Motif ID: IRF1,2,7.p3

Z-value: 3.215


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF7chr11_-_6159200.824.1e-54Click!
IRF1chr5_-_1318264260.784.8e-45Click!
IRF2chr4_-_1853956160.668.8e-29Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr16_-_67970651 108.680 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr11_-_615920 105.788 IRF7
interferon regulatory factor 7
chr11_-_615998 105.474 NM_001572
NM_004029
IRF7

interferon regulatory factor 7

chr16_-_67970734 97.954 NM_002801
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr21_+_42733916 97.843 NM_002463
LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr1_+_948846 83.627 NM_005101
ISG15
ISG15 ubiquitin-like modifier
chr6_+_32821924 79.116 NM_002800
PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr1_+_79086087 73.318 NM_006820
IFI44L
interferon-induced protein 44-like
chr6_-_32812189 73.104 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr6_-_32811773 67.441 NM_148919
PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr1_+_158979681 67.407 NM_001206567
NM_005531
IFI16

interferon, gamma-inducible protein 16

chr21_+_42792441 67.145 NM_001144925
MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr2_-_152146133 65.260 NMI
N-myc (and STAT) interactor
chr11_+_5710816 64.311 NM_001199573
NM_006074
TRIM22

tripartite motif containing 22

chr1_+_174843523 62.452 NM_001243763
RABGAP1L
RAB GTPase activating protein 1-like
chr11_-_615649 62.141 NM_004031
IRF7
interferon regulatory factor 7
chr2_-_152146373 57.928 NM_004688
NMI
N-myc (and STAT) interactor
chr11_+_63304272 53.594 NM_004585
RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr7_+_74188308 52.785 NM_000265
NCF1
NCF1B
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
chr6_-_32821743 52.278 NM_000593
TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr2_-_231084600 51.990 NM_004509
NM_004510
NM_080424
SP110


SP110 nuclear body protein


chr5_-_149792276 51.424 CD74
CD74 molecule, major histocompatibility complex, class II invariant chain
chr15_+_45003659 51.286 NM_004048
B2M
beta-2-microglobulin
chr19_-_17516383 49.330 NM_004335
BST2
bone marrow stromal cell antigen 2
chr12_+_113416267 49.033 NM_001032731
NM_002535
NM_016817
OAS2


2'-5'-oligoadenylate synthetase 2, 69/71kDa


chr19_+_18284578 47.683 NM_006332
IFI30
interferon, gamma-inducible protein 30
chr6_-_32821592 47.434 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr1_+_79115476 44.630 NM_006417
IFI44
interferon-induced protein 44
chr6_+_26440699 43.787 NM_001242803
NM_006994
NM_197974
BTN3A3


butyrophilin, subfamily 3, member A3


chr2_-_89165652 43.515


chr13_+_50070527 42.738 NM_001040444
PHF11
PHD finger protein 11
chr3_-_172241060 42.630 NM_001190943
NM_001190942
NM_003810
TNFSF10


tumor necrosis factor (ligand) superfamily, member 10


chr10_+_91087601 42.629 NM_001549
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr17_+_25958257 42.112 LGALS9
lectin, galactoside-binding, soluble, 9
chr5_-_149792370 42.091 NM_001025158
NM_001025159
NM_004355
CD74


CD74 molecule, major histocompatibility complex, class II invariant chain


chr17_+_25958245 42.066 LGALS9
lectin, galactoside-binding, soluble, 9
chr13_+_50070096 41.706 PHF11
PHD finger protein 11
chr12_+_25205488 41.045 LRMP
lymphoid-restricted membrane protein
chr3_-_30936152 39.735 NM_207359
GADL1
glutamate decarboxylase-like 1
chr19_+_18284631 39.617 IFI30
interferon, gamma-inducible protein 30
chr1_-_25291474 38.897 NM_001031680
RUNX3
runt-related transcription factor 3
chr6_-_133084585 38.404 NM_078488
VNN2
vanin 2
chr19_+_18284619 38.150 IFI30
interferon, gamma-inducible protein 30
chr13_+_50069745 37.223 NM_001040443
PHF11
PHD finger protein 11
chr13_+_31309644 37.067 NM_001629
ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr13_-_41635072 36.583 ELF1
E74-like factor 1 (ets domain transcription factor)
chr7_-_139762339 36.473 PARP12
poly (ADP-ribose) polymerase family, member 12
chr11_-_57335080 36.279 NM_004223
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr1_-_27998719 35.613 NM_002038
NM_022872
NM_022873
IFI6


interferon, alpha-inducible protein 6


chr11_-_104972147 34.819 NM_001007232
NM_001223
NM_033292
NM_033293
NM_033294
NM_033295
CARD17
CASP1




caspase recruitment domain family, member 17
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)




chr10_+_91092238 34.775 NM_001031683
IFIT3
interferon-induced protein with tetratricopeptide repeats 3
chr12_-_10022457 34.482 NM_005127
CLEC2B
C-type lectin domain family 2, member B
chr6_+_26365397 34.460 NM_001197247
NM_001197249
NM_007047
NM_001197248
BTN3A2



butyrophilin, subfamily 3, member A2



chr1_-_27998700 33.425 IFI6
interferon, alpha-inducible protein 6
chr12_+_25205180 32.627 NM_001204126
NM_001204127
NM_006152
LRMP


lymphoid-restricted membrane protein


chr6_-_32821412 32.542 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr12_-_10021932 32.315 CLEC2B
C-type lectin domain family 2, member B
chr15_+_89182038 31.941 NM_002201
ISG20
interferon stimulated exonuclease gene 20kDa
chr13_+_31309690 31.916 ALOX5AP
arachidonate 5-lipoxygenase-activating protein
chr2_-_89442551 31.903 IGKC
IGK@
immunoglobulin kappa constant
immunoglobulin kappa locus
chr6_-_33282006 31.062 NM_003190
NM_172208
NM_172209
TAPBP


TAP binding protein (tapasin)


chr17_-_20370819 31.017 NM_001042685
LGALS9B
lectin, galactoside-binding, soluble, 9B
chr3_-_49851217 30.509 UBA7
ubiquitin-like modifier activating enzyme 7
chr1_-_27998658 30.346 IFI6
interferon, alpha-inducible protein 6
chr1_+_158801105 30.341 NM_002432
MNDA
myeloid cell nuclear differentiation antigen
chr6_-_31239489 29.859 HLA-B
HLA-C
major histocompatibility complex, class I, B
major histocompatibility complex, class I, C
chr17_+_25958217 29.593 LGALS9
lectin, galactoside-binding, soluble, 9
chr1_+_12227050 29.256 NM_001066
TNFRSF1B
tumor necrosis factor receptor superfamily, member 1B
chr13_-_46756295 29.161 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr10_+_91152321 29.047 NM_001548
IFIT1
interferon-induced protein with tetratricopeptide repeats 1
chr3_-_49851356 28.287 NM_003335
UBA7
ubiquitin-like modifier activating enzyme 7
chr19_+_10196757 28.217 NM_018381
C19orf66
chromosome 19 open reading frame 66
chr2_-_191878924 27.988 NM_007315
NM_139266
STAT1

signal transducer and activator of transcription 1, 91kDa

chr17_+_25958151 26.950 NM_002308
NM_009587
LGALS9

lectin, galactoside-binding, soluble, 9

chr17_+_25958192 26.941 LGALS9
lectin, galactoside-binding, soluble, 9
chr11_-_60719116 26.921 NM_016582
SLC15A3
solute carrier family 15, member 3
chr5_-_95158465 26.884 NM_001118890
NM_001243658
NM_001243659
NM_002064
GLRX



glutaredoxin (thioltransferase)



chr6_+_6588933 26.881 NM_004271
LY86
lymphocyte antigen 86
chr9_-_32526164 26.778 NM_014314
DDX58
DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
chr7_-_76829109 26.554 NM_006682
FGL2
fibrinogen-like 2
chr5_-_95158365 26.351 GLRX
glutaredoxin (thioltransferase)
chr3_+_122044010 26.176 NM_005213
CSTA
cystatin A (stefin A)
chr11_-_104839263 26.056 NM_001225
CASP4
caspase 4, apoptosis-related cysteine peptidase
chrX_+_37639246 25.630 NM_000397
CYBB
cytochrome b-245, beta polypeptide
chr5_+_96212167 25.345 ERAP2
endoplasmic reticulum aminopeptidase 2
chr19_-_47217576 25.176 NM_001079882
PRKD2
protein kinase D2
chr1_+_179051111 25.150 NM_022371
TOR3A
torsin family 3, member A
chr10_+_70847857 24.578 SRGN
serglycin
chr2_+_231280906 24.059 SP100
SP100 nuclear antigen
chr2_-_191878882 23.823 STAT1
signal transducer and activator of transcription 1, 91kDa
chr13_-_46756326 23.267 NM_002298
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr6_+_32605182 22.893 NM_002122
HLA-DQA1
major histocompatibility complex, class II, DQ alpha 1
chr21_+_42797977 22.501 NM_002462
NM_001178046
MX1

myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)

chr2_+_90077732 22.079


chr12_+_113344811 21.950 OAS1
2'-5'-oligoadenylate synthetase 1, 40/46kDa
chr6_+_25963398 21.534 TRIM38
tripartite motif containing 38
chr16_+_29831714 21.442 NM_005115
NM_017458
MVP

major vault protein

chr2_-_191878908 21.333 STAT1
signal transducer and activator of transcription 1, 91kDa
chrX_+_80457302 21.185 NM_003022
SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr1_-_154580481 21.145 ADAR
adenosine deaminase, RNA-specific
chr10_+_70847817 21.097 NM_002727
SRGN
serglycin
chr19_+_10196972 20.921 C19orf66
chromosome 19 open reading frame 66
chr6_+_26402464 20.905 NM_001145008
NM_001145009
NM_007048
NM_194441
BTN3A1



butyrophilin, subfamily 3, member A1



chr2_+_231191877 20.905 NM_138402
SP140L
SP140 nuclear body protein-like
chr17_+_6659155 20.761 NM_017523
NM_199139
XAF1

XIAP associated factor 1

chrX_+_37639306 20.745 CYBB
cytochrome b-245, beta polypeptide
chr12_+_6561176 20.507 NM_018009
TAPBPL
TAP binding protein-like
chr1_-_154580632 19.911 ADAR
adenosine deaminase, RNA-specific
chr12_+_94542239 19.896 NM_005761
PLXNC1
plexin C1
chr7_+_80267922 19.882 CD36
CD36 molecule (thrombospondin receptor)
chr1_-_154580677 19.811 NM_001111
NM_015840
NM_015841
ADAR


adenosine deaminase, RNA-specific


chr6_+_29794743 19.670 NM_002127
HLA-G
major histocompatibility complex, class I, G
chr12_+_113376301 19.595 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr2_-_191878883 19.037 STAT1
signal transducer and activator of transcription 1, 91kDa
chr5_+_49962920 18.958 PARP8
poly (ADP-ribose) polymerase family, member 8
chr6_-_33281847 18.957 TAPBP
TAP binding protein (tapasin)
chr1_+_174844655 18.948 NM_001035230
RABGAP1L
RAB GTPase activating protein 1-like
chr20_+_388941 18.917 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr18_+_48405426 18.715 NM_001168335
NM_002396
ME2

malic enzyme 2, NAD(+)-dependent, mitochondrial

chr16_+_29831755 18.605 MVP
major vault protein
chr6_-_31324955 18.580 HLA-B
major histocompatibility complex, class I, B
chr17_-_40264687 18.424 NM_024119
DHX58
DEXH (Asp-Glu-X-His) box polypeptide 58
chr1_+_158149736 18.385 NM_001766
CD1D
CD1d molecule
chr14_+_91580467 18.326 C14orf159
chromosome 14 open reading frame 159
chr14_+_91580967 18.222 NM_001102367
C14orf159
chromosome 14 open reading frame 159
chr13_+_53216564 18.092 HNRNPA1L2
heterogeneous nuclear ribonucleoprotein A1-like 2
chr17_+_18380097 18.041 NM_001040078
LGALS9B
LGALS9C
lectin, galactoside-binding, soluble, 9B
lectin, galactoside-binding, soluble, 9C
chr10_+_51572363 17.870 NM_005437
NCOA4
nuclear receptor coactivator 4
chr14_+_91580713 17.701 C14orf159
chromosome 14 open reading frame 159
chr11_-_4414887 17.629 NM_003141
TRIM21
tripartite motif containing 21
chr2_+_7017795 17.555 NM_080657
RSAD2
radical S-adenosyl methionine domain containing 2
chrX_+_80457559 17.550 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr9_-_97402556 17.235 FBP1
fructose-1,6-bisphosphatase 1
chr12_+_7055753 17.154 PTPN6
protein tyrosine phosphatase, non-receptor type 6
chr4_-_40517913 17.022 NM_019027
RBM47
RNA binding motif protein 47
chr1_-_225616556 16.939 NM_194442
LBR
lamin B receptor
chr1_-_89530890 16.934 NM_002053
GBP1
guanylate binding protein 1, interferon-inducible
chr14_-_100841793 16.825 WARS
tryptophanyl-tRNA synthetase
chr14_-_100841656 16.654 WARS
tryptophanyl-tRNA synthetase
chr7_-_150329285 16.628 GIMAP6
GTPase, IMAP family member 6
chr20_+_388717 16.386 RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr5_+_54398473 16.378 NM_006144
GZMA
granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
chr17_+_72462766 16.301 CD300A
CD300a molecule
chr6_+_87969619 16.271 ZNF292
zinc finger protein 292
chr9_-_97402530 16.270 NM_001127628
FBP1
fructose-1,6-bisphosphatase 1
chr2_-_231090443 16.123 NM_001185015
SP110
SP110 nuclear body protein
chr2_+_68592317 16.000 NM_002664
PLEK
pleckstrin
chr14_-_23284565 15.969 SLC7A7
solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
chr19_+_10197023 15.845 C19orf66
chromosome 19 open reading frame 66
chr2_-_55920947 15.704 NM_033109
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr12_+_113376226 15.631 NM_006187
OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr17_+_46908371 15.572 NM_005831
CALCOCO2
calcium binding and coiled-coil domain 2
chr16_+_2807490 15.508


chr1_-_149908759 15.451 NM_001145862
MTMR11
myotubularin related protein 11
chr10_+_11047274 15.329 CELF2
CUGBP, Elav-like family member 2
chr4_-_169239816 15.174 NM_017631
DDX60
DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
chr12_+_8276227 15.152 NM_016184
NM_194447
NM_194448
NM_194450
CLEC4A



C-type lectin domain family 4, member A



chr18_+_48405486 15.060 ME2
malic enzyme 2, NAD(+)-dependent, mitochondrial
chr4_+_8951476 14.661 NM_001040071
LOC650293
seven transmembrane helix receptor
chr14_+_73525267 14.555 RBM25
RNA binding motif protein 25
chr2_+_69001932 14.425 NM_001166276
NM_014882
ARHGAP25

Rho GTPase activating protein 25

chr13_-_46756291 14.401 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chrX_+_80457597 14.381 SH3BGRL
SH3 domain binding glutamic acid-rich protein like
chr22_+_39473009 14.364 NM_021822
APOBEC3G
apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
chr10_+_97515408 14.258 NM_001164178
NM_001164181
NM_001164179
NM_001164182
NM_001164183
NM_001776
ENTPD1





ectonucleoside triphosphate diphosphohydrolase 1





chr7_-_92747317 14.248 NM_001193307
NM_017654
SAMD9

sterile alpha motif domain containing 9

chr14_+_58711457 13.738 NM_002788
NM_152132
PSMA3

proteasome (prosome, macropain) subunit, alpha type, 3

chr8_+_96145942 13.660 NM_024613
PLEKHF2
pleckstrin homology domain containing, family F (with FYVE domain) member 2
chr2_+_69969105 13.646 NM_001153
ANXA4
annexin A4
chr11_+_1874199 13.640 NM_002339
LSP1
lymphocyte-specific protein 1
chr14_+_58711555 13.545 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr9_-_100881462 13.377 NM_014788
NM_033219
NM_033220
TRIM14


tripartite motif containing 14


chr14_+_58711599 13.356 PSMA3
proteasome (prosome, macropain) subunit, alpha type, 3
chr17_+_6659356 13.228 XAF1
XIAP associated factor 1
chr7_-_77045706 13.200 NM_017439
PION
pigeon homolog (Drosophila)
chr4_+_89300110 13.194 HERC6
hect domain and RLD 6
chr3_+_187086167 13.181 NM_022147
RTP4
receptor (chemosensory) transporter protein 4
chr8_+_95835517 13.149 NM_017864
INTS8
integrator complex subunit 8
chr1_+_36387788 13.073 EIF2C1
eukaryotic translation initiation factor 2C, 1
chr12_+_105501556 13.017


chr8_+_95835586 13.014 INTS8
integrator complex subunit 8
chr12_+_113376001 12.807 OAS3
2'-5'-oligoadenylate synthetase 3, 100kDa
chr17_-_80291639 12.758 SECTM1
secreted and transmembrane 1
chr6_-_24719286 12.726 NM_030939
C6orf62
chromosome 6 open reading frame 62
chr2_-_70475563 12.606 NM_022037
NM_022173
TIA1

TIA1 cytotoxic granule-associated RNA binding protein

chr9_-_100881515 12.600 TRIM14
tripartite motif containing 14
chr11_-_57335756 12.523 NM_198183
UBE2L6
ubiquitin-conjugating enzyme E2L 6
chr11_+_5646206 12.285 NM_021616
TRIM34
tripartite motif containing 34
chrX_+_123095555 12.270 NM_001042750
NM_001042751
NM_006603
STAG2


stromal antigen 2


chr22_-_36556781 12.201 NM_145640
APOL3
apolipoprotein L, 3
chr17_-_80291610 12.200 SECTM1
secreted and transmembrane 1
chr17_+_72462780 12.154 CD300A
CD300a molecule
chr1_-_149908721 12.130 MTMR11
myotubularin related protein 11
chr17_-_76778306 12.109 NM_004762
NM_017456
CYTH1

cytohesin 1

chr15_+_78832746 12.039 NM_001102667
NM_001102668
NM_002789
PSMA4


proteasome (prosome, macropain) subunit, alpha type, 4


chr14_+_73525302 11.973 RBM25
RNA binding motif protein 25
chr6_-_30181113 11.865 TRIM26
tripartite motif containing 26
chr7_+_80275634 11.842 NM_001127443
NM_001127444
CD36

CD36 molecule (thrombospondin receptor)

chr6_-_30181197 11.622 NM_001242783
NM_003449
TRIM26

tripartite motif containing 26

chr14_+_73525187 11.567 NM_021239
RBM25
RNA binding motif protein 25

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
3.03 9.91e-28 GO:0002376 immune system process
3.73 6.93e-27 GO:0006955 immune response
4.66 6.00e-21 GO:0045087 innate immune response
11.22 7.84e-19 GO:0034340 response to type I interferon
10.98 9.13e-18 GO:0060337 type I interferon-mediated signaling pathway
10.98 9.13e-18 GO:0071357 cellular response to type I interferon
3.05 2.05e-17 GO:0006952 defense response
1.97 2.59e-15 GO:0006950 response to stress
5.99 1.11e-14 GO:0009615 response to virus
5.41 1.70e-14 GO:0019221 cytokine-mediated signaling pathway
5.01 1.03e-13 GO:0071345 cellular response to cytokine stimulus
4.26 1.19e-13 GO:0034097 response to cytokine stimulus
1.24 1.36e-13 GO:0009987 cellular process
1.53 4.42e-12 GO:0043170 macromolecule metabolic process
3.24 7.46e-12 GO:0009607 response to biotic stimulus
1.56 4.37e-11 GO:0044260 cellular macromolecule metabolic process
2.49 1.88e-10 GO:0051704 multi-organism process
3.52 3.44e-10 GO:0044419 interspecies interaction between organisms
1.73 6.56e-10 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
3.25 1.91e-09 GO:0051707 response to other organism
1.40 2.04e-09 GO:0044237 cellular metabolic process
1.39 2.53e-09 GO:0044238 primary metabolic process
1.81 3.03e-09 GO:0090304 nucleic acid metabolic process
1.40 3.33e-09 GO:0050896 response to stimulus
2.70 4.85e-09 GO:0071310 cellular response to organic substance
1.64 4.90e-09 GO:0034641 cellular nitrogen compound metabolic process
1.34 6.20e-09 GO:0008152 metabolic process
1.62 6.79e-09 GO:0006807 nitrogen compound metabolic process
18.13 1.89e-07 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
26.18 2.12e-07 GO:0019883 antigen processing and presentation of endogenous antigen
2.45 3.64e-07 GO:0002682 regulation of immune system process
1.82 8.84e-07 GO:0016070 RNA metabolic process
13.09 1.50e-06 GO:0048002 antigen processing and presentation of peptide antigen
1.28 2.09e-06 GO:0065007 biological regulation
2.73 4.50e-06 GO:0050776 regulation of immune response
2.43 5.83e-06 GO:0009057 macromolecule catabolic process
2.55 7.85e-06 GO:0044265 cellular macromolecule catabolic process
2.11 9.08e-06 GO:0070887 cellular response to chemical stimulus
1.28 1.04e-05 GO:0050789 regulation of biological process
5.57 1.28e-05 GO:0034341 response to interferon-gamma
2.42 8.55e-05 GO:0016071 mRNA metabolic process
5.91 1.22e-04 GO:0060333 interferon-gamma-mediated signaling pathway
26.18 1.47e-04 GO:0002483 antigen processing and presentation of endogenous peptide antigen
26.18 1.47e-04 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
1.40 1.59e-04 GO:0051716 cellular response to stimulus
6.19 2.01e-04 GO:0019882 antigen processing and presentation
2.74 3.05e-04 GO:0044257 cellular protein catabolic process
5.39 4.17e-04 GO:0071346 cellular response to interferon-gamma
2.71 6.10e-04 GO:0051603 proteolysis involved in cellular protein catabolic process
1.79 6.52e-04 GO:0010033 response to organic substance
2.44 7.54e-04 GO:0002684 positive regulation of immune system process
1.62 9.30e-04 GO:0048583 regulation of response to stimulus
2.80 1.10e-03 GO:0050778 positive regulation of immune response
1.25 1.33e-03 GO:0050794 regulation of cellular process
2.57 1.44e-03 GO:0030163 protein catabolic process
1.85 1.79e-03 GO:0042981 regulation of apoptosis
1.84 2.05e-03 GO:0010941 regulation of cell death
1.94 2.09e-03 GO:0008219 cell death
1.84 2.41e-03 GO:0043067 regulation of programmed cell death
1.93 2.45e-03 GO:0016265 death
1.51 3.11e-03 GO:0048519 negative regulation of biological process
2.61 3.17e-03 GO:0031347 regulation of defense response
1.47 3.23e-03 GO:0048518 positive regulation of biological process
1.40 3.60e-03 GO:0007165 signal transduction
1.52 3.81e-03 GO:0042221 response to chemical stimulus
2.49 4.11e-03 GO:0034622 cellular macromolecular complex assembly
2.03 4.38e-03 GO:0065003 macromolecular complex assembly
10.18 4.66e-03 GO:0045069 regulation of viral genome replication
1.94 4.78e-03 GO:0048584 positive regulation of response to stimulus
1.99 5.58e-03 GO:0012501 programmed cell death
1.43 6.62e-03 GO:0019538 protein metabolic process
1.90 6.88e-03 GO:0043933 macromolecular complex subunit organization
2.22 7.72e-03 GO:0034621 cellular macromolecular complex subunit organization
1.98 8.04e-03 GO:0006915 apoptosis
2.52 9.21e-03 GO:0019941 modification-dependent protein catabolic process
2.17 9.72e-03 GO:0006974 response to DNA damage stimulus
2.51 1.05e-02 GO:0043632 modification-dependent macromolecule catabolic process
1.73 1.05e-02 GO:0044248 cellular catabolic process
4.31 1.57e-02 GO:0043900 regulation of multi-organism process
5.46 2.01e-02 GO:0032479 regulation of type I interferon production
2.11 2.32e-02 GO:0080134 regulation of response to stress
4.15 2.39e-02 GO:2000045 regulation of G1/S transition of mitotic cell cycle
3.67 2.47e-02 GO:0042770 signal transduction in response to DNA damage
1.56 2.90e-02 GO:0034645 cellular macromolecule biosynthetic process
1.44 3.40e-02 GO:0044267 cellular protein metabolic process
5.14 3.53e-02 GO:0051701 interaction with host
1.83 3.85e-02 GO:0006508 proteolysis
3.96 4.05e-02 GO:0030330 DNA damage response, signal transduction by p53 class mediator
2.64 4.16e-02 GO:0032269 negative regulation of cellular protein metabolic process
3.51 4.31e-02 GO:0071824 protein-DNA complex subunit organization
2.71 4.33e-02 GO:0002253 activation of immune response
1.54 4.56e-02 GO:0009059 macromolecule biosynthetic process
2.95 4.76e-02 GO:0045088 regulation of innate immune response
2.21 4.86e-02 GO:0016032 viral reproduction
2.40 4.88e-02 GO:0006511 ubiquitin-dependent protein catabolic process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.17 1.32e-07 GO:0005622 intracellular
1.17 1.66e-07 GO:0044424 intracellular part
1.24 1.42e-06 GO:0005737 cytoplasm
1.32 2.09e-05 GO:0005634 nucleus
1.20 7.40e-05 GO:0043227 membrane-bounded organelle
1.20 9.75e-05 GO:0043231 intracellular membrane-bounded organelle
2.14 1.43e-03 GO:0030529 ribonucleoprotein complex
9.17 1.54e-03 GO:0005839 proteasome core complex
1.47 4.94e-03 GO:0044428 nuclear part
1.14 8.45e-03 GO:0043226 organelle
1.14 9.71e-03 GO:0043229 intracellular organelle
1.46 1.10e-02 GO:0005829 cytosol
1.21 2.40e-02 GO:0044444 cytoplasmic part

Gene overrepresentation in function category:

enrichment   p-value GO term description
1.21 3.14e-13 GO:0005488 binding
1.38 1.15e-12 GO:0005515 protein binding
2.22 4.43e-07 GO:0003723 RNA binding
7.20 8.56e-05 GO:0003823 antigen binding
1.41 3.93e-04 GO:0003676 nucleic acid binding
8.73 3.64e-03 GO:0004298 threonine-type endopeptidase activity
8.73 3.64e-03 GO:0070003 threonine-type peptidase activity