Motif ID: EGR1..3.p2

Z-value: 2.006


Transcription factors associated with EGR1..3.p2:

Gene SymbolEntrez IDGene Name
EGR1 1958 early growth response 1
EGR2 1959 early growth response 2 (Krox-20 homolog, Drosophila)
EGR3 1960 early growth response 3

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EGR3chr8_-_22550057,
chr8_-_22549901		0.529.1e-17Click!
EGR1chr5_+_1378011780.236.3e-04Click!
EGR2chr10_-_645789260.111.1e-01Click!


Activity profile for motif EGR1..3.p2.

activity profile for motif EGR1..3.p2


Sorted Z-values histogram for motif EGR1..3.p2

Sorted Z-values for motif EGR1..3.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EGR1..3.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_124609775 43.717 NM_001126181
NM_006176
 NRGN

neurogranin (protein kinase C substrate, RC3)

chr11_+_124609841 35.086 NRGN
neurogranin (protein kinase C substrate, RC3)
chr6_-_46459010 34.654 NM_001251974
 RCAN2
regulator of calcineurin 2
chr1_+_6845381 33.173 NM_001195563
NM_001242701
NM_015215
 CAMTA1


calmodulin binding transcription activator 1


chrX_-_47479229 28.142 NM_006950
NM_133499
 SYN1

synapsin I

chr10_-_75255718 27.699 PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr12_+_79258517 24.640 SYT1
synaptotagmin I
chr20_-_50384861 24.146 ATP9A
ATPase, class II, type 9A
chr12_+_79258588 23.089 SYT1
synaptotagmin I
chr11_-_236833 23.088 SIRT3
sirtuin 3
chr4_-_102267952 23.060 PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr14_+_29236882 22.683 FOXG1
forkhead box G1
chr20_-_62130390 22.563 NM_001958
 EEF1A2
eukaryotic translation elongation factor 1 alpha 2
chr7_-_44365019 21.273 NM_001220
NM_172078
NM_172079
NM_172080
NM_172081
NM_172082
NM_172083
NM_172084
 CAMK2B







calcium/calmodulin-dependent protein kinase II beta







chr12_+_79258794 20.671 SYT1
synaptotagmin I
chr7_+_55955129 20.080 ZNF713
zinc finger protein 713
chr7_+_64498643 19.747 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr16_-_19896105 19.267 NM_016235
 GPRC5B
G protein-coupled receptor, family C, group 5, member B
chr7_-_51384458 18.727 NM_015198
 COBL
cordon-bleu homolog (mouse)
chr20_+_10199455 18.121 NM_003081
NM_130811
 SNAP25

synaptosomal-associated protein, 25kDa


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 226 entries
enrichment   p-value GO term description
4.54 9.96e-04 GO:0014047 glutamate secretion
3.69 1.46e-02 GO:0018107 peptidyl-threonine phosphorylation
3.19 4.11e-03 GO:0048489 synaptic vesicle transport
2.88 8.43e-06 GO:0007269 neurotransmitter secretion
2.45 8.79e-05 GO:0001505 regulation of neurotransmitter levels
2.41 8.79e-06 GO:0003001 generation of a signal involved in cell-cell signaling
2.41 8.79e-06 GO:0023061 signal release
2.37 1.79e-05 GO:0050796 regulation of insulin secretion
2.35 7.29e-06 GO:0002791 regulation of peptide secretion
2.35 7.29e-06 GO:0090087 regulation of peptide transport
2.35 1.12e-02 GO:0048638 regulation of developmental growth
2.34 1.24e-05 GO:0090276 regulation of peptide hormone secretion
2.30 2.68e-02 GO:0050770 regulation of axonogenesis
2.28 2.90e-04 GO:0006836 neurotransmitter transport
2.21 3.15e-03 GO:0048754 branching morphogenesis of a tube
2.18 4.57e-02 GO:0050769 positive regulation of neurogenesis
2.15 4.49e-05 GO:0046883 regulation of hormone secretion
2.08 5.56e-03 GO:0050804 regulation of synaptic transmission
2.08 1.76e-02 GO:0010720 positive regulation of cell development
2.07 3.51e-18 GO:0019226 transmission of nerve impulse

Gene overrepresentation in compartment category:

Showing 1 to 20 of 55 entries
enrichment   p-value GO term description
2.78 1.65e-04 GO:0005905 coated pit
2.29 4.92e-05 GO:0019717 synaptosome
2.27 5.91e-04 GO:0030665 clathrin coated vesicle membrane
2.24 3.45e-03 GO:0033267 axon part
2.22 1.11e-03 GO:0008021 synaptic vesicle
2.22 1.11e-03 GO:0008076 voltage-gated potassium channel complex
2.22 1.11e-03 GO:0034705 potassium channel complex
2.04 1.64e-02 GO:0001726 ruffle
2.01 2.88e-05 GO:0030136 clathrin-coated vesicle
1.99 4.77e-14 GO:0045202 synapse
1.98 7.21e-04 GO:0034703 cation channel complex
1.97 1.15e-09 GO:0044456 synapse part
1.97 1.76e-02 GO:0019898 extrinsic to membrane
1.84 6.75e-04 GO:0031252 cell leading edge
1.80 1.21e-02 GO:0045211 postsynaptic membrane
1.77 4.29e-03 GO:0030424 axon
1.76 1.96e-03 GO:0030135 coated vesicle
1.73 1.97e-07 GO:0043005 neuron projection
1.72 8.12e-03 GO:0030425 dendrite
1.64 2.55e-02 GO:0034702 ion channel complex

Gene overrepresentation in function category:

Showing 1 to 20 of 61 entries
enrichment   p-value GO term description
5.68 3.10e-02 GO:0019789 SUMO ligase activity
4.65 6.61e-03 GO:0030742 GTP-dependent protein binding
2.52 2.85e-02 GO:0046332 SMAD binding
2.09 5.46e-03 GO:0005249 voltage-gated potassium channel activity
2.00 4.04e-04 GO:0022843 voltage-gated cation channel activity
2.00 4.88e-02 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.99 2.47e-02 GO:0005057 receptor signaling protein activity
1.96 1.31e-03 GO:0005516 calmodulin binding
1.94 1.15e-05 GO:0000975 regulatory region DNA binding
1.94 1.15e-05 GO:0001067 regulatory region nucleic acid binding
1.94 1.15e-05 GO:0044212 transcription regulatory region DNA binding
1.94 1.60e-02 GO:0015631 tubulin binding
1.90 6.96e-05 GO:0010843 promoter binding
1.89 1.31e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.85 3.77e-02 GO:0005267 potassium channel activity
1.83 1.55e-06 GO:0008134 transcription factor binding
1.80 2.06e-10 GO:0030695 GTPase regulator activity
1.79 1.86e-10 GO:0060589 nucleoside-triphosphatase regulator activity
1.77 1.43e-05 GO:0005083 small GTPase regulator activity
1.73 4.41e-04 GO:0005096 GTPase activator activity