Motif ID: ESRRA.p2

Z-value: 2.666


Transcription factors associated with ESRRA.p2:

Gene SymbolEntrez IDGene Name
ESRRA 2101 estrogen-related receptor alpha

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ESRRAchr11_+_640730400.274.3e-05Click!


Activity profile for motif ESRRA.p2.

activity profile for motif ESRRA.p2


Sorted Z-values histogram for motif ESRRA.p2

Sorted Z-values for motif ESRRA.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ESRRA.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr8_+_145149985 82.272 CYC1
cytochrome c-1
chr2_-_176046120 81.835 NM_001002258
NM_001190329
NM_001689
 ATP5G3


ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)


chr10_+_81107259 80.838 PPIF
peptidylprolyl isomerase F
chr10_+_81107242 80.779 PPIF
peptidylprolyl isomerase F
chr5_+_218428 50.854 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chrX_+_118602391 47.372 SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
chr5_+_218441 45.038 SDHA
succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
chr8_+_145149936 42.879 NM_001916
 CYC1
cytochrome c-1
chr3_-_131221649 42.847 NM_007208
 MRPL3
mitochondrial ribosomal protein L3
chr8_+_145149978 41.774 CYC1
cytochrome c-1
chr10_+_81107219 40.200 NM_005729
 PPIF
peptidylprolyl isomerase F
chr10_+_81107228 40.019 PPIF
peptidylprolyl isomerase F
chr12_-_21810720 37.995 NM_001174097
 LDHB
lactate dehydrogenase B
chr2_-_44223131 37.915 NM_133259
 LRPPRC
leucine-rich PPR-motif containing
chr12_-_21810779 37.865 NM_002300
 LDHB
lactate dehydrogenase B
chr12_-_21810733 37.493 LDHB
lactate dehydrogenase B
chr12_-_21810754 37.309 LDHB
lactate dehydrogenase B
chr19_-_13044459 36.909 FARSA
phenylalanyl-tRNA synthetase, alpha subunit
chr16_+_21964700 36.800 UQCRC2
ubiquinol-cytochrome c reductase core protein II
chr20_+_3776905 36.716 CDC25B
cell division cycle 25 homolog B (S. pombe)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 73 entries
enrichment   p-value GO term description
27.11 3.20e-03 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c
18.07 4.53e-02 GO:0034643 establishment of mitochondrion localization, microtubule-mediated
18.07 4.53e-02 GO:0047497 mitochondrion transport along microtubule
18.07 4.53e-02 GO:0051654 establishment of mitochondrion localization
13.55 7.67e-06 GO:0015985 energy coupled proton transport, down electrochemical gradient
13.55 7.67e-06 GO:0015986 ATP synthesis coupled proton transport
12.51 5.95e-03 GO:0042776 mitochondrial ATP synthesis coupled proton transport
11.16 2.23e-03 GO:0072384 organelle transport along microtubule
11.09 9.70e-12 GO:0042773 ATP synthesis coupled electron transport
11.09 9.70e-12 GO:0042775 mitochondrial ATP synthesis coupled electron transport
10.68 1.08e-07 GO:0009060 aerobic respiration
10.54 2.42e-08 GO:0006120 mitochondrial electron transport, NADH to ubiquinone
10.51 5.56e-12 GO:0006119 oxidative phosphorylation
10.31 2.19e-23 GO:0022904 respiratory electron transport chain
10.17 1.69e-04 GO:0006099 tricarboxylic acid cycle
9.86 1.79e-06 GO:0070585 protein localization in mitochondrion
9.76 2.55e-04 GO:0046356 acetyl-CoA catabolic process
9.62 1.22e-05 GO:0006626 protein targeting to mitochondrion
9.32 1.80e-05 GO:0072655 establishment of protein localization in mitochondrion
8.89 4.14e-24 GO:0045333 cellular respiration

Gene overrepresentation in compartment category:

Showing 1 to 20 of 53 entries
enrichment   p-value GO term description
27.11 6.05e-04 GO:0005749 mitochondrial respiratory chain complex II
27.11 6.05e-04 GO:0045257 succinate dehydrogenase complex (ubiquinone)
27.11 6.05e-04 GO:0045273 respiratory chain complex II
27.11 6.05e-04 GO:0045281 succinate dehydrogenase complex
27.11 6.05e-04 GO:0045283 fumarate reductase complex
14.79 3.22e-04 GO:0005744 mitochondrial inner membrane presequence translocase complex
14.35 7.49e-07 GO:0005753 mitochondrial proton-transporting ATP synthase complex
13.55 6.25e-04 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)
12.84 2.66e-06 GO:0045259 proton-transporting ATP synthase complex
11.11 8.33e-18 GO:0005746 mitochondrial respiratory chain
11.09 2.65e-19 GO:0070469 respiratory chain
9.94 7.35e-30 GO:0044455 mitochondrial membrane part
9.73 1.64e-08 GO:0005747 mitochondrial respiratory chain complex I
9.73 1.64e-08 GO:0030964 NADH dehydrogenase complex
9.73 1.64e-08 GO:0045271 respiratory chain complex I
7.75 2.76e-02 GO:0033177 proton-transporting two-sector ATPase complex, proton-transporting domain
7.18 9.18e-04 GO:0042645 mitochondrial nucleoid
6.97 1.20e-03 GO:0009295 nucleoid
6.94 1.04e-04 GO:0016469 proton-transporting two-sector ATPase complex
6.19 3.12e-32 GO:0005743 mitochondrial inner membrane

Gene overrepresentation in function category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
27.11 8.31e-04 GO:0000104 succinate dehydrogenase activity
27.11 2.25e-02 GO:0004449 isocitrate dehydrogenase (NAD+) activity
15.49 2.66e-02 GO:0008121 ubiquinol-cytochrome-c reductase activity
15.49 2.66e-02 GO:0016679 oxidoreductase activity, acting on diphenols and related substances as donors
15.49 2.66e-02 GO:0016681 oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor
9.68 4.63e-02 GO:0046933 hydrogen ion transporting ATP synthase activity, rotational mechanism
9.53 1.52e-07 GO:0003954 NADH dehydrogenase activity
9.53 1.52e-07 GO:0008137 NADH dehydrogenase (ubiquinone) activity
9.53 1.52e-07 GO:0050136 NADH dehydrogenase (quinone) activity
8.83 1.02e-07 GO:0016655 oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor
7.91 8.22e-03 GO:0004129 cytochrome-c oxidase activity
7.91 8.22e-03 GO:0015002 heme-copper terminal oxidase activity
7.91 8.22e-03 GO:0016675 oxidoreductase activity, acting on a heme group of donors
7.91 8.22e-03 GO:0016676 oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
6.43 3.06e-10 GO:0015078 hydrogen ion transmembrane transporter activity
5.69 2.34e-06 GO:0016651 oxidoreductase activity, acting on NADH or NADPH
3.72 7.01e-06 GO:0015077 monovalent inorganic cation transmembrane transporter activity
3.38 4.92e-06 GO:0022890 inorganic cation transmembrane transporter activity
3.19 2.24e-03 GO:0009055 electron carrier activity
2.69 5.26e-03 GO:0048037 cofactor binding