Motif ID: EVI1.p2

Z-value: 2.472


Transcription factors associated with EVI1.p2:

Gene SymbolEntrez IDGene Name
EVI1 2122 ecotropic viral integration site 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
MECOMchr3_-_1693814170.581.2e-20Click!


Activity profile for motif EVI1.p2.

activity profile for motif EVI1.p2


Sorted Z-values histogram for motif EVI1.p2

Sorted Z-values for motif EVI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EVI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_88450243 91.312 SPARCL1
SPARC-like 1 (hevin)
chr9_+_139871954 68.202 NM_000954
 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr8_-_27115897 62.831 NM_030795
 STMN4
stathmin-like 4
chr17_+_53344966 50.667 HLF
hepatic leukemia factor
chr2_-_224467095 49.880 SCG2
secretogranin II
chr12_-_15038724 48.480 NM_000900
NM_001190839
 MGP

matrix Gla protein

chr6_-_31514620 43.243 NM_001204078
NM_130463
NM_138282
 ATP6V1G2


ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2


chr8_-_27115935 41.642 STMN4
stathmin-like 4
chr10_+_106034886 39.622 NM_001191014
NM_001191015
 GSTO2

glutathione S-transferase omega 2

chr14_-_76447445 39.253 TGFB3
transforming growth factor, beta 3
chr19_-_36643770 38.626 NM_001864
 COX7A1
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
chr2_-_224467049 38.550 SCG2
secretogranin II
chr1_-_93399531 37.088


chr10_+_7745341 36.641 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr15_+_66874506 35.756


chr10_+_7745325 30.903 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr2_-_224467142 30.842 NM_003469
 SCG2
secretogranin II
chr17_-_66951381 30.409 NM_007168
 ABCA8
ATP-binding cassette, sub-family A (ABC1), member 8
chr12_-_16758312 29.744 NM_001243611
 LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_+_31515391 28.886 NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 55 entries
enrichment   p-value GO term description
9.63 2.66e-02 GO:0045026 plasma membrane fusion
8.82 9.95e-03 GO:0046640 regulation of alpha-beta T cell proliferation
7.27 4.86e-02 GO:0032660 regulation of interleukin-17 production
5.88 2.39e-02 GO:0032729 positive regulation of interferon-gamma production
4.99 2.21e-03 GO:0032649 regulation of interferon-gamma production
4.41 4.31e-03 GO:0002822 regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
4.34 5.42e-03 GO:0002819 regulation of adaptive immune response
3.77 7.79e-03 GO:0002699 positive regulation of immune effector process
3.53 3.60e-02 GO:0034754 cellular hormone metabolic process
3.25 3.16e-06 GO:0050867 positive regulation of cell activation
3.21 8.03e-06 GO:0002696 positive regulation of leukocyte activation
3.00 1.54e-03 GO:0002697 regulation of immune effector process
2.94 3.66e-06 GO:0002694 regulation of leukocyte activation
2.91 1.09e-03 GO:0051251 positive regulation of lymphocyte activation
2.90 3.25e-06 GO:0050865 regulation of cell activation
2.90 1.29e-02 GO:0050870 positive regulation of T cell activation
2.84 1.14e-02 GO:0042445 hormone metabolic process
2.79 6.06e-03 GO:0006936 muscle contraction
2.77 2.86e-03 GO:0003012 muscle system process
2.76 4.68e-03 GO:0050863 regulation of T cell activation

Gene overrepresentation in compartment category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
2.13 1.18e-09 GO:0005615 extracellular space
2.00 1.42e-12 GO:0005887 integral to plasma membrane
1.98 5.86e-03 GO:0009986 cell surface
1.96 6.08e-12 GO:0031226 intrinsic to plasma membrane
1.93 5.90e-09 GO:0044421 extracellular region part
1.79 7.59e-16 GO:0044459 plasma membrane part
1.73 1.85e-12 GO:0005576 extracellular region
1.68 3.24e-02 GO:0030054 cell junction
1.50 2.00e-02 GO:0000267 cell fraction
1.46 2.02e-12 GO:0005886 plasma membrane
1.44 8.78e-12 GO:0071944 cell periphery
1.24 6.03e-05 GO:0031224 intrinsic to membrane
1.24 9.17e-05 GO:0016021 integral to membrane
1.23 6.10e-06 GO:0044425 membrane part
1.21 1.17e-06 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 15 of 15 entries
enrichment   p-value GO term description
3.45 3.37e-03 GO:0004867 serine-type endopeptidase inhibitor activity
3.11 4.89e-03 GO:0019955 cytokine binding
2.90 1.17e-03 GO:0004866 endopeptidase inhibitor activity
2.79 2.43e-03 GO:0061135 endopeptidase regulator activity
2.75 3.07e-03 GO:0030414 peptidase inhibitor activity
2.46 7.11e-03 GO:0005125 cytokine activity
2.45 1.53e-02 GO:0005126 cytokine receptor binding
2.40 2.22e-02 GO:0061134 peptidase regulator activity
1.77 3.29e-03 GO:0005509 calcium ion binding
1.57 1.96e-02 GO:0022857 transmembrane transporter activity
1.55 1.85e-02 GO:0022892 substrate-specific transporter activity
1.51 1.24e-02 GO:0005215 transporter activity
1.40 2.66e-02 GO:0004872 receptor activity
1.38 7.62e-03 GO:0004871 signal transducer activity
1.38 7.62e-03 GO:0060089 molecular transducer activity