Motif ID: ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2

Z-value: 3.162


Transcription factors associated with ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2:

Gene SymbolEntrez IDGene Name
ARNT 405 aryl hydrocarbon receptor nuclear translocator
ARNT2 9915 aryl-hydrocarbon receptor nuclear translocator 2
BHLHB2 8553 basic helix-loop-helix domain containing, class B, 2
MAX 4149 MYC associated factor X
MYC 4609 v-myc myelocytomatosis viral oncogene homolog (avian)
USF1 7391 upstream transcription factor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MYCchr8_+_1287483120.733.6e-38Click!
ARNT2chr15_+_80696569-0.491.2e-14Click!
MAXchr14_-_655690560.261.0e-04Click!
ARNTchr1_-_150849211-0.228.5e-04Click!
BHLHE40chr3_+_5021141-0.126.7e-02Click!


Activity profile for motif ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2.

activity profile for motif ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2


Sorted Z-values histogram for motif ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2

Sorted Z-values for motif ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ARNT_ARNT2_BHLHB2_MAX_MYC_USF1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_58146108 302.760 CDK4
cyclin-dependent kinase 4
chr12_-_58146110 299.674 CDK4
cyclin-dependent kinase 4
chr12_-_58146025 299.008 CDK4
cyclin-dependent kinase 4
chr12_-_58146118 271.636 NM_000075
CDK4
cyclin-dependent kinase 4
chr2_-_10588451 157.598 NM_002539
ODC1
ornithine decarboxylase 1
chr14_+_20923341 135.218 APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr8_+_98656428 112.966 MTDH
metadherin
chr2_+_216176818 104.570 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr14_+_20923289 102.646 NM_001244249
NM_001641
NM_080648
NM_080649
APEX1



APEX nuclease (multifunctional DNA repair enzyme) 1



chr19_+_10765106 101.532 ILF3
interleukin enhancer binding factor 3, 90kDa
chr2_+_216176808 101.483 ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
chr8_+_98656329 101.007 NM_178812
MTDH
metadherin
chr1_-_26232890 99.249 NM_001145454
NM_005563
STMN1

stathmin 1

chr8_+_98656494 95.044 MTDH
metadherin
chr3_+_158519911 92.531 MFSD1
major facilitator superfamily domain containing 1
chr14_+_20923705 90.389 APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr4_-_100871431 89.802 H2AFZ
H2A histone family, member Z
chr3_+_158519888 88.588 MFSD1
major facilitator superfamily domain containing 1
chr6_-_43197178 82.437 NM_006443
NM_199184
C6orf108

chromosome 6 open reading frame 108

chr17_+_49337882 81.503 UTP18
UTP18 small subunit (SSU) processome component homolog (yeast)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 119 entries
enrichment   p-value GO term description
6.13 4.60e-03 GO:0009156 ribonucleoside monophosphate biosynthetic process
5.85 2.46e-03 GO:0015682 ferric iron transport
5.85 2.46e-03 GO:0033572 transferrin transport
5.50 1.46e-02 GO:0009161 ribonucleoside monophosphate metabolic process
5.32 2.07e-02 GO:0015988 energy coupled proton transport, against electrochemical gradient
5.32 2.07e-02 GO:0015991 ATP hydrolysis coupled proton transport
5.16 1.02e-02 GO:0006144 purine base metabolic process
4.14 9.90e-03 GO:0009112 nucleobase metabolic process
3.74 6.70e-05 GO:0006414 translational elongation
3.43 3.79e-04 GO:0032984 macromolecular complex disassembly
3.43 3.79e-04 GO:0034623 cellular macromolecular complex disassembly
3.38 2.38e-05 GO:0019058 viral infectious cycle
3.36 3.42e-03 GO:0043241 protein complex disassembly
3.36 3.42e-03 GO:0043624 cellular protein complex disassembly
3.31 2.58e-02 GO:0009116 nucleoside metabolic process
3.31 4.51e-02 GO:0006839 mitochondrial transport
3.25 3.27e-03 GO:0009260 ribonucleotide biosynthetic process
3.21 1.48e-05 GO:0022415 viral reproductive process
3.16 1.00e-03 GO:0042254 ribosome biogenesis
3.11 2.39e-03 GO:0050657 nucleic acid transport

Gene overrepresentation in compartment category:

Showing 1 to 20 of 48 entries
enrichment   p-value GO term description
9.75 4.76e-07 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
8.86 3.90e-02 GO:0016281 eukaryotic translation initiation factor 4F complex
8.86 3.90e-02 GO:0033180 proton-transporting V-type ATPase, V1 domain
8.70 8.41e-03 GO:0005744 mitochondrial inner membrane presequence translocase complex
7.18 5.19e-04 GO:0033176 proton-transporting V-type ATPase complex
4.45 3.48e-03 GO:0016469 proton-transporting two-sector ATPase complex
3.41 8.25e-04 GO:0042470 melanosome
3.41 8.25e-04 GO:0048770 pigment granule
2.84 4.64e-16 GO:0005730 nucleolus
2.62 1.20e-02 GO:0005681 spliceosomal complex
2.61 7.11e-13 GO:0030529 ribonucleoprotein complex
2.55 1.19e-04 GO:0016604 nuclear body
2.36 1.04e-05 GO:0019866 organelle inner membrane
2.30 1.07e-04 GO:0005743 mitochondrial inner membrane
2.22 8.97e-11 GO:0031967 organelle envelope
2.21 1.65e-06 GO:0005740 mitochondrial envelope
2.20 5.05e-06 GO:0031966 mitochondrial membrane
2.18 2.58e-10 GO:0031975 envelope
2.17 1.16e-02 GO:0005635 nuclear envelope
2.04 3.46e-31 GO:0031974 membrane-enclosed lumen

Gene overrepresentation in function category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
7.09 3.48e-03 GO:0046961 proton-transporting ATPase activity, rotational mechanism
6.38 8.95e-03 GO:0003746 translation elongation factor activity
5.70 2.52e-03 GO:0003727 single-stranded RNA binding
4.78 3.76e-02 GO:0019829 cation-transporting ATPase activity
3.74 2.68e-04 GO:0008135 translation factor activity, nucleic acid binding
3.11 4.47e-02 GO:0003729 mRNA binding
2.36 1.70e-15 GO:0003723 RNA binding
2.09 7.98e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.92 2.24e-03 GO:0016874 ligase activity
1.47 1.49e-34 GO:0005515 protein binding
1.40 2.87e-04 GO:0000166 nucleotide binding
1.31 5.43e-04 GO:0003676 nucleic acid binding
1.20 5.28e-03 GO:0003824 catalytic activity
1.17 2.80e-15 GO:0005488 binding