Motif ID: ALX1.p2

Z-value: 1.644


Transcription factors associated with ALX1.p2:

Gene SymbolEntrez IDGene Name
ALX1 8092 ALX homeobox 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ALX1chr12_+_85673884-0.045.9e-01Click!


Activity profile for motif ALX1.p2.

activity profile for motif ALX1.p2


Sorted Z-values histogram for motif ALX1.p2

Sorted Z-values for motif ALX1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ALX1.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_13835313 63.756 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr20_+_34556528 40.369 NM_001207076
NM_080834
C20orf152

chromosome 20 open reading frame 152

chr19_-_21646685 34.645


chr9_-_4742042 31.399 NM_001199853
AK3
adenylate kinase 3
chr19_+_21264952 30.040 NM_182515
ZNF714
zinc finger protein 714
chr1_+_155853546 29.845 SYT11
synaptotagmin XI
chr11_-_117748200 29.731 NM_001164831
FXYD6
FXYD domain containing ion transport regulator 6
chr5_+_36608430 25.916 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr3_+_111717585 25.678 NM_001008272
NM_013259
TAGLN3

transgelin 3

chr19_+_12203077 25.398 ZNF788
zinc finger family member 788
chr17_-_29641068 24.417 EVI2B
ecotropic viral integration site 2B
chr3_-_194072004 23.817 NM_001080513
CPN2
carboxypeptidase N, polypeptide 2
chr8_-_33457491 23.362 DUSP26
dual specificity phosphatase 26 (putative)
chr12_+_101988746 23.272 NM_002465
NM_206819
NM_206820
NM_206821
MYBPC1



myosin binding protein C, slow type



chr6_-_41254392 22.849 NM_001242589
NM_001242590
NM_018643
TREM1


triggering receptor expressed on myeloid cells 1


chr10_-_28571014 22.767 NM_173496
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr1_+_151739130 22.488 NM_016178
OAZ3
ornithine decarboxylase antizyme 3
chr5_+_36606667 21.923 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr18_+_21572736 21.289 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr10_+_49609641 21.286 NM_002750
NM_139046
NM_139047
NM_139049
MAPK8



mitogen-activated protein kinase 8



chr16_-_11375094 20.928 NM_002761
PRM1
protamine 1
chr14_-_101036130 20.753 NM_020836
BEGAIN
brain-enriched guanylate kinase-associated homolog (rat)
chr7_+_20686965 19.058 NM_001163942
NM_001163993
NM_178559
ABCB5


ATP-binding cassette, sub-family B (MDR/TAP), member 5


chr12_-_16759430 18.274 LMO3
LIM domain only 3 (rhombotin-like 2)
chr7_+_102023016 18.243


chr8_-_33457435 18.055 NM_024025
DUSP26
dual specificity phosphatase 26 (putative)
chr6_+_28317687 17.892 NM_001242894
NM_001242895
NM_024493
ZKSCAN3


zinc finger with KRAB and SCAN domains 3


chr19_-_4535202 17.884 NM_001013706
PLIN5
perilipin 5
chr12_-_96390002 17.741 NM_002108
HAL
histidine ammonia-lyase
chr11_+_73661363 17.698 NM_153614
DNAJB13
DnaJ (Hsp40) homolog, subfamily B, member 13
chr12_-_10021932 17.614 CLEC2B
C-type lectin domain family 2, member B
chr4_+_158141735 17.595 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chr12_-_11508509 17.217 NM_005039
NM_199353
NM_199354
PRB1


proline-rich protein BstNI subfamily 1


chr12_-_16759531 17.215 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr16_-_72206348 17.130 NM_001160213
PMFBP1
polyamine modulated factor 1 binding protein 1
chr11_-_114466397 17.114 FAM55D
family with sequence similarity 55, member D
chrX_+_91090459 17.042 NM_001168360
NM_001168361
NM_001168362
NM_001168363
PCDH11X



protocadherin 11 X-linked



chr1_-_157522151 16.876 NM_001195388
NM_031281
FCRL5

Fc receptor-like 5

chr12_-_11422640 16.686 NM_006249
PRB3
proline-rich protein BstNI subfamily 3
chr16_+_15596122 16.540 NM_001142469
C16orf45
chromosome 16 open reading frame 45
chr8_-_110661007 16.457 NM_001099747
NM_001099748
NM_001099749
NM_001099750
NM_017786
SYBU




syntabulin (syntaxin-interacting)




chr4_-_46911223 16.411 NM_130902
COX7B2
cytochrome c oxidase subunit VIIb2
chr12_-_10022457 16.105 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr10_-_42863435 16.039 LOC441666
zinc finger protein 91 pseudogene
chr7_-_115670774 15.835 TFEC
transcription factor EC
chr16_+_31271327 15.569 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr2_+_103089761 15.538 NM_001011552
SLC9A4
solute carrier family 9 (sodium/hydrogen exchanger), member 4
chr18_-_14132426 15.186 NM_145287
ZNF519
zinc finger protein 519
chr4_-_176923572 15.167 NM_005277
NM_201592
GPM6A

glycoprotein M6A

chr19_+_48758931 14.611 LOC100505812
uncharacterized LOC100505812
chr15_+_69307033 14.531 NM_001184779
NM_024505
NOX5

NADPH oxidase, EF-hand calcium binding domain 5

chr12_-_11548485 14.264 NM_006248
PRB1
PRB2
proline-rich protein BstNI subfamily 1
proline-rich protein BstNI subfamily 2
chr2_-_178787522 14.244 NM_001077358
PDE11A
phosphodiesterase 11A
chr16_+_29086269 14.236 RRN3P2
RNA polymerase I transcription factor homolog (S. cerevisiae) pseudogene 2
chr9_-_21368005 14.030 NM_006900
IFNA1
IFNA13
interferon, alpha 1
interferon, alpha 13
chr7_+_143412938 13.961 NM_001130026
FAM115C
family with sequence similarity 115, member C
chr11_-_114466471 13.832 NM_001077639
NM_017678
FAM55D

family with sequence similarity 55, member D

chr15_-_73051650 13.736


chr6_-_26189303 13.634 NM_003539
HIST1H4D
histone cluster 1, H4d
chr20_+_32077904 13.454 NM_001032999
CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr3_-_47555079 13.354 NM_001031703
C3orf75
chromosome 3 open reading frame 75
chr16_+_31271277 13.130 NM_000632
NM_001145808
ITGAM

integrin, alpha M (complement component 3 receptor 3 subunit)

chr16_+_31271311 13.117 ITGAM
integrin, alpha M (complement component 3 receptor 3 subunit)
chr19_+_2328679 12.642 SPPL2B
signal peptide peptidase-like 2B
chr2_-_89165652 12.634


chr19_+_2328628 12.553 NM_001077238
NM_152988
SPPL2B

signal peptide peptidase-like 2B

chr16_+_85061303 12.472 NM_014732
KIAA0513
KIAA0513
chr17_-_3030844 12.410 NM_003555
OR1G1
olfactory receptor, family 1, subfamily G, member 1
chr12_-_4488707 12.351 NM_020638
FGF23
fibroblast growth factor 23
chr1_-_163113129 12.314 RGS5
regulator of G-protein signaling 5
chr6_-_46293404 12.310 RCAN2
regulator of calcineurin 2
chr4_+_156587861 12.301 NM_000856
NM_001130682
NM_001130686
NM_001130687
NM_001130683
NM_001130685
GUCY1A3





guanylate cyclase 1, soluble, alpha 3





chr7_-_99145988 12.095 FAM200A
family with sequence similarity 200, member A
chr19_-_21950322 11.939 NM_173531
ZNF100
zinc finger protein 100
chr12_-_11463353 11.924 NM_002723
PRB4
proline-rich protein BstNI subfamily 4
chr12_-_16759733 11.885 NM_001243610
LMO3
LIM domain only 3 (rhombotin-like 2)
chr2_+_132480063 11.874 NM_013310
C2orf27A
chromosome 2 open reading frame 27A
chr9_-_21217303 11.607 NM_002173
IFNA16
interferon, alpha 16
chr17_-_29641087 11.595 EVI2B
ecotropic viral integration site 2B
chr9_-_21350885 11.395 NM_021002
IFNA6
interferon, alpha 6
chr6_-_110501164 11.323 NM_001024934
NM_001024935
NM_001024936
NM_003931
WASF1



WAS protein family, member 1



chr3_-_9920633 11.276 NM_022094
CIDEC
cell death-inducing DFFA-like effector c
chr2_+_226265601 11.273 NM_020864
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr8_-_110986923 10.988 NM_014379
KCNV1
potassium channel, subfamily V, member 1
chr4_+_71263598 10.941 NM_021225
PROL1
proline rich, lacrimal 1
chrX_-_13835187 10.751 GPM6B
glycoprotein M6B
chr19_-_56348127 10.650 NM_145007
NLRP11
NLR family, pyrin domain containing 11
chr5_-_39270708 10.528 NM_001243093
FYB
FYN binding protein
chr11_-_59950498 10.397 NM_022349
NM_152851
MS4A6A

membrane-spanning 4-domains, subfamily A, member 6A

chr14_+_101295409 10.352 MEG3
maternally expressed 3 (non-protein coding)
chr1_+_151735444 10.304 NM_001134939
OAZ3
ornithine decarboxylase antizyme 3
chr17_-_29641094 10.274 NM_006495
EVI2B
ecotropic viral integration site 2B
chr19_+_36486042 10.223 NM_001042631
SDHAF1
succinate dehydrogenase complex assembly factor 1
chr10_+_74451838 10.106 NM_138357
MCU
mitochondrial calcium uniporter
chr15_+_68908878 10.001 NM_001190456
CORO2B
coronin, actin binding protein, 2B
chr9_+_111624545 9.996 NM_006687
ACTL7A
actin-like 7A
chr5_-_149466173 9.956 CSF1R
colony stimulating factor 1 receptor
chr7_+_37723378 9.811


chrX_+_140982451 9.736 NM_177456
MAGEC3
melanoma antigen family C, 3
chr12_+_54891539 9.482 NCKAP1L
NCK-associated protein 1-like
chr20_-_1472004 9.467 SIRPB2
signal-regulatory protein beta 2
chr19_+_7733971 9.422 NM_001193374
NM_020415
RETN

resistin

chr1_+_202317798 9.389 NM_001167857
NM_001167858
NM_002481
PPP1R12B


protein phosphatase 1, regulatory subunit 12B


chr13_-_99959649 9.351 NM_004951
GPR183
G protein-coupled receptor 183
chr7_-_107880492 9.344 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr1_+_92632608 9.294 NM_015237
KIAA1107
KIAA1107
chr5_-_149466126 9.254 CSF1R
colony stimulating factor 1 receptor
chr20_+_32077780 9.194 CBFA2T2
core-binding factor, runt domain, alpha subunit 2; translocated to, 2
chr17_-_2996289 9.188 NM_002548
OR1D2
olfactory receptor, family 1, subfamily D, member 2
chr9_-_21202201 9.135 NM_021057
IFNA7
interferon, alpha 7
chr19_+_2328685 9.127 SPPL2B
signal peptide peptidase-like 2B
chr3_+_121286777 8.988 NM_001012659
ARGFX
arginine-fifty homeobox
chr1_-_67266930 8.956 NM_005478
INSL5
insulin-like 5
chr4_-_176923480 8.844 GPM6A
glycoprotein M6A
chr11_+_28131830 8.842 METTL15
methyltransferase like 15
chr9_+_102677457 8.792 STX17
syntaxin 17
chr14_-_107013122 8.748 IGHV4-31
IGHG1
immunoglobulin heavy variable 4-31
immunoglobulin heavy constant gamma 1 (G1m marker)
chr5_-_997408 8.691 NM_001242737
LOC100506688
uncharacterized LOC100506688
chr3_-_38835500 8.681 NM_006514
SCN10A
sodium channel, voltage-gated, type X, alpha subunit
chr4_-_120243257 8.583 NM_000134
FABP2
fatty acid binding protein 2, intestinal
chr1_-_42776760 8.526


chr14_+_57046490 8.525 NM_017799
C14orf101
chromosome 14 open reading frame 101
chr9_-_123812535 8.461 NM_001735
C5
complement component 5
chr14_-_23285011 8.393 NM_001126105
SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr6_-_133084585 8.284 NM_078488
VNN2
vanin 2
chr13_-_49018802 8.244 NM_005767
LPAR6
lysophosphatidic acid receptor 6
chr1_-_163113938 8.132 RGS5
regulator of G-protein signaling 5
chr7_-_115670828 8.077 NM_001018058
NM_012252
TFEC

transcription factor EC

chr16_+_15031299 8.033 NM_006985
NPIP
nuclear pore complex interacting protein
chr5_+_140220811 8.032 NM_018911
NM_031856
PCDHA8

protocadherin alpha 8

chr8_-_82359620 8.003 NM_002677
PMP2
peripheral myelin protein 2
chr1_-_163172863 7.906 NM_003617
RGS5
regulator of G-protein signaling 5
chr12_+_54891522 7.844 NCKAP1L
NCK-associated protein 1-like
chr12_-_25150372 7.659 NM_001101339
C12orf77
chromosome 12 open reading frame 77
chr1_-_203198772 7.622 NM_003465
CHIT1
chitinase 1 (chitotriosidase)
chr12_+_54891491 7.614 NM_005337
NCKAP1L
NCK-associated protein 1-like
chr3_+_119187782 7.580 NM_152305
POGLUT1
protein O-glucosyltransferase 1
chr10_-_21186530 7.528 NM_006393
NEBL
nebulette
chr4_+_71248794 7.519 NM_006685
SMR3B
submaxillary gland androgen regulated protein 3B
chr14_+_39703119 7.465 NM_054024
MIA2
melanoma inhibitory activity 2
chr19_+_52873169 7.457 NM_001145434
ZNF880
zinc finger protein 880
chrX_-_49089770 7.389 NM_005183
CACNA1F
calcium channel, voltage-dependent, L type, alpha 1F subunit
chr8_-_98290171 7.216 NM_033512
TSPYL5
TSPY-like 5
chr6_+_27107060 7.184 NM_003495
HIST2H4B
HIST1H4I
histone cluster 2, H4b
histone cluster 1, H4i
chr1_+_241695433 7.109 NM_003679
KMO
kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
chr4_+_70796798 7.033 NM_001025104
NM_001890
CSN1S1

casein alpha s1

chr1_+_182419255 7.032 NM_001137669
RGSL1
regulator of G-protein signaling like 1
chr12_-_91573264 7.018 NM_133503
DCN
decorin
chr10_+_124320180 6.976 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr19_-_18902077 6.971 NM_000095
COMP
cartilage oligomeric matrix protein
chrY_-_2655478 6.916 NM_003140
SRY
sex determining region Y
chr5_-_176326314 6.882 NM_002115
HK3
hexokinase 3 (white cell)
chr18_+_29769986 6.854 NM_005925
MEP1B
meprin A, beta
chr5_+_35856990 6.838 NM_002185
IL7R
interleukin 7 receptor
chr17_+_64960754 6.835 NM_014405
CACNG4
calcium channel, voltage-dependent, gamma subunit 4
chr10_+_104613966 6.823 NM_001136200
NM_144591
C10orf32-AS3MT
C10orf32

C10orf32-AS3MT readthrough
chromosome 10 open reading frame 32

chr17_-_34328530 6.822 CCL14-CCL15
CCL15
CCL14-CCL15 readthrough
chemokine (C-C motif) ligand 15
chr7_-_102283237 6.784 NM_001114403
UPK3BL
uroplakin 3B-like
chr3_-_169899372 6.763 PHC3
polyhomeotic homolog 3 (Drosophila)
chr5_+_140247767 6.737 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr16_-_21314371 6.714 NM_001014444
NM_001888
CRYM

crystallin, mu

chr11_-_77122877 6.649 PAK1
p21 protein (Cdc42/Rac)-activated kinase 1
chr4_-_87028805 6.611 NM_138981
MAPK10
mitogen-activated protein kinase 10
chrX_+_11311532 6.559 NM_001142
NM_182680
NM_182681
AMELX


amelogenin, X-linked


chr19_-_14992166 6.515 NM_030901
OR7A17
olfactory receptor, family 7, subfamily A, member 17
chr22_-_18923963 6.514 NM_001195226
NM_016335
PRODH

proline dehydrogenase (oxidase) 1

chr1_-_20141593 6.506 NM_019062
RNF186
ring finger protein 186
chr19_+_54466289 6.487 NM_031895
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr5_-_149466094 6.440 CSF1R
colony stimulating factor 1 receptor
chrX_+_91089658 6.391 NM_014522
NM_032968
NM_032969
PCDH11X


protocadherin 11 X-linked


chr12_-_16759939 6.371 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr1_+_161185084 6.218 NM_004106
FCER1G
Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
chr19_-_4559713 6.181 NM_032108
SEMA6B
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6B
chrX_-_13835213 6.124 GPM6B
glycoprotein M6B
chr19_-_48614013 6.051 NM_001159322
NM_001159323
NM_003706
PLA2G4C


phospholipase A2, group IVC (cytosolic, calcium-independent)


chr7_-_15601574 6.030 NM_001004320
AGMO
alkylglycerol monooxygenase
chr12_+_9980076 5.989 NM_016523
KLRF1
killer cell lectin-like receptor subfamily F, member 1
chr12_+_20848288 5.981 NM_001145945
NM_001145946
NM_001145944
NM_017435
SLCO1C1



solute carrier organic anion transporter family, member 1C1



chrX_-_102347950 5.974 NM_022052
NXF3
nuclear RNA export factor 3
chr17_+_32683470 5.915 NM_005408
CCL13
chemokine (C-C motif) ligand 13
chr12_+_21679190 5.885 NM_030572
C12orf39
chromosome 12 open reading frame 39
chr16_+_22217369 5.845 NM_013302
EEF2K
eukaryotic elongation factor-2 kinase
chr5_-_177207465 5.809 NM_173663
FAM153A
family with sequence similarity 153, member A
chr10_-_62493077 5.791 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr3_+_35722428 5.723 NM_198399
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chrX_+_66788682 5.706 NM_001011645
AR
androgen receptor
chr3_+_8775485 5.660 NM_001234
NM_033337
CAV3

caveolin 3

chr6_+_30130982 5.641 NM_033229
TRIM15
tripartite motif containing 15
chr4_-_80329354 5.634 NM_033214
GK2
glycerol kinase 2
chr8_+_38585703 5.615 NM_001146216
TACC1
transforming, acidic coiled-coil containing protein 1
chr19_-_23433161 5.603 ZNF724P
zinc finger protein 724, pseudogene
chr1_-_89591685 5.581 NM_004120
GBP2
guanylate binding protein 2, interferon-inducible
chr19_+_827821 5.543 NM_001700
AZU1
azurocidin 1
chr7_-_113559048 5.486 NM_002711
PPP1R3A
protein phosphatase 1, regulatory subunit 3A
chrX_+_107288199 5.467 NM_001170553
NM_182607
VSIG1

V-set and immunoglobulin domain containing 1

chr17_-_34328607 5.466 CCL14-CCL15
CCL14-CCL15 readthrough
chr22_-_43485333 5.423 NM_012263
TTLL1
tubulin tyrosine ligase-like family, member 1
chr4_-_69434215 5.396 NM_001077
UGT2B15
UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B15
UDP glucuronosyltransferase 2 family, polypeptide B17
chr2_-_25466795 5.361 DNMT3A
DNA (cytosine-5-)-methyltransferase 3 alpha
chr18_-_61329113 5.357 NM_006919
SERPINB3
serpin peptidase inhibitor, clade B (ovalbumin), member 3

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
2.41 5.04e-06 GO:0006955 immune response
1.99 3.31e-05 GO:0002376 immune system process
1.94 1.87e-03 GO:0007154 cell communication
1.39 7.34e-03 GO:0023052 signaling
2.38 1.11e-02 GO:0050776 regulation of immune response
1.97 1.31e-02 GO:0006952 defense response
1.98 2.19e-02 GO:0007267 cell-cell signaling
7.37 4.79e-02 GO:0060338 regulation of type I interferon-mediated signaling pathway

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.32 3.44e-11 GO:0005887 integral to plasma membrane
2.30 3.59e-11 GO:0031226 intrinsic to plasma membrane
1.90 7.04e-10 GO:0005576 extracellular region
1.83 4.93e-09 GO:0044459 plasma membrane part
2.22 8.64e-08 GO:0044421 extracellular region part
1.47 1.02e-06 GO:0005886 plasma membrane
1.46 1.81e-06 GO:0071944 cell periphery
2.25 5.84e-06 GO:0005615 extracellular space
3.51 5.23e-03 GO:0034703 cation channel complex
1.25 1.45e-02 GO:0031224 intrinsic to membrane
1.25 1.89e-02 GO:0016021 integral to membrane
1.22 2.41e-02 GO:0044425 membrane part
2.73 2.41e-02 GO:0034702 ion channel complex

Gene overrepresentation in function category:

enrichment   p-value GO term description
3.74 1.97e-05 GO:0005125 cytokine activity
3.51 4.16e-04 GO:0005126 cytokine receptor binding
2.63 1.34e-02 GO:0005261 cation channel activity
1.56 1.59e-02 GO:0004872 receptor activity
1.49 2.03e-02 GO:0004871 signal transducer activity
1.49 2.03e-02 GO:0060089 molecular transducer activity
15.78 2.40e-02 GO:0005132 interferon-alpha/beta receptor binding
2.22 2.76e-02 GO:0015267 channel activity
2.21 2.88e-02 GO:0022803 passive transmembrane transporter activity
2.24 3.14e-02 GO:0005216 ion channel activity
5.49 3.26e-02 GO:0008009 chemokine activity
2.20 4.07e-02 GO:0022838 substrate-specific channel activity