Motif ID: ESR1.p2

Z-value: 1.511


Transcription factors associated with ESR1.p2:

Gene SymbolEntrez IDGene Name
ESR1 2099 estrogen receptor 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESR1chr6_+_1521284530.101.3e-01Click!


Activity profile for motif ESR1.p2.

activity profile for motif ESR1.p2


Sorted Z-values histogram for motif ESR1.p2

Sorted Z-values for motif ESR1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESR1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_122618098 18.228 ANXA5
annexin A5
chr5_+_150400132 17.435 GPX3
glutathione peroxidase 3 (plasma)
chr4_-_122618129 17.346 ANXA5
annexin A5
chr4_-_122618140 16.964 NM_001154
 ANXA5
annexin A5
chr13_+_110959592 16.813 NM_001846
 COL4A2
collagen, type IV, alpha 2
chr4_-_57976550 16.598 NM_001253835
NM_001553
 IGFBP7

insulin-like growth factor binding protein 7

chr11_+_832965 14.888 CD151
CD151 molecule (Raph blood group)
chr17_-_3571905 13.636 NM_001204698
NM_014604
 TAX1BP3

Tax1 (human T-cell leukemia virus type I) binding protein 3

chr5_+_150399980 12.952 NM_002084
 GPX3
glutathione peroxidase 3 (plasma)
chr12_-_56122124 12.747 CD63
CD63 molecule
chr6_+_7541837 12.692 DSP
desmoplakin
chr11_+_129939792 11.672 APLP2
amyloid beta (A4) precursor-like protein 2
chr5_+_178286913 11.602 NM_058230
 ZNF354B
zinc finger protein 354B
chr17_-_74707000 11.556 NM_001008528
NM_001008529
NM_198530
 MXRA7


matrix-remodelling associated 7


chr7_-_47621635 11.450 TNS3
tensin 3
chr7_-_47621741 11.346 NM_022748
 TNS3
tensin 3
chr17_-_3571819 11.339 TAX1BP3
Tax1 (human T-cell leukemia virus type I) binding protein 3
chr14_+_105941061 11.068 NM_001312
 CRIP2
cysteine-rich protein 2
chr1_-_201476248 10.863 NM_001193570
NM_004078
 CSRP1

cysteine and glycine-rich protein 1

chr1_-_201476241 10.847 CSRP1
cysteine and glycine-rich protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 53 entries
enrichment   p-value GO term description
2.26 5.71e-04 GO:0030029 actin filament-based process
2.24 2.72e-03 GO:0001568 blood vessel development
2.24 3.32e-03 GO:0030334 regulation of cell migration
2.23 1.20e-03 GO:0001944 vasculature development
2.22 4.58e-03 GO:2000145 regulation of cell motility
2.21 8.48e-03 GO:0030036 actin cytoskeleton organization
2.17 3.38e-03 GO:0051270 regulation of cellular component movement
2.08 1.82e-02 GO:0040012 regulation of locomotion
2.00 1.91e-02 GO:0032535 regulation of cellular component size
1.95 1.58e-02 GO:0090066 regulation of anatomical structure size
1.92 1.79e-03 GO:0072358 cardiovascular system development
1.92 1.79e-03 GO:0072359 circulatory system development
1.81 1.26e-02 GO:0044283 small molecule biosynthetic process
1.70 3.79e-02 GO:0042060 wound healing
1.67 3.74e-02 GO:0007167 enzyme linked receptor protein signaling pathway
1.65 4.81e-04 GO:0032879 regulation of localization
1.61 8.28e-04 GO:0010646 regulation of cell communication
1.61 1.54e-02 GO:0051128 regulation of cellular component organization
1.59 1.55e-05 GO:0009966 regulation of signal transduction
1.59 3.13e-05 GO:0035556 intracellular signal transduction

Gene overrepresentation in compartment category:

Showing 1 to 20 of 32 entries
enrichment   p-value GO term description
4.11 3.70e-02 GO:0042641 actomyosin
2.75 3.09e-02 GO:0042470 melanosome
2.75 3.09e-02 GO:0048770 pigment granule
2.61 4.16e-02 GO:0005925 focal adhesion
2.55 5.02e-04 GO:0070161 anchoring junction
2.46 4.81e-03 GO:0005912 adherens junction
2.28 2.74e-05 GO:0015629 actin cytoskeleton
2.22 7.36e-03 GO:0005911 cell-cell junction
1.91 5.21e-03 GO:0048471 perinuclear region of cytoplasm
1.72 1.68e-03 GO:0030054 cell junction
1.70 7.13e-05 GO:0005624 membrane fraction
1.68 9.15e-05 GO:0005626 insoluble fraction
1.57 1.72e-04 GO:0000267 cell fraction
1.50 1.05e-02 GO:0005794 Golgi apparatus
1.48 7.79e-03 GO:0005783 endoplasmic reticulum
1.45 4.54e-04 GO:0005856 cytoskeleton
1.39 3.68e-02 GO:0005739 mitochondrion
1.36 1.63e-03 GO:0005829 cytosol
1.35 2.00e-03 GO:0044459 plasma membrane part
1.33 3.31e-14 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

Showing 1 to 10 of 10 entries
enrichment   p-value GO term description
3.35 8.17e-04 GO:0019199 transmembrane receptor protein kinase activity
3.06 1.11e-02 GO:0005201 extracellular matrix structural constituent
2.67 2.10e-02 GO:0019838 growth factor binding
1.99 4.12e-03 GO:0003779 actin binding
1.90 7.09e-05 GO:0008092 cytoskeletal protein binding
1.75 8.30e-05 GO:0019899 enzyme binding
1.62 4.73e-03 GO:0042802 identical protein binding
1.60 3.00e-02 GO:0046983 protein dimerization activity
1.35 4.76e-23 GO:0005515 protein binding
1.14 1.16e-11 GO:0005488 binding