Motif ID: LEF1_TCF7_TCF7L1,2.p2

Z-value: 1.525


Transcription factors associated with LEF1_TCF7_TCF7L1,2.p2:

Gene SymbolEntrez IDGene Name
LEF1 51176 lymphoid enhancer-binding factor 1
TCF7 6932 transcription factor 7 (T-cell specific, HMG-box)
TCF7L1 83439 transcription factor 7-like 1 (T-cell specific, HMG-box)
TCF7L2 6934 transcription factor 7-like 2 (T-cell specific, HMG-box)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TCF7L1chr2_+_853603730.551.4e-18Click!
TCF7L2chr10_+_1147107850.211.6e-03Click!
LEF1chr4_-_109087876-0.186.3e-03Click!
TCF7chr5_+_133451297-0.188.3e-03Click!


Activity profile for motif LEF1_TCF7_TCF7L1,2.p2.

activity profile for motif LEF1_TCF7_TCF7L1,2.p2


Sorted Z-values histogram for motif LEF1_TCF7_TCF7L1,2.p2

Sorted Z-values for motif LEF1_TCF7_TCF7L1,2.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of LEF1_TCF7_TCF7L1,2.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr12_-_91573264 22.838 NM_133503
DCN
decorin
chr9_+_74526527 22.391 C9orf85
chromosome 9 open reading frame 85
chr11_-_117747331 20.993 FXYD6
FXYD domain containing ion transport regulator 6
chr12_-_16759939 19.566 NM_001243613
LMO3
LIM domain only 3 (rhombotin-like 2)
chr13_+_111137249 19.140 COL4A2
collagen, type IV, alpha 2
chr17_-_42992852 18.401 NM_001131019
NM_001242376
NM_002055
GFAP


glial fibrillary acidic protein


chr12_-_16759531 18.146 NM_018640
LMO3
LIM domain only 3 (rhombotin-like 2)
chr18_+_21572736 18.123 NM_153211
TTC39C
tetratricopeptide repeat domain 39C
chr10_+_7745341 17.826 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr7_+_94023872 17.140 NM_000089
COL1A2
collagen, type I, alpha 2
chr4_-_5894695 16.129 NM_001014809
CRMP1
collapsin response mediator protein 1
chr13_+_111134933 14.690 COL4A2
collagen, type IV, alpha 2
chr7_+_94024201 14.491 COL1A2
collagen, type I, alpha 2
chr1_-_182361311 14.089 NM_001033044
NM_002065
GLUL

glutamate-ammonia ligase

chr8_+_80523048 13.654 NM_001199214
NM_007029
STMN2

stathmin-like 2

chr10_+_7745354 13.588 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745325 13.274 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr6_+_7108864 13.053 RREB1
ras responsive element binding protein 1
chr12_-_16759430 12.971 LMO3
LIM domain only 3 (rhombotin-like 2)
chr8_-_22089517 12.966 PHYHIP
phytanoyl-CoA 2-hydroxylase interacting protein

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 49 entries
enrichment   p-value GO term description
3.16 4.54e-03 GO:0007586 digestion
3.02 2.46e-04 GO:0007156 homophilic cell adhesion
2.30 5.33e-05 GO:0007411 axon guidance
2.09 1.78e-04 GO:0007409 axonogenesis
2.06 2.05e-04 GO:0048812 neuron projection morphogenesis
2.06 2.62e-04 GO:0048667 cell morphogenesis involved in neuron differentiation
2.05 4.08e-05 GO:0048858 cell projection morphogenesis
2.03 5.76e-05 GO:0032990 cell part morphogenesis
2.01 1.50e-03 GO:0016477 cell migration
2.00 1.04e-04 GO:0006935 chemotaxis
2.00 1.04e-04 GO:0042330 taxis
1.98 8.33e-07 GO:0030182 neuron differentiation
1.97 9.21e-09 GO:0048699 generation of neurons
1.96 5.75e-04 GO:0031175 neuron projection development
1.95 6.89e-09 GO:0022008 neurogenesis
1.94 5.38e-05 GO:0000902 cell morphogenesis
1.91 1.86e-03 GO:0000904 cell morphogenesis involved in differentiation
1.90 6.20e-03 GO:0048870 cell motility
1.90 6.20e-03 GO:0051674 localization of cell
1.88 5.73e-07 GO:0040011 locomotion

Gene overrepresentation in compartment category:

Showing 1 to 11 of 11 entries
enrichment   p-value GO term description
2.63 1.39e-02 GO:0044420 extracellular matrix part
1.92 3.92e-08 GO:0005615 extracellular space
1.91 5.59e-11 GO:0044421 extracellular region part
1.80 2.55e-02 GO:0031012 extracellular matrix
1.50 3.48e-02 GO:0005626 insoluble fraction
1.48 2.22e-03 GO:0005887 integral to plasma membrane
1.46 3.92e-06 GO:0005576 extracellular region
1.46 3.37e-03 GO:0031226 intrinsic to plasma membrane
1.42 1.55e-05 GO:0044459 plasma membrane part
1.24 8.64e-04 GO:0005886 plasma membrane
1.23 1.78e-03 GO:0071944 cell periphery

Gene overrepresentation in function category:

Showing 1 to 4 of 4 entries
enrichment   p-value GO term description
6.19 3.33e-02 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
3.01 2.04e-02 GO:0005201 extracellular matrix structural constituent
1.62 1.64e-02 GO:0005509 calcium ion binding
1.50 1.27e-02 GO:0005102 receptor binding