Motif ID: HNF1A.p2

Z-value: 2.762


Transcription factors associated with HNF1A.p2:

Gene SymbolEntrez IDGene Name
HNF1A 6927 HNF1 homeobox A

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF1Achr12_+_1214165480.551.0e-18Click!


Activity profile for motif HNF1A.p2.

activity profile for motif HNF1A.p2


Sorted Z-values histogram for motif HNF1A.p2

Sorted Z-values for motif HNF1A.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr4_-_72649734 82.669 NM_000583
 GC
group-specific component (vitamin D binding protein)
chr4_+_74269971 81.924 NM_000477
 ALB
albumin
chr14_-_94854910 78.232 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr14_-_94855120 75.221 NM_000295
 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr17_-_64225496 66.494 NM_000042
 APOH
apolipoprotein H (beta-2-glycoprotein I)
chr4_-_155511838 59.559 NM_000508
NM_021871
 FGA

fibrinogen alpha chain

chr19_-_36303724 56.780 PRODH2
proline dehydrogenase (oxidase) 2
chr19_-_36303766 54.561 PRODH2
proline dehydrogenase (oxidase) 2
chr6_+_161123224 54.341 NM_000301
NM_001168338
 PLG

plasminogen

chr4_+_74347461 53.178 NM_001133
 AFM
afamin
chr11_+_46740769 49.387 F2
coagulation factor II (thrombin)
chr14_+_95027760 48.345 NM_006215
 SERPINA4
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4
chr11_+_46740736 45.480 NM_000506
 F2
coagulation factor II (thrombin)
chr15_+_58724174 44.425 NM_000236
 LIPC
lipase, hepatic
chr8_-_17752847 43.477 NM_147203
NM_201553
NM_004467
NM_201552
 FGL1



fibrinogen-like 1



chr17_+_41052813 40.357 NM_000151
 G6PC
glucose-6-phosphatase, catalytic subunit
chr6_+_31623688 38.462 APOM
apolipoprotein M
chr1_+_159557615 38.331 NM_001639
 APCS
amyloid P component, serum
chr10_+_115312777 37.513 NM_004132
 HABP2
hyaluronan binding protein 2
chr3_+_149192367 35.989 NM_004617
 TM4SF4
transmembrane 4 L six family member 4

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 43 entries
enrichment   p-value GO term description
58.44 6.00e-03 GO:0034392 negative regulation of smooth muscle cell apoptosis
43.83 2.37e-02 GO:0015712 hexose phosphate transport
43.83 2.37e-02 GO:0015760 glucose-6-phosphate transport
38.96 1.48e-03 GO:0034391 regulation of smooth muscle cell apoptosis
25.97 1.20e-02 GO:0009812 flavonoid metabolic process
25.97 1.20e-02 GO:0051918 negative regulation of fibrinolysis
24.35 1.23e-03 GO:0051917 regulation of fibrinolysis
21.25 3.05e-02 GO:0009698 phenylpropanoid metabolic process
21.25 3.05e-02 GO:0010660 regulation of muscle cell apoptosis
17.05 1.30e-04 GO:0017144 drug metabolic process
14.61 4.20e-04 GO:0030195 negative regulation of blood coagulation
14.11 5.46e-04 GO:0050819 negative regulation of coagulation
11.99 3.13e-04 GO:0030193 regulation of blood coagulation
11.13 5.75e-04 GO:0050818 regulation of coagulation
10.55 5.76e-15 GO:0006805 xenobiotic metabolic process
10.55 5.76e-15 GO:0071466 cellular response to xenobiotic stimulus
10.47 6.91e-15 GO:0009410 response to xenobiotic stimulus
9.98 6.60e-03 GO:0006721 terpenoid metabolic process
9.74 1.68e-03 GO:0061041 regulation of wound healing
9.48 4.29e-02 GO:0008206 bile acid metabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
25.05 2.87e-02 GO:0005577 fibrinogen complex
10.39 1.45e-04 GO:0005903 brush border
10.12 3.73e-05 GO:0031983 vesicle lumen
10.08 2.09e-02 GO:0031526 brush border membrane
9.95 2.05e-04 GO:0031093 platelet alpha granule lumen
9.74 2.42e-04 GO:0034774 secretory granule lumen
9.35 3.34e-04 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
8.20 9.28e-04 GO:0031091 platelet alpha granule
5.92 8.14e-07 GO:0016324 apical plasma membrane
5.27 7.06e-07 GO:0045177 apical part of cell
5.25 1.12e-07 GO:0005792 microsome
5.07 2.06e-07 GO:0042598 vesicular fraction
3.38 3.87e-10 GO:0005615 extracellular space
3.21 3.59e-09 GO:0005624 membrane fraction
3.18 2.65e-09 GO:0005626 insoluble fraction
2.86 2.67e-05 GO:0005789 endoplasmic reticulum membrane
2.84 1.37e-08 GO:0044421 extracellular region part
2.82 3.94e-09 GO:0000267 cell fraction
2.79 4.45e-05 GO:0042175 nuclear membrane-endoplasmic reticulum network
2.63 1.12e-04 GO:0044432 endoplasmic reticulum part

Gene overrepresentation in function category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
22.96 1.63e-10 GO:0015020 glucuronosyltransferase activity
21.25 8.12e-03 GO:0001972 retinoic acid binding
19.48 1.19e-03 GO:0008514 organic anion transmembrane transporter activity
14.61 4.19e-02 GO:0015149 hexose transmembrane transporter activity
9.30 2.87e-03 GO:0043498 cell surface binding
9.09 3.35e-03 GO:0019825 oxygen binding
8.35 1.50e-03 GO:0033293 monocarboxylic acid binding
7.79 3.57e-02 GO:0015103 inorganic anion transmembrane transporter activity
7.20 4.66e-03 GO:0005496 steroid binding
6.44 3.71e-05 GO:0008194 UDP-glycosyltransferase activity
6.05 5.71e-03 GO:0004867 serine-type endopeptidase inhibitor activity
5.85 2.14e-02 GO:0004497 monooxygenase activity
5.44 3.59e-02 GO:0015294 solute:cation symporter activity
5.23 2.77e-03 GO:0020037 heme binding
4.91 5.05e-03 GO:0046906 tetrapyrrole binding
4.76 5.11e-04 GO:0016758 transferase activity, transferring hexosyl groups
4.41 1.39e-02 GO:0004866 endopeptidase inhibitor activity
4.32 1.67e-02 GO:0031406 carboxylic acid binding
4.23 2.01e-02 GO:0061135 endopeptidase regulator activity
4.18 2.26e-02 GO:0030414 peptidase inhibitor activity