Motif ID: ETS1,2.p2

Z-value: 2.348


Transcription factors associated with ETS1,2.p2:

Gene SymbolEntrez IDGene Name
ETS1 2113 v-ets erythroblastosis virus E26 oncogene homolog 1 (avian)
ETS2 2114 v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
ETS1chr11_-_1284574520.505.0e-15Click!
ETS2chr21_+_401778470.235.4e-04Click!


Activity profile for motif ETS1,2.p2.

activity profile for motif ETS1,2.p2


Sorted Z-values histogram for motif ETS1,2.p2

Sorted Z-values for motif ETS1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of ETS1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr21_-_46340874 52.542 NM_000211
 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr21_-_46340821 50.174 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr19_+_49838734 45.781 CD37
CD37 molecule
chr13_+_31287614 45.453 NM_001204406
 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr19_+_49838700 45.450 CD37
CD37 molecule
chr9_-_137809710 42.810 NM_002003
 FCN1
ficolin (collagen/fibrinogen domain containing) 1
chr1_-_31230594 41.733 LAPTM5
lysosomal protein transmembrane 5
chr13_-_46756295 41.515 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr21_-_46340776 40.057 ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr1_-_31230673 37.987 NM_006762
 LAPTM5
lysosomal protein transmembrane 5
chr19_+_49838673 37.972 NM_001040031
NM_001774
 CD37

CD37 molecule

chr6_+_31553955 36.079 NM_205838
NM_205839
 LST1

leukocyte specific transcript 1

chr8_+_38034066 35.913 NM_001204878
NM_004874
 BAG4

BCL2-associated athanogene 4

chr19_+_49838646 35.843 CD37
CD37 molecule
chr22_-_17680485 34.682 NM_177405
 CECR1
cat eye syndrome chromosome region, candidate 1
chr9_-_88969323 33.823 NM_001185059
NM_001185074
NM_024617
 ZCCHC6


zinc finger, CCHC domain containing 6


chr16_+_30194925 33.303 CORO1A
coronin, actin binding protein, 1A
chr5_-_149792276 32.319 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr12_-_6798419 31.792 ZNF384
zinc finger protein 384
chr19_+_42387249 31.566 NM_004706
NM_198977
 ARHGEF1

Rho guanine nucleotide exchange factor (GEF) 1


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 100 entries
enrichment   p-value GO term description
2.54 1.86e-04 GO:0050851 antigen receptor-mediated signaling pathway
2.41 6.00e-04 GO:0002429 immune response-activating cell surface receptor signaling pathway
2.40 2.18e-02 GO:0007015 actin filament organization
2.38 5.69e-04 GO:0002768 immune response-regulating cell surface receptor signaling pathway
2.14 7.59e-05 GO:0002757 immune response-activating signal transduction
2.13 6.79e-05 GO:0002764 immune response-regulating signaling pathway
2.12 3.73e-06 GO:0051249 regulation of lymphocyte activation
2.12 3.38e-03 GO:0050870 positive regulation of T cell activation
2.10 3.22e-04 GO:0051251 positive regulation of lymphocyte activation
2.08 4.95e-04 GO:0050863 regulation of T cell activation
2.05 6.71e-06 GO:0002694 regulation of leukocyte activation
2.04 4.21e-04 GO:0050867 positive regulation of cell activation
2.04 5.85e-04 GO:0002696 positive regulation of leukocyte activation
2.03 6.38e-06 GO:0050865 regulation of cell activation
2.03 2.22e-05 GO:0030168 platelet activation
2.03 3.50e-05 GO:0002253 activation of immune response
1.96 4.24e-10 GO:0002684 positive regulation of immune system process
1.95 4.43e-02 GO:0002252 immune effector process
1.94 8.88e-10 GO:0050776 regulation of immune response
1.94 1.52e-04 GO:0045321 leukocyte activation

Gene overrepresentation in compartment category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
3.11 3.26e-03 GO:0032587 ruffle membrane
2.77 3.41e-02 GO:0030120 vesicle coat
2.43 1.24e-02 GO:0031256 leading edge membrane
1.59 5.30e-04 GO:0005768 endosome
1.30 6.56e-03 GO:0005887 integral to plasma membrane
1.29 1.18e-02 GO:0031226 intrinsic to plasma membrane
1.26 1.11e-04 GO:0044459 plasma membrane part
1.26 2.50e-04 GO:0005829 cytosol
1.12 4.15e-03 GO:0005634 nucleus
1.08 8.29e-07 GO:0005622 intracellular
1.08 9.62e-07 GO:0044424 intracellular part
1.08 1.94e-02 GO:0005737 cytoplasm
1.08 2.13e-02 GO:0043227 membrane-bounded organelle
1.07 2.38e-02 GO:0043226 organelle
1.07 3.83e-02 GO:0043229 intracellular organelle
1.07 4.09e-02 GO:0043231 intracellular membrane-bounded organelle
1.03 1.57e-02 GO:0044464 cell part
1.03 1.63e-02 GO:0005623 cell

Gene overrepresentation in function category:

Showing 1 to 17 of 17 entries
enrichment   p-value GO term description
4.23 1.59e-02 GO:0019865 immunoglobulin binding
3.55 2.53e-05 GO:0003823 antigen binding
2.59 6.42e-03 GO:0035591 signaling adaptor activity
2.23 3.63e-03 GO:0005057 receptor signaling protein activity
2.00 1.35e-03 GO:0005085 guanyl-nucleotide exchange factor activity
1.64 1.65e-02 GO:0005083 small GTPase regulator activity
1.63 4.14e-02 GO:0032403 protein complex binding
1.60 4.10e-04 GO:0030695 GTPase regulator activity
1.59 4.77e-04 GO:0060589 nucleoside-triphosphatase regulator activity
1.49 4.10e-02 GO:0019904 protein domain specific binding
1.37 4.63e-02 GO:0016773 phosphotransferase activity, alcohol group as acceptor
1.36 3.92e-03 GO:0001071 nucleic acid binding transcription factor activity
1.36 3.92e-03 GO:0003700 sequence-specific DNA binding transcription factor activity
1.36 7.66e-03 GO:0030234 enzyme regulator activity
1.20 1.96e-16 GO:0005515 protein binding
1.20 3.47e-02 GO:0003677 DNA binding
1.11 1.32e-14 GO:0005488 binding