Motif ID: HBP1_HMGB_SSRP1_UBTF.p2

Z-value: 1.671


Transcription factors associated with HBP1_HMGB_SSRP1_UBTF.p2:

Gene SymbolEntrez IDGene Name
HBP1 26959 HMG-box transcription factor 1
HMGB2 3148 high-mobility group box 2
HMGB3 3149 high-mobility group box 3
SSRP1 6749 structure specific recognition protein 1
UBTF 7343 upstream binding transcription factor, RNA polymerase I

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
SSRP1chr11_-_57103324-0.756.9e-41Click!
HMGB3chrX_+_150151757-0.681.9e-30Click!
HMGB2chr4_-_174255454-0.621.9e-24Click!
UBTFchr17_-_42296865-0.313.3e-06Click!
HBP1chr7_+_1068094050.269.6e-05Click!


Activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2.

activity profile for motif HBP1_HMGB_SSRP1_UBTF.p2


Sorted Z-values histogram for motif HBP1_HMGB_SSRP1_UBTF.p2

Sorted Z-values for motif HBP1_HMGB_SSRP1_UBTF.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HBP1_HMGB_SSRP1_UBTF.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr18_-_52988916 48.464 NM_001243234
NM_001243235
TCF4

transcription factor 4

chrX_-_13835187 40.991 GPM6B
glycoprotein M6B
chr12_-_16757944 38.471 LMO3
LIM domain only 3 (rhombotin-like 2)
chr6_+_89790412 37.966 NM_006813
PNRC1
proline-rich nuclear receptor coactivator 1
chr6_+_89790464 35.709 PNRC1
proline-rich nuclear receptor coactivator 1
chrX_-_13835012 34.599 GPM6B
glycoprotein M6B
chrX_-_13835213 33.494 GPM6B
glycoprotein M6B
chr17_+_36861398 33.484 MLLT6
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6
chr11_+_57365577 31.555 NM_001032295
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr18_-_53177999 31.139 NM_001243231
TCF4
transcription factor 4
chrX_-_13835313 29.596 NM_001001995
NM_001001996
NM_005278
GPM6B


glycoprotein M6B


chr12_-_91573264 29.182 NM_133503
DCN
decorin
chr11_+_57365026 29.048 NM_000062
SERPING1
serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
chr3_+_39509069 27.570 NM_182935
MOBP
myelin-associated oligodendrocyte basic protein
chr6_+_99872769 27.535


chr14_-_92413738 27.471 FBLN5
fibulin 5
chr12_-_91576579 26.889 DCN
decorin
chr18_-_53071225 26.623 NM_001243232
TCF4
transcription factor 4
chr2_+_149633173 26.020


chr12_-_16760935 25.942 NM_001001395
NM_001243609
LMO3

LIM domain only 3 (rhombotin-like 2)


Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 173 entries
enrichment   p-value GO term description
3.24 8.41e-11 GO:0007156 homophilic cell adhesion
3.22 4.09e-02 GO:0048663 neuron fate commitment
3.19 1.39e-02 GO:0001764 neuron migration
3.09 2.24e-03 GO:0032526 response to retinoic acid
2.99 1.40e-03 GO:0048565 digestive tract development
2.95 2.79e-02 GO:0050680 negative regulation of epithelial cell proliferation
2.91 8.55e-04 GO:0048706 embryonic skeletal system development
2.91 2.50e-03 GO:0033189 response to vitamin A
2.88 1.13e-03 GO:0055123 digestive system development
2.76 7.39e-03 GO:0030336 negative regulation of cell migration
2.76 7.39e-03 GO:2000146 negative regulation of cell motility
2.67 9.21e-03 GO:0051271 negative regulation of cellular component movement
2.62 6.88e-05 GO:0048705 skeletal system morphogenesis
2.56 2.69e-05 GO:0045165 cell fate commitment
2.56 1.39e-02 GO:0021537 telencephalon development
2.56 1.39e-02 GO:0040013 negative regulation of locomotion
2.54 3.54e-12 GO:0016337 cell-cell adhesion
2.31 3.18e-04 GO:0030900 forebrain development
2.26 3.12e-03 GO:0048562 embryonic organ morphogenesis
2.21 5.34e-08 GO:0051093 negative regulation of developmental process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 23 entries
enrichment   p-value GO term description
3.69 1.42e-03 GO:0005581 collagen
2.59 7.47e-05 GO:0044420 extracellular matrix part
2.09 3.69e-02 GO:0043292 contractile fiber
2.03 2.07e-06 GO:0005578 proteinaceous extracellular matrix
2.03 1.67e-02 GO:0045211 postsynaptic membrane
1.99 2.46e-03 GO:0005911 cell-cell junction
1.91 4.23e-06 GO:0031012 extracellular matrix
1.91 1.58e-04 GO:0044456 synapse part
1.91 2.58e-02 GO:0030424 axon
1.88 3.78e-02 GO:0031252 cell leading edge
1.78 1.71e-07 GO:0030054 cell junction
1.78 1.05e-04 GO:0045202 synapse
1.70 2.23e-02 GO:0015629 actin cytoskeleton
1.65 9.03e-03 GO:0009986 cell surface
1.52 5.96e-06 GO:0044421 extracellular region part
1.49 1.84e-13 GO:0044459 plasma membrane part
1.46 1.24e-03 GO:0042995 cell projection
1.45 2.58e-05 GO:0005887 integral to plasma membrane
1.43 4.05e-05 GO:0031226 intrinsic to plasma membrane
1.43 1.39e-02 GO:0005615 extracellular space

Gene overrepresentation in function category:

Showing 1 to 20 of 27 entries
enrichment   p-value GO term description
4.98 1.24e-02 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
4.69 2.37e-02 GO:0005212 structural constituent of eye lens
2.90 2.95e-03 GO:0005178 integrin binding
2.79 4.45e-02 GO:0004879 ligand-dependent nuclear receptor activity
2.43 4.22e-03 GO:0004222 metalloendopeptidase activity
2.02 1.77e-03 GO:0000975 regulatory region DNA binding
2.02 1.77e-03 GO:0001067 regulatory region nucleic acid binding
2.02 1.77e-03 GO:0044212 transcription regulatory region DNA binding
2.01 3.26e-03 GO:0010843 promoter binding
1.93 6.23e-05 GO:0016563 transcription activator activity
1.90 2.25e-11 GO:0043565 sequence-specific DNA binding
1.90 1.12e-03 GO:0032403 protein complex binding
1.88 1.63e-16 GO:0001071 nucleic acid binding transcription factor activity
1.88 1.63e-16 GO:0003700 sequence-specific DNA binding transcription factor activity
1.79 1.92e-08 GO:0005509 calcium ion binding
1.69 1.59e-10 GO:0030528 transcription regulator activity
1.66 4.26e-02 GO:0003779 actin binding
1.63 2.95e-02 GO:0000988 protein binding transcription factor activity
1.63 2.95e-02 GO:0000989 transcription factor binding transcription factor activity
1.61 4.96e-02 GO:0003712 transcription cofactor activity