Motif ID: GATA6.p2

Z-value: 2.708


Transcription factors associated with GATA6.p2:

Gene SymbolEntrez IDGene Name
GATA6 2627 GATA binding protein 6

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GATA6chr18_+_197494030.186.2e-03Click!


Activity profile for motif GATA6.p2.

activity profile for motif GATA6.p2


Sorted Z-values histogram for motif GATA6.p2

Sorted Z-values for motif GATA6.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_54689536 44.749 NM_006163
 NFE2
nuclear factor (erythroid-derived 2), 45kDa
chr10_-_99531712 44.371 NM_003015
 SFRP5
secreted frizzled-related protein 5
chr16_+_31539202 44.307 NM_016633
 AHSP
alpha hemoglobin stabilizing protein
chr7_-_142659397 41.601 KEL
Kell blood group, metallo-endopeptidase
chr7_-_142659412 41.216 NM_000420
 KEL
Kell blood group, metallo-endopeptidase
chrX_-_55057408 40.059 NM_000032
NM_001037967
NM_001037968
 ALAS2


aminolevulinate, delta-, synthase 2


chr16_+_202853 38.754 NM_005332
 HBZ
hemoglobin, zeta
chr1_-_158656487 38.278 NM_003126
 SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr19_-_13213973 37.907 NM_005583
 LYL1
lymphoblastic leukemia derived sequence 1
chr8_-_86290333 36.257 NM_001128829
NM_001128830
NM_001128831
NM_001738
 CA1



carbonic anhydrase I



chr22_+_23229959 35.716 NM_001178126
 IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr11_+_92085261 34.388 NM_001008781
 FAT3
FAT tumor suppressor homolog 3 (Drosophila)
chr19_-_12997956 34.143 NM_006563
 KLF1
Kruppel-like factor 1 (erythroid)
chr6_-_33168448 32.923 RXRB
retinoid X receptor, beta
chr12_-_91576579 31.849 DCN
decorin
chr6_-_49604524 31.695 NM_000324
 RHAG
Rh-associated glycoprotein
chr11_-_116708334 31.684 NM_000039
 APOA1
apolipoprotein A-I
chr19_-_13213513 30.194 LYL1
lymphoblastic leukemia derived sequence 1
chr15_-_43513024 29.633 EPB42
erythrocyte membrane protein band 4.2
chr2_+_102927961 27.902 NM_016232
 IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 76 entries
enrichment   p-value GO term description
20.20 2.46e-02 GO:0006705 mineralocorticoid biosynthetic process
20.20 2.46e-02 GO:0008212 mineralocorticoid metabolic process
15.78 1.02e-02 GO:0006704 glucocorticoid biosynthetic process
12.62 5.97e-03 GO:0008211 glucocorticoid metabolic process
12.62 5.97e-03 GO:0044241 lipid digestion
9.47 4.51e-02 GO:0006700 C21-steroid hormone biosynthetic process
8.84 1.54e-02 GO:0072378 blood coagulation, fibrin clot formation
8.42 2.23e-02 GO:0001990 regulation of systemic arterial blood pressure by hormone
8.08 7.30e-03 GO:0008207 C21-steroid hormone metabolic process
7.25 4.19e-13 GO:0007586 digestion
7.21 1.89e-02 GO:0030195 negative regulation of blood coagulation
6.96 2.52e-02 GO:0050819 negative regulation of coagulation
6.46 1.34e-03 GO:0003073 regulation of systemic arterial blood pressure
6.16 6.96e-03 GO:0006721 terpenoid metabolic process
5.51 9.10e-11 GO:0006805 xenobiotic metabolic process
5.51 9.10e-11 GO:0071466 cellular response to xenobiotic stimulus
5.46 1.12e-10 GO:0009410 response to xenobiotic stimulus
5.44 4.13e-04 GO:0019748 secondary metabolic process
5.05 4.29e-04 GO:0002576 platelet degranulation
4.97 8.47e-03 GO:0072376 protein activation cascade

Gene overrepresentation in compartment category:

Showing 1 to 20 of 31 entries
enrichment   p-value GO term description
4.87 3.42e-03 GO:0031091 platelet alpha granule
4.86 8.75e-03 GO:0031983 vesicle lumen
4.84 2.25e-02 GO:0031093 platelet alpha granule lumen
4.73 2.67e-02 GO:0034774 secretory granule lumen
4.55 3.71e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
3.27 1.51e-02 GO:0030016 myofibril
3.13 4.23e-02 GO:0044449 contractile fiber part
3.11 9.31e-03 GO:0009897 external side of plasma membrane
3.08 2.98e-02 GO:0043292 contractile fiber
3.03 3.89e-04 GO:0030141 stored secretory granule
2.88 2.19e-16 GO:0005615 extracellular space
2.86 1.10e-02 GO:0016324 apical plasma membrane
2.81 6.22e-04 GO:0005792 microsome
2.75 3.24e-03 GO:0045177 apical part of cell
2.74 4.58e-19 GO:0044421 extracellular region part
2.71 1.16e-03 GO:0042598 vesicular fraction
2.49 1.42e-04 GO:0009986 cell surface
2.31 3.71e-14 GO:0031226 intrinsic to plasma membrane
2.31 7.40e-14 GO:0005887 integral to plasma membrane
2.31 2.18e-03 GO:0031012 extracellular matrix

Gene overrepresentation in function category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
9.47 1.08e-02 GO:0008395 steroid hydroxylase activity
7.21 4.50e-03 GO:0015020 glucuronosyltransferase activity
6.73 5.98e-05 GO:0019825 oxygen binding
5.44 9.85e-05 GO:0005496 steroid binding
4.10 7.33e-03 GO:0004497 monooxygenase activity
3.79 3.51e-02 GO:0005201 extracellular matrix structural constituent
3.77 1.84e-02 GO:0004867 serine-type endopeptidase inhibitor activity
3.49 3.63e-03 GO:0020037 heme binding
3.47 2.14e-03 GO:0046906 tetrapyrrole binding
3.27 4.67e-02 GO:0019955 cytokine binding
3.25 1.09e-04 GO:0005125 cytokine activity
3.09 1.41e-03 GO:0005126 cytokine receptor binding
3.05 1.30e-02 GO:0031406 carboxylic acid binding
3.02 9.15e-03 GO:0001871 pattern binding
3.02 9.15e-03 GO:0030247 polysaccharide binding
2.92 3.77e-02 GO:0005539 glycosaminoglycan binding
2.66 1.81e-06 GO:0008289 lipid binding
2.56 3.99e-02 GO:0005506 iron ion binding
2.21 1.25e-02 GO:0030246 carbohydrate binding
1.93 2.52e-05 GO:0005102 receptor binding