Motif ID: ATF2.p2

Z-value: 1.624


Transcription factors associated with ATF2.p2:

Gene SymbolEntrez IDGene Name
ATF2 1386 activating transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF2chr2_-_1760328500.092.1e-01Click!


Activity profile for motif ATF2.p2.

activity profile for motif ATF2.p2


Sorted Z-values histogram for motif ATF2.p2

Sorted Z-values for motif ATF2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF2.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr22_-_44258210 57.857 NM_014351
SULT4A1
sulfotransferase family 4A, member 1
chr8_-_27115935 43.092 STMN4
stathmin-like 4
chr4_+_41700736 40.593 LIMCH1
LIM and calponin homology domains 1
chr2_-_224467095 39.620 SCG2
secretogranin II
chr8_-_27115897 39.162 NM_030795
STMN4
stathmin-like 4
chrX_-_13835187 38.062 GPM6B
glycoprotein M6B
chrX_-_13835012 37.662 GPM6B
glycoprotein M6B
chr20_+_10199455 36.169 NM_003081
NM_130811
SNAP25

synaptosomal-associated protein, 25kDa

chrX_-_13956644 35.026 NM_001001994
GPM6B
glycoprotein M6B
chr14_-_93651242 33.624 NM_022151
MOAP1
modulator of apoptosis 1
chr14_-_93651182 32.772 MOAP1
modulator of apoptosis 1
chrX_-_13835313 32.721 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr2_-_224467049 31.725 SCG2
secretogranin II
chr9_+_137967088 31.429 NM_014279
NM_006334
OLFM1

olfactomedin 1

chr6_-_3157696 30.907 NM_001069
TUBB2A
tubulin, beta 2A class IIa
chr3_-_187388105 29.206 NM_001048
SST
somatostatin
chr6_+_39760148 29.082 NM_001201427
DAAM2
dishevelled associated activator of morphogenesis 2
chr5_+_36606456 26.669 NM_001166696
NM_004172
SLC1A3

solute carrier family 1 (glial high affinity glutamate transporter), member 3

chr14_+_101292451 26.573 MEG3
maternally expressed 3 (non-protein coding)
chr1_+_99730067 26.206 LPPR4
lipid phosphate phosphatase-related protein type 4
chr16_+_56225301 26.111 GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr21_-_27253197 26.097 APP
amyloid beta (A4) precursor protein
chrX_-_13835213 26.087 GPM6B
glycoprotein M6B
chr14_+_101292483 25.718


chr6_-_29595746 25.561 GABBR1
gamma-aminobutyric acid (GABA) B receptor, 1
chr5_+_71502700 25.428 MAP1B
microtubule-associated protein 1B
chr9_+_17578952 24.064 NM_003026
SH3GL2
SH3-domain GRB2-like 2
chr4_+_6784453 23.379 NM_001100590
NM_014743
KIAA0232

KIAA0232

chr1_+_110527399 23.373 AHCYL1
adenosylhomocysteinase-like 1
chr20_+_17207680 23.065 PCSK2
proprotein convertase subtilisin/kexin type 2
chr19_+_18723666 23.041 NM_012109
TMEM59L
transmembrane protein 59-like
chr9_+_137967401 22.554 OLFM1
olfactomedin 1
chr13_-_45010937 22.508 TSC22D1
TSC22 domain family, member 1
chr4_+_6784462 22.171 KIAA0232
KIAA0232
chr3_-_33759684 22.130 NM_015097
CLASP2
cytoplasmic linker associated protein 2
chr6_-_46459010 21.944 NM_001251974
RCAN2
regulator of calcineurin 2
chr9_+_137967366 21.796 OLFM1
olfactomedin 1
chr6_-_3227776 21.755 NM_178012
TUBB2B
tubulin, beta 2B class IIb
chr5_+_36606667 21.587 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr4_+_6784487 21.485 KIAA0232
KIAA0232
chr1_+_110527307 21.456 AHCYL1
adenosylhomocysteinase-like 1
chr2_-_224467142 21.340 NM_003469
SCG2
secretogranin II
chr14_+_93389444 21.197 NM_001275
CHGA
chromogranin A (parathyroid secretory protein 1)
chr4_+_113739203 21.083 NM_001127493
ANK2
ankyrin 2, neuronal
chr6_-_46293404 20.602 RCAN2
regulator of calcineurin 2
chr1_+_110527327 20.170 NM_001242673
NM_006621
AHCYL1

adenosylhomocysteinase-like 1

chr10_-_95360959 19.899 NM_006744
RBP4
retinol binding protein 4, plasma
chr1_+_2005083 19.780 NM_001033581
PRKCZ
protein kinase C, zeta
chr1_+_160175146 19.459 PEA15
phosphoprotein enriched in astrocytes 15
chr4_+_158141735 19.272 NM_000826
NM_001083619
NM_001083620
GRIA2


glutamate receptor, ionotropic, AMPA 2


chrX_-_13956530 19.238 GPM6B
glycoprotein M6B
chr5_-_138210992 19.120 CTNNA1
LRRTM2
catenin (cadherin-associated protein), alpha 1, 102kDa
leucine rich repeat transmembrane neuronal 2
chr1_+_110527418 19.063 AHCYL1
adenosylhomocysteinase-like 1
chr17_+_53342356 18.801 HLF
hepatic leukemia factor
chr20_+_5891973 18.570 NM_001819
CHGB
chromogranin B (secretogranin 1)
chr3_+_158991035 18.498 NM_001197107
NM_001197108
NM_014575
SCHIP1


schwannomin interacting protein 1


chr17_+_42385780 17.991 NM_001144825
NM_001144826
NM_006695
RUNDC3A


RUN domain containing 3A


chr20_+_4666796 17.772 NM_000311
NM_001080121
NM_001080122
NM_183079
NM_001080123
PRNP




prion protein




chr4_-_87281177 17.730 MAPK10
mitogen-activated protein kinase 10
chrX_-_47479229 17.590 NM_006950
NM_133499
SYN1

synapsin I

chr9_-_130477918 17.394 NM_001002913
PTRH1
peptidyl-tRNA hydrolase 1 homolog (S. cerevisiae)
chr1_+_160175114 17.264 NM_003768
PEA15
phosphoprotein enriched in astrocytes 15
chr8_-_102803196 16.941 NCALD
neurocalcin delta
chr20_+_17207669 16.678 PCSK2
proprotein convertase subtilisin/kexin type 2
chr8_-_102803178 16.381 NCALD
neurocalcin delta
chr1_-_201476241 16.354 CSRP1
cysteine and glycine-rich protein 1
chr17_+_66508564 15.923 PRKAR1A
protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chrX_+_110339374 15.848 NM_002578
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr1_+_183774214 15.637 RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr1_-_201476218 15.513 CSRP1
cysteine and glycine-rich protein 1
chr3_-_33759540 14.978 CLASP2
cytoplasmic linker associated protein 2
chr14_+_93389491 14.857 CHGA
chromogranin A (parathyroid secretory protein 1)
chr21_-_27512668 14.846 NM_001136016
APP
amyloid beta (A4) precursor protein
chr19_-_57352055 14.598 NM_001146326
NM_001146327
NM_015363
NM_001146184
NM_001146185
NM_001146187
NM_006210
ZIM2


PEG3



zinc finger, imprinted 2


paternally expressed 3



chr1_+_99729847 14.378 NM_001166252
NM_014839
LPPR4

lipid phosphate phosphatase-related protein type 4

chr11_-_123525300 14.354 NM_001040151
NM_018400
SCN3B

sodium channel, voltage-gated, type III, beta

chr22_+_32340435 14.330 NM_003405
YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr5_+_140165875 14.020 NM_018900
NM_031410
NM_031411
PCDHA1


protocadherin alpha 1


chr22_+_32340592 13.679 YWHAH
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide
chr3_+_62304667 13.188 C3orf14
chromosome 3 open reading frame 14
chr7_-_31380507 13.047 NM_022728
NEUROD6
neurogenic differentiation 6
chr14_+_104095491 13.037 NM_001130107
NM_005552
NM_182923
KLC1


kinesin light chain 1


chr10_+_64133915 13.032 NM_014951
NM_199450
NM_199451
ZNF365


zinc finger protein 365


chr1_+_151032150 12.940 NM_006818
MLLT11
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
chr1_+_110527432 12.685 AHCYL1
adenosylhomocysteinase-like 1
chr2_-_224903324 12.616 NM_001136530
SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr4_-_176734181 12.523 NM_201591
GPM6A
glycoprotein M6A
chr2_+_149632772 12.515 NM_004522
KIF5C
kinesin family member 5C
chr15_+_68871285 12.488 NM_006091
CORO2B
coronin, actin binding protein, 2B
chr12_+_10365415 12.443 NM_031412
GABARAPL1
GABA(A) receptor-associated protein like 1
chr8_+_132916339 12.358 NM_015137
EFR3A
EFR3 homolog A (S. cerevisiae)
chr1_-_201476248 12.123 NM_001193570
NM_004078
CSRP1

cysteine and glycine-rich protein 1

chr5_+_140254930 12.075 NM_018903
NM_031864
PCDHA12

protocadherin alpha 12

chr11_-_66725790 12.061 NM_000920
NM_001040716
PC

pyruvate carboxylase

chr7_-_45128492 11.986 NM_001146334
NACAD
NAC alpha domain containing
chr17_+_66508525 11.877 NM_002734
NM_212472
PRKAR1A

protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)

chr2_-_44588622 11.811 NM_001171606
NM_001171613
PREPL

prolyl endopeptidase-like

chr5_-_138211054 11.578 NM_015564
LRRTM2
leucine rich repeat transmembrane neuronal 2
chr1_-_201475966 11.573 NM_001193571
CSRP1
cysteine and glycine-rich protein 1
chr1_+_50575465 11.469 ELAVL4
ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)
chr5_+_140247767 11.423 NM_018902
NM_031861
PCDHA11

protocadherin alpha 11

chr10_+_95517565 11.344 NM_005097
LGI1
leucine-rich, glioma inactivated 1
chr10_-_73848263 11.241 SPOCK2
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr6_-_70506524 11.167 LMBRD1
LMBR1 domain containing 1
chr3_-_48130633 11.156 NM_001134364
NM_002375
NM_030885
MAP4


microtubule-associated protein 4


chr11_-_62474810 11.134 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr1_+_29562947 11.123 NM_001195001
NM_005704
NM_133177
NM_133178
PTPRU



protein tyrosine phosphatase, receptor type, U



chr6_-_70506768 11.008 LMBRD1
LMBR1 domain containing 1
chr14_+_101295409 10.887 MEG3
maternally expressed 3 (non-protein coding)
chr2_+_11052062 10.713 NM_002236
KCNF1
potassium voltage-gated channel, subfamily F, member 1
chr9_+_103947316 10.682 NM_017753
LPPR1
lipid phosphate phosphatase-related protein type 1
chr2_-_216300770 10.328 NM_002026
NM_054034
NM_212474
NM_212476
NM_212478
NM_212482
FN1





fibronectin 1





chr11_+_117070039 10.261 NM_001001522
NM_003186
TAGLN

transgelin

chr17_+_53342320 10.234 NM_002126
HLF
hepatic leukemia factor
chrX_-_13956445 10.234


chr8_+_98788014 10.049 LAPTM4B
lysosomal protein transmembrane 4 beta
chr6_-_46293628 9.937 NM_005822
RCAN2
regulator of calcineurin 2
chr19_-_815243 9.890 LPPR3
lipid phosphate phosphatase-related protein type 3
chr4_+_85504056 9.815 NM_001263
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1
chr3_+_23987514 9.798 NM_001145425
NR1D2
nuclear receptor subfamily 1, group D, member 2
chr17_-_71308118 9.707 NM_012121
CDC42EP4
CDC42 effector protein (Rho GTPase binding) 4
chr12_-_16760935 9.419 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)

chr3_-_8543327 9.412 LOC100288428
uncharacterized LOC100288428
chr20_+_17207596 9.381 NM_001201529
NM_002594
PCSK2

proprotein convertase subtilisin/kexin type 2

chr9_+_126773851 9.362 NM_004789
LHX2
LIM homeobox 2
chr19_-_5340700 9.322 NM_002850
NM_130853
NM_130854
NM_130855
PTPRS



protein tyrosine phosphatase, receptor type, S



chr13_+_48807492 9.084 ITM2B
integral membrane protein 2B
chr4_-_176733901 8.956 GPM6A
glycoprotein M6A
chr6_-_70506843 8.787 NM_018368
LMBRD1
LMBR1 domain containing 1
chr11_+_62475165 8.756 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr9_+_97488993 8.744 C9orf3
chromosome 9 open reading frame 3
chr17_-_41984888 8.648 MPP2
membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2)
chr1_+_28099682 8.574 NM_177424
STX12
syntaxin 12
chr5_+_140767402 8.540 NM_003736
NM_032098
PCDHGB4

protocadherin gamma subfamily B, 4

chr9_+_97488943 8.518 NM_001193331
NM_032823
C9orf3

chromosome 9 open reading frame 3

chr16_+_56225250 8.500 NM_020988
NM_138736
GNAO1

guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O

chr14_+_68086633 8.499 ARG2
arginase, type II
chr11_-_73472057 8.432 NM_001243718
NM_002869
NM_198896
RAB6A


RAB6A, member RAS oncogene family


chr14_-_36278335 8.412 NM_014990
NM_194301
RALGAPA1

Ral GTPase activating protein, alpha subunit 1 (catalytic)

chr1_+_229440128 8.407 NM_006542
SPHAR
S-phase response (cyclin related)
chr16_-_53537112 8.319 NM_001012398
NM_022476
AKTIP

AKT interacting protein

chr4_-_88450243 7.982 SPARCL1
SPARC-like 1 (hevin)
chr14_-_103988829 7.872 CKB
creatine kinase, brain
chr19_-_460995 7.814 NM_012435
SHC2
SHC (Src homology 2 domain containing) transforming protein 2
chr6_+_134758840 7.753 LOC154092
uncharacterized LOC154092
chr1_+_66798095 7.717 PDE4B
phosphodiesterase 4B, cAMP-specific
chr5_+_71403040 7.715 NM_005909
MAP1B
microtubule-associated protein 1B
chr2_-_152955810 7.681 CACNB4
calcium channel, voltage-dependent, beta 4 subunit
chr6_+_148663728 7.512 NM_015278
SASH1
SAM and SH3 domain containing 1
chr19_+_1450117 7.405 NM_005883
APC2
adenomatosis polyposis coli 2
chr6_-_47277646 7.392 NM_014452
TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr19_+_8455200 7.277 NM_004218
RAB11B
RAB11B, member RAS oncogene family
chr5_+_150399980 7.244 NM_002084
GPX3
glutathione peroxidase 3 (plasma)
chr9_+_137967267 7.241 OLFM1
olfactomedin 1
chr8_+_68864341 7.225 PREX2
phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
chr1_+_116925991 7.204 NM_001160234
ATP1A1
ATPase, Na+/K+ transporting, alpha 1 polypeptide
chr10_-_69597768 7.135 NM_021800
NM_201262
DNAJC12

DnaJ (Hsp40) homolog, subfamily C, member 12

chr1_-_150602047 7.053 ENSA
endosulfine alpha
chr6_-_136847078 7.051 NM_001198608
NM_001198609
NM_001198611
MAP7


microtubule-associated protein 7


chr20_+_19915716 7.047 RIN2
Ras and Rab interactor 2
chr6_-_47277511 7.040 TNFRSF21
tumor necrosis factor receptor superfamily, member 21
chr1_+_110527701 7.030 AHCYL1
adenosylhomocysteinase-like 1
chr19_-_46389307 7.021 NM_015649
IRF2BP1
interferon regulatory factor 2 binding protein 1
chr3_-_48130283 7.005 MAP4
microtubule-associated protein 4
chr8_+_38243958 6.999 NM_001199659
NM_144652
LETM2

leucine zipper-EF-hand containing transmembrane protein 2

chr3_-_9811623 6.870 CAMK1
calcium/calmodulin-dependent protein kinase I
chr19_-_14117096 6.814 NM_002918
RFX1
regulatory factor X, 1 (influences HLA class II expression)
chr1_-_150602089 6.812 NM_004436
NM_207042
NM_207043
NM_207044
NM_207168
ENSA




endosulfine alpha




chr5_+_156696351 6.777 NM_014376
CYFIP2
cytoplasmic FMR1 interacting protein 2
chr10_-_99446899 6.758 NM_021732
AVPI1
arginine vasopressin-induced 1
chr19_-_17414083 6.653 NM_024527
ABHD8
abhydrolase domain containing 8
chr7_+_5632453 6.584 FSCN1
fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus)
chr2_-_241759627 6.580 NM_001244008
NM_004321
KIF1A

kinesin family member 1A

chr2_-_74619129 6.570 NM_001190836
DCTN1
dynactin 1
chr11_-_62474666 6.560 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr9_-_32552550 6.506 TOPORS
topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase
chr11_-_62474869 6.391 BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr11_+_64692052 6.374 NM_006244
PPP2R5B
protein phosphatase 2, regulatory subunit B', beta
chr3_-_195310985 6.299 NM_001647
APOD
apolipoprotein D
chr3_-_9811583 6.225 CAMK1
calcium/calmodulin-dependent protein kinase I
chr15_-_83240499 6.116 NM_001079533
NM_001079534
NM_001079535
CPEB1


cytoplasmic polyadenylation element binding protein 1


chr12_+_7282963 6.002 NM_014718
CLSTN3
calsyntenin 3
chr11_+_62475113 5.874 NM_012202
GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr4_+_48833041 5.840 NM_001079840
NM_001079841
NM_017830
NM_001079839
NM_001079842
NM_001168254
OCIAD1





OCIA domain containing 1





chr3_-_9811628 5.836 NM_003656
CAMK1
calcium/calmodulin-dependent protein kinase I
chr1_-_163113938 5.812 RGS5
regulator of G-protein signaling 5
chr8_+_26240522 5.788 NM_004331
BNIP3L
BCL2/adenovirus E1B 19kDa interacting protein 3-like
chr2_+_149632836 5.784 KIF5C
kinesin family member 5C
chr9_-_135996287 5.739 NM_006266
RALGDS
ral guanine nucleotide dissociation stimulator
chr1_-_40157067 5.701 NM_016257
HPCAL4
hippocalcin like 4
chr18_-_33647521 5.643 RPRD1A
regulation of nuclear pre-mRNA domain containing 1A
chr19_+_49122762 5.620 SPHK2
sphingosine kinase 2
chr3_-_133614421 5.588 NM_016577
RAB6B
RAB6B, member RAS oncogene family
chr10_+_123923104 5.585 NM_006997
NM_206860
TACC2

transforming, acidic coiled-coil containing protein 2

chr11_+_120531027 5.578 NM_014619
GRIK4
glutamate receptor, ionotropic, kainate 4
chr3_-_185826748 5.551 NM_004454
ETV5
ets variant 5
chr13_-_45048436 5.542 NM_001243798
TSC22D1
TSC22 domain family, member 1
chr6_+_148663953 5.541 SASH1
SAM and SH3 domain containing 1
chr17_+_40913211 5.492 NM_005854
RAMP2
receptor (G protein-coupled) activity modifying protein 2
chr6_-_47277354 5.469 TNFRSF21
tumor necrosis factor receptor superfamily, member 21

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.57 3.05e-04 GO:0042221 response to chemical stimulus
1.14 4.29e-04 GO:0009987 cellular process
1.71 7.26e-04 GO:0007399 nervous system development
1.43 1.23e-03 GO:0048856 anatomical structure development
1.38 1.51e-03 GO:0032502 developmental process
1.37 3.93e-03 GO:0023052 signaling
1.44 4.03e-03 GO:0048731 system development
1.29 4.30e-03 GO:0032501 multicellular organismal process
2.89 5.02e-03 GO:0008202 steroid metabolic process
1.19 1.86e-02 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
2.24 3.68e-03 GO:0045202 synapse
1.16 8.74e-03 GO:0005737 cytoplasm
1.82 1.29e-02 GO:0031988 membrane-bounded vesicle
1.81 1.64e-02 GO:0016023 cytoplasmic membrane-bounded vesicle
1.78 1.85e-02 GO:0031410 cytoplasmic vesicle
1.76 2.12e-02 GO:0031982 vesicle

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.23 1.00e-04 GO:0005515 protein binding
1.11 4.31e-03 GO:0005488 binding