Motif ID: KLF4.p3

Z-value: 2.485


Transcription factors associated with KLF4.p3:

Gene SymbolEntrez IDGene Name
KLF4 9314 Kruppel-like factor 4 (gut)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
KLF4chr9_-_1102520450.186.5e-03Click!


Activity profile for motif KLF4.p3.

activity profile for motif KLF4.p3


Sorted Z-values histogram for motif KLF4.p3

Sorted Z-values for motif KLF4.p3



Network of associatons between targets according to the STRING database.



First level regulatory network of KLF4.p3

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr19_-_50143350 54.215 NM_006270
 RRAS
related RAS viral (r-ras) oncogene homolog
chr12_-_109125275 54.109 CORO1C
coronin, actin binding protein, 1C
chr11_-_64014140 49.023 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr12_-_109125289 48.163 NM_014325
 CORO1C
coronin, actin binding protein, 1C
chr6_-_4135701 47.450 NM_001166010
NM_006117
NM_206836
 ECI2


enoyl-CoA delta isomerase 2


chr4_-_71705545 45.598 GRSF1
G-rich RNA sequence binding factor 1
chrX_-_153599581 45.028 FLNA
filamin A, alpha
chr22_-_36784001 42.900 MYH9
myosin, heavy chain 9, non-muscle
chr12_-_109125254 41.934 CORO1C
coronin, actin binding protein, 1C
chrX_-_152989822 40.426 NM_005745
 BCAP31
B-cell receptor-associated protein 31
chr8_+_26149080 37.354 PPP2R2A
protein phosphatase 2, regulatory subunit B, alpha
chr19_+_54695103 37.290 NM_001077446
 TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chrX_-_152989851 36.965 BCAP31
B-cell receptor-associated protein 31
chr22_-_36783851 36.581 MYH9
myosin, heavy chain 9, non-muscle
chr11_-_64014264 36.175 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr19_+_54694118 35.504 NM_024075
 TSEN34
tRNA splicing endonuclease 34 homolog (S. cerevisiae)
chr11_-_64014407 34.763 NM_138689
 PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr20_+_56884839 33.258 RAB22A
RAB22A, member RAS oncogene family
chr22_-_36783977 32.144 MYH9
myosin, heavy chain 9, non-muscle
chr11_+_65686908 31.868 DRAP1
DR1-associated protein 1 (negative cofactor 2 alpha)

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 286 entries
enrichment   p-value GO term description
2.03 1.04e-04 GO:0031346 positive regulation of cell projection organization
1.87 3.04e-03 GO:0008629 induction of apoptosis by intracellular signals
1.86 4.36e-02 GO:0030518 steroid hormone receptor signaling pathway
1.82 8.25e-03 GO:0048872 homeostasis of number of cells
1.80 9.77e-05 GO:0007265 Ras protein signal transduction
1.79 1.16e-03 GO:0010720 positive regulation of cell development
1.79 2.77e-02 GO:0050769 positive regulation of neurogenesis
1.77 1.58e-02 GO:0030099 myeloid cell differentiation
1.74 9.35e-06 GO:0031400 negative regulation of protein modification process
1.74 2.13e-03 GO:0042770 signal transduction in response to DNA damage
1.71 2.08e-02 GO:0043523 regulation of neuron apoptosis
1.66 1.18e-02 GO:0043254 regulation of protein complex assembly
1.63 1.07e-06 GO:0072523 purine-containing compound catabolic process
1.63 1.69e-06 GO:0006195 purine nucleotide catabolic process
1.61 1.23e-02 GO:0006184 GTP catabolic process
1.60 4.27e-05 GO:0009261 ribonucleotide catabolic process
1.60 4.98e-05 GO:0009154 purine ribonucleotide catabolic process
1.59 9.28e-03 GO:0046039 GTP metabolic process
1.59 1.72e-02 GO:0016311 dephosphorylation
1.58 1.51e-04 GO:0009203 ribonucleoside triphosphate catabolic process

Gene overrepresentation in compartment category:

Showing 1 to 20 of 65 entries
enrichment   p-value GO term description
2.81 5.78e-04 GO:0030530 heterogeneous nuclear ribonucleoprotein complex
2.03 2.34e-02 GO:0000118 histone deacetylase complex
2.01 2.15e-02 GO:0008287 protein serine/threonine phosphatase complex
1.94 3.55e-02 GO:0017053 transcriptional repressor complex
1.86 2.59e-03 GO:0034399 nuclear periphery
1.84 1.18e-02 GO:0016363 nuclear matrix
1.74 2.65e-03 GO:0016585 chromatin remodeling complex
1.66 9.70e-03 GO:0005925 focal adhesion
1.64 2.16e-04 GO:0005912 adherens junction
1.61 1.49e-04 GO:0070161 anchoring junction
1.61 1.79e-02 GO:0030055 cell-substrate junction
1.61 2.44e-02 GO:0005924 cell-substrate adherens junction
1.48 3.50e-05 GO:0015629 actin cytoskeleton
1.47 1.90e-03 GO:0016604 nuclear body
1.45 2.12e-03 GO:0005635 nuclear envelope
1.44 2.68e-05 GO:0048471 perinuclear region of cytoplasm
1.44 4.20e-03 GO:0000785 chromatin
1.42 1.11e-35 GO:0005829 cytosol
1.42 4.08e-21 GO:0005654 nucleoplasm
1.38 1.17e-08 GO:0044451 nucleoplasm part

Gene overrepresentation in function category:

Showing 1 to 20 of 41 entries
enrichment   p-value GO term description
1.84 1.45e-03 GO:0031625 ubiquitin protein ligase binding
1.54 4.34e-04 GO:0003924 GTPase activity
1.53 3.15e-02 GO:0003714 transcription corepressor activity
1.52 4.57e-17 GO:0019899 enzyme binding
1.50 6.19e-04 GO:0046982 protein heterodimerization activity
1.50 3.42e-02 GO:0004721 phosphoprotein phosphatase activity
1.47 1.98e-06 GO:0000988 protein binding transcription factor activity
1.47 1.98e-06 GO:0000989 transcription factor binding transcription factor activity
1.47 2.96e-06 GO:0003712 transcription cofactor activity
1.46 2.85e-11 GO:0046983 protein dimerization activity
1.45 3.32e-02 GO:0010843 promoter binding
1.44 2.36e-06 GO:0019904 protein domain specific binding
1.44 3.46e-02 GO:0000975 regulatory region DNA binding
1.44 3.46e-02 GO:0001067 regulatory region nucleic acid binding
1.44 3.46e-02 GO:0044212 transcription regulatory region DNA binding
1.43 2.92e-02 GO:0003713 transcription coactivator activity
1.40 4.37e-02 GO:0019900 kinase binding
1.39 1.46e-04 GO:0042803 protein homodimerization activity
1.35 1.05e-02 GO:0005525 GTP binding
1.34 1.39e-06 GO:0042802 identical protein binding