Motif ID: HIC1.p2

Z-value: 3.263


Transcription factors associated with HIC1.p2:

Gene SymbolEntrez IDGene Name
HIC1 3090 hypermethylated in cancer 1

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIC1chr17_+_1958354,
chr17_+_1959512		0.451.7e-12Click!


Activity profile for motif HIC1.p2.

activity profile for motif HIC1.p2


Sorted Z-values histogram for motif HIC1.p2

Sorted Z-values for motif HIC1.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIC1.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_+_222845 76.681 NM_000517
 HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr12_+_121078421 72.117 NM_001033677
 CABP1
calcium binding protein 1
chr1_+_6845381 56.867 NM_001195563
NM_001242701
NM_015215
 CAMTA1


calmodulin binding transcription activator 1


chr16_+_226678 50.724 NM_000558
 HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr19_+_708766 49.337 NM_001040134
NM_002579
 PALM

paralemmin

chr14_+_103243832 49.255 TRAF3
TNF receptor-associated factor 3
chr10_+_126150340 48.916 NM_001167880
NM_022126
 LHPP

phospholysine phosphohistidine inorganic pyrophosphate phosphatase

chr11_-_12030838 47.757 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr15_+_68871285 47.562 NM_006091
 CORO2B
coronin, actin binding protein, 2B
chr11_-_12030882 45.209 NM_013253
 DKK3
dickkopf 3 homolog (Xenopus laevis)
chr8_+_26435339 43.383 NM_001386
 DPYSL2
dihydropyrimidinase-like 2
chr16_+_58497628 43.019 NDRG4
NDRG family member 4
chr9_+_137979513 42.323 OLFM1
olfactomedin 1
chr9_+_130965666 41.660 DNM1
dynamin 1
chr3_+_49027281 41.456 NM_177938
NM_177939
 P4HTM

prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)

chr13_+_27131799 41.161 NM_006646
 WASF3
WAS protein family, member 3
chr5_-_11904127 40.892 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr1_+_10270680 40.471 NM_015074
NM_183416
 KIF1B

kinesin family member 1B

chr5_-_11903964 40.439 NM_001332
 CTNND2
catenin (cadherin-associated protein), delta 2 (neural plakophilin-related arm-repeat protein)
chr15_-_29862926 40.228 NM_015307
 FAM189A1
family with sequence similarity 189, member A1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 317 entries
enrichment   p-value GO term description
2.98 9.38e-03 GO:0051588 regulation of neurotransmitter transport
2.92 2.81e-02 GO:0032231 regulation of actin filament bundle assembly
2.82 1.59e-02 GO:0021954 central nervous system neuron development
2.34 4.20e-02 GO:0048863 stem cell differentiation
2.29 5.38e-04 GO:0050770 regulation of axonogenesis
2.19 1.17e-04 GO:0001505 regulation of neurotransmitter levels
2.19 3.07e-03 GO:0048638 regulation of developmental growth
2.14 1.68e-03 GO:0060485 mesenchyme development
2.10 1.08e-02 GO:0007173 epidermal growth factor receptor signaling pathway
2.09 2.62e-03 GO:0060828 regulation of canonical Wnt receptor signaling pathway
2.08 7.74e-03 GO:0030178 negative regulation of Wnt receptor signaling pathway
2.07 6.34e-06 GO:0001503 ossification
2.07 1.31e-03 GO:0051216 cartilage development
2.07 3.29e-02 GO:0031346 positive regulation of cell projection organization
2.06 6.54e-04 GO:0007188 G-protein signaling, coupled to cAMP nucleotide second messenger
2.05 4.13e-23 GO:0048812 neuron projection morphogenesis
2.05 8.41e-23 GO:0048667 cell morphogenesis involved in neuron differentiation
2.05 1.07e-21 GO:0007409 axonogenesis
2.05 1.63e-02 GO:0021953 central nervous system neuron differentiation
2.04 1.13e-04 GO:0007265 Ras protein signal transduction

Gene overrepresentation in compartment category:

Showing 1 to 20 of 51 entries
enrichment   p-value GO term description
3.09 2.42e-02 GO:0032589 neuron projection membrane
2.19 1.21e-03 GO:0031256 leading edge membrane
2.17 3.41e-05 GO:0008076 voltage-gated potassium channel complex
2.17 3.41e-05 GO:0034705 potassium channel complex
2.13 4.58e-04 GO:0033267 axon part
1.92 4.02e-05 GO:0034703 cation channel complex
1.91 2.01e-03 GO:0019898 extrinsic to membrane
1.90 2.84e-03 GO:0019717 synaptosome
1.85 6.52e-05 GO:0005912 adherens junction
1.83 1.05e-03 GO:0031253 cell projection membrane
1.82 1.73e-05 GO:0030424 axon
1.81 6.86e-05 GO:0070161 anchoring junction
1.74 5.27e-11 GO:0043005 neuron projection
1.71 4.86e-04 GO:0031252 cell leading edge
1.66 8.90e-09 GO:0045202 synapse
1.65 6.16e-03 GO:0043025 neuronal cell body
1.63 8.75e-03 GO:0044297 cell body
1.61 9.57e-04 GO:0016323 basolateral plasma membrane
1.60 3.47e-03 GO:0034702 ion channel complex
1.56 3.00e-02 GO:0030425 dendrite

Gene overrepresentation in function category:

Showing 1 to 20 of 62 entries
enrichment   p-value GO term description
2.24 2.03e-02 GO:0004702 receptor signaling protein serine/threonine kinase activity
2.10 3.89e-05 GO:0005057 receptor signaling protein activity
2.09 1.77e-02 GO:0004714 transmembrane receptor protein tyrosine kinase activity
2.06 2.11e-03 GO:0019199 transmembrane receptor protein kinase activity
2.03 2.63e-02 GO:0030165 PDZ domain binding
2.02 1.06e-03 GO:0005088 Ras guanyl-nucleotide exchange factor activity
1.88 1.05e-04 GO:0022843 voltage-gated cation channel activity
1.87 2.42e-05 GO:0005085 guanyl-nucleotide exchange factor activity
1.85 4.36e-02 GO:0003704 specific RNA polymerase II transcription factor activity
1.83 6.39e-03 GO:0051020 GTPase binding
1.83 2.84e-02 GO:0005249 voltage-gated potassium channel activity
1.74 1.02e-02 GO:0004713 protein tyrosine kinase activity
1.72 3.96e-07 GO:0005083 small GTPase regulator activity
1.70 4.96e-02 GO:0005267 potassium channel activity
1.67 1.48e-03 GO:0010843 promoter binding
1.65 1.98e-03 GO:0000975 regulatory region DNA binding
1.65 1.98e-03 GO:0001067 regulatory region nucleic acid binding
1.65 1.98e-03 GO:0044212 transcription regulatory region DNA binding
1.64 3.09e-09 GO:0030695 GTPase regulator activity
1.64 6.17e-03 GO:0005244 voltage-gated ion channel activity