Motif ID: ATF4.p2

Z-value: 2.316


Transcription factors associated with ATF4.p2:

Gene SymbolEntrez IDGene Name
ATF4 468 activating transcription factor 4 (tax-responsive enhancer element B67)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ATF4chr22_+_399165630.543.1e-18Click!


Activity profile for motif ATF4.p2.

activity profile for motif ATF4.p2


Sorted Z-values histogram for motif ATF4.p2

Sorted Z-values for motif ATF4.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF4.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_123380608 91.173


chr5_-_133561745 70.025 PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr19_+_16187306 69.868 TPM4
tropomyosin 4
chr8_-_17104266 68.307 NM_013354
NM_054026
 CNOT7

CCR4-NOT transcription complex, subunit 7

chr6_+_47445440 62.788 NM_012120
 CD2AP
CD2-associated protein
chr11_+_4116059 61.361 RRM1
ribonucleotide reductase M1
chr22_+_24236579 60.840 MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr22_+_24236575 60.029


chr22_+_24236569 59.882 MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr19_+_16187266 59.790 TPM4
tropomyosin 4
chr19_-_55918980 57.148 UBE2S
ubiquitin-conjugating enzyme E2S
chr22_+_24236586 57.041 MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr22_+_24236556 54.700 NM_002415
 MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr1_+_26496382 54.658 NM_015871
 ZNF593
zinc finger protein 593
chr19_+_16187315 52.173 TPM4
tropomyosin 4
chr8_+_26149004 50.614 NM_002717
 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr8_+_26149043 49.522 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr11_+_4115923 48.082 NM_001033
 RRM1
ribonucleotide reductase M1
chr22_+_24236595 46.073 MIF
macrophage migration inhibitory factor (glycosylation-inhibiting factor)
chr5_-_133561551 45.987 PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 118 entries
enrichment   p-value GO term description
8.05 2.59e-02 GO:0030968 endoplasmic reticulum unfolded protein response
8.05 2.59e-02 GO:0034620 cellular response to unfolded protein
7.28 2.72e-04 GO:0034976 response to endoplasmic reticulum stress
6.56 1.03e-02 GO:0006984 ER-nucleus signaling pathway
5.72 4.12e-03 GO:0006369 termination of RNA polymerase II transcription
5.19 8.59e-10 GO:0050657 nucleic acid transport
5.19 8.59e-10 GO:0050658 RNA transport
5.19 8.59e-10 GO:0051236 establishment of RNA localization
5.12 2.88e-04 GO:0006986 response to unfolded protein
5.06 2.79e-08 GO:0051028 mRNA transport
5.02 2.08e-09 GO:0006403 RNA localization
4.80 4.95e-05 GO:0051168 nuclear export
4.64 2.75e-03 GO:0006405 RNA export from nucleus
4.47 4.12e-08 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
4.16 4.95e-02 GO:0031124 mRNA 3'-end processing
3.47 3.20e-05 GO:0006913 nucleocytoplasmic transport
3.43 4.13e-05 GO:0051169 nuclear transport
3.20 2.53e-02 GO:0051789 response to protein stimulus
3.17 1.30e-04 GO:0000375 RNA splicing, via transesterification reactions
3.09 3.83e-04 GO:0006457 protein folding

Gene overrepresentation in compartment category:

Showing 1 to 20 of 42 entries
enrichment   p-value GO term description
17.48 7.88e-03 GO:0005663 DNA replication factor C complex
4.43 8.99e-04 GO:0005643 nuclear pore
4.15 9.53e-04 GO:0071013 catalytic step 2 spliceosome
3.73 3.82e-03 GO:0000776 kinetochore
3.69 8.47e-03 GO:0046930 pore complex
3.44 1.90e-02 GO:0042470 melanosome
3.44 1.90e-02 GO:0048770 pigment granule
3.14 2.05e-03 GO:0000793 condensed chromosome
3.10 2.56e-03 GO:0031965 nuclear membrane
3.10 4.34e-03 GO:0005681 spliceosomal complex
2.92 1.00e-02 GO:0000775 chromosome, centromeric region
2.88 4.48e-05 GO:0005635 nuclear envelope
2.32 5.45e-06 GO:0030529 ribonucleoprotein complex
2.29 3.27e-06 GO:0005694 chromosome
2.20 1.12e-04 GO:0005730 nucleolus
2.19 3.71e-04 GO:0044427 chromosomal part
2.17 5.93e-14 GO:0005654 nucleoplasm
2.13 2.92e-06 GO:0031967 organelle envelope
2.09 5.84e-06 GO:0031975 envelope
2.03 1.19e-19 GO:0044428 nuclear part

Gene overrepresentation in function category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
21.85 4.54e-02 GO:0005049 nuclear export signal receptor activity
4.15 1.21e-03 GO:0031625 ubiquitin protein ligase binding
3.09 2.70e-02 GO:0051082 unfolded protein binding
2.44 3.58e-02 GO:0003924 GTPase activity
2.27 1.61e-09 GO:0003723 RNA binding
1.99 1.47e-02 GO:0016874 ligase activity
1.82 3.18e-03 GO:0019899 enzyme binding
1.79 1.56e-07 GO:0005524 ATP binding
1.78 1.36e-07 GO:0030554 adenyl nucleotide binding
1.78 1.96e-07 GO:0032559 adenyl ribonucleotide binding
1.77 2.60e-09 GO:0035639 purine ribonucleoside triphosphate binding
1.76 3.24e-09 GO:0017076 purine nucleotide binding
1.76 4.33e-09 GO:0032553 ribonucleotide binding
1.76 4.33e-09 GO:0032555 purine ribonucleotide binding
1.74 3.85e-11 GO:0000166 nucleotide binding
1.74 1.70e-02 GO:0017111 nucleoside-triphosphatase activity
1.71 2.53e-02 GO:0016462 pyrophosphatase activity
1.70 2.83e-02 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.69 3.16e-02 GO:0016817 hydrolase activity, acting on acid anhydrides
1.52 9.37e-31 GO:0005515 protein binding