Motif ID: AIRE.p2

Z-value: 1.304


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
AIREchr21_+_457101470.502.2e-15Click!


Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr19_-_39826676 42.108 NM_004877
GMFG
glia maturation factor, gamma
chr19_-_8642337 28.998 MYO1F
myosin IF
chr7_-_38313232 26.209 NM_001003799
NM_001003806
TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr1_+_161185084 25.188 NM_004106
FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr1_+_161185061 24.432 FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr11_-_73693883 21.864 NM_003355
UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr4_-_74847669 21.048 NM_002619
PF4
platelet factor 4
chr13_-_41556188 19.652 ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_-_169680677 19.422 NM_000655
SELL
selectin L
chr1_-_182357871 19.177 GLUL
glutamate-ammonia ligase
chr19_+_18208596 17.011 NM_015016
MAST3
microtubule associated serine/threonine kinase 3
chr4_-_84035888 16.829 PLAC8
placenta-specific 8
chr18_+_29171729 16.224 NM_000371
TTR
transthyretin
chr18_-_47814691 16.175 NM_001101654
NM_014593
CXXC1

CXXC finger protein 1

chr3_+_46395224 15.572 NM_001123041
NM_001123396
CCR2

chemokine (C-C motif) receptor 2

chr5_+_75699003 15.263 NM_006633
IQGAP2
IQ motif containing GTPase activating protein 2
chr13_+_50070096 15.028 PHF11
PHD finger protein 11
chr22_-_36556781 14.725 NM_145640
APOL3
apolipoprotein L, 3
chr1_-_7973286 14.064 UTS2
urotensin 2
chr12_-_10282680 14.001 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
CLEC7A





C-type lectin domain family 7, member A





chr22_+_23010757 13.899


chr5_-_149792370 13.644 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr13_+_31309644 12.964 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr15_+_58430394 12.559 NM_020980
AQP9
aquaporin 9
chr4_-_84035908 12.088 NM_001130715
NM_016619
PLAC8

placenta-specific 8

chr12_-_46357949 11.998


chr12_+_51318743 11.963 METTL7A
methyltransferase like 7A
chr11_-_73693820 11.817 UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr12_-_53600999 11.750 NM_000889
ITGB7
integrin, beta 7
chr17_-_40021616 11.714 NM_018143
KLHL11
kelch-like 11 (Drosophila)
chr15_+_41576150 11.329 OIP5-AS1
OIP5 antisense RNA 1 (non-protein coding)
chr14_-_106725620 11.114 IGHV4-31
IGHV3-23
IGHA1
IGHG1
IGHM
immunoglobulin heavy variable 4-31
immunoglobulin heavy variable 3-23
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)
immunoglobulin heavy constant mu
chr19_-_48759141 10.958 NM_001184902
NM_001184904
CARD8

caspase recruitment domain family, member 8

chr19_+_21264952 10.721 NM_182515
ZNF714
zinc finger protein 714
chr17_-_34207308 10.645 NM_002985
CCL5
chemokine (C-C motif) ligand 5
chr19_-_14785626 10.629 NM_032571
EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr16_+_81812899 10.499 PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr17_+_41006094 10.455 AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr13_-_41556360 10.334 NM_001145353
ELF1
E74-like factor 1 (ets domain transcription factor)
chr4_+_15704752 10.281 BST1
bone marrow stromal cell antigen 1
chr7_-_115608366 10.152 NM_001244583
TFEC
transcription factor EC
chr7_-_77045706 10.130 NM_017439
PION
pigeon homolog (Drosophila)
chr13_-_41593491 10.117 NM_172373
ELF1
E74-like factor 1 (ets domain transcription factor)
chr16_+_81812897 9.799 NM_002661
PLCG2
phospholipase C, gamma 2 (phosphatidylinositol-specific)
chr11_+_57365026 9.465 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr2_-_87018802 9.456 NM_001768
NM_171827
CD8A

CD8a molecule

chr5_-_64777703 9.438 NM_197941
ADAMTS6
ADAM metallopeptidase with thrombospondin type 1 motif, 6
chr19_+_50936159 9.375 NM_004533
MYBPC2
myosin binding protein C, fast type
chr5_-_997408 9.267 NM_001242737
LOC100506688
uncharacterized LOC100506688
chrX_-_70128560 9.097 NM_001003811
NM_031276
TEX11

testis expressed 11

chr17_-_6983503 9.073 NM_006344
NM_182906
CLEC10A

C-type lectin domain family 10, member A

chr16_+_10522724 9.027 NM_024997
ATF7IP2
activating transcription factor 7 interacting protein 2
chr1_-_89664510 8.818 NM_052941
GBP4
guanylate binding protein 4
chr15_-_45670955 8.801 NM_001482
GATM
glycine amidinotransferase (L-arginine:glycine amidinotransferase)
chr1_+_158801105 8.691 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr1_+_84630575 8.474 NM_001242860
NM_001242861
PRKACB

protein kinase, cAMP-dependent, catalytic, beta

chr19_+_55174425 8.397 LILRB4
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4
chr6_-_99849266 8.263 PNISR
PNN-interacting serine/arginine-rich protein
chr6_-_133078894 8.207 NM_001242350
NM_004665
VNN2

vanin 2

chr4_+_74270832 8.171 ALB
albumin
chr6_+_42897236 8.047 CNPY3
canopy 3 homolog (zebrafish)
chr19_+_52266640 7.981 NM_001462
FPR2
formyl peptide receptor 2
chr5_-_177207465 7.979 NM_173663
FAM153A
family with sequence similarity 153, member A
chr22_+_23029175 7.892 IGLV3-25
immunoglobulin lambda variable 3-25
chr10_+_7745341 7.885 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_+_43282775 7.767 NM_001017922
ERMAP
erythroblast membrane-associated protein (Scianna blood group)
chr13_-_41593405 7.743 ELF1
E74-like factor 1 (ets domain transcription factor)
chr5_-_39203061 7.729 FYB
FYN binding protein
chr19_+_47813074 7.677 NM_001736
C5AR1
complement component 5a receptor 1
chr19_+_24097656 7.476 NM_001244038
ZNF726
zinc finger protein 726
chr1_-_27701302 7.401 NM_003665
NM_173452
FCN3

ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen)

chr16_+_20420854 7.170 NM_017888
ACSM5
acyl-CoA synthetase medium-chain family member 5
chr19_-_48752921 7.101 NM_001184901
NM_001184903
NM_014959
CARD8


caspase recruitment domain family, member 8


chr6_-_32784727 7.047 NM_002120
HLA-DOB
major histocompatibility complex, class II, DO beta
chr4_+_106631966 7.025 NM_001031720
GSTCD
glutathione S-transferase, C-terminal domain containing
chr3_-_15382874 6.917 NM_001018009
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr13_-_46742678 6.889 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr10_+_7745354 6.871 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr11_+_7110164 6.830 NM_014469
RBMXL2
RNA binding motif protein, X-linked-like 2
chr6_+_33244916 6.770 NM_003782
B3GALT4
UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
chr13_+_31309690 6.762 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr2_-_24346143 6.720 NM_199346
PFN4
profilin family, member 4
chr3_-_150920946 6.589 NM_013308
GPR171
G protein-coupled receptor 171
chr17_+_41003184 6.554 NM_003734
AOC3
amine oxidase, copper containing 3 (vascular adhesion protein 1)
chr12_-_8088629 6.463 NM_006931
SLC2A3
solute carrier family 2 (facilitated glucose transporter), member 3
chr10_+_7745284 6.280 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr12_-_8043743 6.276 SLC2A14
solute carrier family 2 (facilitated glucose transporter), member 14
chr13_-_99910548 6.253 NM_001098200
NM_005292
GPR18

G protein-coupled receptor 18

chr1_-_115053758 6.246 NM_015906
NM_033020
TRIM33

tripartite motif containing 33

chr7_-_150329735 6.229 NM_001244071
NM_001244072
NM_024711
GIMAP6


GTPase, IMAP family member 6


chr14_-_106725232 6.133 ZCWPW2
IGHV3-23
IGKV3-20
IGK@
zinc finger, CW type with PWWP domain 2
immunoglobulin heavy variable 3-23
immunoglobulin kappa variable 3-20
immunoglobulin kappa locus
chr6_+_42897184 6.097 CNPY3
canopy 3 homolog (zebrafish)
chr5_-_140013034 6.076 NM_000591
CD14
CD14 molecule
chr16_+_89627081 6.052 NM_033251
RPL13
ribosomal protein L13
chr2_+_218989997 6.051 NM_001168298
CXCR2
chemokine (C-X-C motif) receptor 2
chr12_-_56753856 5.993 STAT2
signal transducer and activator of transcription 2, 113kDa
chr2_+_68592317 5.956 NM_002664
PLEK
pleckstrin
chr19_-_13617037 5.860 NM_000068
NM_001127221
NM_001127222
NM_001174080
NM_023035
CACNA1A




calcium channel, voltage-dependent, P/Q type, alpha 1A subunit




chr1_+_152850797 5.769 NM_030663
SMCP
sperm mitochondria-associated cysteine-rich protein
chr6_-_46703429 5.721 NM_001168357
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr10_+_7745325 5.612 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr6_+_35226685 5.548 ZNF76
zinc finger protein 76
chr22_+_32753853 5.540 NM_001098535
RFPL3
ret finger protein-like 3
chr19_+_22235253 5.410 NM_033468
ZNF257
zinc finger protein 257
chr14_+_35515347 5.238 NM_173607
FAM177A1
family with sequence similarity 177, member A1
chr9_-_99540327 5.220 NM_014930
ZNF510
zinc finger protein 510
chr4_-_88450601 5.210 NM_001128310
NM_004684
SPARCL1

SPARC-like 1 (hevin)

chr11_+_5641173 5.176 NM_001003827
TRIM34
tripartite motif containing 34
chr4_+_69681709 5.175 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr9_-_86571533 5.173 C9orf64
chromosome 9 open reading frame 64
chr19_+_22235278 5.135 ZNF257
zinc finger protein 257
chr18_+_21572736 5.081 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr18_-_61329113 5.080 NM_006919
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3
chr4_+_87968191 5.058 AFF1
AF4/FMR2 family, member 1
chr12_+_133614138 4.995 ZNF84
zinc finger protein 84
chr7_-_102283237 4.930 NM_001114403
UPK3BL
uroplakin 3B-like
chr10_-_42863435 4.875 LOC441666
zinc finger protein 91 pseudogene
chr16_+_89627061 4.868 NM_000977
NM_001243130
NM_001243131
RPL13


ribosomal protein L13


chr12_-_371994 4.844 NM_001190997
NM_001243392
NM_016615
SLC6A13


solute carrier family 6 (neurotransmitter transporter, GABA), member 13


chr4_-_69886112 4.832 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr16_-_4817124 4.767 NM_021646
ZNF500
zinc finger protein 500
chr12_-_30848805 4.763 NM_006390
IPO8
importin 8
chr6_-_90062450 4.753 UBE2J1
ubiquitin-conjugating enzyme E2, J1, U
chr19_-_14939275 4.732 NM_017506
OR7A5
olfactory receptor, family 7, subfamily A, member 5
chr10_-_48390873 4.692 NM_002900
RBP3
retinol binding protein 3, interstitial
chr6_+_32132379 4.656 NM_030652
EGFL8
EGF-like-domain, multiple 8
chr6_+_26365397 4.648 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr19_+_48248792 4.612 NM_015710
GLTSCR2
glioma tumor suppressor candidate region gene 2
chr10_+_135207607 4.606 NM_138384
MTG1
mitochondrial GTPase 1 homolog (S. cerevisiae)
chr2_+_201980873 4.510 NM_001127184
NM_001202516
NM_001202517
NM_001202519
NM_003879
CFLAR




CASP8 and FADD-like apoptosis regulator




chr3_-_56835829 4.491 NM_019555
ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3
chr7_+_2598712 4.489 IQCE
IQ motif containing E
chr19_+_48248798 4.488 GLTSCR2
glioma tumor suppressor candidate region gene 2
chr16_-_28621279 4.485 NM_001055
NM_177529
SULT1A1

sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

chr12_+_133614052 4.451 ZNF84
zinc finger protein 84
chr11_+_65479685 4.448 KAT5
K(lysine) acetyltransferase 5
chr14_-_106610338 4.408 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_+_51318515 4.392 NM_014033
METTL7A
methyltransferase like 7A
chr13_+_23755059 4.330 NM_000231
SGCG
sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
chr7_+_2598676 4.312 IQCE
IQ motif containing E
chr19_-_8408120 4.284 NM_198471
KANK3
KN motif and ankyrin repeat domains 3
chr13_-_48987017 4.207 LPAR6
lysophosphatidic acid receptor 6
chr19_+_50879681 4.107 NM_007121
NR1H2
nuclear receptor subfamily 1, group H, member 2
chr16_-_86588680 4.084 NM_001159380
NM_001159377
NM_001159378
NM_001159379
NM_022764
MTHFSD




methenyltetrahydrofolate synthetase domain containing




chr14_+_95078713 4.029 NM_001085
SERPINA3
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr19_-_21950322 4.017 NM_173531
ZNF100
zinc finger protein 100
chr1_-_89591685 4.007 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr11_-_5526833 3.996 NM_001005567
OR51B5
HBE1
olfactory receptor, family 51, subfamily B, member 5
hemoglobin, epsilon 1
chr8_-_6795783 3.987 NM_001925
DEFA4
defensin, alpha 4, corticostatin
chr12_+_85430098 3.937 NM_001079910
LRRIQ1
leucine-rich repeats and IQ motif containing 1
chr9_-_77503009 3.937 NM_017662
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr1_-_247267625 3.928 NM_001142572
NM_024804
ZNF669

zinc finger protein 669

chr1_+_160709038 3.923 NM_021181
SLAMF7
SLAM family member 7
chr12_+_101988746 3.919 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr4_-_90759446 3.911 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chrY_-_19992072 3.876 NM_001001722
NM_004825
CDY2B
CDY2A
chromodomain protein, Y-linked, 2B
chromodomain protein, Y-linked, 2A
chr4_+_15704691 3.842 BST1
bone marrow stromal cell antigen 1
chr4_+_70146216 3.835 NM_001207004
NM_053039
UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chrY_+_20137666 3.828 NM_001001722
NM_004825
CDY2B
CDY2A
chromodomain protein, Y-linked, 2B
chromodomain protein, Y-linked, 2A
chr20_-_34195409 3.792 FER1L4
fer-1-like 4 (C. elegans) pseudogene
chrY_-_26194115 3.731 NM_001003894
NM_001003895
NM_004680
NM_170723
CDY1B

CDY1

chromodomain protein, Y-linked, 1B

chromodomain protein, Y-linked, 1

chr7_-_99680358 3.723 ZNF3
zinc finger protein 3
chr10_+_97471535 3.723 NM_001098175
ENTPD1
ectonucleoside triphosphate diphosphohydrolase 1
chr1_+_241695433 3.713 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr4_-_39033981 3.710 NM_024943
TMEM156
transmembrane protein 156
chr16_-_3627353 3.596 NM_178844
NLRC3
NLR family, CARD domain containing 3
chr4_+_187148624 3.518 NM_000892
KLKB1
kallikrein B, plasma (Fletcher factor) 1
chr5_+_40909617 3.493 C7
complement component 7
chr14_-_45431121 3.490 NM_017658
KLHL28
kelch-like 28 (Drosophila)
chr10_+_104613966 3.482 NM_001136200
NM_144591
C10orf32-AS3MT
C10orf32

C10orf32-AS3MT readthrough
chromosome 10 open reading frame 32

chr2_+_68592432 3.463 PLEK
pleckstrin
chr2_-_190627923 3.440 NM_022353
OSGEPL1
O-sialoglycoprotein endopeptidase-like 1
chr1_+_84609941 3.419 NM_182948
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr9_-_77502635 3.418 NM_001177310
TRPM6
transient receptor potential cation channel, subfamily M, member 6
chr14_-_106452693 3.370 IGHG1
immunoglobulin heavy constant gamma 1 (G1m marker)
chr12_-_10605928 3.328 NM_002259
NM_007328
KLRC1

killer cell lectin-like receptor subfamily C, member 1

chr4_+_646965 3.300 NM_001145292
PDE6B
phosphodiesterase 6B, cGMP-specific, rod, beta
chr18_-_61311465 3.295 NM_002974
SERPINB4
serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr8_-_41655139 3.293 NM_000037
NM_020475
NM_020476
NM_020477
ANK1



ankyrin 1, erythrocytic



chrX_-_100306859 3.292 TRMT2B
TRM2 tRNA methyltransferase 2 homolog B (S. cerevisiae)
chr1_-_144997110 3.261 NM_001195260
PDE4DIP
phosphodiesterase 4D interacting protein
chr1_-_109618568 3.242 NM_005645
TAF13
TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa
chr9_-_21368005 3.238 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr4_+_40198526 3.189 NM_004310
RHOH
ras homolog gene family, member H
chr14_+_39734475 3.155 NM_203354
CTAGE5
CTAGE family, member 5
chr14_-_78174320 3.138 NM_006020
ALKBH1
alkB, alkylation repair homolog 1 (E. coli)
chr7_+_2598646 3.132 IQCE
IQ motif containing E
chr1_-_153348057 3.099 NM_005621
S100A12
S100 calcium binding protein A12
chr12_-_91452130 3.098 NM_007035
KERA
keratocan
chr17_+_42422665 3.084 GRN
granulin
chr21_-_19775958 3.067 NM_002772
TMPRSS15
transmembrane protease, serine 15
chr9_-_86571631 3.062 C9orf64
chromosome 9 open reading frame 64
chr20_-_42939737 3.043 NM_001080472
FITM2
fat storage-inducing transmembrane protein 2
chr6_-_32977351 3.006 NM_002119
HLA-DOA
major histocompatibility complex, class II, DO alpha
chr18_+_11851388 2.990 NM_020412
CHMP1B
charged multivesicular body protein 1B
chr13_-_48987247 2.947 LPAR6
lysophosphatidic acid receptor 6
chr3_+_46283871 2.932 NM_001164680
NM_001837
NM_178328
NM_178329
CCR3



chemokine (C-C motif) receptor 3



chr19_+_41509825 2.928 CYP2B6
cytochrome P450, family 2, subfamily B, polypeptide 6
chr8_+_38644754 2.903 TACC1
transforming, acidic coiled-coil containing protein 1
chr9_-_136933552 2.870 BRD3
bromodomain containing 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.71 3.95e-07 GO:0006955 immune response
3.17 3.67e-06 GO:0050776 regulation of immune response
2.14 1.13e-05 GO:0002376 immune system process
2.56 2.92e-05 GO:0002682 regulation of immune system process
2.34 1.24e-04 GO:0006952 defense response
3.12 3.27e-03 GO:0050778 positive regulation of immune response
1.69 4.91e-03 GO:0048583 regulation of response to stimulus
2.54 1.17e-02 GO:0002684 positive regulation of immune system process
4.04 1.25e-02 GO:0006805 xenobiotic metabolic process
4.04 1.25e-02 GO:0071466 cellular response to xenobiotic stimulus
4.01 1.37e-02 GO:0009410 response to xenobiotic stimulus
2.69 1.49e-02 GO:0045087 innate immune response
3.41 4.72e-02 GO:0045088 regulation of innate immune response

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.51 3.07e-02 GO:0005576 extracellular region

Nothing significant found in function category.