Motif ID: CRX.p2

Z-value: 0.821


Transcription factors associated with CRX.p2:

Gene SymbolEntrez IDGene Name
CRX 1406 cone-rod homeobox

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
CRXchr19_+_48325098-0.091.7e-01Click!


Activity profile for motif CRX.p2.

activity profile for motif CRX.p2


Sorted Z-values histogram for motif CRX.p2

Sorted Z-values for motif CRX.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of CRX.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_47655603 8.089 PDZK1IP1
PDZK1 interacting protein 1
chr1_-_47655723 7.557 NM_005764
PDZK1IP1
PDZK1 interacting protein 1
chr9_-_75567915 7.123 ALDH1A1
aldehyde dehydrogenase 1 family, member A1
chr8_+_86376130 6.338 NM_000067
CA2
carbonic anhydrase II
chr12_-_89746244 5.581 NM_001946
NM_022652
DUSP6

dual specificity phosphatase 6

chr14_-_61748510 5.166 NM_001017970
TMEM30B
transmembrane protein 30B
chr4_+_88896868 4.980 SPP1
secreted phosphoprotein 1
chr4_+_88896838 4.925 SPP1
secreted phosphoprotein 1
chr4_+_88896899 4.819 SPP1
secreted phosphoprotein 1
chr12_-_89746238 4.777 DUSP6
dual specificity phosphatase 6
chr2_-_20251788 4.695 NM_014713
LAPTM4A
lysosomal protein transmembrane 4 alpha
chr17_-_39092714 4.465 KRT23
keratin 23 (histone deacetylase inducible)
chr17_+_68100994 4.403 NM_170742
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr14_-_61747956 4.398 TMEM30B
transmembrane protein 30B
chr3_+_149192367 4.377 NM_004617
TM4SF4
transmembrane 4 L six family member 4
chr16_+_31539202 4.150 NM_016633
AHSP
alpha hemoglobin stabilizing protein
chr8_-_80993009 3.847 NM_001025252
TPD52
tumor protein D52
chr21_-_43187265 3.811 RIPK4
receptor-interacting serine-threonine kinase 4
chr3_+_122044010 3.618 NM_005213
CSTA
cystatin A (stefin A)
chr9_-_104198045 3.555 NM_000035
ALDOB
aldolase B, fructose-bisphosphate
chr1_+_153330329 3.407 NM_002965
S100A9
S100 calcium binding protein A9
chr4_+_25658085 3.378 NM_001177999
SLC34A2
solute carrier family 34 (sodium phosphate), member 2
chr18_+_3453771 3.342 NM_173211
TGIF1
TGFB-induced factor homeobox 1
chr12_-_89745997 3.331 DUSP6
dual specificity phosphatase 6
chr2_-_96947640 3.282 SNRNP200
small nuclear ribonucleoprotein 200kDa (U5)
chr6_-_31704272 3.278 CLIC1
chloride intracellular channel 1
chrX_-_131573638 3.254 NM_018388
NM_133486
MBNL3

muscleblind-like 3 (Drosophila)

chr9_-_112191105 3.218 NM_001145371
NM_001145372
PTPN3

protein tyrosine phosphatase, non-receptor type 3

chr6_+_32407618 3.199 NM_019111
HLA-DRA
major histocompatibility complex, class II, DR alpha
chr15_+_80364902 3.148 NM_001242915
NM_001242916
ZFAND6

zinc finger, AN1-type domain 6

chr2_-_183387063 3.144 NM_005019
NM_001003683
PDE1A

phosphodiesterase 1A, calmodulin-dependent

chr6_-_31704281 3.128 CLIC1
chloride intracellular channel 1
chr7_+_115863004 3.126 NM_152829
TES
testis derived transcript (3 LIM domains)
chr4_+_74281884 3.113 ALB
albumin
chr2_+_234590583 3.108 NM_019077
UGT1A7
UDP glucuronosyltransferase 1 family, polypeptide A7
chr3_-_150320949 2.994 SERP1
stress-associated endoplasmic reticulum protein 1
chr1_+_212475147 2.990 NM_001199756
PPP2R5A
protein phosphatase 2, regulatory subunit B', alpha
chr1_+_22328148 2.957 NM_005747
CELA3A
chymotrypsin-like elastase family, member 3A
chr2_-_89513056 2.917 IGKC
immunoglobulin kappa constant
chr1_-_202927699 2.914 NM_001127687
ADIPOR1
adiponectin receptor 1
chr6_-_31704287 2.850 CLIC1
chloride intracellular channel 1
chr14_+_23341360 2.843 LRP10
low density lipoprotein receptor-related protein 10
chr12_-_53012332 2.834 NM_175068
KRT73
keratin 73
chr4_-_57976355 2.818 IGFBP7
insulin-like growth factor binding protein 7
chr4_-_69886112 2.790 NM_001075
NM_001144767
UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr17_+_78518742 2.750 RPTOR
regulatory associated protein of MTOR, complex 1
chr6_-_31704304 2.693 CLIC1
chloride intracellular channel 1
chrX_+_129139163 2.680 NM_021946
BCORL1
BCL6 corepressor-like 1
chr9_+_97521930 2.622 NM_001193329
C9orf3
chromosome 9 open reading frame 3
chr6_-_31704318 2.591 NM_001288
CLIC1
chloride intracellular channel 1
chr9_-_86584079 2.575 HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr16_-_20338808 2.561 NM_001007240
NM_001007241
NM_001007242
NM_001502
GP2



glycoprotein 2 (zymogen granule membrane)



chr4_+_74269971 2.532 NM_000477
ALB
albumin
chr11_-_118900078 2.473 NM_001164280
SLC37A4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
chr2_+_3627725 2.470 RPS7
ribosomal protein S7
chr2_-_89619820 2.464 IGKC
immunoglobulin kappa constant
chrX_+_119738542 2.459 NM_001137554
MCTS1
malignant T cell amplified sequence 1
chr5_-_150467220 2.426 NM_001252390
TNIP1
TNFAIP3 interacting protein 1
chr10_-_126849556 2.401 NM_001083914
CTBP2
C-terminal binding protein 2
chr7_+_80275634 2.339 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chr2_-_89292396 2.338 IGKC
immunoglobulin kappa constant
chr15_-_43513024 2.311 EPB42
erythrocyte membrane protein band 4.2
chr11_+_69467210 2.252 CCND1
cyclin D1
chr19_-_51530781 2.228 NM_144947
KLK11
kallikrein-related peptidase 11
chr22_+_23213671 2.225 IGLV4-3
immunoglobulin lambda variable 4-3
chr10_+_5005685 2.173 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr6_+_16143281 2.171 MYLIP
myosin regulatory light chain interacting protein
chr12_+_7942025 2.162 NANOG
Nanog homeobox
chr1_+_207277577 2.156 NM_000715
C4BPA
complement component 4 binding protein, alpha
chr2_+_85804724 2.114 VAMP8
vesicle-associated membrane protein 8 (endobrevin)
chr10_+_123754141 2.107 TACC2
transforming, acidic coiled-coil containing protein 2
chr20_+_4702499 2.105 NM_012409
PRND
prion protein 2 (dublet)
chr17_+_52978022 2.056 NM_005486
TOM1L1
target of myb1 (chicken)-like 1
chr22_+_22758538 2.056


chr21_+_39628869 2.039 NM_170736
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr10_+_124320180 2.002 NM_004406
NM_007329
NM_017579
DMBT1


deleted in malignant brain tumors 1


chr2_+_108994366 2.000 NM_006588
SULT1C4
sulfotransferase family, cytosolic, 1C, member 4
chr2_+_37571752 1.989 NM_012413
QPCT
glutaminyl-peptide cyclotransferase
chr9_+_36190885 1.979 CLTA
clathrin, light chain A
chr13_+_73633097 1.977 NM_001730
KLF5
Kruppel-like factor 5 (intestinal)
chr11_-_59950498 1.977 NM_022349
NM_152851
MS4A6A

membrane-spanning 4-domains, subfamily A, member 6A

chr4_-_140060601 1.971 NM_201999
ELF2
E74-like factor 2 (ets domain transcription factor)
chr9_+_134000939 1.953 NM_005085
NUP214
nucleoporin 214kDa
chr21_+_39628663 1.953 NM_002243
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr4_-_155533800 1.934 FGG
fibrinogen gamma chain
chr16_-_28414940 1.923 EIF3C
eukaryotic translation initiation factor 3, subunit C
chr2_+_102608305 1.907 NM_004633
IL1R2
interleukin 1 receptor, type II
chr10_-_98336445 1.900 TM9SF3
transmembrane 9 superfamily member 3
chr22_-_37975937 1.887 NM_006498
LGALS2
lectin, galactoside-binding, soluble, 2
chr4_-_186877413 1.881 SORBS2
sorbin and SH3 domain containing 2
chr9_+_36190852 1.869 NM_001076677
NM_001184760
NM_001184761
NM_001184762
NM_001833
NM_007096
CLTA





clathrin, light chain A





chr6_+_4890225 1.799 NM_001143971
CDYL
chromodomain protein, Y-like
chr4_+_88896801 1.783 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
SPP1




secreted phosphoprotein 1




chr4_-_155533757 1.773 FGG
fibrinogen gamma chain
chr10_-_126716452 1.763 NM_022802
CTBP2
C-terminal binding protein 2
chr20_+_44098392 1.758 NM_006103
WFDC2
WAP four-disulfide core domain 2
chr1_-_110950489 1.750 NM_006402
HBXIP
hepatitis B virus x interacting protein
chr4_+_71296208 1.741 NM_001145006
MUC7
mucin 7, secreted
chr1_-_202927269 1.736 ADIPOR1
adiponectin receptor 1
chr6_+_7107799 1.734 NM_001168344
RREB1
ras responsive element binding protein 1
chr2_+_234580504 1.733 NM_021027
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr3_-_158390266 1.724 NM_020169
LXN
latexin
chr2_+_234545099 1.716 NM_019075
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr1_-_202927460 1.715 NM_015999
ADIPOR1
adiponectin receptor 1
chr1_-_165667539 1.696 ALDH9A1
aldehyde dehydrogenase 9 family, member A1
chr6_-_133078894 1.687 NM_001242350
NM_004665
VNN2

vanin 2

chrX_+_119737743 1.678 NM_014060
MCTS1
malignant T cell amplified sequence 1
chr18_+_29171729 1.656 NM_000371
TTR
transthyretin
chr8_-_28347733 1.651 NM_172366
FBXO16
ZNF395
F-box protein 16
zinc finger protein 395
chr16_+_28722781 1.637 NM_001099661
NM_001037808
NM_003752
EIF3CL
EIF3C

eukaryotic translation initiation factor 3, subunit C-like
eukaryotic translation initiation factor 3, subunit C

chr3_+_184033936 1.632 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr19_-_12997956 1.628 NM_006563
KLF1
Kruppel-like factor 1 (erythroid)
chr1_+_45477801 1.617 NM_000374
UROD
uroporphyrinogen decarboxylase
chr21_-_34852282 1.611 NM_006134
TMEM50B
transmembrane protein 50B
chr4_+_70146216 1.606 NM_001207004
NM_053039
UGT2B28

UDP glucuronosyltransferase 2 family, polypeptide B28

chrX_-_11284094 1.597 NM_013423
ARHGAP6
Rho GTPase activating protein 6
chr11_+_71903172 1.596 NM_016729
FOLR1
folate receptor 1 (adult)
chr10_-_14372807 1.587 NM_018027
FRMD4A
FERM domain containing 4A
chr1_+_151739130 1.584 NM_016178
OAZ3
ornithine decarboxylase antizyme 3
chr1_-_161601752 1.579 NM_000570
FCGR3B
Fc fragment of IgG, low affinity IIIb, receptor (CD16b)
chr18_+_33234532 1.576 NM_020474
GALNT1
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)
chr17_+_7210929 1.569 EIF5A
eukaryotic translation initiation factor 5A
chr2_-_163008913 1.559 NM_002054
GCG
glucagon
chr16_-_68033355 1.551 NM_022355
DPEP2
dipeptidase 2
chr4_-_186732047 1.550 NM_001145672
SORBS2
sorbin and SH3 domain containing 2
chr1_-_202927439 1.534 ADIPOR1
adiponectin receptor 1
chr22_+_22569155 1.530


chr2_-_190927321 1.519 NM_005259
MSTN
myostatin
chr17_-_79881304 1.515 NM_032711
MAFG
v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)
chr8_-_67090690 1.514 NM_000756
CRH
corticotropin releasing hormone
chr7_+_116660291 1.512 ST7
suppression of tumorigenicity 7
chr9_+_36190928 1.482 CLTA
clathrin, light chain A
chr4_-_88312221 1.480 HSD17B11
hydroxysteroid (17-beta) dehydrogenase 11
chr22_+_44395090 1.462 NM_001003828
PARVB
parvin, beta
chr10_-_5045967 1.446 NM_001135241
AKR1C2
aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr1_-_202927410 1.441 ADIPOR1
adiponectin receptor 1
chr10_-_98321823 1.425 TM9SF3
transmembrane 9 superfamily member 3
chr16_+_29690464 1.415 QPRT
quinolinate phosphoribosyltransferase
chr4_+_69962191 1.414 NM_001074
UGT2B7
UDP glucuronosyltransferase 2 family, polypeptide B7
chr15_+_58430394 1.408 NM_020980
AQP9
aquaporin 9
chr4_-_155533882 1.392 NM_000509
NM_021870
FGG

fibrinogen gamma chain

chr20_-_44538654 1.380 PLTP
phospholipid transfer protein
chr22_-_43355886 1.375 NM_001184971
PACSIN2
protein kinase C and casein kinase substrate in neurons 2
chr12_+_50135292 1.358 NM_003217
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr1_+_180897572 1.352


chr8_-_17752847 1.347 NM_147203
NM_201553
NM_004467
NM_201552
FGL1



fibrinogen-like 1



chr1_+_45477888 1.342 UROD
uroporphyrinogen decarboxylase
chr11_-_36619776 1.333 NM_000536
NM_001243785
NM_001243786
RAG2


recombination activating gene 2


chr2_-_26101301 1.333 NM_018263
ASXL2
additional sex combs like 2 (Drosophila)
chr7_+_80231503 1.332 NM_001001547
CD36
CD36 molecule (thrombospondin receptor)
chr12_+_56915587 1.331 NM_002898
RBMS2
RNA binding motif, single stranded interacting protein 2
chr6_-_144385647 1.319 NM_001080951
NM_001080955
PLAGL1

pleiomorphic adenoma gene-like 1

chr4_-_72669757 1.318 NM_001204307
GC
group-specific component (vitamin D binding protein)
chr4_-_71532341 1.306 NM_144646
IGJ
immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
chrX_-_24690740 1.300 NM_001163264
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr6_+_31913708 1.300 NM_001710
CFB
complement factor B
chr16_+_29690328 1.299 NM_014298
QPRT
quinolinate phosphoribosyltransferase
chr18_+_29027731 1.296 NM_001944
DSG3
desmoglein 3
chr12_-_91398757 1.285 NM_004950
EPYC
epiphycan
chr10_+_5005453 1.284 NM_001353
AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr9_+_12693385 1.283 NM_000550
TYRP1
tyrosinase-related protein 1
chr11_+_7618416 1.282 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr10_-_124605690 1.281 NM_022034
CUZD1
CUB and zona pellucida-like domains 1
chr1_-_158656487 1.274 NM_003126
SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chrX_+_153533408 1.270 NM_001145934
TKTL1
transketolase-like 1
chr15_-_43513234 1.267 NM_000119
NM_001114134
EPB42

erythrocyte membrane protein band 4.2

chr4_-_155533850 1.267 FGG
fibrinogen gamma chain
chr2_-_26101329 1.258 ASXL2
additional sex combs like 2 (Drosophila)
chr2_-_73869493 1.243 NM_003960
NAT8
N-acetyltransferase 8 (GCN5-related, putative)
chr11_+_129991582 1.234 APLP2
amyloid beta (A4) precursor-like protein 2
chr6_+_31913763 1.230 CFB
complement factor B
chr7_-_150329735 1.226 NM_001244071
NM_001244072
NM_024711
GIMAP6


GTPase, IMAP family member 6


chr11_-_1629614 1.223 NM_001012708
KRTAP5-3
keratin associated protein 5-3
chr12_-_13248581 1.222 NM_001206843
NM_001206845
NM_031289
NM_153823
GSG1



germ cell associated 1



chr2_+_228356287 1.216 AGFG1
ArfGAP with FG repeats 1
chr1_-_182354649 1.210 GLUL
glutamate-ammonia ligase
chr1_+_26872306 1.192 RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr1_-_108231122 1.176 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr9_+_117349993 1.175 NM_004888
ATP6V1G1
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
chr3_+_149192479 1.156 TM4SF4
transmembrane 4 L six family member 4
chr1_-_1310553 1.155 NM_001127230
NM_001127229
AURKAIP1

aurora kinase A interacting protein 1

chr4_-_186877869 1.152 NM_021069
SORBS2
sorbin and SH3 domain containing 2
chr6_+_31553955 1.148 NM_205838
NM_205839
LST1

leukocyte specific transcript 1

chr2_-_88427535 1.148 NM_001443
FABP1
fatty acid binding protein 1, liver
chr10_-_82049178 1.144 NM_000429
MAT1A
methionine adenosyltransferase I, alpha
chr16_-_10674443 1.143 NM_001424
EMP2
epithelial membrane protein 2
chr3_-_10362837 1.143 NM_183352
SEC13
SEC13 homolog (S. cerevisiae)
chr10_-_7682741 1.140 ITIH5
inter-alpha-trypsin inhibitor heavy chain family, member 5
chr12_-_31479120 1.138 NM_001135811
NM_021238
NM_001135812
FAM60A


family with sequence similarity 60, member A


chr2_+_33359607 1.136 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr11_-_59952138 1.136 NM_001247999
NM_152852
MS4A6A

membrane-spanning 4-domains, subfamily A, member 6A

chr9_-_35072545 1.135 VCP
valosin containing protein
chr12_+_21525801 1.135 NM_000415
IAPP
islet amyloid polypeptide
chr3_+_49059490 1.130 NDUFAF3
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, assembly factor 3
chr1_+_104159953 1.122 NM_000699
AMY2A
amylase, alpha 2A (pancreatic)
chr8_+_39771327 1.121 NM_002164
IDO1
indoleamine 2,3-dioxygenase 1
chr17_+_41052813 1.121 NM_000151
G6PC
glucose-6-phosphatase, catalytic subunit
chr12_-_31479084 1.113 FAM60A
family with sequence similarity 60, member A
chr6_-_132910824 1.110 NM_003967
TAAR5
trace amine associated receptor 5
chr9_+_125132823 1.109 PTGS1
prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.16 8.39e-08 GO:0009987 cellular process
1.23 1.11e-05 GO:0008152 metabolic process
1.94 2.28e-04 GO:0006082 organic acid metabolic process
1.65 9.33e-04 GO:0002376 immune system process
1.87 2.02e-03 GO:0019752 carboxylic acid metabolic process
1.87 2.02e-03 GO:0043436 oxoacid metabolic process
1.21 3.59e-03 GO:0044238 primary metabolic process
1.83 4.30e-03 GO:0042180 cellular ketone metabolic process
1.41 1.02e-02 GO:0042221 response to chemical stimulus
2.25 1.04e-02 GO:0032787 monocarboxylic acid metabolic process
1.20 1.17e-02 GO:0050896 response to stimulus
1.27 1.39e-02 GO:0051716 cellular response to stimulus
2.48 1.83e-02 GO:0006631 fatty acid metabolic process
4.49 2.05e-02 GO:0006690 icosanoid metabolic process
2.82 2.18e-02 GO:0042445 hormone metabolic process
1.19 2.48e-02 GO:0044237 cellular metabolic process
1.39 3.04e-02 GO:0065008 regulation of biological quality
4.23 3.95e-02 GO:0033559 unsaturated fatty acid metabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.44 5.84e-04 GO:0005576 extracellular region
1.65 8.36e-04 GO:0044421 extracellular region part
1.75 9.93e-04 GO:0005615 extracellular space
1.19 4.57e-03 GO:0044444 cytoplasmic part
1.37 9.25e-03 GO:0044459 plasma membrane part
1.63 1.33e-02 GO:0005626 insoluble fraction
1.14 1.61e-02 GO:0005737 cytoplasm
1.52 1.99e-02 GO:0000267 cell fraction
1.34 4.48e-02 GO:0005829 cytosol
1.58 4.88e-02 GO:0005624 membrane fraction

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.17 3.76e-03 GO:0005515 protein binding
1.98 5.25e-03 GO:0008289 lipid binding
4.00 1.78e-02 GO:0042562 hormone binding
14.67 2.36e-02 GO:0032052 bile acid binding
5.24 4.95e-02 GO:0016229 steroid dehydrogenase activity