Motif ID: AIRE.p2

Z-value: 1.304


Transcription factors associated with AIRE.p2:

Gene SymbolEntrez IDGene Name
AIRE 326 autoimmune regulator

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
AIREchr21_+_457101470.502.2e-15Click!


Activity profile for motif AIRE.p2.

activity profile for motif AIRE.p2


Sorted Z-values histogram for motif AIRE.p2

Sorted Z-values for motif AIRE.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of AIRE.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_39826676 42.108 NM_004877
 GMFG
glia maturation factor, gamma
chr19_-_8642337 28.998 MYO1F
myosin IF
chr7_-_38313232 26.209 NM_001003799
NM_001003806
 TARP

TRGV9
TCR gamma alternate reading frame protein

T cell receptor gamma variable 9
chr1_+_161185084 25.188 NM_004106
 FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr1_+_161185061 24.432 FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr11_-_73693883 21.864 NM_003355
 UCP2
uncoupling protein 2 (mitochondrial, proton carrier)
chr4_-_74847669 21.048 NM_002619
 PF4
platelet factor 4
chr13_-_41556188 19.652 ELF1
E74-like factor 1 (ets domain transcription factor)
chr1_-_169680677 19.422 NM_000655
 SELL
selectin L
chr1_-_182357871 19.177 GLUL
glutamate-ammonia ligase
chr19_+_18208596 17.011 NM_015016
 MAST3
microtubule associated serine/threonine kinase 3
chr4_-_84035888 16.829 PLAC8
placenta-specific 8
chr18_+_29171729 16.224 NM_000371
 TTR
transthyretin
chr18_-_47814691 16.175 NM_001101654
NM_014593
 CXXC1

CXXC finger protein 1

chr3_+_46395224 15.572 NM_001123041
NM_001123396
 CCR2

chemokine (C-C motif) receptor 2

chr5_+_75699003 15.263 NM_006633
 IQGAP2
IQ motif containing GTPase activating protein 2
chr13_+_50070096 15.028 PHF11
PHD finger protein 11
chr22_-_36556781 14.725 NM_145640
 APOL3
apolipoprotein L, 3
chr1_-_7973286 14.064 UTS2
urotensin 2
chr12_-_10282680 14.001 NM_022570
NM_197947
NM_197948
NM_197949
NM_197950
NM_197954
 CLEC7A





C-type lectin domain family 7, member A






Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
4.04 1.25e-02 GO:0006805 xenobiotic metabolic process
4.04 1.25e-02 GO:0071466 cellular response to xenobiotic stimulus
4.01 1.37e-02 GO:0009410 response to xenobiotic stimulus
3.41 4.72e-02 GO:0045088 regulation of innate immune response
3.17 3.67e-06 GO:0050776 regulation of immune response
3.12 3.27e-03 GO:0050778 positive regulation of immune response
2.71 3.95e-07 GO:0006955 immune response
2.69 1.49e-02 GO:0045087 innate immune response
2.56 2.92e-05 GO:0002682 regulation of immune system process
2.54 1.17e-02 GO:0002684 positive regulation of immune system process
2.34 1.24e-04 GO:0006952 defense response
2.14 1.13e-05 GO:0002376 immune system process
1.69 4.91e-03 GO:0048583 regulation of response to stimulus

Gene overrepresentation in compartment category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
1.51 3.07e-02 GO:0005576 extracellular region

Nothing significant found in function category.