Motif ID: HIF1A.p2

Z-value: 2.833


Transcription factors associated with HIF1A.p2:

Gene SymbolEntrez IDGene Name
HIF1A 3091 hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HIF1Achr14_+_621643390.621.0e-24Click!


Activity profile for motif HIF1A.p2.

activity profile for motif HIF1A.p2


Sorted Z-values histogram for motif HIF1A.p2

Sorted Z-values for motif HIF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HIF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr7_+_156931631 117.088 NM_014671
 UBE3C
ubiquitin protein ligase E3C
chr1_-_8939150 108.355 NM_001428
 ENO1
enolase 1, (alpha)
chr7_+_156931663 103.755 UBE3C
ubiquitin protein ligase E3C
chr3_-_81810618 72.415 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr1_-_8938745 69.538 ENO1
enolase 1, (alpha)
chr12_+_131356617 68.439 RAN
RAN, member RAS oncogene family
chr11_+_18416111 68.012 LDHA
lactate dehydrogenase A
chr11_+_18416106 66.001 LDHA
lactate dehydrogenase A
chr3_-_81810914 65.846 NM_000158
 GBE1
glucan (1,4-alpha-), branching enzyme 1
chr1_+_193091220 65.468 CDC73
cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
chr1_-_8938727 63.730 ENO1
enolase 1, (alpha)
chr6_-_7910278 62.360 NM_001145549
 TXNDC5
thioredoxin domain containing 5 (endoplasmic reticulum)
chr11_-_64014140 61.224 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr2_-_198364997 59.104 NM_199440
 HSPD1
heat shock 60kDa protein 1 (chaperonin)
chr1_-_8938691 59.064 ENO1
enolase 1, (alpha)
chr2_+_113403433 56.140 NM_005415
 SLC20A1
solute carrier family 20 (phosphate transporter), member 1
chr11_+_18415917 55.913 NM_001135239
NM_001165415
NM_001165416
NM_005566
 LDHA



lactate dehydrogenase A



chr3_+_52719935 54.380 NM_014366
NM_206825
NM_206826
 GNL3


guanine nucleotide binding protein-like 3 (nucleolar)


chr8_+_48920969 52.138 NM_003350
 UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr17_+_49230938 50.997 NME1
NME1-NME2
non-metastatic cells 1, protein (NM23A) expressed in
NME1-NME2 readthrough

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 127 entries
enrichment   p-value GO term description
4.48 4.74e-02 GO:0005977 glycogen metabolic process
4.12 4.84e-03 GO:0044264 cellular polysaccharide metabolic process
4.03 3.03e-02 GO:0006458 'de novo' protein folding
3.54 2.20e-06 GO:0042254 ribosome biogenesis
3.40 1.50e-03 GO:0006364 rRNA processing
3.24 6.30e-03 GO:0034637 cellular carbohydrate biosynthetic process
3.22 3.96e-03 GO:0016072 rRNA metabolic process
3.14 3.87e-04 GO:0050657 nucleic acid transport
3.14 3.87e-04 GO:0050658 RNA transport
3.14 3.87e-04 GO:0051236 establishment of RNA localization
3.04 7.79e-04 GO:0006403 RNA localization
3.04 3.79e-03 GO:0051028 mRNA transport
2.98 1.73e-06 GO:0022613 ribonucleoprotein complex biogenesis
2.97 6.72e-07 GO:0071843 cellular component biogenesis at cellular level
2.91 3.58e-02 GO:0006414 translational elongation
2.85 2.69e-04 GO:0043623 cellular protein complex assembly
2.83 2.07e-03 GO:0006006 glucose metabolic process
2.81 2.41e-03 GO:0015931 nucleobase, nucleoside, nucleotide and nucleic acid transport
2.77 2.21e-04 GO:0006913 nucleocytoplasmic transport
2.74 2.96e-04 GO:0051169 nuclear transport

Gene overrepresentation in compartment category:

Showing 1 to 20 of 58 entries
enrichment   p-value GO term description
10.19 1.39e-02 GO:0030686 90S preribosome
7.61 1.05e-03 GO:0032592 integral to mitochondrial membrane
6.76 8.66e-04 GO:0031519 PcG protein complex
4.20 3.44e-02 GO:0022627 cytosolic small ribosomal subunit
3.92 3.01e-02 GO:0031970 organelle envelope lumen
3.50 2.51e-02 GO:0015935 small ribosomal subunit
3.31 7.74e-03 GO:0005643 nuclear pore
2.92 2.37e-02 GO:0046930 pore complex
2.85 2.23e-08 GO:0005635 nuclear envelope
2.83 2.05e-04 GO:0031965 nuclear membrane
2.74 2.27e-02 GO:0005925 focal adhesion
2.73 3.94e-03 GO:0044455 mitochondrial membrane part
2.64 2.48e-02 GO:0030055 cell-substrate junction
2.61 4.56e-02 GO:0005924 cell-substrate adherens junction
2.54 4.82e-13 GO:0005730 nucleolus
2.47 1.13e-03 GO:0031252 cell leading edge
2.44 8.92e-03 GO:0044445 cytosolic part
2.29 1.71e-13 GO:0031967 organelle envelope
2.25 6.03e-13 GO:0031975 envelope
2.04 3.78e-06 GO:0030529 ribonucleoprotein complex

Gene overrepresentation in function category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
4.13 2.56e-02 GO:0019205 nucleobase, nucleoside, nucleotide kinase activity
2.30 1.01e-02 GO:0003682 chromatin binding
1.89 1.60e-07 GO:0003723 RNA binding
1.57 2.99e-02 GO:0019899 enzyme binding
1.47 4.44e-07 GO:0000166 nucleotide binding
1.44 6.65e-35 GO:0005515 protein binding
1.38 5.21e-03 GO:0035639 purine ribonucleoside triphosphate binding
1.37 5.56e-03 GO:0017076 purine nucleotide binding
1.37 6.00e-03 GO:0032553 ribonucleotide binding
1.37 6.00e-03 GO:0032555 purine ribonucleotide binding
1.26 1.71e-06 GO:0003824 catalytic activity
1.17 3.10e-17 GO:0005488 binding