Motif ID: HAND1,2.p2

Z-value: 2.383


Transcription factors associated with HAND1,2.p2:

Gene SymbolEntrez IDGene Name
HAND1 9421 heart and neural crest derivatives expressed 1
HAND2 9464 heart and neural crest derivatives expressed 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HAND1chr5_-_1538577820.718.1e-35Click!
HAND2chr4_-_1744513560.544.5e-18Click!


Activity profile for motif HAND1,2.p2.

activity profile for motif HAND1,2.p2


Sorted Z-values histogram for motif HAND1,2.p2

Sorted Z-values for motif HAND1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HAND1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_149792370 66.726 NM_001025158
NM_001025159
NM_004355
 CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr19_-_37701385 54.330 NM_152279
 ZNF585B
zinc finger protein 585B
chr5_-_149792276 52.404 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr14_-_107179043 52.365 IGHA1
immunoglobulin heavy constant alpha 1
chr22_+_22723972 49.381


chr22_+_23213671 47.061 IGLV4-3
immunoglobulin lambda variable 4-3
chr19_-_9695166 43.532 NM_001008727
 ZNF121
zinc finger protein 121
chr1_-_155904201 43.308 KIAA0907
KIAA0907
chrX_+_128913881 43.223 NM_018990
 SASH3
SAM and SH3 domain containing 3
chr11_+_71927818 37.976 NM_000803
NM_001113534
NM_001113535
NM_001113536
 FOLR2



folate receptor 2 (fetal)



chrX_+_128913897 37.425 SASH3
SAM and SH3 domain containing 3
chr3_-_195310985 37.392 NM_001647
 APOD
apolipoprotein D
chr18_+_21572736 36.141 NM_153211
 TTC39C
tetratricopeptide repeat domain 39C
chr19_+_507475 33.730 NM_033513
 TPGS1
tubulin polyglutamylase complex subunit 1
chr7_+_142560512 31.217 EPHB6
EPH receptor B6
chr6_+_6588933 29.726 NM_004271
 LY86
lymphocyte antigen 86
chr3_-_20227618 28.854 NM_001012409
NM_001012410
NM_001012411
NM_001012412
NM_001012413
NM_138484
NM_001199251
NM_001199252
NM_001199253
NM_001199254
NM_001199255
NM_001199256
NM_001199257
 SGOL1












shugoshin-like 1 (S. pombe)












chr14_-_106208537 28.825


chr3_-_195310770 28.683 APOD
apolipoprotein D
chr14_-_107013474 27.671 IGHA1
IGHG1
immunoglobulin heavy constant alpha 1
immunoglobulin heavy constant gamma 1 (G1m marker)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 26 entries
enrichment   p-value GO term description
10.46 1.80e-02 GO:0001516 prostaglandin biosynthetic process
10.46 1.80e-02 GO:0046457 prostanoid biosynthetic process
8.14 2.37e-02 GO:0006693 prostaglandin metabolic process
6.70 2.93e-02 GO:0006692 prostanoid metabolic process
5.54 4.73e-02 GO:0046456 icosanoid biosynthetic process
4.70 3.26e-02 GO:0006690 icosanoid metabolic process
3.66 4.95e-02 GO:0006959 humoral immune response
3.44 6.73e-05 GO:0006936 muscle contraction
3.29 1.02e-04 GO:0003012 muscle system process
2.58 1.33e-02 GO:0008202 steroid metabolic process
2.39 6.22e-05 GO:0050776 regulation of immune response
2.05 4.03e-02 GO:0007268 synaptic transmission
1.95 4.76e-04 GO:0007267 cell-cell signaling
1.91 1.71e-03 GO:0006955 immune response
1.83 2.61e-02 GO:0002682 regulation of immune system process
1.77 1.45e-03 GO:0007154 cell communication
1.70 1.91e-02 GO:0006629 lipid metabolic process
1.67 2.24e-03 GO:0002376 immune system process
1.53 1.98e-03 GO:0048583 regulation of response to stimulus
1.42 4.19e-02 GO:0065008 regulation of biological quality

Gene overrepresentation in compartment category:

Showing 1 to 16 of 16 entries
enrichment   p-value GO term description
6.98 4.14e-02 GO:0032982 myosin filament
2.28 8.68e-10 GO:0005615 extracellular space
2.27 5.84e-03 GO:0015629 actin cytoskeleton
2.05 3.86e-09 GO:0044421 extracellular region part
2.04 4.77e-11 GO:0005887 integral to plasma membrane
2.01 1.68e-10 GO:0031226 intrinsic to plasma membrane
2.01 2.31e-02 GO:0009986 cell surface
1.85 1.26e-13 GO:0005576 extracellular region
1.81 3.15e-13 GO:0044459 plasma membrane part
1.80 1.40e-05 GO:0000267 cell fraction
1.78 1.09e-03 GO:0005626 insoluble fraction
1.78 1.44e-03 GO:0005624 membrane fraction
1.46 8.88e-10 GO:0005886 plasma membrane
1.45 1.58e-09 GO:0071944 cell periphery
1.20 5.94e-03 GO:0044425 membrane part
1.18 2.85e-03 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
5.76 8.76e-04 GO:0003823 antigen binding
5.58 4.27e-04 GO:0019825 oxygen binding
3.17 3.36e-02 GO:0005179 hormone activity
2.91 8.35e-03 GO:0004252 serine-type endopeptidase activity
2.63 2.37e-02 GO:0008236 serine-type peptidase activity
2.59 3.08e-02 GO:0017171 serine hydrolase activity
2.53 1.94e-02 GO:0005529 sugar binding
2.12 6.72e-03 GO:0030246 carbohydrate binding
2.01 4.64e-02 GO:0004175 endopeptidase activity
1.49 5.72e-03 GO:0004872 receptor activity
1.43 5.64e-03 GO:0004871 signal transducer activity
1.43 5.64e-03 GO:0060089 molecular transducer activity