Motif ID: E2F1..5.p2

Z-value: 7.086


Transcription factors associated with E2F1..5.p2:

Gene SymbolEntrez IDGene Name
E2F1 1869 E2F transcription factor 1
E2F2 1870 E2F transcription factor 2
E2F3 1871 E2F transcription factor 3
E2F4 1874 E2F transcription factor 4, p107/p130-binding
E2F5 1875 E2F transcription factor 5, p130-binding

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
E2F1chr20_-_322740700.761.1e-42Click!
E2F3chr6_+_204020400.693.2e-32Click!
E2F2chr1_-_23857284-0.505.6e-15Click!
E2F5chr8_+_860896180.425.8e-11Click!
E2F4chr16_+_672260700.186.5e-03Click!


Activity profile for motif E2F1..5.p2.

activity profile for motif E2F1..5.p2


Sorted Z-values histogram for motif E2F1..5.p2

Sorted Z-values for motif E2F1..5.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of E2F1..5.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_136633934 271.584 MCM6
minichromosome maintenance complex component 6
chr6_-_52149541 265.258 NM_002388
 MCM3
minichromosome maintenance complex component 3
chr2_-_136634002 263.986 NM_005915
 MCM6
minichromosome maintenance complex component 6
chr2_+_10262853 242.470 NM_001034
 RRM2
ribonucleotide reductase M2
chr6_-_52149516 237.550 MCM3
minichromosome maintenance complex component 3
chr6_-_52149472 228.893 MCM3
minichromosome maintenance complex component 3
chr10_+_62538250 226.166 CDK1
cyclin-dependent kinase 1
chr2_+_10262694 223.015 NM_001165931
 RRM2
ribonucleotide reductase M2
chr10_+_62538088 211.912 NM_001170406
NM_001170407
NM_001786
NM_033379
 CDK1



cyclin-dependent kinase 1



chr8_-_124408665 205.731 ATAD2
ATPase family, AAA domain containing 2
chr22_+_20105145 203.658 RANBP1
RAN binding protein 1
chr7_-_99698993 203.573 MCM7
minichromosome maintenance complex component 7
chr7_-_99699030 203.412 MCM7
minichromosome maintenance complex component 7
chrX_-_53449548 201.544 SMC1A
structural maintenance of chromosomes 1A
chr8_-_124408688 200.968 NM_014109
 ATAD2
ATPase family, AAA domain containing 2
chr20_-_5100443 200.759 NM_182649
 PCNA
proliferating cell nuclear antigen
chr22_+_20105076 196.971 RANBP1
RAN binding protein 1
chr22_+_20105095 196.736 RANBP1
RAN binding protein 1
chr15_-_64673569 196.103 NM_001029989
NM_014736
 KIAA0101

KIAA0101

chr22_+_35796104 189.616 NM_006739
 MCM5
minichromosome maintenance complex component 5

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 186 entries
enrichment   p-value GO term description
18.70 1.89e-02 GO:0019985 translesion synthesis
14.03 1.55e-06 GO:0071897 DNA biosynthetic process
12.47 3.94e-03 GO:0002566 somatic diversification of immune receptors via somatic mutation
12.47 3.94e-03 GO:0016446 somatic hypermutation of immunoglobulin genes
11.69 4.94e-02 GO:0000731 DNA synthesis involved in DNA repair
11.69 4.94e-02 GO:0045910 negative regulation of DNA recombination
11.22 9.41e-03 GO:0006301 postreplication repair
11.05 2.05e-08 GO:0006270 DNA-dependent DNA replication initiation
10.69 1.58e-10 GO:0006271 DNA strand elongation involved in DNA replication
10.29 2.47e-06 GO:0000083 regulation of transcription involved in G1/S phase of mitotic cell cycle
9.97 6.83e-10 GO:0022616 DNA strand elongation
9.84 2.57e-05 GO:0032201 telomere maintenance via semi-conservative replication
9.35 4.89e-05 GO:0000722 telomere maintenance via recombination
9.35 2.56e-04 GO:0007062 sister chromatid cohesion
9.35 1.34e-03 GO:0006297 nucleotide-excision repair, DNA gap filling
8.42 8.01e-04 GO:0006298 mismatch repair
8.42 8.01e-04 GO:2000104 negative regulation of DNA-dependent DNA replication
8.13 2.61e-04 GO:0090329 regulation of DNA-dependent DNA replication
8.02 1.33e-03 GO:0002562 somatic diversification of immune receptors via germline recombination within a single locus
8.02 1.33e-03 GO:0016444 somatic cell DNA recombination

Gene overrepresentation in compartment category:

Showing 1 to 20 of 69 entries
enrichment   p-value GO term description
14.03 2.45e-04 GO:0042555 MCM complex
12.47 7.01e-04 GO:0035098 ESC/E(Z) complex
11.43 9.20e-08 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
9.35 6.70e-03 GO:0032300 mismatch repair complex
8.86 8.22e-05 GO:0031519 PcG protein complex
7.08 1.16e-06 GO:0005657 replication fork
5.95 4.28e-02 GO:0043596 nuclear replication fork
5.68 6.64e-10 GO:0071013 catalytic step 2 spliceosome
5.29 2.94e-05 GO:0034708 methyltransferase complex
5.29 2.94e-05 GO:0035097 histone methyltransferase complex
4.89 9.38e-13 GO:0005681 spliceosomal complex
4.36 3.90e-16 GO:0000228 nuclear chromosome
4.33 1.96e-05 GO:0000790 nuclear chromatin
4.29 2.61e-12 GO:0044454 nuclear chromosome part
4.25 3.60e-02 GO:0000792 heterochromatin
4.13 9.80e-04 GO:0034399 nuclear periphery
4.07 1.19e-03 GO:0005643 nuclear pore
4.01 1.35e-02 GO:0016605 PML body
3.92 8.21e-03 GO:0016363 nuclear matrix
3.76 8.08e-12 GO:0016604 nuclear body

Gene overrepresentation in function category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
14.96 2.18e-02 GO:0019238 cyclohydrolase activity
9.35 1.71e-03 GO:0030983 mismatched DNA binding
7.19 2.52e-04 GO:0003887 DNA-directed DNA polymerase activity
7.09 7.85e-05 GO:0034061 DNA polymerase activity
5.58 2.22e-06 GO:0003697 single-stranded DNA binding
5.05 1.18e-05 GO:0008094 DNA-dependent ATPase activity
4.68 3.40e-03 GO:0003684 damaged DNA binding
4.68 2.03e-02 GO:0003678 DNA helicase activity
3.89 1.43e-03 GO:0003729 mRNA binding
3.54 1.84e-02 GO:0042393 histone binding
3.42 1.53e-07 GO:0003682 chromatin binding
3.03 2.97e-05 GO:0043566 structure-specific DNA binding
2.57 5.54e-17 GO:0003723 RNA binding
2.06 1.50e-02 GO:0016887 ATPase activity
1.73 6.24e-13 GO:0000166 nucleotide binding
1.72 6.46e-03 GO:0017111 nucleoside-triphosphatase activity
1.71 6.02e-03 GO:0016462 pyrophosphatase activity
1.71 6.87e-03 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.70 8.62e-19 GO:0003676 nucleic acid binding
1.70 7.83e-03 GO:0016817 hydrolase activity, acting on acid anhydrides