Motif ID: FOXA2.p3

Z-value: 1.816


Transcription factors associated with FOXA2.p3:

Gene SymbolEntrez IDGene Name
FOXA2 3170 forkhead box A2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXA2chr20_-_225650500.486.7e-14Click!


Activity profile for motif FOXA2.p3.

activity profile for motif FOXA2.p3


Sorted Z-values histogram for motif FOXA2.p3

Sorted Z-values for motif FOXA2.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of FOXA2.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_15038724 43.435 NM_000900
NM_001190839
 MGP

matrix Gla protein

chr17_-_26697224 36.676 VTN
vitronectin
chr17_-_26697310 32.739 VTN
vitronectin
chr12_-_91572328 29.142 NM_133504
NM_133505
NM_133506
NM_133507
 DCN



decorin



chr4_-_69886112 27.907 NM_001075
NM_001144767
 UGT2B10

UDP glucuronosyltransferase 2 family, polypeptide B10

chr17_-_26697293 26.487 VTN
vitronectin
chr12_-_9268440 25.651 A2M
alpha-2-macroglobulin
chr12_-_9268513 24.014 A2M
alpha-2-macroglobulin
chr4_-_70080448 23.824 NM_001073
 UGT2B11
UGT2B10
UDP glucuronosyltransferase 2 family, polypeptide B11
UDP glucuronosyltransferase 2 family, polypeptide B10
chr12_-_9268475 21.833 A2M
alpha-2-macroglobulin
chrX_-_101112548 21.446 NM_032946
 NXF5
nuclear RNA export factor 5
chr10_+_51549552 20.995 NM_002443
NM_138634
 MSMB

microseminoprotein, beta-

chr4_+_70861647 19.551 NM_001009181
NM_003154
 STATH

statherin

chr12_-_9268522 19.326 NM_000014
 A2M
alpha-2-macroglobulin
chr12_-_71551564 18.973 TSPAN8
tetraspanin 8
chr17_-_10452939 17.804 NM_001100112
NM_017534
 MYH2

myosin, heavy chain 2, skeletal muscle, adult

chr4_-_72671236 17.655 NM_001204306
 GC
group-specific component (vitamin D binding protein)
chr2_-_21225640 17.640 APOB
apolipoprotein B (including Ag(x) antigen)
chr17_-_64225496 17.585 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr15_+_66874506 16.862



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 53 entries
enrichment   p-value GO term description
12.33 3.78e-02 GO:0070168 negative regulation of biomineral tissue development
10.76 1.43e-02 GO:0006067 ethanol metabolic process
10.76 1.43e-02 GO:0006069 ethanol oxidation
10.76 1.43e-02 GO:0034308 primary alcohol metabolic process
9.87 8.74e-04 GO:0015721 bile acid and bile salt transport
6.26 1.45e-04 GO:0031214 biomineral tissue development
5.87 3.13e-03 GO:0008206 bile acid metabolic process
5.34 1.14e-03 GO:0045807 positive regulation of endocytosis
4.53 3.74e-03 GO:0072376 protein activation cascade
4.20 8.93e-05 GO:0007586 digestion
4.14 2.54e-02 GO:0015718 monocarboxylic acid transport
3.41 5.04e-04 GO:0006805 xenobiotic metabolic process
3.41 5.04e-04 GO:0071466 cellular response to xenobiotic stimulus
3.39 5.79e-04 GO:0009410 response to xenobiotic stimulus
2.95 4.93e-02 GO:0001503 ossification
2.66 2.66e-02 GO:0006725 cellular aromatic compound metabolic process
2.52 1.45e-02 GO:0008202 steroid metabolic process
2.47 1.55e-02 GO:0051241 negative regulation of multicellular organismal process
2.37 1.19e-02 GO:0006954 inflammatory response
2.16 2.40e-03 GO:0050776 regulation of immune response

Gene overrepresentation in compartment category:

Showing 1 to 20 of 20 entries
enrichment   p-value GO term description
4.55 2.60e-03 GO:0031983 vesicle lumen
4.34 9.96e-03 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
4.20 3.07e-02 GO:0031093 platelet alpha granule lumen
4.11 3.70e-02 GO:0034774 secretory granule lumen
3.81 3.56e-02 GO:0031091 platelet alpha granule
2.90 7.75e-10 GO:0031012 extracellular matrix
2.84 1.15e-07 GO:0005578 proteinaceous extracellular matrix
2.65 5.02e-17 GO:0005615 extracellular space
2.61 7.68e-22 GO:0044421 extracellular region part
2.45 2.45e-03 GO:0005792 microsome
2.37 4.69e-03 GO:0042598 vesicular fraction
2.02 2.00e-20 GO:0005576 extracellular region
1.99 8.62e-11 GO:0005887 integral to plasma membrane
1.96 3.09e-10 GO:0031226 intrinsic to plasma membrane
1.91 1.83e-05 GO:0005624 membrane fraction
1.90 1.51e-05 GO:0005626 insoluble fraction
1.79 6.70e-06 GO:0000267 cell fraction
1.73 1.04e-11 GO:0044459 plasma membrane part
1.35 4.68e-06 GO:0005886 plasma membrane
1.34 1.20e-05 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
13.15 6.76e-04 GO:0004022 alcohol dehydrogenase (NAD) activity
12.33 8.98e-03 GO:0005132 interferon-alpha/beta receptor binding
4.93 4.82e-03 GO:0043498 cell surface binding
4.31 8.55e-03 GO:0042562 hormone binding
4.19 2.25e-04 GO:0005201 extracellular matrix structural constituent
3.82 3.04e-02 GO:0005319 lipid transporter activity
3.10 2.87e-02 GO:0004222 metalloendopeptidase activity
2.82 9.08e-03 GO:0005539 glycosaminoglycan binding
2.61 2.99e-02 GO:0001871 pattern binding
2.61 2.99e-02 GO:0030247 polysaccharide binding
1.63 5.60e-03 GO:0005102 receptor binding