Motif ID: HMGA1,2.p2

Z-value: 1.133


Transcription factors associated with HMGA1,2.p2:

Gene SymbolEntrez IDGene Name
HMGA1 3159 high mobility group AT-hook 1
HMGA2 8091 high mobility group AT-hook 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HMGA2chr12_+_662188790.212.1e-03Click!
HMGA1chr6_+_34204928-0.082.4e-01Click!


Activity profile for motif HMGA1,2.p2.

activity profile for motif HMGA1,2.p2


Sorted Z-values histogram for motif HMGA1,2.p2

Sorted Z-values for motif HMGA1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HMGA1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_88450243 51.498 SPARCL1
SPARC-like 1 (hevin)
chr4_-_88450601 22.265 NM_001128310
NM_004684
 SPARCL1

SPARC-like 1 (hevin)

chr4_+_88896801 18.506 NM_000582
NM_001040058
NM_001040060
NM_001251829
NM_001251830
 SPP1




secreted phosphoprotein 1




chr4_+_88896868 17.536 SPP1
secreted phosphoprotein 1
chr4_+_88896838 16.938 SPP1
secreted phosphoprotein 1
chr10_-_118680978 14.791 KIAA1598
KIAA1598
chr2_-_216259197 14.702 FN1
fibronectin 1
chr1_-_163113938 13.164 RGS5
regulator of G-protein signaling 5
chr10_+_5005453 12.859 NM_001353
 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr12_+_48516428 12.784 NM_001166687
NM_001166688
 PFKM

phosphofructokinase, muscle

chr10_+_5005601 11.153 AKR1C1
AKR1C3
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chrX_-_137949716 11.121 NM_001139502
 FGF13
fibroblast growth factor 13
chr7_+_23286420 10.007 GPNMB
glycoprotein (transmembrane) nmb
chr2_-_175712276 10.005 NM_001206602
 CHN1
chimerin (chimaerin) 1
chr10_+_5005685 9.970 AKR1C1
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr3_-_195310985 9.778 NM_001647
 APOD
apolipoprotein D
chr7_+_23286384 9.646 GPNMB
glycoprotein (transmembrane) nmb
chrX_+_83116153 9.569 NM_021118
 CYLC1
cylicin, basic protein of sperm head cytoskeleton 1
chr7_+_23286277 9.482 NM_001005340
NM_002510
 GPNMB

glycoprotein (transmembrane) nmb

chrX_+_103031797 9.305 PLP1
proteolipid protein 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 19 of 19 entries
enrichment   p-value GO term description
4.02 1.54e-02 GO:0060338 regulation of type I interferon-mediated signaling pathway
3.12 5.79e-09 GO:0007156 homophilic cell adhesion
2.51 3.58e-04 GO:0006805 xenobiotic metabolic process
2.51 3.58e-04 GO:0071466 cellular response to xenobiotic stimulus
2.49 4.40e-04 GO:0009410 response to xenobiotic stimulus
1.90 4.07e-03 GO:0016337 cell-cell adhesion
1.80 2.22e-02 GO:0032787 monocarboxylic acid metabolic process
1.68 3.45e-05 GO:0006082 organic acid metabolic process
1.67 6.19e-05 GO:0019752 carboxylic acid metabolic process
1.67 6.19e-05 GO:0043436 oxoacid metabolic process
1.65 1.13e-04 GO:0042180 cellular ketone metabolic process
1.55 3.54e-03 GO:0007155 cell adhesion
1.55 3.54e-03 GO:0022610 biological adhesion
1.30 2.27e-03 GO:0042221 response to chemical stimulus
1.30 5.66e-03 GO:0065008 regulation of biological quality
1.25 9.45e-05 GO:0023052 signaling
1.23 4.65e-03 GO:0007165 signal transduction
1.20 2.40e-03 GO:0051716 cellular response to stimulus
1.11 4.80e-02 GO:0065007 biological regulation

Gene overrepresentation in compartment category:

Showing 1 to 12 of 12 entries
enrichment   p-value GO term description
1.79 4.93e-10 GO:0005615 extracellular space
1.69 3.72e-10 GO:0044421 extracellular region part
1.54 1.14e-04 GO:0005626 insoluble fraction
1.52 4.81e-04 GO:0005624 membrane fraction
1.46 1.38e-04 GO:0000267 cell fraction
1.43 1.76e-04 GO:0005887 integral to plasma membrane
1.42 1.61e-04 GO:0031226 intrinsic to plasma membrane
1.41 2.12e-02 GO:0042995 cell projection
1.36 2.52e-06 GO:0044459 plasma membrane part
1.30 8.28e-04 GO:0005576 extracellular region
1.21 7.55e-05 GO:0005886 plasma membrane
1.21 1.16e-04 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 5 of 5 entries
enrichment   p-value GO term description
9.28 1.13e-02 GO:0032052 bile acid binding
6.96 2.79e-02 GO:0005132 interferon-alpha/beta receptor binding
2.01 5.70e-03 GO:0005125 cytokine activity
1.96 2.75e-02 GO:0005126 cytokine receptor binding
1.67 1.76e-05 GO:0005509 calcium ion binding