Motif ID: EWSR1-FLI1.p2

Z-value: 0.990


Transcription factors associated with EWSR1-FLI1.p2:

fusion protein between EWSR1 and FLI1 in an oncogenic event

Gene SymbolEntrez IDGene Name
EWSR1 2130 Ewing sarcoma breakpoint region 1
FLI1 2313 Friend leukemia virus integration 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FLI1chr11_+_128563973-0.412.8e-10Click!
EWSR1chr22_+_29664216-0.171.5e-02Click!


Activity profile for motif EWSR1-FLI1.p2.

activity profile for motif EWSR1-FLI1.p2


Sorted Z-values histogram for motif EWSR1-FLI1.p2

Sorted Z-values for motif EWSR1-FLI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of EWSR1-FLI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_+_73357222 49.908 NM_001130033
NM_021200
 PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr3_-_42307661 34.506 NM_000729
 CCK
cholecystokinin
chr8_+_104152876 18.693 NM_001024372
NM_024812
 BAALC

brain and acute leukemia, cytoplasmic

chr2_+_65215577 13.532 NM_001193493
 SLC1A4
solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
chr2_+_79740059 13.261 NM_001164883
NM_004389
 CTNNA2

catenin (cadherin-associated protein), alpha 2

chr3_+_115342302 11.639 GAP43
growth associated protein 43
chr19_-_47551881 10.982 NM_017854
 TMEM160
transmembrane protein 160
chr12_-_49351297 9.353 ARF3
ADP-ribosylation factor 3
chr12_-_49351129 9.047 ARF3
ADP-ribosylation factor 3
chr12_-_49351263 8.955


chr12_-_49351251 8.588 NM_001659
 ARF3
ADP-ribosylation factor 3
chr18_-_5630629 8.509 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr12_-_49351240 8.354 ARF3
ADP-ribosylation factor 3
chr7_+_16793320 8.277 NM_014399
 TSPAN13
tetraspanin 13
chrX_-_148586666 8.269 NM_000202
NM_001166550
NM_006123
 IDS


iduronate 2-sulfatase


chr1_-_156470565 8.035 MEF2D
myocyte enhancer factor 2D
chr12_-_49351245 7.947 ARF3
ADP-ribosylation factor 3
chr1_-_20812727 7.918 NM_018584
 CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr6_-_134496833 7.896 SGK1
serum/glucocorticoid regulated kinase 1
chr12_-_16759939 7.883 NM_001243613
 LMO3
LIM domain only 3 (rhombotin-like 2)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 33 entries
enrichment   p-value GO term description
4.44 2.48e-05 GO:0007409 axonogenesis
4.42 1.17e-05 GO:0048812 neuron projection morphogenesis
4.28 4.47e-05 GO:0048667 cell morphogenesis involved in neuron differentiation
4.08 2.10e-05 GO:0032990 cell part morphogenesis
4.00 6.34e-05 GO:0031175 neuron projection development
3.93 8.56e-05 GO:0048858 cell projection morphogenesis
3.77 3.48e-04 GO:0000904 cell morphogenesis involved in differentiation
3.62 1.75e-04 GO:0048666 neuron development
3.55 6.16e-03 GO:0051094 positive regulation of developmental process
3.54 1.94e-05 GO:0030182 neuron differentiation
3.46 2.04e-04 GO:0032989 cellular component morphogenesis
3.33 1.33e-03 GO:0000902 cell morphogenesis
3.26 1.02e-03 GO:0030030 cell projection organization
3.25 3.49e-02 GO:0048646 anatomical structure formation involved in morphogenesis
3.20 2.46e-05 GO:0048699 generation of neurons
3.12 2.40e-05 GO:0022008 neurogenesis
3.11 3.40e-02 GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
2.91 1.76e-02 GO:0007167 enzyme linked receptor protein signaling pathway
2.90 4.02e-08 GO:0007399 nervous system development
2.89 3.66e-04 GO:0048468 cell development

Gene overrepresentation in compartment category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
23.27 4.55e-02 GO:0071564 npBAF complex
7.76 2.22e-02 GO:0030427 site of polarized growth
3.12 3.08e-02 GO:0043005 neuron projection
1.18 2.75e-02 GO:0044424 intracellular part

Gene overrepresentation in function category:

Showing 1 to 1 of 1 entries
enrichment   p-value GO term description
1.39 6.07e-04 GO:0005515 protein binding