependent
1.54 2.59e-05 GO:0044085 cellular component biogenesis
3.11 2.79e-05 GO:0043241 protein complex disassembly
3.11 2.79e-05 GO:0043624 cellular protein complex disassembly
1.65 2.97e-05 GO:0033554 cellular response to stress
1.33 3.08e-05 GO:0031326 regulation of cellular biosynthetic process
1.33 3.19e-05 GO:0009889 regulation of biosynthetic process
1.77 3.49e-05 GO:0051276 chromosome organization
1.78 3.88e-05 GO:0071822 protein complex subunit organization
4.44 5.20e-05 GO:0006413 translational initiation
2.47 5.75e-05 GO:0051169 nuclear transport
1.67 5.96e-05 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.36 6.54e-05 GO:0051252 regulation of RNA metabolic process
1.58 7.13e-05 GO:0006357 regulation of transcription from RNA polymerase II promoter
1.67 7.81e-05 GO:0010557 positive regulation of macromolecule biosynthetic process
2.81 9.29e-05 GO:0031018 endocrine pancreas development
1.65 9.54e-05 GO:0051173 positive regulation of nitrogen compound metabolic process
1.62 1.14e-04 GO:0009891 positive regulation of biosynthetic process
1.40 1.18e-04 GO:0044281 small molecule metabolic process
2.44 1.21e-04 GO:0006913 nucleocytoplasmic transport
1.99 1.28e-04 GO:0051301 cell division
1.62 1.38e-04 GO:0031328 positive regulation of cellular biosynthetic process
1.54 2.39e-04 GO:0007049 cell cycle
2.33 3.33e-04 GO:0034470 ncRNA processing
1.76 5.09e-04 GO:0044265 cellular macromolecule catabolic process
1.33 9.20e-04 GO:0042221 response to chemical stimulus
1.65 9.40e-04 GO:0051254 positive regulation of RNA metabolic process
1.24 9.67e-04 GO:0032502 developmental process
3.01 1.02e-03 GO:0051168 nuclear export
1.68 1.24e-03 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.67 2.01e-03 GO:0006259 DNA metabolic process
1.66 2.21e-03 GO:0009057 macromolecule catabolic process
1.66 2.21e-03 GO:0051172 negative regulation of nitrogen compound metabolic process
1.56 2.56e-03 GO:0051128 regulation of cellular component organization
1.69 2.92e-03 GO:0051253 negative regulation of RNA metabolic process
1.32 3.02e-03 GO:0065008 regulation of biological quality
2.53 3.10e-03 GO:0042254 ribosome biogenesis
2.92 3.14e-03 GO:0022618 ribonucleoprotein complex assembly
2.31 3.20e-03 GO:0006417 regulation of translation
2.25 3.36e-03 GO:0035270 endocrine system development
1.66 3.47e-03 GO:0042060 wound healing
1.28 3.64e-03 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.94 3.72e-03 GO:0051130 positive regulation of cellular component organization
2.51 3.75e-03 GO:0006403 RNA localization
1.65 4.20e-03 GO:0010629 negative regulation of gene expression
3.48 4.28e-03 GO:0051701 interaction with host
1.61 4.29e-03 GO:0009719 response to endogenous stimulus
1.43 4.38e-03 GO:0010033 response to organic substance
1.63 4.78e-03 GO:0045893 positive regulation of transcription, DNA-dependent
1.60 4.99e-03 GO:0010628 positive regulation of gene expression
1.27 5.46e-03 GO:0051171 regulation of nitrogen compound metabolic process
2.51 5.49e-03 GO:0050657 nucleic acid transport
2.51 5.49e-03 GO:0050658 RNA transport
2.51 5.49e-03 GO:0051236 establishment of RNA localization
1.65 5.78e-03 GO:0000278 mitotic cell cycle
1.59 6.42e-03 GO:0009890 negative regulation of biosynthetic process
3.13 7.60e-03 GO:0031124 mRNA 3'-end processing
1.59 7.78e-03 GO:0031327 negative regulation of cellular biosynthetic process
1.78 7.89e-03 GO:0051247 positive regulation of protein metabolic process
3.23 7.98e-03 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
1.54 8.56e-03 GO:0031399 regulation of protein modification process
1.81 9.10e-03 GO:0034622 cellular macromolecular complex assembly
1.24 9.37e-03 GO:0048856 anatomical structure development
1.61 1.01e-02 GO:2000113 negative regulation of cellular macromolecule biosynthetic process
2.75 1.02e-02 GO:0071826 ribonucleoprotein complex subunit organization
1.52 1.12e-02 GO:0022402 cell cycle process
1.59 1.23e-02 GO:0010558 negative regulation of macromolecule biosynthetic process
1.26 1.27e-02 GO:0048731 system development
1.20 1.39e-02 GO:0051716 cellular response to stimulus
1.79 1.70e-02 GO:0016568 chromatin modification
2.99 1.70e-02 GO:0006405 RNA export from nucleus
1.56 1.72e-02 GO:0065003 macromolecular complex assembly
3.83 1.74e-02 GO:0042278 purine nucleoside metabolic process
3.83 1.74e-02 GO:0046128 purine ribonucleoside metabolic process
1.44 1.77e-02 GO:0022607 cellular component assembly
1.68 2.37e-02 GO:0006325 chromatin organization
2.47 2.51e-02 GO:0051028 mRNA transport
1.59 2.53e-02 GO:0009725 response to hormone stimulus
1.67 2.81e-02 GO:0072358 cardiovascular system development
1.67 2.81e-02 GO:0072359 circulatory system development
1.63 2.91e-02 GO:0045892 negative regulation of transcription, DNA-dependent
2.80 3.13e-02 GO:0006353 transcription termination, DNA-dependent
1.95 3.30e-02 GO:0032269 negative regulation of cellular protein metabolic process
1.78 3.67e-02 GO:0018193 peptidyl-amino acid modification
1.79 3.90e-02 GO:0071495 cellular response to endogenous stimulus
1.28 4.05e-02 GO:0006355 regulation of transcription, DNA-dependent
1.66 4.31e-02 GO:0048646 anatomical structure formation involved in morphogenesis
1.40 4.65e-02 GO:0044248 cellular catabolic process
1.95 4.65e-02 GO:0051129 negative regulation of cellular component organization
1.91 4.67e-02 GO:0051248 negative regulation of protein metabolic process
2.23 4.94e-02 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.26 1.19e-55 GO:0044424 intracellular part
1.25 5.61e-55 GO:0005622 intracellular
1.30 7.50e-46 GO:0043229 intracellular organelle
1.30 1.13e-45 GO:0043226 organelle
1.33 1.07e-41 GO:0043231 intracellular membrane-bounded organelle
1.32 2.05e-41 GO:0043227 membrane-bounded organelle
1.50 4.50e-41 GO:0044446 intracellular organelle part
1.49 6.06e-41 GO:0044422 organelle part
1.89 1.60e-39 GO:0031974 membrane-enclosed lumen
1.90 6.86e-39 GO:0070013 intracellular organelle lumen
1.89 1.24e-38 GO:0043233 organelle lumen
1.33 8.94e-37 GO:0005737 cytoplasm
1.88 1.13e-35 GO:0044428 nuclear part
1.44 2.50e-32 GO:0005634 nucleus
1.92 1.27e-31 GO:0031981 nuclear lumen
1.40 1.74e-29 GO:0044444 cytoplasmic part
2.01 5.49e-26 GO:0005654 nucleoplasm
1.54 7.69e-26 GO:0032991 macromolecular complex
2.72 1.04e-25 GO:0030529 ribonucleoprotein complex
1.68 8.99e-21 GO:0005829 cytosol
1.47 1.26e-13 GO:0043228 non-membrane-bounded organelle
1.47 1.26e-13 GO:0043232 intracellular non-membrane-bounded organelle
1.07 1.75e-12 GO:0044464 cell part
1.07 1.85e-12 GO:0005623 cell
2.87 3.42e-10 GO:0005840 ribosome
1.38 1.78e-09 GO:0043234 protein complex
1.82 1.03e-08 GO:0044451 nucleoplasm part
1.55 9.38e-08 GO:0005739 mitochondrion
1.90 5.33e-07 GO:0005730 nucleolus
3.46 3.29e-06 GO:0022626 cytosolic ribosome
6.57 6.00e-06 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
1.67 2.60e-05 GO:0044429 mitochondrial part
2.58 5.60e-05 GO:0005681 spliceosomal complex
2.47 5.69e-05 GO:0044445 cytosolic part
2.01 4.66e-04 GO:0005759 mitochondrial matrix
1.46 4.81e-04 GO:0005783 endoplasmic reticulum
1.58 5.73e-04 GO:0031967 organelle envelope
2.87 1.09e-03 GO:0071013 catalytic step 2 spliceosome
1.55 1.34e-03 GO:0031975 envelope
3.07 2.76e-03 GO:0015934 large ribosomal subunit
3.73 3.77e-03 GO:0022625 cytosolic large ribosomal subunit
1.98 3.83e-03 GO:0016604 nuclear body
1.91 5.51e-03 GO:0005667 transcription factor complex
1.27 1.39e-02 GO:0031090 organelle membrane
4.67 2.00e-02 GO:0031519 PcG protein complex
3.87 2.38e-02 GO:0001725 stress fiber

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.42 2.17e-46 GO:0005515 protein binding
1.18 1.64e-29 GO:0005488 binding
2.29 9.18e-25 GO:0003723 RNA binding
1.51 4.48e-13 GO:0000166 nucleotide binding
1.39 3.35e-12 GO:0003676 nucleic acid binding
2.88 7.08e-08 GO:0003735 structural constituent of ribosome
1.38 3.99e-05 GO:0035639 purine ribonucleoside triphosphate binding
3.90 6.48e-05 GO:0003743 translation initiation factor activity
1.36 1.16e-04 GO:0017076 purine nucleotide binding
1.36 1.62e-04 GO:0032553 ribonucleotide binding
1.36 1.62e-04 GO:0032555 purine ribonucleotide binding
2.92 7.72e-04 GO:0008135 translation factor activity, nucleic acid binding
3.85 8.62e-04 GO:0043021 ribonucleoprotein binding
1.37 1.80e-03 GO:0005524 ATP binding
1.46 1.91e-03 GO:0030528 transcription regulator activity
1.35 3.28e-03 GO:0030554 adenyl nucleotide binding
1.35 4.96e-03 GO:0032559 adenyl ribonucleotide binding
2.44 5.07e-03 GO:0051082 unfolded protein binding
1.58 6.01e-03 GO:0005198 structural molecule activity
1.83 9.35e-03 GO:0008134 transcription factor binding
1.53 1.31e-02 GO:0046983 protein dimerization activity
2.62 2.30e-02 GO:0031625 ubiquitin protein ligase binding
1.15 2.83e-02 GO:0003824 catalytic activity
1.29 3.67e-02 GO:0016740 transferase activity
3.87 3.95e-02 GO:0003727 single-stranded RNA binding
1.41 4.13e-02 GO:0016772 transferase activity, transferring phosphorus-containing groups