Motif ID: ATF5_CREB3.p2

Z-value: 3.226


Transcription factors associated with ATF5_CREB3.p2:

Gene SymbolEntrez IDGene Name
ATF5 22809 activating transcription factor 5
CREB3 10488 cAMP responsive element binding protein 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CREB3chr9_+_357326290.235.0e-04Click!
ATF5chr19_+_50431958-0.101.3e-01Click!


Activity profile for motif ATF5_CREB3.p2.

activity profile for motif ATF5_CREB3.p2


Sorted Z-values histogram for motif ATF5_CREB3.p2

Sorted Z-values for motif ATF5_CREB3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ATF5_CREB3.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_123380608 137.756


chr19_+_16187047 76.118 NM_003290
 TPM4
tropomyosin 4
chr8_-_17104266 73.607 NM_013354
NM_054026
 CNOT7

CCR4-NOT transcription complex, subunit 7

chr17_-_685385 73.480 NM_016080
 GLOD4
glyoxalase domain containing 4
chr19_+_16187306 70.349 TPM4
tropomyosin 4
chr5_+_138211084 68.554 CTNNA1
catenin (cadherin-associated protein), alpha 1, 102kDa
chr8_-_17104103 66.190 CNOT7
CCR4-NOT transcription complex, subunit 7
chr3_+_38206968 65.284 NM_005109
 OXSR1
oxidative-stress responsive 1
chr12_+_69004684 64.073 RAP1B
RAP1B, member of RAS oncogene family
chr11_+_4116059 63.841 RRM1
ribonucleotide reductase M1
chr2_+_172821874 62.892 HAT1
histone acetyltransferase 1
chr12_+_69004710 60.552 RAP1B
RAP1B, member of RAS oncogene family
chr19_+_16187266 60.115 TPM4
tropomyosin 4
chr1_-_53704121 59.151 NM_002370
 MAGOH
mago-nashi homolog, proliferation-associated (Drosophila)
chr19_+_16187315 58.465 TPM4
tropomyosin 4
chr11_+_4116077 54.788 RRM1
ribonucleotide reductase M1
chr11_+_4115923 53.319 NM_001033
 RRM1
ribonucleotide reductase M1
chr5_-_133561745 52.302 PPP2CA
protein phosphatase 2, catalytic subunit, alpha isozyme
chr6_-_53213586 49.711 ELOVL5
ELOVL fatty acid elongase 5
chr19_+_1941157 49.708 NM_001319
 CSNK1G2
casein kinase 1, gamma 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 170 entries
enrichment   p-value GO term description
6.10 3.18e-03 GO:0048199 vesicle targeting, to, from or within Golgi
5.59 2.77e-03 GO:0006901 vesicle coating
5.37 4.57e-03 GO:0006900 membrane budding
5.01 6.61e-05 GO:0006888 ER to Golgi vesicle-mediated transport
4.47 3.82e-02 GO:0006984 ER-nucleus signaling pathway
3.68 1.06e-03 GO:0031124 mRNA 3'-end processing
3.62 1.40e-03 GO:0006986 response to unfolded protein
3.33 1.90e-07 GO:0048193 Golgi vesicle transport
3.25 4.67e-03 GO:0031123 RNA 3'-end processing
3.18 1.25e-02 GO:0002755 MyD88-dependent toll-like receptor signaling pathway
3.18 2.14e-02 GO:0034130 toll-like receptor 1 signaling pathway
3.18 2.14e-02 GO:0034134 toll-like receptor 2 signaling pathway
3.05 2.37e-02 GO:0034142 toll-like receptor 4 signaling pathway
2.90 6.22e-04 GO:0050657 nucleic acid transport
2.90 6.22e-04 GO:0050658 RNA transport
2.90 6.22e-04 GO:0051236 establishment of RNA localization
2.88 4.41e-04 GO:0051789 response to protein stimulus
2.87 3.69e-02 GO:0002224 toll-like receptor signaling pathway
2.83 4.45e-03 GO:0051028 mRNA transport
2.80 1.30e-03 GO:0006403 RNA localization

Gene overrepresentation in compartment category:

Showing 1 to 20 of 62 entries
enrichment   p-value GO term description
9.15 3.45e-03 GO:0030127 COPII vesicle coat
7.46 9.62e-06 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
6.10 6.73e-03 GO:0012507 ER to Golgi transport vesicle membrane
5.14 3.16e-02 GO:0030134 ER to Golgi transport vesicle
3.76 2.04e-02 GO:0030120 vesicle coat
3.62 1.94e-03 GO:0005798 Golgi-associated vesicle
3.42 1.57e-02 GO:0030658 transport vesicle membrane
2.78 2.66e-02 GO:0071013 catalytic step 2 spliceosome
2.61 4.30e-02 GO:0042470 melanosome
2.61 4.30e-02 GO:0048770 pigment granule
2.56 2.42e-02 GO:0030133 transport vesicle
2.55 1.62e-03 GO:0005681 spliceosomal complex
2.44 1.69e-02 GO:0016607 nuclear speck
2.28 2.73e-02 GO:0000793 condensed chromosome
2.11 2.63e-02 GO:0005819 spindle
2.07 6.29e-08 GO:0030529 ribonucleoprotein complex
2.06 8.82e-07 GO:0044427 chromosomal part
2.03 8.58e-03 GO:0005635 nuclear envelope
2.01 2.18e-02 GO:0016604 nuclear body
2.00 1.67e-07 GO:0005694 chromosome

Gene overrepresentation in function category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
3.76 2.92e-02 GO:0019783 small conjugating protein-specific protease activity
2.86 1.55e-02 GO:0008135 translation factor activity, nucleic acid binding
2.48 2.62e-02 GO:0051082 unfolded protein binding
2.37 1.65e-04 GO:0003924 GTPase activity
2.12 3.04e-03 GO:0019787 small conjugating protein ligase activity
2.02 2.56e-02 GO:0004842 ubiquitin-protein ligase activity
2.01 8.13e-12 GO:0003723 RNA binding
1.96 1.29e-02 GO:0016881 acid-amino acid ligase activity
1.94 7.72e-03 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.84 7.39e-03 GO:0005525 GTP binding
1.81 4.59e-07 GO:0016462 pyrophosphatase activity
1.81 9.55e-07 GO:0017111 nucleoside-triphosphatase activity
1.80 5.81e-07 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.79 7.35e-07 GO:0016817 hydrolase activity, acting on acid anhydrides
1.79 1.77e-02 GO:0019001 guanyl nucleotide binding
1.79 1.77e-02 GO:0032561 guanyl ribonucleotide binding
1.73 1.42e-02 GO:0019904 protein domain specific binding
1.69 2.43e-02 GO:0016874 ligase activity
1.59 4.32e-03 GO:0019899 enzyme binding
1.58 2.54e-13 GO:0000166 nucleotide binding