Motif ID: GFI1.p2

Z-value: 1.599


Transcription factors associated with GFI1.p2:

Gene SymbolEntrez IDGene Name
GFI1 2672 growth factor independent 1 transcription repressor

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GFI1chr1_-_92952429-0.414.4e-10Click!


Activity profile for motif GFI1.p2.

activity profile for motif GFI1.p2


Sorted Z-values histogram for motif GFI1.p2

Sorted Z-values for motif GFI1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GFI1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr3_+_172468469 33.767 ECT2
epithelial cell transforming sequence 2 oncogene
chr19_-_14247267 28.288 ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr19_-_14247400 26.128 NM_018154
 ASF1B
ASF1 anti-silencing function 1 homolog B (S. cerevisiae)
chr9_+_91926109 23.486 NM_001827
 CKS2
CDC28 protein kinase regulatory subunit 2
chr14_-_55658205 23.014 NM_001146015
NM_014750
 DLGAP5

discs, large (Drosophila) homolog-associated protein 5

chr17_-_38574042 22.942 NM_001067
 TOP2A
topoisomerase (DNA) II alpha 170kDa
chr12_-_120315074 19.586 NM_001206999
NM_007174
 CIT

citron (rho-interacting, serine/threonine kinase 21)

chr12_+_104324157 19.554 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr8_-_25315941 18.777 NM_017634
 KCTD9
potassium channel tetramerisation domain containing 9
chrX_-_107334749 18.737 NM_002814
NM_170750
 PSMD10

proteasome (prosome, macropain) 26S subunit, non-ATPase, 10

chrX_+_154444700 18.343 NM_003372
 VBP1
von Hippel-Lindau binding protein 1
chr12_+_104324192 17.652 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr1_+_62902325 17.468 NM_003368
 USP1
ubiquitin specific peptidase 1
chr17_-_76183074 17.451 NM_003258
 TK1
thymidine kinase 1, soluble
chr8_-_101964248 16.639 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_-_101964247 16.516 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr12_+_104324214 16.437 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1
chr8_-_101964268 16.354 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr8_-_101964236 16.216 YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
chr12_+_104324186 16.037 NM_003299
 HSP90B1
heat shock protein 90kDa beta (Grp94), member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 104 entries
enrichment   p-value GO term description
4.36 1.01e-02 GO:0030071 regulation of mitotic metaphase/anaphase transition
4.10 4.33e-03 GO:0007051 spindle organization
3.96 3.30e-02 GO:0000819 sister chromatid segregation
3.48 1.08e-12 GO:0000075 cell cycle checkpoint
3.44 2.04e-03 GO:0000216 M/G1 transition of mitotic cell cycle
3.41 1.44e-12 GO:0071156 regulation of cell cycle arrest
3.35 4.48e-05 GO:0000084 S phase of mitotic cell cycle
3.29 6.82e-05 GO:0051320 S phase
3.18 4.95e-06 GO:0000082 G1/S transition of mitotic cell cycle
3.18 1.32e-02 GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
2.86 1.30e-10 GO:0051325 interphase
2.86 2.00e-10 GO:0051329 interphase of mitotic cell cycle
2.81 3.37e-03 GO:0007093 mitotic cell cycle checkpoint
2.77 2.38e-09 GO:0000087 M phase of mitotic cell cycle
2.76 5.51e-05 GO:0006260 DNA replication
2.76 3.02e-02 GO:0000086 G2/M transition of mitotic cell cycle
2.74 1.03e-10 GO:0010564 regulation of cell cycle process
2.73 2.29e-02 GO:0031570 DNA integrity checkpoint
2.68 1.30e-17 GO:0000278 mitotic cell cycle
2.68 5.57e-03 GO:0006310 DNA recombination

Gene overrepresentation in compartment category:

Showing 1 to 20 of 49 entries
enrichment   p-value GO term description
7.31 2.60e-02 GO:0005744 mitochondrial inner membrane presequence translocase complex
5.96 9.59e-03 GO:0000159 protein phosphatase type 2A complex
4.47 3.03e-03 GO:0005758 mitochondrial intermembrane space
4.02 1.02e-02 GO:0031970 organelle envelope lumen
3.78 4.20e-02 GO:0005876 spindle microtubule
3.64 1.98e-03 GO:0030496 midbody
3.50 9.39e-04 GO:0005643 nuclear pore
3.45 2.17e-03 GO:0000922 spindle pole
3.07 4.00e-03 GO:0046930 pore complex
3.05 2.63e-03 GO:0000776 kinetochore
3.00 1.18e-07 GO:0005819 spindle
2.60 1.51e-04 GO:0044454 nuclear chromosome part
2.55 2.60e-03 GO:0000775 chromosome, centromeric region
2.43 1.33e-04 GO:0000228 nuclear chromosome
2.41 1.53e-02 GO:0000793 condensed chromosome
2.23 3.07e-08 GO:0044427 chromosomal part
2.10 4.68e-08 GO:0005694 chromosome
2.07 2.02e-03 GO:0005874 microtubule
2.05 1.35e-02 GO:0005635 nuclear envelope
2.04 3.88e-09 GO:0015630 microtubule cytoskeleton

Gene overrepresentation in function category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
6.70 1.21e-03 GO:0008601 protein phosphatase type 2A regulator activity
3.83 2.53e-02 GO:0019888 protein phosphatase regulator activity
1.96 3.19e-03 GO:0016887 ATPase activity
1.94 3.28e-02 GO:0042623 ATPase activity, coupled
1.76 3.65e-05 GO:0019899 enzyme binding
1.69 2.17e-04 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
1.68 2.61e-04 GO:0016817 hydrolase activity, acting on acid anhydrides
1.68 3.39e-04 GO:0016462 pyrophosphatase activity
1.67 8.07e-04 GO:0017111 nucleoside-triphosphatase activity
1.45 9.65e-04 GO:0005524 ATP binding
1.44 9.42e-04 GO:0032559 adenyl ribonucleotide binding
1.43 1.30e-03 GO:0030554 adenyl nucleotide binding
1.39 3.82e-28 GO:0005515 protein binding
1.37 2.23e-04 GO:0000166 nucleotide binding
1.37 3.69e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.36 4.50e-03 GO:0032553 ribonucleotide binding
1.36 4.50e-03 GO:0032555 purine ribonucleotide binding
1.36 6.32e-03 GO:0017076 purine nucleotide binding
1.16 4.72e-15 GO:0005488 binding