Motif ID: IRF1,2,7.p3

Z-value: 3.215


Transcription factors associated with IRF1,2,7.p3:

Gene SymbolEntrez IDGene Name
IRF1 3659 interferon regulatory factor 1
IRF2 3660 interferon regulatory factor 2
IRF7 3665 interferon regulatory factor 7

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
IRF7chr11_-_6159200.824.1e-54Click!
IRF1chr5_-_1318264260.784.8e-45Click!
IRF2chr4_-_1853956160.668.8e-29Click!


Activity profile for motif IRF1,2,7.p3.

activity profile for motif IRF1,2,7.p3


Sorted Z-values histogram for motif IRF1,2,7.p3

Sorted Z-values for motif IRF1,2,7.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of IRF1,2,7.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr16_-_67970651 108.680 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr11_-_615920 105.788 IRF7
interferon regulatory factor 7
chr11_-_615998 105.474 NM_001572
NM_004029
 IRF7

interferon regulatory factor 7

chr16_-_67970734 97.954 NM_002801
 PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr21_+_42733916 97.843 NM_002463
 LOC100131190
MX2
uncharacterized LOC100131190
myxovirus (influenza virus) resistance 2 (mouse)
chr1_+_948846 83.627 NM_005101
 ISG15
ISG15 ubiquitin-like modifier
chr6_+_32821924 79.116 NM_002800
 PSMB9
proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2)
chr1_+_79086087 73.318 NM_006820
 IFI44L
interferon-induced protein 44-like
chr6_-_32812189 73.104 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr6_-_32811773 67.441 NM_148919
 PSMB8
proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)
chr1_+_158979681 67.407 NM_001206567
NM_005531
 IFI16

interferon, gamma-inducible protein 16

chr21_+_42792441 67.145 NM_001144925
 MX1
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)
chr2_-_152146133 65.260 NMI
N-myc (and STAT) interactor
chr11_+_5710816 64.311 NM_001199573
NM_006074
 TRIM22

tripartite motif containing 22

chr1_+_174843523 62.452 NM_001243763
 RABGAP1L
RAB GTPase activating protein 1-like
chr11_-_615649 62.141 NM_004031
 IRF7
interferon regulatory factor 7
chr2_-_152146373 57.928 NM_004688
 NMI
N-myc (and STAT) interactor
chr11_+_63304272 53.594 NM_004585
 RARRES3
retinoic acid receptor responder (tazarotene induced) 3
chr7_+_74188308 52.785 NM_000265
 NCF1
NCF1B
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
chr6_-_32821743 52.278 NM_000593
 TAP1
transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 95 entries
enrichment   p-value GO term description
26.18 2.12e-07 GO:0019883 antigen processing and presentation of endogenous antigen
26.18 1.47e-04 GO:0002483 antigen processing and presentation of endogenous peptide antigen
26.18 1.47e-04 GO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I
18.13 1.89e-07 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
13.09 1.50e-06 GO:0048002 antigen processing and presentation of peptide antigen
11.22 7.84e-19 GO:0034340 response to type I interferon
10.98 9.13e-18 GO:0060337 type I interferon-mediated signaling pathway
10.98 9.13e-18 GO:0071357 cellular response to type I interferon
10.18 4.66e-03 GO:0045069 regulation of viral genome replication
6.19 2.01e-04 GO:0019882 antigen processing and presentation
5.99 1.11e-14 GO:0009615 response to virus
5.91 1.22e-04 GO:0060333 interferon-gamma-mediated signaling pathway
5.57 1.28e-05 GO:0034341 response to interferon-gamma
5.46 2.01e-02 GO:0032479 regulation of type I interferon production
5.41 1.70e-14 GO:0019221 cytokine-mediated signaling pathway
5.39 4.17e-04 GO:0071346 cellular response to interferon-gamma
5.14 3.53e-02 GO:0051701 interaction with host
5.01 1.03e-13 GO:0071345 cellular response to cytokine stimulus
4.66 6.00e-21 GO:0045087 innate immune response
4.31 1.57e-02 GO:0043900 regulation of multi-organism process

Gene overrepresentation in compartment category:

Showing 1 to 13 of 13 entries
enrichment   p-value GO term description
9.17 1.54e-03 GO:0005839 proteasome core complex
2.14 1.43e-03 GO:0030529 ribonucleoprotein complex
1.47 4.94e-03 GO:0044428 nuclear part
1.46 1.10e-02 GO:0005829 cytosol
1.32 2.09e-05 GO:0005634 nucleus
1.24 1.42e-06 GO:0005737 cytoplasm
1.21 2.40e-02 GO:0044444 cytoplasmic part
1.20 7.40e-05 GO:0043227 membrane-bounded organelle
1.20 9.75e-05 GO:0043231 intracellular membrane-bounded organelle
1.17 1.32e-07 GO:0005622 intracellular
1.17 1.66e-07 GO:0044424 intracellular part
1.14 8.45e-03 GO:0043226 organelle
1.14 9.71e-03 GO:0043229 intracellular organelle

Gene overrepresentation in function category:

Showing 1 to 7 of 7 entries
enrichment   p-value GO term description
8.73 3.64e-03 GO:0004298 threonine-type endopeptidase activity
8.73 3.64e-03 GO:0070003 threonine-type peptidase activity
7.20 8.56e-05 GO:0003823 antigen binding
2.22 4.43e-07 GO:0003723 RNA binding
1.41 3.93e-04 GO:0003676 nucleic acid binding
1.38 1.15e-12 GO:0005515 protein binding
1.21 3.14e-13 GO:0005488 binding