Motif ID: GUCAGUU

Z-value: 1.044


Mature miRNA associated with seed GUCAGUU:

NamemiRBase Accession
hsa-miR-223 MIMAT0000280



Activity profile for motif GUCAGUU.

activity profile for motif GUCAGUU


Sorted Z-values histogram for motif GUCAGUU

Sorted Z-values for motif GUCAGUU



Network of associatons between targets according to the STRING database.



First level regulatory network of GUCAGUU

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chrX_-_13956644 19.323 NM_001001994
GPM6B
glycoprotein M6B
chr3_-_149688638 16.933 NM_002628
NM_053024
PFN2

profilin 2

chrX_-_13835313 16.515 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr1_+_204913353 14.962 NM_001160331
NFASC
neurofascin
chr5_+_71403040 13.168 NM_005909
MAP1B
microtubule-associated protein 1B
chr4_-_153303663 11.284 NM_001013415
FBXW7
F-box and WD repeat domain containing 7
chr1_+_169075869 10.867 NM_001677
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr4_-_153456152 10.559 NM_033632
FBXW7
F-box and WD repeat domain containing 7
chr2_+_149632772 10.339 NM_004522
KIF5C
kinesin family member 5C
chr1_-_9884549 10.278 NM_001009566
NM_014944
CLSTN1

calsyntenin 1

chr11_+_73359734 9.953 NM_001130036
PLEKHB1
pleckstrin homology domain containing, family B (evectins) member 1
chr8_+_104152876 9.895 NM_001024372
NM_024812
BAALC

brain and acute leukemia, cytoplasmic

chr11_+_73357222 9.526 NM_001130033
NM_021200
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr1_+_204797774 9.389 NM_001005388
NM_001005389
NM_001160332
NM_001160333
NM_015090
NFASC




neurofascin




chr11_+_73358593 9.160 NM_001130034
NM_001130035
PLEKHB1

pleckstrin homology domain containing, family B (evectins) member 1

chr15_+_91643429 8.909 NM_014848
SV2B
synaptic vesicle glycoprotein 2B
chr4_-_90759446 8.556 NM_001146055
SNCA
synuclein, alpha (non A4 component of amyloid precursor)
chr12_+_79257772 8.436 NM_001135805
SYT1
synaptotagmin I
chr9_+_137967088 8.360 NM_014279
NM_006334
OLFM1

olfactomedin 1

chr12_+_79439432 8.245 NM_001135806
SYT1
synaptotagmin I

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 14 of 14 entries
enrichment   p-value GO term description
8.97 1.33e-02 GO:0031111 negative regulation of microtubule polymerization or depolymerization
7.43 1.15e-16 GO:0007156 homophilic cell adhesion
3.59 1.96e-07 GO:0016337 cell-cell adhesion
3.32 1.52e-02 GO:0051493 regulation of cytoskeleton organization
2.68 4.96e-02 GO:0030334 regulation of cell migration
2.54 7.94e-08 GO:0007155 cell adhesion
2.54 7.94e-08 GO:0022610 biological adhesion
2.17 4.88e-02 GO:0031175 neuron projection development
2.11 3.47e-09 GO:0007399 nervous system development
2.10 3.31e-02 GO:0048666 neuron development
1.82 2.18e-02 GO:0007154 cell communication
1.48 3.53e-03 GO:0048731 system development
1.46 2.64e-03 GO:0048856 anatomical structure development
1.37 1.76e-02 GO:0032502 developmental process

Gene overrepresentation in compartment category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
22.11 4.35e-02 GO:0042583 chromaffin granule
22.11 4.35e-02 GO:0042584 chromaffin granule membrane
22.11 4.35e-02 GO:0060199 clathrin sculpted glutamate transport vesicle
22.11 4.35e-02 GO:0060203 clathrin sculpted glutamate transport vesicle membrane
2.81 4.79e-06 GO:0045202 synapse
2.54 2.96e-04 GO:0043005 neuron projection
2.36 4.03e-02 GO:0044456 synapse part
2.03 7.36e-03 GO:0030054 cell junction
1.88 3.11e-03 GO:0042995 cell projection
1.78 5.13e-04 GO:0031226 intrinsic to plasma membrane
1.76 1.02e-03 GO:0005887 integral to plasma membrane
1.69 1.72e-06 GO:0044459 plasma membrane part
1.45 2.10e-06 GO:0071944 cell periphery
1.45 3.32e-06 GO:0005886 plasma membrane
1.23 6.15e-04 GO:0016020 membrane
1.23 1.15e-02 GO:0044425 membrane part
1.07 6.09e-03 GO:0044464 cell part
1.07 6.20e-03 GO:0005623 cell

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
10.53 2.62e-02 GO:0005248 voltage-gated sodium channel activity
2.49 3.95e-07 GO:0005509 calcium ion binding
2.35 1.59e-04 GO:0008092 cytoskeletal protein binding
2.35 2.92e-02 GO:0003779 actin binding
1.31 3.37e-02 GO:0046872 metal ion binding
1.30 4.14e-02 GO:0043169 cation binding
1.30 4.70e-02 GO:0043167 ion binding
1.21 1.26e-02 GO:0005515 protein binding
1.15 3.32e-05 GO:0005488 binding