Motif ID: HNF4A_NR2F1,2.p2

Z-value: 2.788


Transcription factors associated with HNF4A_NR2F1,2.p2:

Gene SymbolEntrez IDGene Name
HNF4A 3172 hepatocyte nuclear factor 4, alpha
NR2F1 7025 nuclear receptor subfamily 2, group F, member 1
NR2F2 7026 nuclear receptor subfamily 2, group F, member 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HNF4Achr20_+_430298650.631.9e-25Click!
NR2F2chr15_+_96876568-0.291.1e-05Click!
NR2F1chr5_+_929189240.243.5e-04Click!


Activity profile for motif HNF4A_NR2F1,2.p2.

activity profile for motif HNF4A_NR2F1,2.p2


Sorted Z-values histogram for motif HNF4A_NR2F1,2.p2

Sorted Z-values for motif HNF4A_NR2F1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HNF4A_NR2F1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr5_-_42811959 42.392 NM_001085486
NM_001093726
NM_005410
 SEPP1


selenoprotein P, plasma, 1


chr16_+_222845 41.295 NM_000517
 HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr19_+_35629727 36.722 NM_021902
 FXYD1
FXYD domain containing ion transport regulator 1
chr14_-_94855120 36.451 NM_000295
 SERPINA1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
chr6_+_31982538 35.634 NM_001242823
NM_001252204
NM_007293
NM_001002029
 LOC100293534
C4A

C4B
complement C4-B-like
complement component 4A (Rodgers blood group)

complement component 4B (Chido blood group)
chr22_+_23229959 35.111 NM_001178126
 IGLL5
IGLC1
immunoglobulin lambda-like polypeptide 5
immunoglobulin lambda constant 1 (Mcg marker)
chr14_-_24777184 34.151 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_24777160 33.593 CIDEB
cell death-inducing DFFA-like effector b
chr14_-_24777153 33.130 CIDEB
cell death-inducing DFFA-like effector b
chr22_+_22569155 30.375


chr3_-_52479042 30.227 NM_020163
 SEMA3G
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
chr1_-_230849847 28.262 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr14_-_24777064 27.978


chr1_-_230849863 27.380 AGT
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
chr22_-_20104695 25.560 TRMT2A
TRM2 tRNA methyltransferase 2 homolog A (S. cerevisiae)
chr1_-_173886401 25.030 SERPINC1
serpin peptidase inhibitor, clade C (antithrombin), member 1
chr4_+_159593233 24.799 NM_004453
 ETFDH
electron-transferring-flavoprotein dehydrogenase
chr1_-_151345156 24.506 NM_003944
 SELENBP1
selenium binding protein 1
chr17_-_34329083 24.493 NM_032965
 CCL15
chemokine (C-C motif) ligand 15
chr9_+_74526527 23.907 C9orf85
chromosome 9 open reading frame 85

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 78 entries
enrichment   p-value GO term description
2.84 2.73e-03 GO:0072376 protein activation cascade
2.10 1.60e-03 GO:0006936 muscle contraction
2.06 1.41e-03 GO:0003012 muscle system process
2.04 2.16e-02 GO:0002252 immune effector process
1.98 3.39e-04 GO:0008202 steroid metabolic process
1.93 1.45e-02 GO:0006874 cellular calcium ion homeostasis
1.92 3.34e-03 GO:0006631 fatty acid metabolic process
1.87 3.81e-02 GO:0055074 calcium ion homeostasis
1.87 3.81e-02 GO:0072503 cellular divalent inorganic cation homeostasis
1.82 1.87e-02 GO:0032101 regulation of response to external stimulus
1.80 6.39e-03 GO:0006875 cellular metal ion homeostasis
1.79 1.12e-03 GO:0032787 monocarboxylic acid metabolic process
1.79 2.27e-03 GO:0034097 response to cytokine stimulus
1.79 5.05e-03 GO:0055065 metal ion homeostasis
1.79 8.48e-03 GO:0048545 response to steroid hormone stimulus
1.74 1.82e-02 GO:0006954 inflammatory response
1.73 1.55e-09 GO:0006955 immune response
1.72 1.37e-04 GO:0002684 positive regulation of immune system process
1.71 2.39e-02 GO:0030003 cellular cation homeostasis
1.70 2.27e-04 GO:0050776 regulation of immune response

Gene overrepresentation in compartment category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
1.76 2.82e-13 GO:0005626 insoluble fraction
1.74 3.47e-12 GO:0005624 membrane fraction
1.69 6.57e-15 GO:0000267 cell fraction
1.67 3.05e-16 GO:0005887 integral to plasma membrane
1.67 4.26e-02 GO:0005792 microsome
1.65 2.20e-15 GO:0031226 intrinsic to plasma membrane
1.62 3.14e-08 GO:0005615 extracellular space
1.52 6.07e-19 GO:0044459 plasma membrane part
1.49 1.16e-06 GO:0044421 extracellular region part
1.34 1.58e-02 GO:0005794 Golgi apparatus
1.30 4.46e-02 GO:0005783 endoplasmic reticulum
1.26 1.18e-02 GO:0012505 endomembrane system
1.25 1.43e-03 GO:0005576 extracellular region
1.21 4.19e-06 GO:0005886 plasma membrane
1.20 4.55e-06 GO:0071944 cell periphery
1.15 2.32e-05 GO:0044444 cytoplasmic part
1.12 6.82e-06 GO:0005737 cytoplasm
1.10 2.33e-03 GO:0016020 membrane

Gene overrepresentation in function category:

Showing 1 to 18 of 18 entries
enrichment   p-value GO term description
4.22 4.54e-04 GO:0070330 aromatase activity
3.89 1.70e-03 GO:0016712 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
3.69 3.01e-06 GO:0019825 oxygen binding
2.83 6.37e-03 GO:0003707 steroid hormone receptor activity
2.81 4.40e-03 GO:0004879 ligand-dependent nuclear receptor activity
2.53 1.47e-03 GO:0004497 monooxygenase activity
2.43 7.19e-06 GO:0046906 tetrapyrrole binding
2.41 2.96e-05 GO:0020037 heme binding
2.06 2.47e-05 GO:0005506 iron ion binding
1.54 1.70e-02 GO:0042803 protein homodimerization activity
1.53 2.68e-02 GO:0008289 lipid binding
1.51 7.92e-04 GO:0046983 protein dimerization activity
1.39 3.06e-02 GO:0042802 identical protein binding
1.32 1.21e-02 GO:0005215 transporter activity
1.22 3.63e-02 GO:0004871 signal transducer activity
1.22 3.63e-02 GO:0060089 molecular transducer activity
1.13 3.03e-05 GO:0005515 protein binding
1.09 2.46e-08 GO:0005488 binding