Motif ID: GTF2A1,2.p2

Z-value: 2.182


Transcription factors associated with GTF2A1,2.p2:

Gene SymbolEntrez IDGene Name
GTF2A1 2957 general transcription factor IIA, 1, 19/37kDa
GTF2A2 2958 general transcription factor IIA, 2, 12kDa

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
GTF2A2chr15_-_59949536-0.768.3e-43Click!
GTF2A1chr14_-_816875740.627.3e-25Click!


Activity profile for motif GTF2A1,2.p2.

activity profile for motif GTF2A1,2.p2


Sorted Z-values histogram for motif GTF2A1,2.p2

Sorted Z-values for motif GTF2A1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of GTF2A1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_+_33182689 61.781 NM_001105570
 NUDT19
nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr11_-_111782447 45.610 NM_001885
 CRYAB
crystallin, alpha B
chr18_-_74728963 41.003 MBP
myelin basic protein
chr18_-_74729049 40.254 NM_001025081
NM_001025090
NM_001025092
NM_002385
 MBP



myelin basic protein



chr9_+_139872014 31.784 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr1_-_57888785 29.541 DAB1
disabled homolog 1 (Drosophila)
chr19_-_57336373 28.951 NM_001146186
 PEG3
paternally expressed 3
chr1_-_57044980 27.688 PPAP2B
phosphatidic acid phosphatase type 2B
chr1_-_57045214 26.902 PPAP2B
phosphatidic acid phosphatase type 2B
chr20_+_36149606 26.015 NM_005386
NM_181689
 NNAT

neuronatin

chr1_-_57045129 25.888 PPAP2B
phosphatidic acid phosphatase type 2B
chr13_-_45150601 25.214 NM_001243799
NM_183422
 TSC22D1

TSC22 domain family, member 1

chr1_+_152635871 24.591 NM_178430
 LCE2D
late cornified envelope 2D
chr1_-_57045235 24.442 NM_003713
 PPAP2B
phosphatidic acid phosphatase type 2B
chr6_-_46293628 23.795 NM_005822
 RCAN2
regulator of calcineurin 2
chr16_+_22825806 23.457 NM_006043
 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr16_+_22825481 22.097 HS3ST2
heparan sulfate (glucosamine) 3-O-sulfotransferase 2
chr20_-_44455932 22.018 NM_003279
 TNNC2
troponin C type 2 (fast)
chr12_+_109577201 21.940 NM_001093
 ACACB
acetyl-CoA carboxylase beta
chr17_+_1665233 21.183 NM_002615
 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 45 entries
enrichment   p-value GO term description
4.44 1.40e-02 GO:0044259 multicellular organismal macromolecule metabolic process
4.37 4.29e-02 GO:0032963 collagen metabolic process
2.20 2.48e-02 GO:0003012 muscle system process
2.13 4.27e-04 GO:0006954 inflammatory response
1.96 2.78e-02 GO:0001568 blood vessel development
1.95 1.73e-02 GO:0001944 vasculature development
1.85 1.48e-07 GO:0007267 cell-cell signaling
1.77 1.00e-07 GO:0009611 response to wounding
1.70 4.95e-07 GO:0007154 cell communication
1.68 3.23e-05 GO:0040011 locomotion
1.66 2.05e-02 GO:0006928 cellular component movement
1.64 1.82e-02 GO:0042060 wound healing
1.64 2.99e-02 GO:0050878 regulation of body fluid levels
1.62 1.72e-03 GO:0007155 cell adhesion
1.62 1.72e-03 GO:0022610 biological adhesion
1.59 1.29e-04 GO:0009605 response to external stimulus
1.57 1.43e-02 GO:0006955 immune response
1.55 9.03e-07 GO:0007399 nervous system development
1.53 1.85e-02 GO:0006952 defense response
1.52 1.14e-02 GO:0006811 ion transport

Gene overrepresentation in compartment category:

Showing 1 to 20 of 22 entries
enrichment   p-value GO term description
3.42 2.91e-03 GO:0031983 vesicle lumen
3.31 1.62e-02 GO:0031093 platelet alpha granule lumen
3.24 2.09e-02 GO:0034774 secretory granule lumen
3.11 3.43e-02 GO:0044309 neuron spine
3.11 3.43e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
2.92 4.23e-02 GO:0031091 platelet alpha granule
2.36 2.08e-02 GO:0044420 extracellular matrix part
2.06 2.64e-06 GO:0031012 extracellular matrix
2.00 1.75e-04 GO:0005578 proteinaceous extracellular matrix
1.92 1.09e-14 GO:0044421 extracellular region part
1.88 5.16e-10 GO:0005615 extracellular space
1.77 2.43e-03 GO:0044463 cell projection part
1.74 5.40e-03 GO:0043005 neuron projection
1.65 3.90e-09 GO:0005887 integral to plasma membrane
1.63 1.01e-08 GO:0031226 intrinsic to plasma membrane
1.60 5.66e-14 GO:0005576 extracellular region
1.57 1.16e-02 GO:0030054 cell junction
1.56 2.55e-04 GO:0042995 cell projection
1.54 2.62e-12 GO:0044459 plasma membrane part
1.37 4.09e-02 GO:0000267 cell fraction

Gene overrepresentation in function category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
3.27 1.94e-02 GO:0042379 chemokine receptor binding
2.78 1.39e-02 GO:0005201 extracellular matrix structural constituent
2.10 1.75e-02 GO:0005126 cytokine receptor binding
2.06 1.53e-02 GO:0005125 cytokine activity
1.60 1.03e-05 GO:0005102 receptor binding
1.45 1.56e-02 GO:0022857 transmembrane transporter activity
1.41 4.38e-02 GO:0001071 nucleic acid binding transcription factor activity
1.41 4.38e-02 GO:0003700 sequence-specific DNA binding transcription factor activity
1.38 2.62e-02 GO:0005215 transporter activity
1.13 2.71e-03 GO:0005515 protein binding
1.07 3.23e-03 GO:0005488 binding