Motif ID: HSF1,2.p2

Z-value: 1.281


Transcription factors associated with HSF1,2.p2:

Gene SymbolEntrez IDGene Name
HSF1 3297 heat shock transcription factor 1
HSF2 3298 heat shock transcription factor 2

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
HSF1chr8_+_145515244,
chr8_+_145515279		-0.202.9e-03Click!
HSF2chr6_+_1227206850.143.7e-02Click!


Activity profile for motif HSF1,2.p2.

activity profile for motif HSF1,2.p2


Sorted Z-values histogram for motif HSF1,2.p2

Sorted Z-values for motif HSF1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of HSF1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr11_-_111782447 21.064 NM_001885
 CRYAB
crystallin, alpha B
chr2_-_224903324 17.865 NM_001136530
 SERPINE2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
chr6_+_31783280 17.535 NM_005345
 HSPA1A
heat shock 70kDa protein 1A
chr3_-_123411185 15.659 MYLK
myosin light chain kinase
chr6_+_31783314 14.919 HSPA1A
HSPA1B
heat shock 70kDa protein 1A
heat shock 70kDa protein 1B
chr18_+_29171729 14.036 NM_000371
 TTR
transthyretin
chr4_+_41258895 11.757 NM_004181
 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr6_+_151646634 11.154 NM_144497
 AKAP12
A kinase (PRKA) anchor protein 12
chr4_+_41258909 11.119 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr4_+_41258941 11.023 UCHL1
ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
chr9_-_88715024 10.747 NM_177937
 GOLM1
golgi membrane protein 1
chr7_+_75931829 10.149 NM_001540
 HSPB1
heat shock 27kDa protein 1
chr7_+_75931991 10.062 HSPB1
heat shock 27kDa protein 1
chr7_+_134464417 9.919 CALD1
caldesmon 1
chr14_-_60097531 9.685 NM_206852
 RTN1
reticulon 1
chr12_+_119616594 9.653 NM_014365
 HSPB8
heat shock 22kDa protein 8
chr8_-_110620220 9.390 SYBU
syntabulin (syntaxin-interacting)
chr7_+_134464161 9.032 NM_004342
NM_033138
NM_033157
 CALD1


caldesmon 1


chr3_+_158787040 8.948 NM_001197113
NM_001197114
NM_001042705
NM_001042706
NM_001197100
 IQCJ-SCHIP1

IQCJ


IQCJ-SCHIP1 readthrough

IQ motif containing J


chr17_-_42992852 8.579 NM_001131019
NM_001242376
NM_002055
 GFAP


glial fibrillary acidic protein



Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 97 entries
enrichment   p-value GO term description
10.76 1.67e-05 GO:0060678 dichotomous subdivision of terminal units involved in ureteric bud branching
10.76 2.11e-02 GO:0032569 gene-specific transcription from RNA polymerase II promoter
9.57 1.38e-04 GO:0048880 sensory system development
9.57 1.38e-04 GO:0048892 lateral line nerve development
9.57 1.38e-04 GO:0048895 lateral line nerve glial cell differentiation
9.57 1.38e-04 GO:0048925 lateral line system development
9.57 1.38e-04 GO:0048937 lateral line nerve glial cell development
9.57 1.38e-04 GO:0050935 iridophore differentiation
8.81 7.12e-05 GO:0060600 dichotomous subdivision of an epithelial terminal unit
8.07 2.61e-04 GO:0048846 axon extension involved in axon guidance
7.18 2.75e-04 GO:0030513 positive regulation of BMP signaling pathway
7.18 2.75e-04 GO:0048484 enteric nervous system development
7.18 5.86e-03 GO:0090184 positive regulation of kidney development
5.62 6.16e-04 GO:0048588 developmental cell growth
5.00 1.09e-03 GO:0021545 cranial nerve development
4.78 5.56e-03 GO:0048483 autonomic nervous system development
4.74 1.71e-02 GO:0001755 neural crest cell migration
4.19 5.44e-03 GO:0021675 nerve development
4.12 1.59e-02 GO:0014032 neural crest cell development
3.97 1.16e-02 GO:0014033 neural crest cell differentiation

Gene overrepresentation in compartment category:

Showing 1 to 20 of 24 entries
enrichment   p-value GO term description
3.44 5.60e-03 GO:0031093 platelet alpha granule lumen
3.36 7.45e-03 GO:0034774 secretory granule lumen
3.23 1.28e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
3.11 2.14e-02 GO:0031983 vesicle lumen
3.02 1.75e-02 GO:0031091 platelet alpha granule
2.15 4.33e-02 GO:0034703 cation channel complex
1.99 1.52e-02 GO:0030141 stored secretory granule
1.95 3.92e-05 GO:0009986 cell surface
1.94 5.77e-05 GO:0031012 extracellular matrix
1.90 1.26e-14 GO:0044421 extracellular region part
1.89 1.27e-10 GO:0005615 extracellular space
1.80 1.06e-03 GO:0043005 neuron projection
1.79 1.16e-02 GO:0005578 proteinaceous extracellular matrix
1.67 4.59e-10 GO:0005887 integral to plasma membrane
1.65 1.30e-09 GO:0031226 intrinsic to plasma membrane
1.58 1.48e-04 GO:0005626 insoluble fraction
1.57 1.70e-04 GO:0042995 cell projection
1.55 8.33e-04 GO:0005624 membrane fraction
1.54 1.37e-12 GO:0044459 plasma membrane part
1.47 6.43e-09 GO:0005576 extracellular region

Gene overrepresentation in function category:

Showing 1 to 9 of 9 entries
enrichment   p-value GO term description
2.55 2.33e-02 GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
2.52 8.70e-03 GO:0019838 growth factor binding
2.31 2.12e-02 GO:0005267 potassium channel activity
2.20 2.81e-02 GO:0022843 voltage-gated cation channel activity
2.02 3.29e-02 GO:0005244 voltage-gated ion channel activity
2.02 3.29e-02 GO:0022832 voltage-gated channel activity
1.59 8.44e-06 GO:0005102 receptor binding
1.17 9.01e-07 GO:0005515 protein binding
1.09 8.28e-06 GO:0005488 binding