Motif ID: HES1.p2

Z-value: 2.018


Transcription factors associated with HES1.p2:

Gene SymbolEntrez IDGene Name
HES1 3280 hairy and enhancer of split 1, (Drosophila)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HES1chr3_+_193853937-0.195.9e-03Click!


Activity profile for motif HES1.p2.

activity profile for motif HES1.p2


Sorted Z-values histogram for motif HES1.p2

Sorted Z-values for motif HES1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HES1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_-_10588451 33.060 NM_002539
 ODC1
ornithine decarboxylase 1
chr9_+_91926109 32.218 NM_001827
 CKS2
CDC28 protein kinase regulatory subunit 2
chr1_-_94374986 30.923 NM_002061
 GCLM
glutamate-cysteine ligase, modifier subunit
chr9_+_131451519 29.113 SET
SET nuclear oncogene
chr1_+_165797060 28.561 UCK2
uridine-cytidine kinase 2
chr1_-_94375028 27.267 GCLM
glutamate-cysteine ligase, modifier subunit
chr1_+_165796652 25.749 NM_012474
 UCK2
uridine-cytidine kinase 2
chr6_-_13814546 25.679 NM_001031713
 CCDC90A
coiled-coil domain containing 90A
chr1_-_94374949 24.873 GCLM
glutamate-cysteine ligase, modifier subunit
chr12_+_131356640 24.866 RAN
RAN, member RAS oncogene family
chr12_-_123380608 24.776


chr16_+_29817810 24.685 NM_001042539
NM_002383
 MAZ

MYC-associated zinc finger protein (purine-binding transcription factor)

chr5_-_133340823 23.187 NM_003374
 VDAC1
voltage-dependent anion channel 1
chr1_-_11120081 23.164 NM_003132
 SRM
spermidine synthase
chrX_+_21958714 22.525 NM_004595
 SMS
spermine synthase
chr2_+_113403433 20.918 NM_005415
 SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr7_+_155089614 20.917 INSIG1
insulin induced gene 1
chr17_+_73257992 20.695 MRPS7
mitochondrial ribosomal protein S7
chr3_+_184081178 20.326 NM_006232
 POLR2H
polymerase (RNA) II (DNA directed) polypeptide H
chr17_+_73257944 20.207 MRPS7
mitochondrial ribosomal protein S7

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 192 entries
enrichment   p-value GO term description
4.11 1.29e-02 GO:0050773 regulation of dendrite development
3.51 6.38e-03 GO:0006458 'de novo' protein folding
2.86 1.29e-04 GO:0009260 ribonucleotide biosynthetic process
2.83 8.12e-03 GO:0009142 nucleoside triphosphate biosynthetic process
2.74 5.48e-05 GO:0042254 ribosome biogenesis
2.73 2.66e-03 GO:0009152 purine ribonucleotide biosynthetic process
2.65 1.85e-02 GO:0018196 peptidyl-asparagine modification
2.65 1.85e-02 GO:0018279 protein N-linked glycosylation via asparagine
2.57 1.13e-03 GO:0050657 nucleic acid transport
2.57 1.13e-03 GO:0050658 RNA transport
2.57 1.13e-03 GO:0051236 establishment of RNA localization
2.56 3.69e-07 GO:0000375 RNA splicing, via transesterification reactions
2.55 2.60e-07 GO:0071843 cellular component biogenesis at cellular level
2.55 3.20e-06 GO:0006260 DNA replication
2.54 1.12e-06 GO:0022613 ribonucleoprotein complex biogenesis
2.52 1.37e-06 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile
2.52 1.37e-06 GO:0000398 nuclear mRNA splicing, via spliceosome
2.50 1.58e-10 GO:0051329 interphase of mitotic cell cycle
2.50 7.38e-03 GO:0051320 S phase
2.49 1.35e-10 GO:0051325 interphase

Gene overrepresentation in compartment category:

Showing 1 to 20 of 59 entries
enrichment   p-value GO term description
5.27 1.76e-03 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
4.49 2.93e-02 GO:0031519 PcG protein complex
3.16 1.58e-04 GO:0005643 nuclear pore
3.09 2.68e-05 GO:0046930 pore complex
3.09 4.40e-02 GO:0016469 proton-transporting two-sector ATPase complex
2.50 9.04e-03 GO:0016585 chromatin remodeling complex
2.30 1.51e-15 GO:0005730 nucleolus
2.29 7.96e-03 GO:0044455 mitochondrial membrane part
2.21 7.24e-14 GO:0030529 ribonucleoprotein complex
2.17 6.80e-04 GO:0005819 spindle
2.14 3.47e-05 GO:0005635 nuclear envelope
2.13 3.68e-17 GO:0031967 organelle envelope
2.13 1.45e-07 GO:0019866 organelle inner membrane
2.11 2.10e-10 GO:0005740 mitochondrial envelope
2.10 1.91e-06 GO:0005743 mitochondrial inner membrane
2.09 2.14e-16 GO:0031975 envelope
2.09 2.98e-02 GO:0031965 nuclear membrane
2.07 3.47e-09 GO:0031966 mitochondrial membrane
1.99 2.03e-03 GO:0005813 centrosome
1.98 2.25e-12 GO:0044429 mitochondrial part

Gene overrepresentation in function category:

Showing 1 to 20 of 34 entries
enrichment   p-value GO term description
2.82 3.91e-03 GO:0042393 histone binding
2.59 2.74e-02 GO:0003729 mRNA binding
2.58 1.93e-02 GO:0008135 translation factor activity, nucleic acid binding
2.57 1.35e-02 GO:0008565 protein transporter activity
2.51 2.04e-02 GO:0035257 nuclear hormone receptor binding
2.36 6.21e-04 GO:0008022 protein C-terminus binding
2.35 1.52e-02 GO:0016779 nucleotidyltransferase activity
2.24 1.70e-04 GO:0003682 chromatin binding
2.08 1.52e-18 GO:0003723 RNA binding
1.79 8.20e-05 GO:0016874 ligase activity
1.75 3.35e-03 GO:0003712 transcription cofactor activity
1.74 3.68e-03 GO:0000988 protein binding transcription factor activity
1.74 3.68e-03 GO:0000989 transcription factor binding transcription factor activity
1.73 1.02e-03 GO:0019904 protein domain specific binding
1.73 4.03e-02 GO:0016879 ligase activity, forming carbon-nitrogen bonds
1.72 4.57e-07 GO:0019899 enzyme binding
1.55 4.68e-16 GO:0000166 nucleotide binding
1.50 1.37e-07 GO:0005524 ATP binding
1.49 1.24e-07 GO:0032559 adenyl ribonucleotide binding
1.49 1.25e-07 GO:0030554 adenyl nucleotide binding