Motif ID: EN1,2.p2

Z-value: 2.005


Transcription factors associated with EN1,2.p2:

Gene SymbolEntrez IDGene Name
EN1 2019 engrailed homeobox 1
EN2 2020 engrailed homeobox 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
EN2chr7_+_1552507050.426.7e-11Click!
EN1chr2_-_1196057580.091.8e-01Click!


Activity profile for motif EN1,2.p2.

activity profile for motif EN1,2.p2


Sorted Z-values histogram for motif EN1,2.p2

Sorted Z-values for motif EN1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EN1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_139872014 54.739 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr9_+_139871954 52.893 NM_000954
 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr11_-_5248180 52.413 NM_000518
 HBB
hemoglobin, beta
chr14_-_21271002 46.105 NM_002933
NM_198234
NM_198235
 RNASE1


ribonuclease, RNase A family, 1 (pancreatic)


chr14_-_21270537 37.932 NM_198232
 RNASE1
ribonuclease, RNase A family, 1 (pancreatic)
chr12_+_21679190 27.923 NM_030572
 C12orf39
chromosome 12 open reading frame 39
chr8_-_87755880 27.037 NM_019098
 CNGB3
cyclic nucleotide gated channel beta 3
chr5_+_40909558 25.191 NM_000587
 C7
complement component 7
chr3_-_38835500 24.054 NM_006514
 SCN10A
sodium channel, voltage-gated, type X, alpha subunit
chr20_+_34556528 22.600 NM_001207076
NM_080834
 C20orf152

chromosome 20 open reading frame 152

chr1_-_163172624 22.187 NM_001195303
 RGS5
regulator of G-protein signaling 5
chr2_+_103035148 22.135 NM_003853
 IL18RAP
interleukin 18 receptor accessory protein
chr14_-_53620032 21.985 NM_001160147
NM_001160148
NM_030637
 DDHD1


DDHD domain containing 1


chr5_+_40909617 21.924 C7
complement component 7
chr16_+_31085751 21.876 ZNF646
zinc finger protein 646
chr6_-_32013806 20.334 NM_032470
 TNXB
tenascin XB
chr17_+_4046417 20.074 NM_144611
 CYB5D2
cytochrome b5 domain containing 2
chr4_+_74281884 19.996 ALB
albumin
chr15_-_74659926 19.902 NM_000781
 CYP11A1
cytochrome P450, family 11, subfamily A, polypeptide 1
chr16_+_31085722 19.889 NM_014699
 ZNF646
zinc finger protein 646

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 64 entries
enrichment   p-value GO term description
7.67 3.17e-02 GO:0015721 bile acid and bile salt transport
4.66 1.21e-07 GO:0007586 digestion
4.03 1.43e-02 GO:0072376 protein activation cascade
3.96 1.75e-02 GO:0031294 lymphocyte costimulation
3.96 1.75e-02 GO:0031295 T cell costimulation
3.96 1.75e-02 GO:0060333 interferon-gamma-mediated signaling pathway
3.87 1.14e-02 GO:0071346 cellular response to interferon-gamma
3.73 4.66e-03 GO:0006959 humoral immune response
3.51 2.12e-02 GO:0034341 response to interferon-gamma
2.96 1.13e-04 GO:0019221 cytokine-mediated signaling pathway
2.92 3.39e-05 GO:0071345 cellular response to cytokine stimulus
2.90 1.33e-02 GO:0006805 xenobiotic metabolic process
2.90 1.33e-02 GO:0071466 cellular response to xenobiotic stimulus
2.88 1.51e-02 GO:0009410 response to xenobiotic stimulus
2.72 3.90e-02 GO:0002252 immune effector process
2.70 1.21e-05 GO:0006954 inflammatory response
2.65 7.54e-03 GO:0050867 positive regulation of cell activation
2.64 4.18e-02 GO:0009615 response to virus
2.59 1.68e-02 GO:0002696 positive regulation of leukocyte activation
2.57 4.38e-02 GO:0051251 positive regulation of lymphocyte activation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
8.77 7.84e-03 GO:0042627 chylomicron
7.02 3.66e-02 GO:0034706 sodium channel complex
3.71 4.58e-02 GO:0031983 vesicle lumen
3.18 7.87e-05 GO:0009897 external side of plasma membrane
2.57 9.84e-18 GO:0005615 extracellular space
2.41 1.38e-19 GO:0044421 extracellular region part
2.21 4.30e-18 GO:0005887 integral to plasma membrane
2.17 2.54e-17 GO:0031226 intrinsic to plasma membrane
2.11 6.90e-04 GO:0009986 cell surface
2.04 2.87e-03 GO:0031012 extracellular matrix
2.03 5.01e-24 GO:0005576 extracellular region
2.01 2.26e-02 GO:0005578 proteinaceous extracellular matrix
1.88 2.11e-19 GO:0044459 plasma membrane part
1.72 8.75e-04 GO:0005624 membrane fraction
1.71 7.98e-04 GO:0005626 insoluble fraction
1.68 7.07e-05 GO:0000267 cell fraction
1.49 2.55e-14 GO:0071944 cell periphery
1.49 3.16e-14 GO:0005886 plasma membrane
1.20 4.94e-04 GO:0044425 membrane part
1.20 6.19e-03 GO:0031224 intrinsic to membrane

Gene overrepresentation in function category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
9.57 6.57e-03 GO:0030553 cGMP binding
8.77 1.25e-02 GO:0019002 GMP binding
5.85 1.89e-02 GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
5.61 2.64e-02 GO:0004112 cyclic-nucleotide phosphodiesterase activity
4.58 3.77e-03 GO:0008009 chemokine activity
4.46 8.99e-04 GO:0042562 hormone binding
4.13 1.18e-02 GO:0042379 chemokine receptor binding
3.01 2.16e-02 GO:0005179 hormone activity
2.98 7.77e-06 GO:0005125 cytokine activity
2.73 6.29e-04 GO:0005126 cytokine receptor binding
2.45 2.29e-02 GO:0001664 G-protein-coupled receptor binding
1.98 4.96e-03 GO:0015267 channel activity
1.97 3.72e-09 GO:0005102 receptor binding
1.97 5.29e-03 GO:0022803 passive transmembrane transporter activity
1.72 2.29e-04 GO:0022857 transmembrane transporter activity
1.67 4.73e-04 GO:0022892 substrate-specific transporter activity
1.67 1.38e-02 GO:0015075 ion transmembrane transporter activity
1.64 5.95e-03 GO:0022891 substrate-specific transmembrane transporter activity
1.58 1.28e-03 GO:0005215 transporter activity
1.47 3.46e-02 GO:0004888 transmembrane receptor activity