Motif ID: KLF12.p2

Z-value: 3.542


Transcription factors associated with KLF12.p2:

Gene SymbolEntrez IDGene Name
KLF12 11278 Kruppel-like factor 12

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF12chr13_-_747083610.624.1e-24Click!


Activity profile for motif KLF12.p2.

activity profile for motif KLF12.p2


Sorted Z-values histogram for motif KLF12.p2

Sorted Z-values for motif KLF12.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF12.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr9_+_139871954 89.293 NM_000954
 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr12_+_79258517 82.728 SYT1
synaptotagmin I
chr12_+_79258588 74.338 SYT1
synaptotagmin I
chr12_+_79258448 68.987 NM_005639
 SYT1
synaptotagmin I
chr2_+_203499819 67.296 NM_173511
 FAM117B
family with sequence similarity 117, member B
chr7_+_64498643 58.727 CCT6P3
chaperonin containing TCP1, subunit 6 (zeta) pseudogene 3
chr1_+_6845381 52.896 NM_001195563
NM_001242701
NM_015215
 CAMTA1


calmodulin binding transcription activator 1


chr21_-_48024985 50.461 NM_006272
 S100B
S100 calcium binding protein B
chr9_+_139872014 50.002 PTGDS
prostaglandin D2 synthase 21kDa (brain)
chr10_-_32636134 49.588 EPC1
enhancer of polycomb homolog 1 (Drosophila)
chr5_+_175792444 48.829 NM_173664
 ARL10
ADP-ribosylation factor-like 10
chr17_+_1665342 48.635 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1665281 47.628 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr17_+_1665306 47.019 SERPINF1
serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
chr9_-_133454818 44.648 LOC100272217
uncharacterized LOC100272217
chr5_+_137801166 43.910 EGR1
early growth response 1
chr11_+_62475165 43.431 GNG3
guanine nucleotide binding protein (G protein), gamma 3
chr17_+_38119225 43.062 NM_178171
 GSDMA
gasdermin A
chr8_-_27115935 42.977 STMN4
stathmin-like 4
chr5_+_137801178 42.681 NM_001964
 EGR1
early growth response 1

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 191 entries
enrichment   p-value GO term description
3.43 3.99e-03 GO:0071396 cellular response to lipid
2.74 1.26e-02 GO:0003014 renal system process
2.65 1.48e-02 GO:0060349 bone morphogenesis
2.50 7.61e-03 GO:0033993 response to lipid
2.45 8.05e-03 GO:0060348 bone development
2.36 8.51e-03 GO:0034339 regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor
2.16 1.73e-02 GO:0010721 negative regulation of cell development
2.11 1.97e-05 GO:0048705 skeletal system morphogenesis
2.11 6.73e-04 GO:0051924 regulation of calcium ion transport
1.98 1.64e-03 GO:0010959 regulation of metal ion transport
1.95 3.63e-02 GO:0045761 regulation of adenylate cyclase activity
1.93 2.94e-02 GO:0001822 kidney development
1.89 6.24e-03 GO:0034329 cell junction assembly
1.87 2.69e-03 GO:0034330 cell junction organization
1.87 2.69e-03 GO:0043269 regulation of ion transport
1.86 9.50e-03 GO:0007187 G-protein signaling, coupled to cyclic nucleotide second messenger
1.83 9.77e-09 GO:0007411 axon guidance
1.83 1.10e-05 GO:0030168 platelet activation
1.83 2.95e-02 GO:0030111 regulation of Wnt receptor signaling pathway
1.82 7.59e-03 GO:0019935 cyclic-nucleotide-mediated signaling

Gene overrepresentation in compartment category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
2.65 3.08e-02 GO:0034704 calcium channel complex
2.64 1.30e-03 GO:0043679 axon terminus
2.52 3.81e-03 GO:0044306 neuron projection terminus
2.27 1.30e-04 GO:0033267 axon part
2.11 1.28e-03 GO:0030139 endocytic vesicle
1.91 4.40e-06 GO:0030424 axon
1.76 2.25e-04 GO:0030425 dendrite
1.71 3.25e-02 GO:0034703 cation channel complex
1.70 3.29e-03 GO:0044297 cell body
1.68 4.17e-08 GO:0043005 neuron projection
1.67 1.12e-02 GO:0043025 neuronal cell body
1.66 1.13e-07 GO:0045202 synapse
1.65 3.44e-05 GO:0044456 synapse part
1.59 1.30e-02 GO:0034702 ion channel complex
1.53 6.44e-17 GO:0005887 integral to plasma membrane
1.52 9.49e-17 GO:0031226 intrinsic to plasma membrane
1.51 1.68e-02 GO:0012506 vesicle membrane
1.49 4.47e-02 GO:0030659 cytoplasmic vesicle membrane
1.48 1.10e-02 GO:0044433 cytoplasmic vesicle part
1.47 1.35e-08 GO:0005626 insoluble fraction

Gene overrepresentation in function category:

Showing 1 to 20 of 30 entries
enrichment   p-value GO term description
2.54 4.95e-04 GO:0003707 steroid hormone receptor activity
2.49 5.34e-04 GO:0004879 ligand-dependent nuclear receptor activity
2.25 3.75e-04 GO:0005262 calcium channel activity
2.03 4.17e-02 GO:0005200 structural constituent of cytoskeleton
1.96 4.25e-02 GO:0019199 transmembrane receptor protein kinase activity
1.87 1.02e-03 GO:0005516 calmodulin binding
1.79 5.26e-03 GO:0022843 voltage-gated cation channel activity
1.64 3.96e-04 GO:0005261 cation channel activity
1.62 7.31e-12 GO:0043565 sequence-specific DNA binding
1.62 3.27e-02 GO:0005244 voltage-gated ion channel activity
1.62 3.27e-02 GO:0022832 voltage-gated channel activity
1.58 7.11e-04 GO:0022836 gated channel activity
1.56 1.96e-14 GO:0001071 nucleic acid binding transcription factor activity
1.56 1.96e-14 GO:0003700 sequence-specific DNA binding transcription factor activity
1.52 2.89e-04 GO:0015267 channel activity
1.51 3.36e-04 GO:0022803 passive transmembrane transporter activity
1.49 2.05e-03 GO:0005216 ion channel activity
1.48 2.75e-03 GO:0022838 substrate-specific channel activity
1.45 4.31e-03 GO:0042803 protein homodimerization activity
1.41 2.18e-04 GO:0046983 protein dimerization activity