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• Mean activities

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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: ATF5_CREB3.p2

Z-value: 3.226

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr12_-_123380608	137.756
chr19_+_16187047	76.118	NM_003290	TPM4	tropomyosin 4
chr8_-_17104266	73.607	NM_013354 NM_054026	CNOT7	CCR4-NOT transcription complex, subunit 7
chr17_-_685385	73.480	NM_016080	GLOD4	glyoxalase domain containing 4
chr19_+_16187306	70.349		TPM4	tropomyosin 4
chr5_+_138211084	68.554		CTNNA1	catenin (cadherin-associated protein), alpha 1, 102kDa
chr8_-_17104103	66.190		CNOT7	CCR4-NOT transcription complex, subunit 7
chr3_+_38206968	65.284	NM_005109	OXSR1	oxidative-stress responsive 1
chr12_+_69004684	64.073		RAP1B	RAP1B, member of RAS oncogene family
chr11_+_4116059	63.841		RRM1	ribonucleotide reductase M1
chr2_+_172821874	62.892		HAT1	histone acetyltransferase 1
chr12_+_69004710	60.552		RAP1B	RAP1B, member of RAS oncogene family
chr19_+_16187266	60.115		TPM4	tropomyosin 4
chr1_-_53704121	59.151	NM_002370	MAGOH	mago-nashi homolog, proliferation-associated (Drosophila)
chr19_+_16187315	58.465		TPM4	tropomyosin 4
chr11_+_4116077	54.788		RRM1	ribonucleotide reductase M1
chr11_+_4115923	53.319	NM_001033	RRM1	ribonucleotide reductase M1
chr5_-_133561745	52.302		PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme
chr6_-_53213586	49.711		ELOVL5	ELOVL fatty acid elongase 5
chr19_+_1941157	49.708	NM_001319	CSNK1G2	casein kinase 1, gamma 2
chr12_+_72148653	49.436	NM_014999	RAB21	RAB21, member RAS oncogene family
chr1_+_26496382	48.626	NM_015871	ZNF593	zinc finger protein 593
chr10_-_97416367	48.491		ALDH18A1	aldehyde dehydrogenase 18 family, member A1
chr11_+_18416111	48.246		LDHA	lactate dehydrogenase A
chr11_+_18416106	47.585		LDHA	lactate dehydrogenase A
chr3_-_150263899	45.810		SERP1	stress-associated endoplasmic reticulum protein 1
chr8_-_101964268	45.667		YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_-_245025958	44.753		HNRNPU	heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
chr3_-_185655833	44.630	NM_001243879 NM_004593	TRA2B	transformer 2 beta homolog (Drosophila)
chr4_+_113558119	44.133	NM_016648	LARP7	La ribonucleoprotein domain family, member 7
chr3_-_195808934	44.060		TFRC	transferrin receptor (p90, CD71)
chr3_+_170075521	43.819		SKIL	SKI-like oncogene
chr8_-_117768032	43.729		EIF3H	eukaryotic translation initiation factor 3, subunit H
chr8_-_101964247	43.700		YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_-_101964236	43.510		YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_-_101964248	43.357		YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr12_+_69004614	43.279	NM_001010942 NM_001251917 NM_001251918 NM_001251921 NM_001251922 NM_015646	RAP1B	RAP1B, member of RAS oncogene family
chr8_-_117768059	43.044	NM_003756	EIF3H	eukaryotic translation initiation factor 3, subunit H
chr1_+_52082755	42.934		OSBPL9	oxysterol binding protein-like 9
chr14_+_105219466	42.771	NM_006427 NM_021709	SIVA1	SIVA1, apoptosis-inducing factor
chr3_-_185655806	42.726		TRA2B	transformer 2 beta homolog (Drosophila)
chr5_-_133561551	42.704		PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme
chr3_-_185655648	42.046		TRA2B	transformer 2 beta homolog (Drosophila)
chr3_-_195808997	41.742	NM_001128148	TFRC	transferrin receptor (p90, CD71)
chr8_+_26149080	41.718		PPP2R2A	protein phosphatase 2, regulatory subunit B, alpha
chr1_+_228327982	41.341		GUK1	guanylate kinase 1
chr2_-_10588273	41.286		ODC1	ornithine decarboxylase 1
chr3_-_195808958	41.256	NM_003234	TFRC	transferrin receptor (p90, CD71)
chr8_-_101964258	41.231		YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_+_228327966	40.406		GUK1	guanylate kinase 1
chr2_-_98408868	40.305		TMEM131	transmembrane protein 131
chr21_-_44846927	39.535	NM_173354	SIK1	salt-inducible kinase 1
chr1_-_32110464	39.334		PEF1	penta-EF-hand domain containing 1
chr2_-_10588451	39.259	NM_002539	ODC1	ornithine decarboxylase 1
chr8_-_101964334	39.216	NM_145690	YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr7_-_25164902	38.524	NM_018947	CYCS	cytochrome c, somatic
chr1_-_19536741	38.438	NM_020765	UBR4	ubiquitin protein ligase E3 component n-recognin 4
chr12_-_14956367	38.409	NM_016312	WBP11	WW domain binding protein 11
chr1_+_228328003	38.237		GUK1	guanylate kinase 1
chr2_+_118572254	37.826	NM_006773	DDX18	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr11_-_6633400	37.774		TAF10	TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
chr8_-_101964197	37.696		YWHAZ	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr1_-_89357181	37.685		GTF2B	general transcription factor IIB
chr16_+_31044414	37.647		STX4	syntaxin 4
chr12_-_6862131	37.494		MLF2	myeloid leukemia factor 2
chr15_-_91537724	37.085	NM_003981 NM_199413 NM_199414	PRC1	protein regulator of cytokinesis 1
chr15_+_80352018	37.024		ZFAND6	zinc finger, AN1-type domain 6
chr6_+_47445440	37.022	NM_012120	CD2AP	CD2-associated protein
chr12_-_132628841	36.944	NM_175066	DDX51	DEAD (Asp-Glu-Ala-Asp) box polypeptide 51
chr10_-_97416564	36.669	NM_001017423 NM_002860	ALDH18A1	aldehyde dehydrogenase 18 family, member A1
chr6_-_90062439	36.394		UBE2J1	ubiquitin-conjugating enzyme E2, J1, U
chr12_-_14956315	36.152		WBP11	WW domain binding protein 11
chr3_-_186524226	35.978	NM_002916	RFC4	replication factor C (activator 1) 4, 37kDa
chr5_-_133561805	35.785	NM_002715	PPP2CA	protein phosphatase 2, catalytic subunit, alpha isozyme
chr2_+_118572283	35.656		DDX18	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr16_+_2564000	35.532		ATP6V0C	ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr6_+_44214786	35.499	NM_007355	HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1
chr6_-_90062349	35.404		UBE2J1	ubiquitin-conjugating enzyme E2, J1, U
chr1_-_150602041	35.397		ENSA	endosulfine alpha
chr20_+_19915716	35.132		RIN2	Ras and Rab interactor 2
chr12_-_14956408	35.100		WBP11	WW domain binding protein 11
chr11_-_8680382	34.456	NM_014818	TRIM66	tripartite motif containing 66
chr1_+_228327784	34.441	NM_001242839 NM_000858 NM_001159390 NM_001242840	GUK1	guanylate kinase 1
chr2_+_118572284	34.405		DDX18	DEAD (Asp-Glu-Ala-Asp) box polypeptide 18
chr12_+_132629014	34.328		NOC4L	nucleolar complex associated 4 homolog (S. cerevisiae)
chr5_+_177631533	34.273		HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B
chr3_-_57583080	34.153		ARF4	ADP-ribosylation factor 4
chr8_+_64081108	34.108	NM_152758	YTHDF3	YTH domain family, member 3
chr1_+_228328015	34.074		GUK1	guanylate kinase 1
chr18_+_20513277	33.892	NM_002894	RBBP8	retinoblastoma binding protein 8
chr17_-_48474678	33.694		LRRC59	leucine rich repeat containing 59
chr7_+_117824085	33.654	NM_016200	NAA38	N(alpha)-acetyltransferase 38, NatC auxiliary subunit
chr17_-_48474910	33.579	NM_018509	LRRC59	leucine rich repeat containing 59
chr2_-_64881040	33.031	NM_014755	SERTAD2	SERTA domain containing 2
chr15_+_66679107	33.007	NM_002755	MAP2K1	mitogen-activated protein kinase kinase 1
chr8_+_64081187	32.555		YTHDF3	YTH domain family, member 3
chr5_+_10353980	32.394
chr15_+_80351909	32.211	NM_001242911 NM_001242912 NM_001242917 NM_001242918 NM_019006	ZFAND6	zinc finger, AN1-type domain 6
chr12_-_82752154	31.892	NM_014167	CCDC59	coiled-coil domain containing 59
chr10_-_75006963	31.861	NM_015190	DNAJC9	DnaJ (Hsp40) homolog, subfamily C, member 9
chr6_+_64281910	31.807	NM_003463	PTP4A1	protein tyrosine phosphatase type IVA, member 1
chr12_-_123380682	31.754	NM_024667	VPS37B	vacuolar protein sorting 37 homolog B (S. cerevisiae)
chr15_+_80352257	31.610	NM_001242913	ZFAND6	zinc finger, AN1-type domain 6
chr3_-_185655776	31.438		TRA2B	transformer 2 beta homolog (Drosophila)
chr12_+_108079516	31.212	NM_007062	PWP1	PWP1 homolog (S. cerevisiae)
chr7_+_56019552	31.021	NM_015969	MRPS17	mitochondrial ribosomal protein S17
chr10_+_112257624	30.916	NM_004419	DUSP5	dual specificity phosphatase 5
chr6_+_44214853	30.866		HSP90AB1	heat shock protein 90kDa alpha (cytosolic), class B member 1
chr5_+_177631534	30.754		HNRNPAB	heterogeneous nuclear ribonucleoprotein A/B
chr4_-_104119475	30.682	NM_001813	CENPE	centromere protein E, 312kDa
chr17_+_57697036	30.646	NM_004859	CLTC	clathrin, heavy chain (Hc)
chr17_+_33914278	30.516	NM_001030006 NM_001282	AP2B1	adaptor-related protein complex 2, beta 1 subunit
chr2_-_240964717	30.308		NDUFA10	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr7_+_107531585	30.233	NM_000108	DLD	dihydrolipoamide dehydrogenase
chr1_+_162531349	30.152		UAP1	UDP-N-acteylglucosamine pyrophosphorylase 1
chr4_+_113558611	30.035	NM_015454	LARP7	La ribonucleoprotein domain family, member 7
chr15_-_23034307	29.980		NIPA2	non imprinted in Prader-Willi/Angelman syndrome 2
chr15_+_80352043	29.965		ZFAND6	zinc finger, AN1-type domain 6
chr11_+_74660290	29.815	NM_014752	LOC653566 SPCS2	signal peptidase complex subunit 2 homolog pseudogene signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr4_+_146019368	29.795		ABCE1	ATP-binding cassette, sub-family E (OABP), member 1
chr12_-_6862081	29.762	NM_005439	MLF2	myeloid leukemia factor 2
chr6_-_86352650	29.725		SYNCRIP	synaptotagmin binding, cytoplasmic RNA interacting protein
chr3_+_152017193	29.678	NM_207293 NM_207294 NM_207295 NM_207296 NM_207297	MBNL1	muscleblind-like (Drosophila)
chr2_-_62115714	29.547		CCT4	chaperonin containing TCP1, subunit 4 (delta)
chr4_-_122744782	29.517		CCNA2	cyclin A2
chr1_-_43736600	29.499		EBNA1BP2	EBNA1 binding protein 2
chr4_-_122744978	29.405	NM_001237	CCNA2	cyclin A2
chr6_-_31774579	29.326		LSM2	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr6_-_31774725	29.149	NM_021177	LSM2	LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr1_-_1822501	28.906		GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1
chr2_+_187350870	28.897	NM_018471	ZC3H15	zinc finger CCCH-type containing 15
chr18_+_158480	28.820	NM_001037334 NM_005151	USP14	ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
chr12_-_46766019	28.802		SLC38A2	solute carrier family 38, member 2
chr14_+_100705101	28.774	NM_003403	YY1	YY1 transcription factor
chr5_+_139889635	28.670
chr2_-_240964807	28.644	NM_004544	NDUFA10	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 10, 42kDa
chr7_-_25164869	28.542		CYCS	cytochrome c, somatic
chr7_+_107531618	28.540		DLD	dihydrolipoamide dehydrogenase
chr19_+_10362886	28.516		MRPL4	mitochondrial ribosomal protein L4
chr6_+_111195986	28.363	NM_001634 NM_001033059	AMD1	adenosylmethionine decarboxylase 1
chr7_+_107531616	28.331		DLD	dihydrolipoamide dehydrogenase
chr11_-_14521328	28.305		COPB1	coatomer protein complex, subunit beta 1
chr19_-_47617008	28.113	NM_015168	ZC3H4	zinc finger CCCH-type containing 4
chrX_-_16887974	28.084	NM_001198719	RBBP7	retinoblastoma binding protein 7
chr6_+_64282449	28.044		PTP4A1	protein tyrosine phosphatase type IVA, member 1
chr1_+_39456887	27.985	NM_001136275 NM_024595	AKIRIN1	akirin 1
chr11_-_14521386	27.831	NM_016451 NM_001144062 NM_001144061	COPB1	coatomer protein complex, subunit beta 1
chr3_+_44803280	27.826		KIF15	kinesin family member 15
chr6_-_86352656	27.784		SYNCRIP	synaptotagmin binding, cytoplasmic RNA interacting protein
chr7_+_26240830	27.761	NM_007276	CBX3	chromobox homolog 3
chr15_+_66797632	27.396		ZWILCH	Zwilch, kinetochore associated, homolog (Drosophila)
chr6_-_32812711	27.263	NM_004159	PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr4_+_146019486	27.223		ABCE1	ATP-binding cassette, sub-family E (OABP), member 1
chr17_+_685512	27.152	NM_018146	RNMTL1	RNA methyltransferase like 1
chr13_+_114239047	27.136	NM_007111	TFDP1	transcription factor Dp-1
chr2_-_62115726	27.131		CCT4	chaperonin containing TCP1, subunit 4 (delta)
chr17_+_66508525	27.090	NM_002734 NM_212472	PRKAR1A	protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue specific extinguisher 1)
chr6_-_7910716	27.062	NM_030810	TXNDC5	thioredoxin domain containing 5 (endoplasmic reticulum)
chr19_-_55918980	27.027		UBE2S	ubiquitin-conjugating enzyme E2S
chr7_+_100273776	26.985		GNB2	guanine nucleotide binding protein (G protein), beta polypeptide 2
chr5_-_137878808	26.831		ETF1	eukaryotic translation termination factor 1
chr19_+_49375679	26.813		PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr17_-_17184500	26.693		COPS3	COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
chr3_-_57582866	26.678		ARF4	ADP-ribosylation factor 4
chr2_+_187351032	26.649		ZC3H15	zinc finger CCCH-type containing 15
chr17_+_40985444	26.625		PSME3	proteasome (prosome, macropain) activator subunit 3 (PA28 gamma; Ki)
chr14_+_93651295	26.539	NM_015676 NM_001098621	C14orf109	chromosome 14 open reading frame 109
chr10_-_111683201	26.520		XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
chr6_+_24775154	26.442	NM_001251989 NM_001251990 NM_015895	GMNN	geminin, DNA replication inhibitor
chr6_-_32812409	26.374		PSMB8	proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr11_+_74660317	26.346		SPCS2	signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr2_-_62115641	26.191		CCT4	chaperonin containing TCP1, subunit 4 (delta)
chr19_+_49375677	26.171		PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr3_+_101292987	26.155		PCNP	PEST proteolytic signal containing nuclear protein
chr7_-_66057331	26.116		LOC493754	RAB guanine nucleotide exchange factor (GEF) 1 pseudogene
chr8_-_121457625	26.115	NM_014078	MRPL13	mitochondrial ribosomal protein L13
chr8_-_103876390	26.061	NM_015878 NM_148174	AZIN1	antizyme inhibitor 1
chr6_+_30585485	26.041	NM_014046	MRPS18B	mitochondrial ribosomal protein S18B
chr11_-_61584451	25.769	NM_013402	FADS1	fatty acid desaturase 1
chr19_+_49375638	25.718	NM_014330	PPP1R15A	protein phosphatase 1, regulatory subunit 15A
chr1_+_161284165	25.711	NM_001035511 NM_001035512 NM_001035513 NM_003001	SDHC	succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
chr3_-_52312655	25.710	NM_025222	WDR82	WD repeat domain 82
chr8_-_121457387	25.695		MRPL13	mitochondrial ribosomal protein L13
chr17_+_57642885	25.575	NM_001166301 NM_024612	DHX40	DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr2_+_109271267	25.384	NM_001193485	LIMS1	LIM and senescent cell antigen-like domains 1
chr10_-_111683245	25.352	NM_001167604 NM_020383	XPNPEP1	X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
chr2_-_3605918	25.289		RNASEH1	ribonuclease H1
chr3_+_52719935	25.213	NM_014366 NM_206825 NM_206826	GNL3	guanine nucleotide binding protein-like 3 (nucleolar)
chr2_+_172778907	25.157	NM_003642	HAT1	histone acetyltransferase 1
chr8_-_121457333	25.138		MRPL13	mitochondrial ribosomal protein L13
chr14_+_35452103	24.998	NM_001146282 NM_003136	SRP54	signal recognition particle 54kDa
chr17_+_685606	24.903		RNMTL1	RNA methyltransferase like 1
chr12_-_46766563	24.801	NM_018976	SLC38A2	solute carrier family 38, member 2
chr1_+_52082545	24.759	NM_024586 NM_148906 NM_148908 NM_148909	OSBPL9	oxysterol binding protein-like 9
chr11_-_65667858	24.636		FOSL1	FOS-like antigen 1
chr1_-_1822493	24.602		GNB1	guanine nucleotide binding protein (G protein), beta polypeptide 1
chr11_+_74660321	24.559		SPCS2	signal peptidase complex subunit 2 homolog (S. cerevisiae)
chr5_-_133340427	24.493		VDAC1	voltage-dependent anion channel 1
chr3_+_45017749	24.454		EXOSC7	exosome component 7
chr4_+_146019155	24.422	NM_001040876 NM_002940	ABCE1	ATP-binding cassette, sub-family E (OABP), member 1

Gene overrepresentation in process category:

enrichment	p-value	GO term	description
1.54	9.54e-44	GO:0044237	cellular metabolic process
1.68	1.55e-39	GO:0044260	cellular macromolecule metabolic process
1.43	3.96e-35	GO:0008152	metabolic process
1.25	8.54e-34	GO:0009987	cellular process
1.56	5.20e-32	GO:0043170	macromolecule metabolic process
1.45	1.22e-31	GO:0044238	primary metabolic process
1.75	1.28e-25	GO:0006139	nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
1.64	1.60e-22	GO:0034641	cellular nitrogen compound metabolic process
1.80	4.50e-22	GO:0090304	nucleic acid metabolic process
1.61	2.05e-21	GO:0006807	nitrogen compound metabolic process
1.80	1.22e-17	GO:0010467	gene expression
1.84	1.95e-17	GO:0009059	macromolecule biosynthetic process
2.31	2.15e-17	GO:0046907	intracellular transport
1.84	4.38e-17	GO:0034645	cellular macromolecule biosynthetic process
1.65	4.86e-17	GO:0044267	cellular protein metabolic process
1.64	1.53e-15	GO:0044249	cellular biosynthetic process
2.01	2.16e-15	GO:0051649	establishment of localization in cell
1.61	4.74e-15	GO:0009058	biosynthetic process
1.77	5.11e-15	GO:0016070	RNA metabolic process
1.49	2.44e-14	GO:0071840	cellular component organization or biogenesis
1.90	2.59e-14	GO:0051641	cellular localization
1.90	1.42e-12	GO:0044248	cellular catabolic process
1.46	4.87e-12	GO:0016043	cellular component organization
1.52	7.01e-12	GO:0071841	cellular component organization or biogenesis at cellular level
1.49	1.45e-11	GO:0019538	protein metabolic process
1.99	6.58e-11	GO:0045184	establishment of protein localization
1.99	9.03e-11	GO:0015031	protein transport
2.30	9.74e-11	GO:0044265	cellular macromolecule catabolic process
2.14	3.30e-10	GO:0006396	RNA processing
1.75	3.78e-10	GO:0033036	macromolecule localization
1.71	5.40e-10	GO:0009056	catabolic process
2.14	1.12e-09	GO:0009057	macromolecule catabolic process
1.49	1.44e-09	GO:0071842	cellular component organization at cellular level
1.84	2.00e-09	GO:0007049	cell cycle
2.43	3.32e-09	GO:0006886	intracellular protein transport
1.81	3.77e-09	GO:0008104	protein localization
1.62	1.10e-08	GO:0006996	organelle organization
1.95	2.11e-08	GO:0016192	vesicle-mediated transport
2.51	2.64e-08	GO:0019941	modification-dependent protein catabolic process
1.90	3.39e-08	GO:0022402	cell cycle process
2.50	3.55e-08	GO:0043632	modification-dependent macromolecule catabolic process
2.45	8.47e-08	GO:0051603	proteolysis involved in cellular protein catabolic process
2.48	9.89e-08	GO:0006511	ubiquitin-dependent protein catabolic process
2.12	1.45e-07	GO:0070727	cellular macromolecule localization
2.49	1.77e-07	GO:0008380	RNA splicing
3.33	1.90e-07	GO:0048193	Golgi vesicle transport
2.40	1.96e-07	GO:0044257	cellular protein catabolic process
2.04	2.18e-07	GO:0000278	mitotic cell cycle
2.11	2.57e-07	GO:0034613	cellular protein localization
1.69	3.66e-07	GO:0044085	cellular component biogenesis
2.05	7.89e-07	GO:0016071	mRNA metabolic process
2.25	9.00e-07	GO:0006397	mRNA processing
2.78	9.56e-07	GO:0000375	RNA splicing, via transesterification reactions
2.28	1.27e-06	GO:0030163	protein catabolic process
2.75	1.36e-06	GO:0006605	protein targeting
1.80	1.85e-06	GO:0033554	cellular response to stress
1.89	2.47e-06	GO:0022403	cell cycle phase
1.42	3.17e-06	GO:0006950	response to stress
2.73	4.62e-06	GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.73	4.62e-06	GO:0000398	nuclear mRNA splicing, via spliceosome
1.70	9.63e-06	GO:0032774	RNA biosynthetic process
2.45	9.66e-06	GO:0009166	nucleotide catabolic process
2.26	1.26e-05	GO:0009259	ribonucleotide metabolic process
2.24	1.82e-05	GO:0070647	protein modification by small protein conjugation or removal
2.53	2.13e-05	GO:0009261	ribonucleotide catabolic process
2.62	2.48e-05	GO:0006457	protein folding
2.33	3.94e-05	GO:0034655	nucleobase, nucleoside, nucleotide and nucleic acid catabolic process
2.33	3.94e-05	GO:0034656	nucleobase, nucleoside and nucleotide catabolic process
2.11	4.22e-05	GO:0006163	purine nucleotide metabolic process
2.50	4.79e-05	GO:0009154	purine ribonucleotide catabolic process
2.41	5.04e-05	GO:0072523	purine-containing compound catabolic process
1.46	5.67e-05	GO:0006464	protein modification process
2.22	6.01e-05	GO:0009150	purine ribonucleotide metabolic process
2.42	6.31e-05	GO:0006195	purine nucleotide catabolic process
5.01	6.61e-05	GO:0006888	ER to Golgi vesicle-mediated transport
1.68	1.14e-04	GO:0006351	transcription, DNA-dependent
1.43	1.23e-04	GO:0043412	macromolecule modification
1.84	1.59e-04	GO:0071822	protein complex subunit organization
2.43	2.34e-04	GO:0009203	ribonucleoside triphosphate catabolic process
2.43	2.34e-04	GO:0009207	purine ribonucleoside triphosphate catabolic process
2.24	2.52e-04	GO:0032446	protein modification by small protein conjugation
2.42	2.70e-04	GO:0009146	purine nucleoside triphosphate catabolic process
2.58	2.83e-04	GO:0006913	nucleocytoplasmic transport
2.17	3.14e-04	GO:0006412	translation
1.59	3.19e-04	GO:0022607	cellular component assembly
2.16	3.52e-04	GO:0044270	cellular nitrogen compound catabolic process
2.55	3.85e-04	GO:0051169	nuclear transport
2.38	4.07e-04	GO:0009143	nucleoside triphosphate catabolic process
1.79	4.11e-04	GO:0051726	regulation of cell cycle
1.32	4.12e-04	GO:0051234	establishment of localization
2.88	4.41e-04	GO:0051789	response to protein stimulus
1.96	4.99e-04	GO:0072521	purine-containing compound metabolic process
2.15	5.62e-04	GO:0046700	heterocycle catabolic process
2.90	6.22e-04	GO:0050657	nucleic acid transport
2.90	6.22e-04	GO:0050658	RNA transport
2.90	6.22e-04	GO:0051236	establishment of RNA localization
2.16	6.40e-04	GO:0009144	purine nucleoside triphosphate metabolic process
1.31	6.81e-04	GO:0006810	transport
2.62	7.11e-04	GO:0010498	proteasomal protein catabolic process
2.62	7.11e-04	GO:0043161	proteasomal ubiquitin-dependent protein catabolic process
1.28	8.64e-04	GO:0051179	localization
1.63	9.08e-04	GO:0008219	cell death
1.35	9.54e-04	GO:0048522	positive regulation of cellular process
1.85	9.85e-04	GO:0006753	nucleoside phosphate metabolic process
1.85	9.85e-04	GO:0009117	nucleotide metabolic process
3.68	1.06e-03	GO:0031124	mRNA 3'-end processing
1.80	1.08e-03	GO:0050878	regulation of body fluid levels
2.14	1.14e-03	GO:0009205	purine ribonucleoside triphosphate metabolic process
1.63	1.16e-03	GO:0016265	death
2.13	1.27e-03	GO:0009199	ribonucleoside triphosphate metabolic process
2.80	1.30e-03	GO:0006403	RNA localization
2.11	1.39e-03	GO:0009141	nucleoside triphosphate metabolic process
3.62	1.40e-03	GO:0006986	response to unfolded protein
2.50	1.45e-03	GO:0043687	post-translational protein modification
1.15	1.91e-03	GO:0065007	biological regulation
1.17	2.13e-03	GO:0050794	regulation of cellular process
1.54	2.52e-03	GO:0051246	regulation of protein metabolic process
1.55	2.69e-03	GO:0032268	regulation of cellular protein metabolic process
2.08	2.71e-03	GO:0048285	organelle fission
1.16	2.74e-03	GO:0050789	regulation of biological process
5.59	2.77e-03	GO:0006901	vesicle coating
6.10	3.18e-03	GO:0048199	vesicle targeting, to, from or within Golgi
1.61	3.30e-03	GO:0043933	macromolecular complex subunit organization
1.82	3.30e-03	GO:0007596	blood coagulation
1.82	3.30e-03	GO:0050817	coagulation
2.16	3.42e-03	GO:0016567	protein ubiquitination
1.81	4.19e-03	GO:0007599	hemostasis
1.87	4.40e-03	GO:0000279	M phase
2.83	4.45e-03	GO:0051028	mRNA transport
5.37	4.57e-03	GO:0006900	membrane budding
3.25	4.67e-03	GO:0031123	RNA 3'-end processing
1.27	4.71e-03	GO:0060255	regulation of macromolecule metabolic process
2.58	4.84e-03	GO:0015931	nucleobase, nucleoside, nucleotide and nucleic acid transport
2.56	5.65e-03	GO:0006184	GTP catabolic process
2.04	5.80e-03	GO:0000087	M phase of mitotic cell cycle
2.06	6.03e-03	GO:0000280	nuclear division
2.06	6.03e-03	GO:0007067	mitosis
1.30	6.56e-03	GO:0048518	positive regulation of biological process
2.25	7.13e-03	GO:0033365	protein localization to organelle
1.38	7.24e-03	GO:0044281	small molecule metabolic process
1.25	7.67e-03	GO:0031323	regulation of cellular metabolic process
1.64	8.59e-03	GO:0006915	apoptosis
1.63	8.84e-03	GO:0012501	programmed cell death
1.73	9.12e-03	GO:0055086	nucleobase, nucleoside and nucleotide metabolic process
1.34	9.65e-03	GO:0048523	negative regulation of cellular process
1.82	1.09e-02	GO:0016044	cellular membrane organization
1.46	1.24e-02	GO:0010033	response to organic substance
3.18	1.25e-02	GO:0002755	MyD88-dependent toll-like receptor signaling pathway
1.81	1.27e-02	GO:0061024	membrane organization
2.00	1.34e-02	GO:0051329	interphase of mitotic cell cycle
1.61	1.48e-02	GO:0071844	cellular component assembly at cellular level
1.83	1.74e-02	GO:0016032	viral reproduction
1.69	1.75e-02	GO:0006259	DNA metabolic process
1.74	1.76e-02	GO:0006974	response to DNA damage stimulus
2.41	2.11e-02	GO:0046039	GTP metabolic process
3.18	2.14e-02	GO:0034130	toll-like receptor 1 signaling pathway
3.18	2.14e-02	GO:0034134	toll-like receptor 2 signaling pathway
1.96	2.17e-02	GO:0051325	interphase
3.05	2.37e-02	GO:0034142	toll-like receptor 4 signaling pathway
2.13	2.56e-02	GO:0071156	regulation of cell cycle arrest
2.15	2.61e-02	GO:0000075	cell cycle checkpoint
1.22	3.69e-02	GO:0019222	regulation of metabolic process
2.87	3.69e-02	GO:0002224	toll-like receptor signaling pathway
1.24	3.74e-02	GO:0080090	regulation of primary metabolic process
4.47	3.82e-02	GO:0006984	ER-nucleus signaling pathway
1.73	3.84e-02	GO:0006461	protein complex assembly
2.50	4.44e-02	GO:0045333	cellular respiration
1.69	4.65e-02	GO:0044282	small molecule catabolic process
1.72	4.74e-02	GO:0070271	protein complex biogenesis
1.47	4.87e-02	GO:0010941	regulation of cell death

Gene overrepresentation in compartment category:

enrichment	p-value	GO term	description
1.27	5.98e-45	GO:0044424	intracellular part
1.25	8.09e-41	GO:0005622	intracellular
1.35	1.00e-38	GO:0043231	intracellular membrane-bounded organelle
1.35	1.75e-38	GO:0043227	membrane-bounded organelle
1.53	4.02e-37	GO:0044446	intracellular organelle part
1.37	1.09e-36	GO:0005737	cytoplasm
1.52	1.59e-36	GO:0044422	organelle part
1.29	3.31e-32	GO:0043229	intracellular organelle
1.28	8.10e-32	GO:0043226	organelle
1.44	2.24e-28	GO:0044444	cytoplasmic part
1.89	4.66e-28	GO:0044428	nuclear part
1.88	1.15e-22	GO:0031981	nuclear lumen
1.75	3.13e-22	GO:0031974	membrane-enclosed lumen
1.74	1.81e-21	GO:0043233	organelle lumen
1.75	2.84e-21	GO:0070013	intracellular organelle lumen
1.39	2.10e-19	GO:0005634	nucleus
1.93	2.75e-17	GO:0005654	nucleoplasm
1.70	3.67e-17	GO:0005829	cytosol
1.49	1.91e-16	GO:0032991	macromolecular complex
1.43	1.24e-09	GO:0043234	protein complex
1.51	3.32e-09	GO:0031090	organelle membrane
2.07	6.29e-08	GO:0030529	ribonucleoprotein complex
1.40	1.06e-07	GO:0043228	non-membrane-bounded organelle
1.40	1.06e-07	GO:0043232	intracellular non-membrane-bounded organelle
1.55	1.48e-07	GO:0012505	endomembrane system
2.00	1.67e-07	GO:0005694	chromosome
1.06	7.12e-07	GO:0044464	cell part
1.06	7.40e-07	GO:0005623	cell
2.06	8.82e-07	GO:0044427	chromosomal part
7.46	9.62e-06	GO:0030530	heterogeneous nuclear ribonucleoprotein complex
1.61	1.03e-05	GO:0005783	endoplasmic reticulum
1.75	1.94e-05	GO:0044451	nucleoplasm part
1.70	1.33e-04	GO:0031967	organelle envelope
1.69	1.59e-04	GO:0031975	envelope
1.85	5.17e-04	GO:0005768	endosome
1.63	5.26e-04	GO:0031410	cytoplasmic vesicle
1.79	6.58e-04	GO:0005730	nucleolus
1.66	8.58e-04	GO:0042175	nuclear membrane-endoplasmic reticulum network
1.59	1.25e-03	GO:0031982	vesicle
1.62	1.28e-03	GO:0016023	cytoplasmic membrane-bounded vesicle
2.55	1.62e-03	GO:0005681	spliceosomal complex
1.52	1.82e-03	GO:0005794	Golgi apparatus
3.62	1.94e-03	GO:0005798	Golgi-associated vesicle
1.64	2.02e-03	GO:0005789	endoplasmic reticulum membrane
1.59	2.79e-03	GO:0031988	membrane-bounded vesicle
1.67	2.84e-03	GO:0044431	Golgi apparatus part
9.15	3.45e-03	GO:0030127	COPII vesicle coat
1.58	4.01e-03	GO:0044432	endoplasmic reticulum part
6.10	6.73e-03	GO:0012507	ER to Golgi transport vesicle membrane
2.03	8.58e-03	GO:0005635	nuclear envelope
3.42	1.57e-02	GO:0030658	transport vesicle membrane
2.44	1.69e-02	GO:0016607	nuclear speck
3.76	2.04e-02	GO:0030120	vesicle coat
2.01	2.18e-02	GO:0016604	nuclear body
2.56	2.42e-02	GO:0030133	transport vesicle
2.11	2.63e-02	GO:0005819	spindle
2.78	2.66e-02	GO:0071013	catalytic step 2 spliceosome
2.28	2.73e-02	GO:0000793	condensed chromosome
5.14	3.16e-02	GO:0030134	ER to Golgi transport vesicle
1.37	4.05e-02	GO:0005739	mitochondrion
2.61	4.30e-02	GO:0042470	melanosome
2.61	4.30e-02	GO:0048770	pigment granule

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
1.46	9.32e-44	GO:0005515	protein binding
1.17	3.98e-20	GO:0005488	binding
1.58	2.54e-13	GO:0000166	nucleotide binding
2.01	8.13e-12	GO:0003723	RNA binding
1.55	2.96e-09	GO:0017076	purine nucleotide binding
1.54	5.21e-09	GO:0032553	ribonucleotide binding
1.54	5.21e-09	GO:0032555	purine ribonucleotide binding
1.55	5.51e-09	GO:0035639	purine ribonucleoside triphosphate binding
1.81	4.59e-07	GO:0016462	pyrophosphatase activity
1.80	5.81e-07	GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.79	7.35e-07	GO:0016817	hydrolase activity, acting on acid anhydrides
1.81	9.55e-07	GO:0017111	nucleoside-triphosphatase activity
1.23	9.82e-06	GO:0003824	catalytic activity
1.31	2.07e-05	GO:0003676	nucleic acid binding
1.48	2.76e-05	GO:0030554	adenyl nucleotide binding
1.47	5.02e-05	GO:0032559	adenyl ribonucleotide binding
1.47	7.57e-05	GO:0005524	ATP binding
2.37	1.65e-04	GO:0003924	GTPase activity
2.12	3.04e-03	GO:0019787	small conjugating protein ligase activity
1.59	4.32e-03	GO:0019899	enzyme binding
1.84	7.39e-03	GO:0005525	GTP binding
1.94	7.72e-03	GO:0016879	ligase activity, forming carbon-nitrogen bonds
1.96	1.29e-02	GO:0016881	acid-amino acid ligase activity
1.73	1.42e-02	GO:0019904	protein domain specific binding
2.86	1.55e-02	GO:0008135	translation factor activity, nucleic acid binding
1.79	1.77e-02	GO:0019001	guanyl nucleotide binding
1.79	1.77e-02	GO:0032561	guanyl ribonucleotide binding
1.69	2.43e-02	GO:0016874	ligase activity
2.02	2.56e-02	GO:0004842	ubiquitin-protein ligase activity
2.48	2.62e-02	GO:0051082	unfolded protein binding
3.76	2.92e-02	GO:0019783	small conjugating protein-specific protease activity